LOCUS       NM_019346               1393 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 14 member 1 (Kidd blood
            group) (Slc14a1), mRNA.
ACCESSION   NM_019346 XM_346515
VERSION     NM_019346.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Song,W., Qi,X., Zhang,W., Zhao,Y., Cao,Y., Wang,F. and Yang,C.
  TITLE     Abnormal Expression of Urea Transporter Protein in a Rat Model of
            Hepatorenal Syndrome Induced by Succinylated Gelatin
  JOURNAL   Med Sci Monit 21, 2905-2911 (2015)
   PUBMED   26414230
  REMARK    GeneRIF: Urea Transporter Protein is abnormally expressed in a rat
            model of hepatorenal syndrome induced by succinylated gelatin
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Guo,L., Meng,J., Xuan,C., Ge,J., Sun,W., O'Rourke,S.T. and Sun,C.
  TITLE     High salt-diet reduces SLC14A1 gene expression in the choroid
            plexus of Dahl salt sensitive rats
  JOURNAL   Biochem Biophys Res Commun 461 (2), 254-259 (2015)
   PUBMED   25869070
  REMARK    GeneRIF: UT-B expression in the choroid plexus was reduced by high
            salt diet.
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Esteva-Font,C., Phuan,P.W., Lee,S., Su,T., Anderson,M.O. and
            Verkman,A.S.
  TITLE     Structure-activity analysis of thiourea analogs as inhibitors of
            UT-A and UT-B urea transporters
  JOURNAL   Biochim Biophys Acta 1848 (5), 1075-1080 (2015)
   PUBMED   25613743
  REMARK    GeneRIF: Report thiourea analogs as inhibitors of UT-B mediated
            urea transport.
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Li,F., Lei,T., Zhu,J., Wang,W., Sun,Y., Chen,J., Dong,Z., Zhou,H.
            and Yang,B.
  TITLE     A novel small-molecule thienoquinolin urea transporter inhibitor
            acts as a potential diuretic
  JOURNAL   Kidney Int 83 (6), 1076-1086 (2013)
   PUBMED   23486518
  REMARK    GeneRIF: Thienoquinoline PU-14 is a selective UT inhibitor and has
            urea-selective diuretic activity.
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Levin,E.J., Quick,M. and Zhou,M.
  TITLE     Crystal structure of a bacterial homologue of the kidney urea
            transporter
  JOURNAL   Nature 462 (7274), 757-761 (2009)
   PUBMED   19865084
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   Yang,B., Bankir,L., Gillespie,A., Epstein,C.J. and Verkman,A.S.
  TITLE     Urea-selective concentrating defect in transgenic mice lacking urea
            transporter UT-B
  JOURNAL   J Biol Chem 277 (12), 10633-10637 (2002)
   PUBMED   11792714
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Timmer,R.T., Klein,J.D., Bagnasco,S.M., Doran,J.J., Verlander,J.W.,
            Gunn,R.B. and Sands,J.M.
  TITLE     Localization of the urea transporter UT-B protein in human and rat
            erythrocytes and tissues
  JOURNAL   Am J Physiol Cell Physiol 281 (4), C1318-C1325 (2001)
   PUBMED   11546670
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Shayakul,C., Tsukaguchi,H., Berger,U.V. and Hediger,M.A.
  TITLE     Molecular characterization of a novel urea transporter from kidney
            inner medullary collecting ducts
  JOURNAL   Am J Physiol Renal Physiol 280 (3), F487-F494 (2001)
   PUBMED   11181411
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   Karakashian,A., Timmer,R.T., Klein,J.D., Gunn,R.B., Sands,J.M. and
            Bagnasco,S.M.
  TITLE     Cloning and characterization of two new isoforms of the rat kidney
            urea transporter: UT-A3 and UT-A4
  JOURNAL   J Am Soc Nephrol 10 (2), 230-237 (1999)
   PUBMED   10215321
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Couriaud,C., Ripoche,P. and Rousselet,G.
  TITLE     Cloning and functional characterization of a rat urea transporter:
            expression in the brain
  JOURNAL   Biochim Biophys Acta 1309 (3), 197-199 (1996)
   PUBMED   8982255
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019346.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U81518.1, FQ211495.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000018.1  73864541-73864643   c
            104-260             JAXUCZ010000018.1  73857697-73857853   c
            261-450             JAXUCZ010000018.1  73857059-73857248   c
            451-579             JAXUCZ010000018.1  73854900-73855028   c
            580-772             JAXUCZ010000018.1  73852708-73852900   c
            773-920             JAXUCZ010000018.1  73851272-73851419   c
            921-1055            JAXUCZ010000018.1  73850951-73851085   c
            1056-1105           JAXUCZ010000018.1  73844738-73844787   c
            1106-1393           JAXUCZ010000018.1  73842701-73842988   c
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..1393
                     /gene="Slc14a1"
                     /gene_synonym="HUT11; UrT2; UT-B; UT3; UTB1"
                     /note="solute carrier family 14 member 1 (Kidd blood
                     group)"
                     /db_xref="GeneID:54301"
                     /db_xref="RGD:3688"
     exon            1..103
                     /gene="Slc14a1"
                     /gene_synonym="HUT11; UrT2; UT-B; UT3; UTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            104..260
                     /gene="Slc14a1"
                     /gene_synonym="HUT11; UrT2; UT-B; UT3; UTB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1279
                     /gene="Slc14a1"
                     /gene_synonym="HUT11; UrT2; UT-B; UT3; UTB1"
                     /note="urea transporter B; urea transporter, erythrocyte;
                     solute carrier family 14 (urea transporter), member 1
                     (Kidd blood group)"
                     /codon_start=1
                     /product="urea transporter 1"
                     /protein_id="NP_062219.3"
                     /db_xref="GeneID:54301"
                     /db_xref="RGD:3688"
                     /translation="MAMEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFAN
                     WLKDKPVVLQFMDWILRGISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTL
                     TALLLSQDRSAIAAGLQGYNATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSA
                     LSSLFSKWDLPVFTLPFNMALSLYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALE
                     LLKSLPVGVGQIYGCDNPWTGAIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFK
                     DIYSGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMTHLMAAVHLPA
                     CTWSFCLATLLFLLLTTENPNIYRMPLSKVTYSEENRIFYLQNKKRVVDSPL"
     exon            261..450
                     /gene="Slc14a1"
                     /gene_synonym="HUT11; UrT2; UT-B; UT3; UTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..579
                     /gene="Slc14a1"
                     /gene_synonym="HUT11; UrT2; UT-B; UT3; UTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..772
                     /gene="Slc14a1"
                     /gene_synonym="HUT11; UrT2; UT-B; UT3; UTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..920
                     /gene="Slc14a1"
                     /gene_synonym="HUT11; UrT2; UT-B; UT3; UTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1055
                     /gene="Slc14a1"
                     /gene_synonym="HUT11; UrT2; UT-B; UT3; UTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1105
                     /gene="Slc14a1"
                     /gene_synonym="HUT11; UrT2; UT-B; UT3; UTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1393
                     /gene="Slc14a1"
                     /gene_synonym="HUT11; UrT2; UT-B; UT3; UTB1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcctctt ctgcaccacc tctccagggc actgcacctc ttaagagagc ctggctgccc
       61 tttatcagac actgccttct gccaccggga agcccgctgg agggagccag aggaagaaat
      121 ggccatggaa gatattccca ctatggttaa agtagaccga ggtgaaagcc agattttatc
      181 ctgccggggg agaaggtgtg gcctcaaagt acttggctat gtcacgggag atatgaagga
      241 attcgccaac tggcttaaag acaagcctgt ggtgctccag ttcatggact ggatacttcg
      301 tggcatatcc caggtggtgt ttgtcagcaa ccccatcagt ggaatcctga ttctggcggg
      361 acttctggtc cagaacccct ggtgggcgct ctgtggctgt gtaggaaccg tggtctccac
      421 tctgaccgcc ctcttgctta gccaagacag atcagcgata gcagccgggc tccagggtta
      481 caatgccacc ctggtgggaa tactcatggc tgtcttctca gacaagggcg actacttctg
      541 gtggttgata ttccctgtat ctgctatgtc tatgacttgc ccggttttct cgagcgcgtt
      601 gagctccctg ttcagcaagt gggacctgcc cgtcttcact cttcctttca acatggcttt
      661 gtcgctgtac ctttcagcca caggacacta caatacgttt ttcccaagta aactcttcat
      721 gcctgtcagc tccgtgccca acatcacgtg gtccgagctc agcgccctgg agctgttgaa
      781 gtctcttccg gtgggagtcg gtcagatata tggctgtgat aacccgtgga caggggccat
      841 tttcctgtgt gccatcctgc tttcctcccc actcatgtgc ctgcacgctg ctatcggatc
      901 gttgctggga gtcatcgcag gtctcagtct tgcagctccg tttaaagata tctactctgg
      961 gctctggggt ttcaacagtt ccctggcttg cattgcgatc ggagggatgt tcatggcact
     1021 cacctggcag acccatctcc tggcccttgc ctgtgccctg ttcactgcct actttggagc
     1081 ctgtatgaca cacctgatgg ctgcggttca cctgccagct tgtacctggt ccttctgctt
     1141 ggccacacta ctctttctcc tgctgaccac ggaaaatccc aatatctaca ggatgcccct
     1201 cagcaaagtt acctactccg aggagaaccg catcttctac ctacaaaaca agaaaagggt
     1261 ggtcgacagc ccgctgtaag agcaactcca cccaaccgcc gtggtcacgg gtcaattcta
     1321 agcagagttc tagttgcctt ccgggttctc ccaattgctt ttcttcactt ggaacagctc
     1381 tcgtactatc agg
//
