LOCUS       NM_012716               2517 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Rattus norvegicus solute carrier family 16 member 1 (Slc16a1),
            mRNA.
ACCESSION   NM_012716
VERSION     NM_012716.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2517)
  AUTHORS   Xu,L., Yang,M., Wei,A., Wei,Z., Qin,Y., Wang,K., Li,B., Chen,K.,
            Liu,C., Li,C. and Wang,T.
  TITLE     Aerobic exercise-induced HIF-1alpha upregulation in heart failure:
            exploring potential impacts on MCT1 and MPC1 regulation
  JOURNAL   Mol Med 30 (1), 83 (2024)
   PUBMED   38867145
  REMARK    GeneRIF: Aerobic exercise-induced HIF-1alpha upregulation in heart
            failure: exploring potential impacts on MCT1 and MPC1 regulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2517)
  AUTHORS   Wu,X., Wang,Z., Li,H., Xie,X., Wu,J., Shen,H., Li,X., Wang,Z. and
            Chen,G.
  TITLE     Loss of monocarboxylate transporter 1 aggravates white matter
            injury after experimental subarachnoid hemorrhage in rats
  JOURNAL   Front Med 15 (6), 887-902 (2021)
   PUBMED   34874512
  REMARK    GeneRIF: Loss of monocarboxylate transporter 1 aggravates white
            matter injury after experimental subarachnoid hemorrhage in rats.
REFERENCE   3  (bases 1 to 2517)
  AUTHORS   Kopnick,A.L., Geistlinger,K. and Beitz,E.
  TITLE     Cysteine 159 delineates a hinge region of the alternating access
            monocarboxylate transporter 1 and is targeted by cysteine-modifying
            inhibitors
  JOURNAL   FEBS J 288 (20), 6052-6062 (2021)
   PUBMED   33999492
REFERENCE   4  (bases 1 to 2517)
  AUTHORS   Ahmadi,A., Sheikholeslami-Vatani,D., Ghaeeni,S. and Baazm,M.
  TITLE     The effects of different training modalities on monocarboxylate
            transporters MCT1 and MCT4, hypoxia inducible factor-1alpha
            (HIF-1alpha), and PGC-1alpha gene expression in rat skeletal
            muscles
  JOURNAL   Mol Biol Rep 48 (3), 2153-2161 (2021)
   PUBMED   33625690
  REMARK    GeneRIF: The effects of different training modalities on
            monocarboxylate transporters MCT1 and MCT4, hypoxia inducible
            factor-1alpha (HIF-1alpha), and PGC-1alpha gene expression in rat
            skeletal muscles.
REFERENCE   5  (bases 1 to 2517)
  AUTHORS   Elizondo-Vega,R., Oyarce,K., Salgado,M., Barahona,M.J., Recabal,A.,
            Ordenes,P., Lopez,S., Pincheira,R., Luz-Crawford,P. and
            Garcia-Robles,M.A.
  TITLE     Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects
            Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide
            Expressions
  JOURNAL   Mol Neurobiol 57 (2), 896-909 (2020)
   PUBMED   31578706
  REMARK    GeneRIF: Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions
            Affects Food Intake and Alters Orexigenic and Anorexigenic
            Neuropeptide Expressions.
REFERENCE   6  (bases 1 to 2517)
  AUTHORS   Orsenigo,M.N., Tosco,M., Bazzini,C., Laforenza,U. and Faelli,A.
  TITLE     A monocarboxylate transporter MCT1 is located at the basolateral
            pole of rat jejunum
  JOURNAL   Exp Physiol 84 (6), 1033-1042 (1999)
   PUBMED   10564700
REFERENCE   7  (bases 1 to 2517)
  AUTHORS   Broer,S., Schneider,H.P., Broer,A., Rahman,B., Hamprecht,B. and
            Deitmer,J.W.
  TITLE     Characterization of the monocarboxylate transporter 1 expressed in
            Xenopus laevis oocytes by changes in cytosolic pH
  JOURNAL   Biochem J 333 (Pt 1) (Pt 1), 167-174 (1998)
   PUBMED   9639576
REFERENCE   8  (bases 1 to 2517)
  AUTHORS   Broer,S., Rahman,B., Pellegri,G., Pellerin,L., Martin,J.L.,
            Verleysdonk,S., Hamprecht,B. and Magistretti,P.J.
  TITLE     Comparison of lactate transport in astroglial cells and
            monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis
            oocytes. Expression of two different monocarboxylate transporters
            in astroglial cells and neurons
  JOURNAL   J Biol Chem 272 (48), 30096-30102 (1997)
   PUBMED   9374487
REFERENCE   9  (bases 1 to 2517)
  AUTHORS   Takanaga,H., Tamai,I., Inaba,S., Sai,Y., Higashida,H., Yamamoto,H.
            and Tsuji,A.
  TITLE     cDNA cloning and functional characterization of rat intestinal
            monocarboxylate transporter
  JOURNAL   Biochem Biophys Res Commun 217 (1), 370-377 (1995)
   PUBMED   8526936
REFERENCE   10 (bases 1 to 2517)
  AUTHORS   Jackson,V.N., Price,N.T. and Halestrap,A.P.
  TITLE     cDNA cloning of MCT1, a monocarboxylate transporter from rat
            skeletal muscle
  JOURNAL   Biochim Biophys Acta 1238 (2), 193-196 (1995)
   PUBMED   7548134
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078877.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012716.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078877.1, D63834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2517
                     /gene="Slc16a1"
                     /gene_synonym="MCT1; RATMCT1; RNMCT1"
                     /note="solute carrier family 16 member 1"
                     /db_xref="GeneID:25027"
                     /db_xref="RGD:3690"
     exon            1..148
                     /gene="Slc16a1"
                     /gene_synonym="MCT1; RATMCT1; RNMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..408
                     /gene="Slc16a1"
                     /gene_synonym="MCT1; RATMCT1; RNMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..552
                     /gene="Slc16a1"
                     /gene_synonym="MCT1; RATMCT1; RNMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1398
                     /gene="Slc16a1"
                     /gene_synonym="MCT1; RATMCT1; RNMCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..2494
                     /gene="Slc16a1"
                     /gene_synonym="MCT1; RATMCT1; RNMCT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgacgtg actggtcggt cgtgtaggtg ctgcagccaa cgagcccggt ggcgggcaag
       61 ggacacgagc aggacccccg gctccgaaga attgcggccc gcgccgccgc gtcacgcaca
      121 ctctgggcgc cgcgagatac acataacgat actaggtttt cgccgcatct tggaattcat
      181 cgacacctaa gatgccacct gcgattggcg ggccagtggg gtacaccccc ccagatggag
      241 gctggggctg ggcggtggta gttggagcct tcatttctat tggcttctcc tatgcatttc
      301 ccaaatccat cactgtcttc tttaaagaga ttgaaattat attcagtgca acgaccagtg
      361 aagtgtcatg gatatcgtcc atcatgctgg ctgtcatgta tgccggaggt cctatcagca
      421 gtatcttggt gaataaatat ggcagccgtc cagtaatgat tgctggtggc tgcctgtctg
      481 gctgtggctt gattgcagct tctttctgta acacggtgca ggaactttac ttctgcattg
      541 gtgtcattgg aggtcttggg cttgctttca acttgaaccc agctctgact atgattggca
      601 agtatttcta caagaagcga ccattggcca atggcctggc tatggcaggc agcccagtgt
      661 tcctctctac cctggctcca cttaatcagg ctttctttgg tatttttggc tggagaggaa
      721 gcttcctaat tcttgggggc ctcctcctca actgttgtgt agctggatcc ctgatgcgac
      781 caatagggcc tcagcaaggc aaggtggaaa aactcaagtc caaagagtct ctccaggaag
      841 ctgggaagtc tgatgcaaat acagatctca ttggaggaag tcccaaagga gaaaagctgt
      901 cagtcttcca aacagttaat aaattcctgg acttgtccct gtttacccat agaggctttt
      961 tgctgtacct gtctggaaat gtggtcatgt tctttgggct ctttacccct ttggtctttc
     1021 ttagtaatta tggtaagagt aagcattttt ccagtgagaa gtcagccttc ctcctttcca
     1081 ttttggcttt tgttgatatg gtggccagac cgtccatggg tcttgcagcc aacaccaggt
     1141 ggatcagacc tcgagtccag tacttttttg ctgcttctgt tgttgcgaat ggagtgtgcc
     1201 atttgctggc acctttgtct acgacctatg ttgggttctg catctacgcg ggagtctttg
     1261 gatttgcctt tggttggctc agctccgtat tgtttgagac gttgatggac ctcgttggac
     1321 cccagaggtt ctccagtgct gtgggcttgg tgaccattgt ggaatgttgt cctgtcctcc
     1381 tgggaccacc acttttaggc cgcctcaatg acatgtatgg agactacaaa tacacatact
     1441 gggcttgtgg cgtgatcctc atcatcgcag gcctctacct cttcattggt atgggcatca
     1501 attatcgact tgtggccaaa gaacagaaag cggaggaaaa gaagagggac ggtaaagagg
     1561 acgagaccag cactgatgtt gatgagaagc ccaagaagac aatgaaagaa acacagtcgc
     1621 cagcgccact gcagaacagc tctggagacc ccgcggagga ggagagccca gtctgacctg
     1681 tggagcatga agagagcagg tgtgacccga gacatccgaa accattctgc tggcctctag
     1741 tctaccagtg gtgctccgtg cagacagtgg acatttgtgt ggaaaaccca ccaggtgttc
     1801 attggtggga tttttttttt tcactcctta ccaatgcctg gatttaaaat atactctgct
     1861 ttaggtaggg agtggttgac aaagaatatg gggaagaagc agtgatctgt ttgtttgttt
     1921 gtttgtttgt ttgtttgttt gttttaatct tagcttttaa cagtgtcatg aagattataa
     1981 tatgtgcctt aagttttagt ttttagaact ctttagagag ccttaacttt taaaaccatt
     2041 ctgctgaatt catctgttta aaacgtcatt ttaagaggaa aaataacaac tagcttgctt
     2101 gaggtaacta accttaatct tgttttgttg ttgttgtaat gctttgtcag acagacattg
     2161 ttaccggaac atttatgaat agaaatactg cttaaaggtc acaggtttat aaaatactga
     2221 ctaaagtatt tttctagcat tatagttgcc tggtacatct gctgctaggt atatatttga
     2281 gaaatttgaa gcataaaatt ctggatcttg gcagttccag ccacagcctg tcacctgctg
     2341 ggcacctctt ctggaatgct cactacagtc tagtgctaag gtgttgccac tgaattgata
     2401 cctttgctcc tattcagaga cactgtgtgg ttagaagtaa ttggccattt ttgaaatcaa
     2461 atgcaaaaag ttagtattaa aatctacaaa acaaaaaaaa aaaaaaaaaa aaaaaaa
//
