LOCUS       NM_057121               3026 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 15 member 1 (Slc15a1),
            transcript variant 1, mRNA.
ACCESSION   NM_057121 XM_346478
VERSION     NM_057121.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Shao,Z., Hong,J., Chen,M., Zheng,Y., Lin,Z., Yang,X., Sun,R. and
            Liu,J.
  TITLE     [Role of cholinergic anti-inflammatory pathway in Ghrelin
            regulation of peptide transporter 1 expression in small intestinal
            epithelium of septic rats]
  JOURNAL   Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 34 (11), 1132-1137 (2022)
   PUBMED   36567554
  REMARK    GeneRIF: [Role of cholinergic anti-inflammatory pathway in Ghrelin
            regulation of peptide transporter 1 expression in small intestinal
            epithelium of septic rats].
REFERENCE   2  (bases 1 to 3026)
  AUTHORS   Alghamdi,O.A., King,N., Andronicos,N.M., Jones,G.L., Chami,B.,
            Witting,P.K. and Moens,P.D.J.
  TITLE     Hypertension alters the function and expression profile of the
            peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal
            tubule
  JOURNAL   Amino Acids 54 (7), 1001-1011 (2022)
   PUBMED   35386060
  REMARK    GeneRIF: Hypertension alters the function and expression profile of
            the peptide cotransporters PEPT1 and PEPT2 in the rodent renal
            proximal tubule.
REFERENCE   3  (bases 1 to 3026)
  AUTHORS   Yin,H., Shao,H., Liu,J., Qin,Y. and Deng,W.
  TITLE     Sex-specific and concentration-dependent influence of Cremophor RH
            40 on ampicillin absorption via its effect on intestinal membrane
            transporters in rats
  JOURNAL   PLoS One 17 (2), e0263692 (2022)
   PUBMED   35226682
  REMARK    GeneRIF: Sex-specific and concentration-dependent influence of
            Cremophor RH 40 on ampicillin absorption via its effect on
            intestinal membrane transporters in rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3026)
  AUTHORS   Liang,L.M., Zhou,J.J., Xu,F., Liu,P.H., Qin,L., Liu,L. and Liu,X.D.
  TITLE     Diabetes downregulates peptide transporter 1 in the rat jejunum:
            possible involvement of cholate-induced FXR activation
  JOURNAL   Acta Pharmacol Sin 41 (11), 1465-1475 (2020)
   PUBMED   32341465
  REMARK    GeneRIF: Diabetes downregulates peptide transporter 1 in the rat
            jejunum: possible involvement of cholate-induced FXR activation.
REFERENCE   5  (bases 1 to 3026)
  AUTHORS   Minocha,E., Chaturvedi,C.P. and Nityanand,S.
  TITLE     Renogenic characterization and in vitro differentiation of rat
            amniotic fluid stem cells into renal proximal tubular- and
            juxtaglomerular-like cells
  JOURNAL   In Vitro Cell Dev Biol Anim 55 (2), 138-147 (2019)
   PUBMED   30645697
REFERENCE   6  (bases 1 to 3026)
  AUTHORS   Fei,Y.J., Sugawara,M., Liu,J.C., Li,H.W., Ganapathy,V.,
            Ganapathy,M.E. and Leibach,F.H.
  TITLE     cDNA structure, genomic organization, and promoter analysis of the
            mouse intestinal peptide transporter PEPT1
  JOURNAL   Biochim Biophys Acta 1492 (1), 145-154 (2000)
   PUBMED   11004485
REFERENCE   7  (bases 1 to 3026)
  AUTHORS   Miyamoto,K., Shiraga,T., Morita,K., Yamamoto,H., Haga,H.,
            Taketani,Y., Tamai,I., Sai,Y., Tsuji,A. and Takeda,E.
  TITLE     Sequence, tissue distribution and developmental changes in rat
            intestinal oligopeptide transporter
  JOURNAL   Biochim Biophys Acta 1305 (1-2), 34-38 (1996)
   PUBMED   8605246
REFERENCE   8  (bases 1 to 3026)
  AUTHORS   Saito,H., Okuda,M., Terada,T., Sasaki,S. and Inui,K.
  TITLE     Cloning and characterization of a rat H+/peptide cotransporter
            mediating absorption of beta-lactam antibiotics in the intestine
            and kidney
  JOURNAL   J Pharmacol Exp Ther 275 (3), 1631-1637 (1995)
   PUBMED   8531138
REFERENCE   9  (bases 1 to 3026)
  AUTHORS   Erickson,R.H., Gum,J.R. Jr., Lindstrom,M.M., McKean,D. and Kim,Y.S.
  TITLE     Regional expression and dietary regulation of rat small intestinal
            peptide and amino acid transporter mRNAs
  JOURNAL   Biochem Biophys Res Commun 216 (1), 249-257 (1995)
   PUBMED   7488096
REFERENCE   10 (bases 1 to 3026)
  AUTHORS   Liang,R., Fei,Y.J., Prasad,P.D., Ramamoorthy,S., Han,H.,
            Yang-Feng,T.L., Hediger,M.A., Ganapathy,V. and Leibach,F.H.
  TITLE     Human intestinal H+/peptide cotransporter. Cloning, functional
            expression, and chromosomal localization
  JOURNAL   J Biol Chem 270 (12), 6456-6463 (1995)
   PUBMED   7896779
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 26, 2020 this sequence version replaced NM_057121.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (PepT1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50664.1, SRR26643293.61135.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000015.1  104989317-104989368 c
            53-69               JAXUCZ010000015.1  104975538-104975554 c
            70-151              JAXUCZ010000015.1  104975064-104975145 c
            152-293             JAXUCZ010000015.1  104974813-104974954 c
            294-413             JAXUCZ010000015.1  104973328-104973447 c
            414-513             JAXUCZ010000015.1  104970401-104970500 c
            514-604             JAXUCZ010000015.1  104970078-104970168 c
            605-688             JAXUCZ010000015.1  104968597-104968680 c
            689-771             JAXUCZ010000015.1  104966980-104967062 c
            772-858             JAXUCZ010000015.1  104965591-104965677 c
            859-948             JAXUCZ010000015.1  104964984-104965073 c
            949-993             JAXUCZ010000015.1  104962573-104962617 c
            994-1026            JAXUCZ010000015.1  104962409-104962441 c
            1027-1115           JAXUCZ010000015.1  104962236-104962324 c
            1116-1197           JAXUCZ010000015.1  104960831-104960912 c
            1198-1317           JAXUCZ010000015.1  104959630-104959749 c
            1318-1467           JAXUCZ010000015.1  104957472-104957621 c
            1468-1517           JAXUCZ010000015.1  104955750-104955799 c
            1518-1625           JAXUCZ010000015.1  104950039-104950146 c
            1626-1737           JAXUCZ010000015.1  104949786-104949897 c
            1738-1881           JAXUCZ010000015.1  104949096-104949239 c
            1882-1989           JAXUCZ010000015.1  104946905-104947012 c
            1990-3026           JAXUCZ010000015.1  104944463-104945499 c
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24"
     gene            1..3026
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /note="solute carrier family 15 member 1"
                     /db_xref="GeneID:117261"
                     /db_xref="RGD:621736"
     exon            1..52
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2181
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /note="isoform PepT1 is encoded by transcript variant 1;
                     pineal gland-specific PEPT1; peptide transporter 1;
                     intestinal H(+)/peptide cotransporter; proton-coupled
                     dipeptide cotransporter; solute carrier family 15
                     (oligopeptide transporter), member 1"
                     /codon_start=1
                     /product="solute carrier family 15 member 1 isoform PepT1"
                     /protein_id="NP_476462.2"
                     /db_xref="GeneID:117261"
                     /db_xref="RGD:621736"
                     /translation="MGMSKSRGCFGYPLSIFFIVVNEFCERFSYYGMRALLVLYFRNF
                     LGWDDDLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVISVSS
                     INDLTDHDHDGSPNNLPLHVALSMIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRN
                     RFFSIFYLAINAGSLLSTIITPILRVQQCGIHSQQACYPLAFGVPAALMAVALIVFVL
                     GSGMYKKFQPQGNIMGKVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQ
                     IKMVTKVMFLYIPLPMFWALFDQQGSRWTLQATTMTGKIGTIEIQPDQMQTVNAILIV
                     IMVPIVDAVVYPLIAKCGFNFTSLKKMTVGMFLASMAFVVAAIVQVEIDKTLPVFPSG
                     NQVQIKVLNIGNNDMAVYFPGKNVTVAQMSQTDTFMTFDVDQLTSINVSSPGSPGVTT
                     VAHEFEPGHRHTLLVWGPNLYRVVKDGLNQKPEKGENGIRFVSTLNEMITIKMSGKVY
                     ENVTSHSASNYQFFPSGQKDYTINTTEIAPNCSSDFKSSNLDFGSAYTYVIRSRASDG
                     CLEVKEFEDIPPNTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGW
                     LLTVAIGNIIVLIVAEAGHFDKQWAEYVLFASLLLVVCIIFAIMARFYTYINPAEIEA
                     QFDEDEKKKGVGKENPYSSLEPVSQTNM"
     exon            53..69
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..151
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            152..293
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..413
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..513
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..604
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..688
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..771
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..858
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..948
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..993
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1026
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1115
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1197
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1317
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1467
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1517
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1625
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1737
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1881
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1989
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..3026
                     /gene="Slc15a1"
                     /gene_synonym="Pept1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaactcctg cttgccagtc gccggtcagg agcctcggag ccgccacaat ggggatgtcc
       61 aagtctcggg gttgctttgg ctacccattg agcatcttct tcatcgtggt caatgaattc
      121 tgtgaaagat tctcctacta tgggatgcga gctctcctgg ttctgtactt caggaacttc
      181 cttggctggg atgatgacct ctccacggcc atctaccata cgtttgttgc cctctgctac
      241 ctgacgccaa ttcttggagc tctgatcgca gactcgtggc tggggaagtt caagacaatt
      301 gtctcactat ccatcgtcta cacgatcgga caggccgtca tctcagtgag ctcaattaat
      361 gaccttacag accatgacca cgacggcagt cctaacaacc ttcctttgca cgtagcactg
      421 tccatgatcg gcctggccct gatagccctt ggtacaggag gaatcaagcc ctgtgtgtct
      481 gcatttggtg gcgatcagtt tgaagagggt caggaaaaac agcgaaaccg gttcttttcc
      541 atcttttatt tggctatcaa cgcaggaagc ctgctctcca cgatcatcac tcccatactc
      601 agagttcagc agtgcggaat ccacagccaa caagcttgtt acccactggc ctttggggtt
      661 ccggcagctc tcatggctgt tgccctaatt gtgtttgtcc tcggcagtgg aatgtacaag
      721 aagtttcagc cccagggcaa catcatgggc aaagtggcca agtgcattgg ctttgccatc
      781 aaaaacaggt ttcggcaccg aagtaaggca tttcccaaga gggaacactg gctggactgg
      841 gctaaagaga aatacgatga gaggctcatc tcgcagatta agatggtgac gaaggtgatg
      901 ttcctgtaca ttcccctccc catgttttgg gccttgtttg accagcaggg ttccaggtgg
      961 acactgcaag caacgaccat gactgggaaa attggaacaa ttgagattca gccggaccag
     1021 atgcagacgg tgaacgccat cttgattgtc atcatggtcc ccattgtgga cgccgtggtg
     1081 tatccgctca ttgcaaaatg tggtttcaac ttcacctccc tgaagaagat gaccgttggg
     1141 atgttcctgg catccatggc ctttgtggtg gctgcaattg tgcaggtgga aatcgataaa
     1201 actcttccag tcttccccag cggaaatcaa gttcaaatta aggtcttgaa cattggaaac
     1261 aatgacatgg ccgtgtattt tcctggaaag aatgtgacag ttgcccaaat gtctcagaca
     1321 gacacattca tgactttcga tgtagaccag ctgacaagca taaacgtgtc ttctcccgga
     1381 tctccaggcg tcaccacggt agctcatgag tttgagccgg gtcaccggca cacccttcta
     1441 gtgtggggcc ccaatctata ccgtgtggta aaagacggtc ttaaccaaaa gccagagaaa
     1501 ggggagaacg gaatcagatt cgtcagcacc cttaacgaga tgatcaccat caaaatgagt
     1561 ggaaaagtgt acgaaaatgt caccagtcac agcgccagca actaccagtt tttcccttct
     1621 ggccaaaaag actacacaat aaacaccaca gagattgcac caaactgttc atctgatttt
     1681 aaatcttcca accttgactt cggcagcgcg tacacctacg tgatcagaag tagggcgagt
     1741 gatggctgcc tggaagtgaa ggaattcgaa gacatcccac ccaacacggt gaacatggcc
     1801 ctgcagatcc cacagtactt cctcctcacc tgcggcgagg tggtcttctc tgtcacagga
     1861 ctggagttct cctattccca ggccccgtct aacatgaagt ccgtgcttca ggcaggatgg
     1921 cttctaaccg tggccatcgg taatatcatt gtcctcattg tggctgaggc aggccacttc
     1981 gacaaacagt gggctgagta tgttctgttc gcctccttgc tcctggtcgt ctgcatcata
     2041 tttgccatta tggcccgatt ctacacctac atcaacccag cagagatcga ggcacagttc
     2101 gatgaggatg agaagaaaaa gggcgtaggg aaggaaaacc cgtattcctc gttggaacct
     2161 gtctcacaga caaacatgtg aagatcagaa agcaagtgga gaacatacca agtccagcat
     2221 tcaccatgac ctctacccaa gggacaggac cctccaccac agagtccttg ctggagaaag
     2281 acttcagaca tgtgagccaa aataataaca aagcaggttt tcaggctgac ggctgtgaat
     2341 ctgaaactct aggggagcct ttttaatttg tttttcttga gacagggtat ctctgtgtaa
     2401 ccctggctat cctggaactc actctataga ccaggctggc ctcgaactca cagatatctg
     2461 tctgcctctg cctcctaagt actgggattc aaggcatgta cggcaactgc ccagctaaaa
     2521 tattatttat aacatgcact ttctgggttt tttgttttta aaacatactt tttttttaac
     2581 actgggccat ttctaacatt tctgccacag aagtggattt agctcagatt aacttaattt
     2641 tgaaaaggta acagtactgt ttttttttcc ttaatgctct tatgaaaaca atgttgaatt
     2701 tacagagggc tttttgtgtt tttgtttttt tgttttttgt tttttgtttg ggagctgggg
     2761 accgaaccca gggccttgag cttcctaggt aagcgctcta tcactgagct aaatccccag
     2821 ccgacagagg gcttttttag tagtgtgtag tgagtatcag ctgattcgag ctaataactt
     2881 taccttgggg tttttgtttg tttgttttcc tggtctcctt tgcctgacct ctttttaaat
     2941 tatgtgtaat tcaaaagact attcaagtga tggttagtca tgagtcgtga cgtttgactg
     3001 gtgtgaagta aattcttgtt cttaag
//
