LOCUS       NM_030834               2118 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 16 member 3 (Slc16a3),
            mRNA.
ACCESSION   NM_030834
VERSION     NM_030834.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2118)
  AUTHORS   Ahmadi,A., Sheikholeslami-Vatani,D., Ghaeeni,S. and Baazm,M.
  TITLE     The effects of different training modalities on monocarboxylate
            transporters MCT1 and MCT4, hypoxia inducible factor-1alpha
            (HIF-1alpha), and PGC-1alpha gene expression in rat skeletal
            muscles
  JOURNAL   Mol Biol Rep 48 (3), 2153-2161 (2021)
   PUBMED   33625690
  REMARK    GeneRIF: The effects of different training modalities on
            monocarboxylate transporters MCT1 and MCT4, hypoxia inducible
            factor-1alpha (HIF-1alpha), and PGC-1alpha gene expression in rat
            skeletal muscles.
REFERENCE   2  (bases 1 to 2118)
  AUTHORS   Elizondo-Vega,R., Oyarce,K., Salgado,M., Barahona,M.J., Recabal,A.,
            Ordenes,P., Lopez,S., Pincheira,R., Luz-Crawford,P. and
            Garcia-Robles,M.A.
  TITLE     Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects
            Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide
            Expressions
  JOURNAL   Mol Neurobiol 57 (2), 896-909 (2020)
   PUBMED   31578706
  REMARK    GeneRIF: Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions
            Affects Food Intake and Alters Orexigenic and Anorexigenic
            Neuropeptide Expressions.
REFERENCE   3  (bases 1 to 2118)
  AUTHORS   Bisetto,S., Wright,M.C., Nowak,R.A., Lepore,A.C., Khurana,T.S.,
            Loro,E. and Philp,N.J.
  TITLE     New Insights into the Lactate Shuttle: Role of MCT4 in the
            Modulation of the Exercise Capacity
  JOURNAL   iScience 22, 507-518 (2019)
   PUBMED   31837519
REFERENCE   4  (bases 1 to 2118)
  AUTHORS   Cao,J., Ng,M. and Felmlee,M.A.
  TITLE     Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter
            Expression and Membrane Trafficking
  JOURNAL   J Pharm Pharm Sci 20 (1), 435-444 (2017)
   PUBMED   29249221
  REMARK    GeneRIF: The MCT4 membrane expression varied with estrous cycle
            stage with expression significantly lower than males. MCT4 membrane
            expression in OVX females was also lower than males, suggesting
            that androgens play a role in membrane expression of MCT4.
REFERENCE   5  (bases 1 to 2118)
  AUTHORS   Takahashi,T., Friedmacher,F., Zimmer,J. and Puri,P.
  TITLE     Decreased expression of monocarboxylate transporter 1 and 4 in the
            branching airway epithelium of nitrofen-induced congenital
            diaphragmatic hernia
  JOURNAL   J Pediatr Surg 51 (6), 896-899 (2016)
   PUBMED   26996590
  REMARK    GeneRIF: Decreased expression of MCT1/4 in distal airway epithelium
            may disrupt lung branching morphogenesis and thus contribute to the
            development of pulmonary hypoplasia in the nitrofen-induced
            congenital diaphragmatic hernia model.
REFERENCE   6  (bases 1 to 2118)
  AUTHORS   Wilson,M.C., Meredith,D., Fox,J.E., Manoharan,C., Davies,A.J. and
            Halestrap,A.P.
  TITLE     Basigin (CD147) is the target for organomercurial inhibition of
            monocarboxylate transporter isoforms 1 and 4: the ancillary protein
            for the insensitive MCT2 is EMBIGIN (gp70)
  JOURNAL   J Biol Chem 280 (29), 27213-27221 (2005)
   PUBMED   15917240
REFERENCE   7  (bases 1 to 2118)
  AUTHORS   Bergersen,L., Waerhaug,O., Helm,J., Thomas,M., Laake,P.,
            Davies,A.J., Wilson,M.C., Halestrap,A.P. and Ottersen,O.P.
  TITLE     A novel postsynaptic density protein: the monocarboxylate
            transporter MCT2 is co-localized with delta-glutamate receptors in
            postsynaptic densities of parallel fiber-Purkinje cell synapses
  JOURNAL   Exp Brain Res 136 (4), 523-534 (2001)
   PUBMED   11291733
REFERENCE   8  (bases 1 to 2118)
  AUTHORS   Dimmer,K.S., Friedrich,B., Lang,F., Deitmer,J.W. and Broer,S.
  TITLE     The low-affinity monocarboxylate transporter MCT4 is adapted to the
            export of lactate in highly glycolytic cells
  JOURNAL   Biochem J 350 Pt 1 (Pt 1), 219-227 (2000)
   PUBMED   10926847
REFERENCE   9  (bases 1 to 2118)
  AUTHORS   Kirk,P., Wilson,M.C., Heddle,C., Brown,M.H., Barclay,A.N. and
            Halestrap,A.P.
  TITLE     CD147 is tightly associated with lactate transporters MCT1 and MCT4
            and facilitates their cell surface expression
  JOURNAL   EMBO J 19 (15), 3896-3904 (2000)
   PUBMED   10921872
REFERENCE   10 (bases 1 to 2118)
  AUTHORS   Wilson,M.C., Jackson,V.N., Heddle,C., Price,N.T., Pilegaard,H.,
            Juel,C., Bonen,A., Montgomery,I., Hutter,O.F. and Halestrap,A.P.
  TITLE     Lactic acid efflux from white skeletal muscle is catalyzed by the
            monocarboxylate transporter isoform MCT3
  JOURNAL   J Biol Chem 273 (26), 15920-15926 (1998)
   PUBMED   9632638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U87627.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U87627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2118
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..2118
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; MCT4"
                     /note="solute carrier family 16 member 3"
                     /db_xref="GeneID:80878"
                     /db_xref="RGD:620603"
     exon            1..68
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; MCT4"
                     /inference="alignment:Splign:2.1.0"
     exon            69..312
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; MCT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1505
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; MCT4"
                     /note="MCT 3; MCT 4; monocarboxylate transporter 3; solute
                     carrier family 16 (monocarboxylic acid transporters),
                     member 3; solute carrier family 16 (monocarboxylate
                     transporter), member 3; solute carrier family 16, member 3
                     (monocarboxylic acid transporter 4)"
                     /codon_start=1
                     /product="monocarboxylate transporter 4"
                     /protein_id="NP_110461.1"
                     /db_xref="GeneID:80878"
                     /db_xref="RGD:620603"
                     /translation="MGGAVVDEGPTGIKAPDGGWGWAVLFGCFIITGFSYAFPKAVSV
                     FFKELMHEFGIGYSDTAWISSILLAMLYGTGPLCSMCVNRFGCRPVMLVGGLFASLGM
                     VAASFCRSIIQIYLTTGVITGLGLALNFQPSLIMLNRYFNKRRPMANGLAAAGSPVFL
                     CALSPLGQLLQDHYGWRGGFLILGGLLLNCCVCAALMRPLVAPQASGGAEPHGPQRPS
                     PRLLDLSVFRDRGFLIYAVAASIMVLGLFVPPVFVVSYAKDMGVPDTKAAFLLTILGF
                     IDIFARPTAGFITGLKKVRPYSVYLFSFAMFFNGFTDLTGSTASDYGGLVVFCIFFGI
                     SYGMVGALQFEVLMAIVGTQKFSSAIGLVLLLEAVAVLIGPPSGGKLLDATKVYKYVF
                     ILAGAEVLTSSLVLLLGNFFCIGKRKRPEVTKPEEVASEEEKLHKPPVDVRVDSREVE
                     HFLKAEPEKNGEVVHTPETSV"
     exon            313..456
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; MCT4"
                     /inference="alignment:Splign:2.1.0"
     exon            457..1224
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; MCT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..2118
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; MCT4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggatgagca gtgactactc gtacaccgct aggatgttgg gcaaaggggc actgatgaca
       61 ctaccaaggt gaaaccagcc ctcctggcca tgggaggagc tgtggtggac gagggtccca
      121 ccggcatcaa ggcccccgat gggggctggg gctgggccgt cctctttggc tgtttcatca
      181 tcacgggctt ctcctatgcc ttccccaaag cggtcagtgt ttttttcaag gagctcatgc
      241 atgagtttgg gattggctac agcgacacag cttggatctc ctccatcctg ctggctatgc
      301 tgtatggcac aggcccactc tgcagtatgt gtgtgaaccg ctttggctgc cggcccgtca
      361 tgcttgtggg tggcctcttt gcgtccctgg ggatggtggc tgcatccttc tgcagaagca
      421 ttatccagat ctacctcacc acaggggtca tcactggctt gggtctggct ctcaacttcc
      481 agccctccct catcatgctc aatcgatact tcaacaagcg ccgccctatg gccaatgggc
      541 tggcagcagc aggcagtccc gtgttccttt gtgcactgtc tccactgggg cagctgctgc
      601 aggaccacta tggctggcgg ggtggcttcc tcatcctggg aggcctgctg ctcaactgct
      661 gcgtgtgtgc tgcactcatg agaccactgg tagcacccca ggcgagtgga ggggctgagc
      721 cccatggacc ccagcggccg tctccgcgcc tgctagacct gagtgtcttc cgagaccgtg
      781 gcttcctcat ctatgctgtg gctgcctcaa tcatggtgct ggggctcttt gtgcctccgg
      841 tctttgtggt gagctatgct aaggatatgg gtgtgcctga cacaaaggct gccttccttc
      901 tcaccatcct gggcttcatc gacatctttg ccaggcccac ggcaggtttc ataacagggc
      961 tcaagaaggt gcggccctac tctgtctacc tcttcagctt tgccatgttc ttcaatggct
     1021 tcactgacct gacaggctcc acggccagtg actacggtgg cctggtggtc ttttgcatct
     1081 tctttgggat ctcgtatggc atggtgggag cgctacagtt tgaggtgctc atggctatcg
     1141 tgggcactca aaagttctcc agtgccattg gtctcgtgct gctgttagag gctgtggctg
     1201 tgctcatcgg acccccatca ggaggcaagc tgctggacgc aacgaaagtt tacaagtatg
     1261 tgttcatcct ggcgggggct gaggtgctca cctcctccct tgtgctgctg ctgggcaact
     1321 tcttctgcat cgggaagagg aagaggcccg aggtgacaaa gcctgaggag gtggcctcag
     1381 aggaggagaa gctccacaag ccccctgtgg acgtgagggt ggactcgagg gaggtggagc
     1441 acttcctgaa ggcagagcct gagaaaaacg gggaggtggt tcataccccg gaaaccagcg
     1501 tgtgagcggc ctggccgggc gggcagggag cagggaagag gtccagagac tggcaacgct
     1561 catatttatt tcacaaacag gaccagctga ggcggggcca tcggctcagc tcttggctgc
     1621 ctggtcagcg ggtcagtgtt ttgcggggag aggtggcggg gtgggaaccg cgtcattcca
     1681 aagtggatct gcggtgaagc caaggaagcc ccacagttac cagccgccta taaccaggga
     1741 cccagcctgc tgagcccaag cagcctgtgg ctcccccgcc cccaccactg tggccaagga
     1801 cctagaaacc cacacttagg agacaacacg actttaatca gagggcaggg ctgggacagg
     1861 ctggcaggtg ggcactgcct gcagggtcct ccctgatccc caccatccta cccccaactt
     1921 cagccccagt ctcctatatt gccaatcctc catatctctg tctaggggac aaagaactcc
     1981 ttctacctga gaaggcagag atagacatct ctgtgggagg atcaccaaag ggcctgtctc
     2041 taggagctgt gtggtttctg ggcagtggtc tgttcaccct gagtcccacc tttgttaaat
     2101 aacaaactcc tgattctt
//
