LOCUS       NM_001191637            1876 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 16, member 12 (Slc16a12),
            mRNA.
ACCESSION   NM_001191637 XM_220057
VERSION     NM_001191637.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Jomura,R., Tanno,Y., Akanuma,S.I., Kubo,Y., Tachikawa,M. and
            Hosoya,K.I.
  TITLE     Contribution of monocarboxylate transporter 12 to blood supply of
            creatine on the sinusoidal membrane of the hepatocytes
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 321 (2), G113-G122 (2021)
   PUBMED   34075817
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Verouti,S.N., Lambert,D., Mathis,D., Pathare,G., Escher,G., Vogt,B.
            and Fuster,D.G.
  TITLE     Solute carrier SLC16A12 is critical for creatine and
            guanidinoacetate handling in the kidney
  JOURNAL   Am J Physiol Renal Physiol 320 (3), F351-F358 (2021)
   PUBMED   33459166
  REMARK    GeneRIF: Solute carrier SLC16A12 is critical for creatine and
            guanidinoacetate handling in the kidney.
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Jomura,R., Tanno,Y., Akanuma,S.I., Kubo,Y., Tachikawa,M. and
            Hosoya,K.I.
  TITLE     Monocarboxylate transporter 12 as a guanidinoacetate efflux
            transporter in renal proximal tubular epithelial cells
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (11), 183434 (2020)
   PUBMED   32781157
  REMARK    GeneRIF: Monocarboxylate transporter 12 as a guanidinoacetate
            efflux transporter in renal proximal tubular epithelial cells.
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Abplanalp,J., Laczko,E., Philp,N.J., Neidhardt,J., Zuercher,J.,
            Braun,P., Schorderet,D.F., Munier,F.L., Verrey,F., Berger,W.,
            Camargo,S.M. and Kloeckener-Gruissem,B.
  TITLE     The cataract and glucosuria associated monocarboxylate transporter
            MCT12 is a new creatine transporter
  JOURNAL   Hum Mol Genet 22 (16), 3218-3226 (2013)
   PUBMED   23578822
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Castorino,J.J., Gallagher-Colombo,S.M., Levin,A.V.,
            Fitzgerald,P.G., Polishook,J., Kloeckener-Gruissem,B., Ostertag,E.
            and Philp,N.J.
  TITLE     Juvenile cataract-associated mutation of solute carrier SLC16A12
            impairs trafficking of the protein to the plasma membrane
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6774-6784 (2011)
   PUBMED   21778275
  REMARK    GeneRIF: a model whereby the SLC16A12 (c.643C>T) mutation causes
            juvenile cataract by a defect in protein trafficking rather than by
            haploinsufficiency.
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 17, 2011 this sequence version replaced XM_220057.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.4700.1,
                                           SRR26643288.6974.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000001.1  241621607-241621716 c
            111-214             JAXUCZ010000001.1  241608971-241609074 c
            215-358             JAXUCZ010000001.1  241605846-241605989 c
            359-938             JAXUCZ010000001.1  241603636-241604215 c
            939-1198            JAXUCZ010000001.1  241601272-241601531 c
            1199-1876           JAXUCZ010000001.1  241599066-241599743 c
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1876
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="solute carrier family 16, member 12"
                     /db_xref="GeneID:309525"
                     /db_xref="RGD:1311468"
     CDS             1..1461
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 12; solute carrier family 16, member
                     12 (monocarboxylic acid transporter 12)"
                     /codon_start=1
                     /product="monocarboxylate transporter 12"
                     /protein_id="NP_001178566.1"
                     /db_xref="GeneID:309525"
                     /db_xref="RGD:1311468"
                     /translation="MTKITRVGSASPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFV
                     EFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGLILG
                     SFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRKAFAYGIAMSGSGIGTFIL
                     APVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDPSGPEKSHDRDAQRED
                     CKQASPYSPLTKEWTETRLCCSLQQGYGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVP
                     YALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCY
                     LCLPMLQSFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPY
                     LVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFAKIAKRMKRTQVPFLVKDSDP
                     KLHLWTNGSVAYSIAKELDQKDEESLAKARTGCNLT"
     exon            1..110
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            111..214
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            215..358
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            359..938
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1198
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1876
                     /gene="Slc16a12"
                     /gene_synonym="MCT 12; RGD1311468"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgacgaaga taactagagt tggttccgca tcccctccag atggaggctg gggatggatg
       61 attgtggccg gctgctttct tgttaccatc tgcacccggg cagtcaccag gtgtatctcc
      121 atattttttg tggagtttca gacgtacttt gctcaggatt attcccaaac agcatggatc
      181 cattccattg tagactgcat gacaatgctc tgtgctccgc ttgggagtgt tgtcagtaac
      241 caattatcct gtcaagcggg gatcatgctg ggtggcttgc tggcatctac tggtctcatc
      301 ctgggctcat ttgccaccag tttgaagcac ctctacctca gtctgggagt tctcacaggt
      361 cttggatttg cactttgtta ctccccagca attgccatgg tgggcaagta cttcagcagg
      421 cggaaagcct tcgcttacgg gattgccatg tcaggcagtg gcattggtac cttcatcctg
      481 gcccctgtgg ttcagctcct cattgaacag ttctcctggc gaggagcact gctcattctt
      541 ggtgggttcg ttctgaatct ctgcgtctgc ggcgcgctga tgcgtccaat tacccttaaa
      601 gaggacccgt caggcccaga gaagagtcac gaccgtgacg ctcagagaga agactgtaag
      661 caggcatctc cctattcacc tttgaccaaa gaatggacag agacccgtct ttgctgctct
      721 ttgcagcaag gatacggctt tttactgatg tcagacttcg tcgtgctggc tgtctctgtt
      781 ctgttcatgg cctacggctg cagccctctc tttgtgtacc tggtgcctta tgctttgagt
      841 gtcggagtga gtcaccatca agctgctttc ctcatgtcca tcctcggagt gattgatatt
      901 gtcggcaaca tcacgtttgg ctggctaact gacagaaggt gtctgaagaa ttaccgatat
      961 gtttgctacc tctttgctgt ggcactagat gggctgtgct atctgtgtct cccaatgctt
     1021 caaagcttcc cccttcttgt gcctttctct tgtacctttg gctacttcga cggagcctac
     1081 gttaccttga tcccagtagt gactgcagag atagtaggga ccacctcttt gtcatcagca
     1141 cttggcgtgg tctacttcct ccatgcagtg ccatacttgg tgagcccacc cattgcagga
     1201 tggctggtgg acacgacggg cagctatact gcagccttcc ttctttgtgg atttgccatg
     1261 atatttagtt ccatcctgct tggctttgcc aaaattgcaa aaagaatgaa aagaacacag
     1321 gtgcccttcc tggtcaaaga ctcagatccc aagctgcatc tgtggaccaa tggatcagtg
     1381 gcctactcta tagcgaagga gttagatcag aaagatgagg aatccctggc taaagctagg
     1441 actggttgca atctcacatg acctgtgtgg ccttgtcctg ggaatctgca aggctggtgg
     1501 ataccaggcc accaggttgt tcacagtctg gaaatatttt attttgacag agtatcacct
     1561 cccaagtaaa ttattaatac tgttttgtta acatatttat atggggacaa taatgagcaa
     1621 caaagaaatc tggagttagc ctggagtttt ctcattcagg atttgtactc actacaaact
     1681 tagctctggg agaagggcag gacacagttg acagggtcag ttgtatttca ggacaactct
     1741 aagcagaggc cactgtgaag agttttcata aaatctgccc caccccctca ttctgaacag
     1801 aagcagtggt ggttgtgctg gcagtgggga tgcagaggtg acttgagaac agagcgcctc
     1861 aatgtttaga gtggca
//
