LOCUS       NM_144758               2730 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus solute carrier family 15 member 4 (Slc15a4),
            mRNA.
ACCESSION   NM_144758
VERSION     NM_144758.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2730)
  AUTHORS   Hu,Y., Xie,Y., Keep,R.F. and Smith,D.E.
  TITLE     Divergent developmental expression and function of the
            proton-coupled oligopeptide transporters PepT2 and PhT1 in regional
            brain slices of mouse and rat
  JOURNAL   J Neurochem 129 (6), 955-965 (2014)
   PUBMED   24548120
  REMARK    GeneRIF: We found marked changes in protein expression and
            functional activity of PhT1 and PepT2, the former predominating in
            adult and the latter in neonate
REFERENCE   2  (bases 1 to 2730)
  AUTHORS   Romano,A., Barca,A., Kottra,G., Daniel,H., Storelli,C. and Verri,T.
  TITLE     Functional expression of SLC15 peptide transporters in rat thyroid
            follicular cells
  JOURNAL   Mol Cell Endocrinol 315 (1-2), 174-181 (2010)
   PUBMED   19913073
  REMARK    GeneRIF: These findings represent the first evidence that peptide
            transport via SLC15a1, 2, 3, and 4 occurs in thyroid follicular
            cells.
REFERENCE   3  (bases 1 to 2730)
  AUTHORS   Yamashita,T., Shimada,S., Guo,W., Sato,K., Kohmura,E., Hayakawa,T.,
            Takagi,T. and Tohyama,M.
  TITLE     Cloning and functional expression of a brain peptide/histidine
            transporter
  JOURNAL   J Biol Chem 272 (15), 10205-10211 (1997)
   PUBMED   9092568
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB000280.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000280.1, BC087709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q14"
     gene            1..2730
                     /gene="Slc15a4"
                     /note="solute carrier family 15 member 4"
                     /db_xref="GeneID:246280"
                     /db_xref="RGD:708469"
     exon            1..572
                     /gene="Slc15a4"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1742
                     /gene="Slc15a4"
                     /note="rPHT1; peptide transporter 4; peptide/histidine
                     transporter 1; solute carrier family 15 (oligopeptide
                     transporter), member 4"
                     /codon_start=1
                     /product="solute carrier family 15 member 4"
                     /protein_id="NP_653359.1"
                     /db_xref="GeneID:246280"
                     /db_xref="RGD:708469"
                     /translation="MEGERAPLLGSRRAAAAAGVFAGRRAACGAVLLAELLERAAFYG
                     VTANLVLFLNGAPFNWEGAQASQALLLFMGLTYLGSPFGGWLADARLGRARAILLSLA
                     LYLLGMLAFPLLAAPRSRSFLCGDPHPELVRNCSAPFPNGTAVCPDAAARRCAPATFA
                     GLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQ
                     QNVSFLTGYLIPTVCVAIAFLVFLCGQSVFITKPPDGSAFTDMFRILTYSCCSQRGGQ
                     RRSGEGLGVFQQSSKHSLFDSCKMSRGGPFTEDKVEDVKALVKIVPVFLALIPYWTVY
                     FQMQTTYVLQSLHLKIPEISSITTTHHTLPAAWLTMFDAVLILLLIPLKDKLVDPVLR
                     RHGLLPSSLKRIAVGMFFVTCSAFAAGILESKRLDLVKEKTINQTIGGVVYHAADLPI
                     WWQIPQYVLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGIGSFVGSGLLAL
                     VSLKAIGWMSSHTDFGNINSCHLHYYFFLLAAIQGATLLLFLIVSVKYDRQRARTDGG
                     TASTRT"
     exon            573..862
                     /gene="Slc15a4"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1031
                     /gene="Slc15a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1109
                     /gene="Slc15a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1278
                     /gene="Slc15a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1434
                     /gene="Slc15a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1593
                     /gene="Slc15a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..2730
                     /gene="Slc15a4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2730
                     /gene="Slc15a4"
                     /note="19 a nucleotides"
ORIGIN      
        1 accgggtcct tagggaacca gccatggagg gcgagcgggc gccgctgtta ggttcgcggc
       61 gtgcggcggc agcagctggg gtgtttgcgg ggcgtcgtgc ggcgtgcggg gcggtactgt
      121 tggccgaact gctggagcgc gcggccttct acggcgtcac ggccaaccta gtgttattct
      181 tgaatggcgc gccgttcaac tgggagggcg cgcaggccag ccaggcactg ctgctcttca
      241 tgggcctcac ctacctggga tccccgttcg ggggatggct cgctgacgcg cgactcggcc
      301 gggcgcgcgc catcctgctc agcctggcgc tctacctgct gggcatgctg gccttcccgc
      361 tgctggccgc gccccgctcg cgctcttttc tctgcgggga tccgcacccg gagctggtgc
      421 gcaactgctc ggctcccttc cctaacggaa cggcggtctg tcccgatgct gccgcgcgcc
      481 gctgtgctcc cgccaccttc gcgggtctag tgctcgtggg actcggtgtg gccacggtca
      541 aggccaacat cacacccttt ggagcggatc aggtcaaaga tcgaggtcca gaggccactc
      601 ggagattttt caattggttt tactggagca ttaatttggg agcaatcctg tcattaggag
      661 gtattgccta tattcagcag aatgtgagct ttctcacagg ctacctgatt cctacagtct
      721 gcgtggccat tgctttcctg gtcttcctct gtggccagag tgtcttcatc accaagcctc
      781 ctgatggcag tgccttcact gacatgttca ggattctgac ctacagctgc tgctcccaga
      841 gaggagggca gcggagaagt ggtgaaggcc ttggagtctt tcagcaatct tctaaacaca
      901 gtctgtttga ttcatgtaag atgtcgcgtg gagggccgtt cacagaggac aaagtggaag
      961 acgtgaaagc cctggtcaag attgtgcccg tgttcttggc tctgattcct tactggacag
     1021 tgtatttcca aatgcagacc acatatgttt tacagagtct tcatttgaag attccagaaa
     1081 tctcaagtat caccaccacc catcacacgc tgcctgcagc ttggctcacc atgtttgatg
     1141 cggtgctcat cctcctgctc atcccactga aggacaagct agtggacccg gtgctgagga
     1201 gacacggcct gctcccatcc tccctgaaga ggattgccgt ggggatgttc ttcgtcacat
     1261 gctctgcctt tgctgcagga atcctggaga gtaaaaggct ggacctggtg aaggagaaga
     1321 ccatcaacca gaccattggt ggtgtggtct accatgctgc tgacctgccc atctggtggc
     1381 agatcccaca gtatgtgctc attggcatca gtgagatatt tgcaagtata gcaggtctgg
     1441 agtttgcgta ctcggctgcc cccaagtcca tgcagagtgc catcatggga ctcttcttct
     1501 tcttctctgg cattgggtcc ttcgtgggct caggactgct ggccctggtg tctctcaagg
     1561 ccatcgggtg gatgagcagt catacagact ttgggaacat caacagctgc cacctgcatt
     1621 actacttctt cctgctggcc gccatccagg gagctacgct gctgctcttc ctcattgtgt
     1681 ctgtgaagta cgaccgccag cgagccagga cagatggggg gacagccagc acgaggacct
     1741 gatgcagcca gccagcatgc tcacaggttc tgcagactat aaggcctcag ggcttgctaa
     1801 ctaccagggc actgccagca agcaggttga ggctagatgg ttggtgtccc aacttctgaa
     1861 cttgcatgtt gtctggactg gcttctccct ccctgtgccc agatgatggt ggtgagtgcc
     1921 ttactgtggc ccgtctcatg tgcactgggc ctaccaggag atgagaatgt ggcttctctc
     1981 actgaaggtc tctgcccgtt ctgagccagc catgctttct cttttagaat cctgagcagc
     2041 ccctgtcctg ctgctgggca tccttattcc ttacaaacac tgttactttc atagcatctc
     2101 ctgtaagatt agcaagcatt tccatcaagc ggtaggagga ttctcttcag agatcaaagt
     2161 gtggttgatg gcgagagagc cccatgagct gtttctgctc cattgatggt ctcttgtcac
     2221 agatcttgct gatgccaagg cctttgtggg tcagtagtgt agactcatct gctcaaaaag
     2281 tagttttgtt ggctaaggtg aagaagtgtt tcttattaca ctaggctggc ctcactaggc
     2341 tgacctcaaa cttggtgctg cctcctgtct gcttctcaag tgctaagatc tcagatgtcc
     2401 atcaccatgg tcagcaggac ttaggtcatg aactactgat ctgctttaag cacatgcatc
     2461 agtggtgagt gaggacacca tgttctcact gagaccagac agcagctggc aggagattgg
     2521 catttacacc tggcagatct tttctgagaa cttgactttg tgtagcagta agattggagg
     2581 caggtggtga gtggggaaaa cacgggagct gttgggctgg tcgcccacct ttgtattgtt
     2641 actgacatat ctggggttct gagtgtgtca actaaaccat tttatgtgtt gctgtgtctt
     2701 gtataatttg ataaaagctt ctcagacatg
//
