LOCUS       NM_031672               3970 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 15 member 2 (Slc15a2),
            mRNA.
ACCESSION   NM_031672
VERSION     NM_031672.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3970)
  AUTHORS   Parker,J.L., Deme,J.C., Wu,Z., Kuteyi,G., Huo,J., Owens,R.J.,
            Biggin,P.C., Lea,S.M. and Newstead,S.
  TITLE     Cryo-EM structure of PepT2 reveals structural basis for
            proton-coupled peptide and prodrug transport in mammals
  JOURNAL   Sci Adv 7 (35) (2021)
   PUBMED   34433568
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3970)
  AUTHORS   Alghamdi,O., King,N., Jones,G.L. and Moens,P.D.J.
  TITLE     Effect of ageing and hypertension on the expression and activity of
            PEPT2 in normal and hypertrophic hearts
  JOURNAL   Amino Acids 53 (2), 183-193 (2021)
   PUBMED   33404911
  REMARK    GeneRIF: Effect of ageing and hypertension on the expression and
            activity of PEPT2 in normal and hypertrophic hearts.
REFERENCE   3  (bases 1 to 3970)
  AUTHORS   Minocha,E., Chaturvedi,C.P. and Nityanand,S.
  TITLE     Renogenic characterization and in vitro differentiation of rat
            amniotic fluid stem cells into renal proximal tubular- and
            juxtaglomerular-like cells
  JOURNAL   In Vitro Cell Dev Biol Anim 55 (2), 138-147 (2019)
   PUBMED   30645697
REFERENCE   4  (bases 1 to 3970)
  AUTHORS   Gukasyan,H.J., Uchiyama,T., Kim,K.J., Ehrhardt,C., Wu,S.K.,
            Borok,Z., Crandall,E.D. and Lee,V.H.L.
  TITLE     Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is
            Mediated by Pept2
  JOURNAL   Pharm Res 34 (12), 2488-2497 (2017)
   PUBMED   28831683
  REMARK    GeneRIF: This study confirms the absence of Pept1 from rat lung
            alveolar epithelium in vitro. Functional Slc15a2/PEPT2 expression
            in type II-like cell monolayers suggests its involvement in
            oligopeptide lung disposition, and offers rationale for therapeutic
            development of di/tripeptides, peptidomimetics employing pulmonary
            drug delivery.
REFERENCE   5  (bases 1 to 3970)
  AUTHORS   Beale,J.H., Parker,J.L., Samsudin,F., Barrett,A.L., Senan,A.,
            Bird,L.E., Scott,D., Owens,R.J., Sansom,M.S.P., Tucker,S.J.,
            Meredith,D., Fowler,P.W. and Newstead,S.
  TITLE     Crystal Structures of the Extracellular Domain from PepT1 and PepT2
            Provide Novel Insights into Mammalian Peptide Transport
  JOURNAL   Structure 23 (10), 1889-1899 (2015)
   PUBMED   26320580
  REMARK    GeneRIF: Crystal structures of the extracellular domain from PepT1
            and PepT2 provide novel insights into mammalian peptide transport.
REFERENCE   6  (bases 1 to 3970)
  AUTHORS   Rubio-Aliaga,I., Boll,M. and Daniel,H.
  TITLE     Cloning and characterization of the gene encoding the mouse peptide
            transporter PEPT2
  JOURNAL   Biochem Biophys Res Commun 276 (2), 734-741 (2000)
   PUBMED   11027540
REFERENCE   7  (bases 1 to 3970)
  AUTHORS   Ganapathy,M.E., Huang,W., Rajan,D.P., Carter,A.L., Sugawara,M.,
            Iseki,K., Leibach,F.H. and Ganapathy,V.
  TITLE     beta-lactam antibiotics as substrates for OCTN2, an organic
            cation/carnitine transporter
  JOURNAL   J Biol Chem 275 (3), 1699-1707 (2000)
   PUBMED   10636865
REFERENCE   8  (bases 1 to 3970)
  AUTHORS   Chen,X.Z., Zhu,T., Smith,D.E. and Hediger,M.A.
  TITLE     Stoichiometry and kinetics of the high-affinity H+-coupled peptide
            transporter PepT2
  JOURNAL   J Biol Chem 274 (5), 2773-2779 (1999)
   PUBMED   9915809
REFERENCE   9  (bases 1 to 3970)
  AUTHORS   Saito,H., Terada,T., Okuda,M., Sasaki,S. and Inui,K.
  TITLE     Molecular cloning and tissue distribution of rat peptide
            transporter PEPT2
  JOURNAL   Biochim Biophys Acta 1280 (2), 173-177 (1996)
   PUBMED   8639691
REFERENCE   10 (bases 1 to 3970)
  AUTHORS   Liu,W., Liang,R., Ramamoorthy,S., Fei,Y.J., Ganapathy,M.E.,
            Hediger,M.A., Ganapathy,V. and Leibach,F.H.
  TITLE     Molecular cloning of PEPT 2, a new member of the H+/peptide
            cotransporter family, from human kidney
  JOURNAL   Biochim Biophys Acta 1235 (2), 461-466 (1995)
   PUBMED   7756356
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085327.1.
            
            On Sep 12, 2012 this sequence version replaced NM_031672.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085327.1, D63149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3970              BC085327.1         1-3970
FEATURES             Location/Qualifiers
     source          1..3970
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..3970
                     /gene="Slc15a2"
                     /note="solute carrier family 15 member 2"
                     /db_xref="GeneID:60577"
                     /db_xref="RGD:61972"
     exon            1..277
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..2362
                     /gene="Slc15a2"
                     /note="peptide transporter 2; kidney H(+)/peptide
                     cotransporter; solute carrier family 15 (H+/peptide
                     transporter), member 2; solute carrier family 15
                     (oligopeptide transporter), member 2"
                     /codon_start=1
                     /product="solute carrier family 15 member 2"
                     /protein_id="NP_113860.2"
                     /db_xref="GeneID:60577"
                     /db_xref="RGD:61972"
                     /translation="MLEERESKEPAMNPFQKNESKETLFSPVSTEEMLPRPPSPPKKS
                     PPKIFGSSYPVSIAFIVVNEFCERFSYYGMKAVLTLYFLYFLHWNEDTSTSVYHAFSS
                     LCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVFKSLGAIPILGGKMLHTILSLVG
                     LSLIALGTGGIKPCVAAFGGDQFEEEHAEARTRYFSVFYLAINAGSLISTFITPMLRG
                     DVKCFGQDCYALAFGVPGLLMVLALVVFAMGSKMYRKPPPEGNIVAQVIKCIWFALCN
                     RFRNRSGDLPKRQHWLDWAAEKYPKHLIADVKALTRVLFLYIPLPMFWALLDQQGSRW
                     TLQANKMNGDLGFFVLQPDQMQVLNPFLVLIFIPLFDLVIYRLISKCRINFSSLRKMA
                     VGMILACLAFAVAALVETKINGMIHPQPASQEIFLQVLNLADGDVKVTVLGSRNNSLL
                     VESVSSFQNTTHYSKLHLEAKSQDLHFHLKYNSLSVHNDHSVEEKNCYQLLIHQDGES
                     ISSMLVKDTGIKPANGMAAIRFINTLHKDLNISLDTDAPLSVGKDYGVSAYRTVLRGK
                     YPAVHCETEDKVFSLDLGQLDFGTTYLFVITNITSQGLQAWKAEDIPVNKLSIAWQLP
                     QYVLVTAAEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLVVAQFSGLAQ
                     WAEFVLFSCLLLVVCLIFSVMAYYYVPLKSEDTREATDKQIPAVQGNMINLETKNTRL
                     "
     exon            278..365
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..507
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..600
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..700
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..791
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..869
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            870..952
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1039
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1129
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1174
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1207
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1296
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1378
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1513
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1678
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1725
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1836
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1933
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2080
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2185
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..3943
                     /gene="Slc15a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccagttctg ctctgaggct ggcagctact gaaactgaca cacacagggt taaacctatt
       61 tgctgtggcc atccctcctc cccctagtcc cccttttcac tgtaggctgg cagcagtcct
      121 aactgcctac tgaagccaaa tgcttgagga gagagagagt aaggagccag ccatgaatcc
      181 tttccagaaa aatgagtcca aggaaacgct tttttcacct gtctctactg aggagatgct
      241 gcctagacct ccgagccctc caaagaagtc acctccgaaa atctttggct ccagctaccc
      301 agtcagcatt gccttcatcg tggtgaatga attctgcgag cgattttcct attatggcat
      361 gaaagctgtg ctgaccttgt acttcctgta tttcctgcac tggaatgaag acacgtccac
      421 ctctgtctac catgccttca gcagcctctg ctatttcact cccatcttgg gtgcggccat
      481 tgctgactcc tggctgggaa aattcaagac aatcatctat ctctccctgg tgtatgttct
      541 tggccatgta ttcaagtctt tgggtgccat accaatactg ggaggaaaaa tgctacatac
      601 aatcttatca ttggttggtc tgagtctaat tgctctggga acaggaggta tcaaaccctg
      661 tgtggcagct ttcggcggag accagtttga agaggaacat gcagaggcac ggactagata
      721 cttctcagtc ttctacctcg ccatcaatgc ggggagcttg atttccacgt tcatcacacc
      781 catgctgaga ggagatgtga agtgttttgg ccaagactgc tatgcactgg cttttggagt
      841 tccaggattg ctcatggtgc tggcacttgt tgtgtttgca atgggaagca agatgtacag
      901 gaaaccacct cctgaaggga acatagtggc tcaagttatc aaatgcatat ggtttgctct
      961 ctgcaaccgc ttcaggaacc gttctgggga ccttccgaag cgacaacact ggctagactg
     1021 ggcagcagaa aaatatccaa agcatctcat cgcagatgtg aaggccctga ccagggtact
     1081 gtttctttat atcccactgc ccatgttctg ggcacttttg gaccaacagg gctcgcggtg
     1141 gactctgcaa gctaacaaga tgaatggtga cttgggtttt tttgtacttc agccggatca
     1201 gatgcaggtg ctaaatccct ttctggttct tatcttcatc cccttgtttg accttgtcat
     1261 ttaccggctg atctccaagt gcagaattaa cttctcatca ctcaggaaaa tggcagttgg
     1321 tatgatccta gcgtgcttgg cttttgcagt tgcagcactt gtcgagacaa aaataaatgg
     1381 aatgatccat ccccagccag cttcccaaga gatattttta caagtcttga atttggcaga
     1441 tggtgatgta aaggtgaccg tgctgggcag tagaaataat tctctcttgg tggagtccgt
     1501 cagctctttt cagaacacaa cgcactattc aaaactacac ctggaggcaa agagccaaga
     1561 tttacatttt catctgaagt ataacagctt gtctgtccac aatgaccatt ctgtagagga
     1621 gaagaactgt taccagctgc tcattcacca ggacggggag agtatctcca gcatgctggt
     1681 caaggataca ggaatcaaac cagccaatgg gatggcagcc atcaggttta ttaacacttt
     1741 gcataaagac ttgaacatct ccttggatac agacgctcct ctcagcgtgg gcaaagacta
     1801 cggagtgtct gcatacagaa ctgtgctaag aggaaagtat cctgcagtgc actgtgaaac
     1861 tgaagacaaa gtcttttctc tcgatttagg tcaactagac tttggtacaa catatttgtt
     1921 cgtgatcact aatatcacca gtcagggtct tcaggcctgg aaggcagagg acattccagt
     1981 caataaacta tccattgcat ggcagctacc acagtatgtc ctggttacag cagcagaggt
     2041 catgttctca gtcacaggac ttgaattttc ttattctcag gcaccatcta gcatgaaatc
     2101 tgtgctccag gcggcctggt tgttgaccgt tgcagttggg aatatcattg tgcttgtcgt
     2161 ggctcagttc agtggcctgg cacagtgggc cgagttcgtt ttgttttcct gcctcctcct
     2221 ggtggtctgc ctgatcttct ccgtcatggc ctactactac gttcctctaa agtcagaaga
     2281 tacccgtgag gcaacagata agcagattcc tgccgtgcag gggaatatga ttaacctaga
     2341 aaccaagaat acaaggctct gatgacttgc tgatggatac ctgacccctg gctctgattt
     2401 cagccactgc ttattttcaa gcaacaacca ttttcctcag gccaggttag gagaaggaga
     2461 cagcatctat ctgaatggat tgcctccagt tccctaccac agtagaggca attctaggac
     2521 taagttttca gatacatctt taaacaggga tccgagactc cgtgccctac aggccgttga
     2581 tcaacttggt aaacgtcagg tgatgtctct caggctggcc cagtatctcc gagtgcccat
     2641 gaaaaataca aatgtgtaga agagataagt ctcacgggtc tgctaagttt gagggattcc
     2701 tttaccaggt atttggagcc tatagctcta cttgtcgatg tgttggttac agaatactgg
     2761 ttttccaagt ttctttatca gtcgtataac ttcgctattc atgaggatgt caaaaaacgt
     2821 tacatatagt atgacccaat ccagaggcta gcttgtcagc taggaagtct aacatgattt
     2881 taatagatgg cagactatag aatggcgttg tatctacaca tggaagatac ctcttttctg
     2941 atttaccaca gtggtttatc aacttaccca accaggcttt tctcagatcc tgaaaaccac
     3001 aattaaggac agtagtcaga atcgtgggga cacgggggtg cacataaact attcattctc
     3061 ctgtactaca ggatactaaa gaactctcct gctcctggcc tgggccgtgc tcctctgtga
     3121 acatctgtct aagaaactaa ctataacttt gcaacccagg cttttccgtg gcgctgggac
     3181 agcttatctt tttcagtgca tcttattctg cgtattacag caagtcttca ataacaaaat
     3241 gttcttctaa cccaacttcc tgtaattttt ttctatttag ctcctttgtt atgcatcttt
     3301 acttttcctg taatttttgt ttacatttct ccctttgggc ttagcagttt cttgtttatt
     3361 gaaaagggat aatactaaca tcctaggtct gaagcgctaa actgtgctag tcatcaaatg
     3421 gacaaggacc tgcatgagaa acttattaaa aatctgtggc gaggtgggac aggtgcaggt
     3481 tttgtttgtg cgtgtgaaca aaaggagttg agaggcattg tctcacgtgt aataacgtgg
     3541 gtcaggggac gagtttggga tgtcaggact gtgtcatgta ttcctaggag aaaacgttcc
     3601 ctgcccctat atgaaagacc tctcatttct gttcctttta ctacactgtt cccttcaacg
     3661 gccatgttga attgcacatt attagtaatg taatatattc ttaagcgaat ctgctccagt
     3721 tcgtcaagct ttaaatactt cagtatttaa gtaccgagat ttcagaaagc ataaaagagg
     3781 tcacaatacc atctactttc ctcagatgac ttaatgagaa cctgtccaga ctcctttaga
     3841 aggtgttcac tttccagaag ctttaactca aactctttga tgaattttgt tttaaaagat
     3901 gttaacactg atctgtgaat aaaatttttt acatacaggt aaaaaaaaaa aaaaaaaaaa
     3961 aaaaaaaaaa
//
