LOCUS       NM_001105797            1779 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 16, member 11 (Slc16a11),
            mRNA.
ACCESSION   NM_001105797 XM_001079593 XM_213334
VERSION     NM_001105797.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1779)
  AUTHORS   Rusu,V., Hoch,E., Mercader,J.M., Tenen,D.E., Gymrek,M.,
            Hartigan,C.R., DeRan,M., von Grotthuss,M., Fontanillas,P.,
            Spooner,A., Guzman,G., Deik,A.A., Pierce,K.A., Dennis,C.,
            Clish,C.B., Carr,S.A., Wagner,B.K., Schenone,M., Ng,M.C.Y.,
            Chen,B.H., Centeno-Cruz,F., Zerrweck,C., Orozco,L., Altshuler,D.M.,
            Schreiber,S.L., Florez,J.C., Jacobs,S.B.R. and Lander,E.S.
  CONSRTM   MEDIA Consortium; SIGMA T2D Consortium
  TITLE     Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two
            Distinct Mechanisms
  JOURNAL   Cell 170 (1), 199-212 (2017)
   PUBMED   28666119
REFERENCE   2  (bases 1 to 1779)
  AUTHORS   Williams,A.L., Jacobs,S.B., Moreno-Macias,H., Huerta-Chagoya,A.,
            Churchhouse,C., Marquez-Luna,C., Garcia-Ortiz,H.,
            Gomez-Vazquez,M.J., Burtt,N.P., Aguilar-Salinas,C.A.,
            Gonzalez-Villalpando,C., Florez,J.C., Orozco,L., Haiman,C.A.,
            Tusie-Luna,T. and Altshuler,D.
  CONSRTM   SIGMA Type 2 Diabetes Consortium
  TITLE     Sequence variants in SLC16A11 are a common risk factor for type 2
            diabetes in Mexico
  JOURNAL   Nature 506 (7486), 97-101 (2014)
   PUBMED   24390345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 1, 2008 this sequence version replaced NM_001105797.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1524198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                JAXUCZ010000010.1  55427955-55427984
            31-213              JAXUCZ010000010.1  55428910-55429092
            214-386             JAXUCZ010000010.1  55429318-55429490
            387-594             JAXUCZ010000010.1  55429734-55429941
            595-738             JAXUCZ010000010.1  55430184-55430327
            739-1506            JAXUCZ010000010.1  55430552-55431319
            1507-1779           JAXUCZ010000010.1  55431406-55431678
FEATURES             Location/Qualifiers
     source          1..1779
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1779
                     /gene="Slc16a11"
                     /note="solute carrier family 16, member 11"
                     /db_xref="GeneID:287450"
                     /db_xref="RGD:1311125"
     exon            1..30
                     /gene="Slc16a11"
                     /inference="alignment:Splign:2.1.0"
     exon            31..213
                     /gene="Slc16a11"
                     /inference="alignment:Splign:2.1.0"
     exon            214..386
                     /gene="Slc16a11"
                     /inference="alignment:Splign:2.1.0"
     exon            387..594
                     /gene="Slc16a11"
                     /inference="alignment:Splign:2.1.0"
     CDS             393..1736
                     /gene="Slc16a11"
                     /note="monocarboxylic acid transporters; solute carrier
                     family 16 (monocarboxylic acid transporters), member 11;
                     solute carrier family 16, member 11 (monocarboxylic acid
                     transporter 11)"
                     /codon_start=1
                     /product="monocarboxylate transporter 11"
                     /protein_id="NP_001099267.2"
                     /db_xref="GeneID:287450"
                     /db_xref="RGD:1311125"
                     /translation="MTPKPAGPPDGGWGWVVAAAAFAVNGLSYGLLRSLGLALPDLAE
                     HFERSAQDTAWVSALALAVQQAASPVGSALSTRWGARPVVMVGGVLTSLGLVFSAFAR
                     SLLHLYLGLGLLAGSGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPAL
                     QFLLDTFGWRGALLLLGAVTLHLTPCGALLRPLALSGDPLAPPRTPLAALGLGLFRRP
                     AFSVFALGTALIGGGYFVPYVHLGPHALDQGMGGYGAALVVAVAAVGDASARLVSGWL
                     ADQGWVPLPRLLVVFGSLTGLGVLAVGLVPTVGTEEGWGAPLLAAAGAYGLSAGSYAP
                     LVFGVLPGLVGIGGVVQATGLVMMLMSLGGLLGPPLSGFLRDKTGDFSASFLVCSSFI
                     LSGSFIYMGLPRALPSCRPASPPATPPPERGELLPVPQVSLLSTGGSSSIRDTTC"
     exon            595..738
                     /gene="Slc16a11"
                     /inference="alignment:Splign:2.1.0"
     exon            739..1506
                     /gene="Slc16a11"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1779
                     /gene="Slc16a11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttcacagac agctcctggc tggtgaacca tgagggcatg ctggccattg gaggccagga
       61 atttgatttc ggagctttac gggatcctca gcaacaagtt tgagaatcca agaactcatt
      121 caggttttag agaccaccgc tattttcatg cgtgggcagc gggccgggca aggattgcaa
      181 cccggctctt cttgcgtgcg cagccgtcgg caggtggctc gggcccctgt ggtgatctct
      241 gtttaccgga gagagcggtc caagttgggc tccatctctg ccctggctag ctgctccgca
      301 gaaccctgcc tgcccggaaa gcgcggagaa aattcagccg aacccactct cgccctttcc
      361 ctacccccaa cgcctggaga ggtcggacgg cgatgacccc caagccagcc ggacccccgg
      421 acgggggctg gggctgggtg gtggcggccg cagcattcgc cgtgaacggg ctctcctacg
      481 ggctcttacg ctccctgggc cttgccctcc ccgacctcgc ggagcacttt gaacgaagcg
      541 cccaggacac tgcgtgggtc agcgccctgg ccttggccgt gcagcaggca gccagcccag
      601 tgggcagcgc cctgagcact cgctgggggg cacgccccgt ggtgatggtt gggggagtcc
      661 taacctcgct tggcttggtc ttctcggctt tcgcccgaag cctcctgcac ctctacctcg
      721 gcctgggcct cctcgctggc tctggctggg ctctggtgtt cgccccagcc ctgggtaccc
      781 tctctcgata cttctcccgc cgtcgggtct tggcagtagg gttggcgctc accggtaatg
      841 gggcatcctc gctgctcctg gcacctgcct tgcagttcct ccttgatact ttcggctggc
      901 ggggtgcctt gctcctcctt ggcgctgtca cccttcacct cacaccctgt ggcgccttgc
      961 tacggccttt agctctctct ggtgacccgc tggccccacc tcgcaccccc ctagctgccc
     1021 ttggcctagg tctgttcagg cgcccggcct tttcagtctt tgctttgggc accgccttga
     1081 ttgggggcgg atacttcgtc ccttatgtgc acttgggtcc gcacgcttta gatcagggca
     1141 tgggtggata cggggcagcg ttggtggtgg ctgtcgctgc agttggagat gcaagtgccc
     1201 gattggtcag cggatggctg gcagaccagg gctgggtgcc ccttccgagg cttctggtgg
     1261 tgtttgggtc tctgactgga ttaggggtac tggcagtggg actagtgccc actgtgggga
     1321 cggaggaggg ttggggagct cctctgctag ccgctgctgg ggcctatggc ctgagtgccg
     1381 ggagttacgc cccactggtt ttcggtgtgc tccctgggct ggtaggcatt ggaggtgtgg
     1441 tgcaggccac agggttggtg atgatgctga tgagcctcgg gggactcctg ggccctcctc
     1501 tgtcaggctt cctaagggat aagacaggag acttcagtgc ctctttcctg gtgtgcagtt
     1561 ctttcatcct ctctggcagc ttcatctaca tggggctgcc cagagccctc ccctcctgcc
     1621 gcccagcctc acctcccgct acccctccgc ctgagagagg ggaactgctc ccagtcccac
     1681 aagtctccct gctctccacg gggggcagca gctccatccg ggataccact tgttgatcat
     1741 tttcttggtt gactccctta ataaagaatt tttatctta
//
