LOCUS       NM_170668               3205 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus solute carrier family 13 member 5 (Slc13a5),
            mRNA.
ACCESSION   NM_170668
VERSION     NM_170668.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3205)
  AUTHORS   Pesta,D.H., Perry,R.J., Guebre-Egziabher,F., Zhang,D., Jurczak,M.,
            Fischer-Rosinsky,A., Daniels,M.A., Willmes,D.M., Bhanot,S.,
            Bornstein,S.R., Knauf,F., Samuel,V.T., Shulman,G.I. and
            Birkenfeld,A.L.
  TITLE     Prevention of diet-induced hepatic steatosis and hepatic insulin
            resistance by second generation antisense oligonucleotides targeted
            to the longevity gene mIndy (Slc13a5)
  JOURNAL   Aging (Albany NY) 7 (12), 1086-1093 (2015)
   PUBMED   26647160
  REMARK    GeneRIF: These data suggest that inducible liver-selective
            reduction of mIndy in rats is able to ameliorate hepatic steatosis
            and insulin resistance, conditions occurring with high calorie
            diets and during aging.
REFERENCE   2  (bases 1 to 3205)
  AUTHORS   Neuschafer-Rube,F., Schraplau,A., Schewe,B., Lieske,S.,
            Krutzfeldt,J.M., Ringel,S., Henkel,J., Birkenfeld,A.L. and
            Puschel,G.P.
  TITLE     Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as
            possible contributor to benzo[a]pyrene-induced lipid accumulation
            in hepatocytes
  JOURNAL   Toxicology 337, 1-9 (2015)
   PUBMED   26303333
  REMARK    GeneRIF: This study thus identified the Slc13a5 as an AhR target
            gene
REFERENCE   3  (bases 1 to 3205)
  AUTHORS   Hardies,K., de Kovel,C.G., Weckhuysen,S., Asselbergh,B., Geuens,T.,
            Deconinck,T., Azmi,A., May,P., Brilstra,E., Becker,F., Barisic,N.,
            Craiu,D., Braun,K.P., Lal,D., Thiele,H., Schubert,J., Weber,Y., van
            't Slot,R., Nurnberg,P., Balling,R., Timmerman,V., Lerche,H.,
            Maudsley,S., Helbig,I., Suls,A., Koeleman,B.P. and De Jonghe,P.
  CONSRTM   autosomal recessive working group of the EuroEPINOMICS RES
            Consortium
  TITLE     Recessive mutations in SLC13A5 result in a loss of citrate
            transport and cause neonatal epilepsy, developmental delay and
            teeth hypoplasia
  JOURNAL   Brain 138 (Pt 11), 3238-3250 (2015)
   PUBMED   26384929
REFERENCE   4  (bases 1 to 3205)
  AUTHORS   Neuschafer-Rube,F., Lieske,S., Kuna,M., Henkel,J., Perry,R.J.,
            Erion,D.M., Pesta,D., Willmes,D.M., Brachs,S., von Loeffelholz,C.,
            Tolkachov,A., Schupp,M., Pathe-Neuschafer-Rube,A., Pfeiffer,A.F.,
            Shulman,G.I., Puschel,G.P. and Birkenfeld,A.L.
  TITLE     The mammalian INDY homolog is induced by CREB in a rat model of
            type 2 diabetes
  JOURNAL   Diabetes 63 (3), 1048-1057 (2014)
   PUBMED   24222346
  REMARK    GeneRIF: suggest that mIndy is a CREB-dependent glucagon target
            gene that is induced in fasting and in type 2 diabetes
REFERENCE   5  (bases 1 to 3205)
  AUTHORS   Brauburger,K., Burckhardt,G. and Burckhardt,B.C.
  TITLE     The sodium-dependent di- and tricarboxylate transporter, NaCT, is
            not responsible for the uptake of D-, L-2-hydroxyglutarate and
            3-hydroxyglutarate into neurons
  JOURNAL   J Inherit Metab Dis 34 (2), 477-482 (2011)
   PUBMED   21264516
REFERENCE   6  (bases 1 to 3205)
  AUTHORS   Gopal,E., Miyauchi,S., Martin,P.M., Ananth,S., Srinivas,S.R.,
            Smith,S.B., Prasad,P.D. and Ganapathy,V.
  TITLE     Expression and functional features of NaCT, a sodium-coupled
            citrate transporter, in human and rat livers and cell lines
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 292 (1), G402-G408 (2007)
   PUBMED   16973915
  REMARK    GeneRIF: Expression and function of NaCT in a cell line and in
            primary hepatocytes from rat liver.
REFERENCE   7  (bases 1 to 3205)
  AUTHORS   Yodoya,E., Wada,M., Shimada,A., Katsukawa,H., Okada,N.,
            Yamamoto,A., Ganapathy,V. and Fujita,T.
  TITLE     Functional and molecular identification of sodium-coupled
            dicarboxylate transporters in rat primary cultured cerebrocortical
            astrocytes and neurons
  JOURNAL   J Neurochem 97 (1), 162-173 (2006)
   PUBMED   16524379
REFERENCE   8  (bases 1 to 3205)
  AUTHORS   Inoue,K., Fei,Y.J., Zhuang,L., Gopal,E., Miyauchi,S. and
            Ganapathy,V.
  TITLE     Functional features and genomic organization of mouse NaCT, a
            sodium-coupled transporter for tricarboxylic acid cycle
            intermediates
  JOURNAL   Biochem J 378 (Pt 3), 949-957 (2004)
   PUBMED   14656221
REFERENCE   9  (bases 1 to 3205)
  AUTHORS   Inoue,K., Zhuang,L., Maddox,D.M., Smith,S.B. and Ganapathy,V.
  TITLE     Structure, function, and expression pattern of a novel
            sodium-coupled citrate transporter (NaCT) cloned from mammalian
            brain
  JOURNAL   J Biol Chem 277 (42), 39469-39476 (2002)
   PUBMED   12177002
  REMARK    GeneRIF: NaCT is expressed in liver, testis and brain in rat and
            shows preference for citrate over dicarboxylates; it may play a
            role in cellular utilization of citrate in blood for the synthesis
            of fatty acids and cholesterol and for the generation of energy
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 17, 2022 this sequence version replaced NM_170668.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF522186.1, SRR26643286.30938.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000010.1  57388709-57388848   c
            141-269             JAXUCZ010000010.1  57384205-57384333   c
            270-406             JAXUCZ010000010.1  57383802-57383938   c
            407-594             JAXUCZ010000010.1  57382392-57382579   c
            595-763             JAXUCZ010000010.1  57381244-57381412   c
            764-886             JAXUCZ010000010.1  57379650-57379772   c
            887-1105            JAXUCZ010000010.1  57374430-57374648   c
            1106-1206           JAXUCZ010000010.1  57373503-57373603   c
            1207-1325           JAXUCZ010000010.1  57372326-57372444   c
            1326-1487           JAXUCZ010000010.1  57370126-57370287   c
            1488-1625           JAXUCZ010000010.1  57368016-57368153   c
            1626-3205           JAXUCZ010000010.1  57364806-57366385   c
FEATURES             Location/Qualifiers
     source          1..3205
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3205
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /note="solute carrier family 13 member 5"
                     /db_xref="GeneID:266998"
                     /db_xref="RGD:631374"
     exon            1..140
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1757
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /note="sodium-dependent citrate transporter;
                     sodium-coupled citrate transporter; solute carrier family
                     13 (sodium-dependent citrate transporter), member 5"
                     /codon_start=1
                     /product="Na(+)/citrate cotransporter"
                     /protein_id="NP_733768.1"
                     /db_xref="GeneID:266998"
                     /db_xref="RGD:631374"
                     /translation="MASAKTYVTKFKSFVILFFAPILLLPLIILVPDKFARCAYVIIL
                     MAIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQVCVQYMTDTNMLFLGSLIVATAVER
                     WELHKRIALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMV
                     ATNVAVDASQRTMELLDKNKASELPGSQVVFEDPSVQKQEDEETKNMYKAMNLCVCYA
                     ASIGGTATLTGTGPNVVLLGQMQELFPDSKDVMNFASWFAFALPNMLLMLVMAWLWLL
                     CFYMRPNLKKTCICCGRKKKDTEKIASKVLYEEYRKLGPLSYAECNVLFCFGLLIILW
                     FSRDPGFMPGWLSIAWIEGNTKHVTDATVAIFVAILLFIVPSQKPKFNFSRQTEEERK
                     TPFYPPPLLNWKVTQEKVPWGIVLLLGGGFAMAKGCETSGLSEWMARQMEPLSSVRPA
                     IITLILSCIVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTLSASLAFML
                     PVATPPNAIVFAYGHLKVIDMVKTGLVMNILGIASVFLSVNTWGRAVFNLDKFPDWAN
                     LTHINT"
     exon            141..269
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
     exon            270..406
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
     exon            407..594
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
     exon            595..763
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
     exon            764..886
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1105
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1206
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1325
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1487
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1625
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..3205
                     /gene="Slc13a5"
                     /gene_synonym="Nact"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caatcttttc tccctccagt ctgtctccct ttcacgcgat ggcttcggcg aagacttatg
       61 tgaccaagtt caagtccttc gtgattttgt tcttcgcccc gatcctgctg cttccactca
      121 tcattctggt acctgacaag tttgccaggt gtgcctatgt tataatcctc atggccatct
      181 actggtgcac agatgtcatc ccagtggcta tcacctccct cctgcctgtc ttactcttcc
      241 cacttttgaa ggttctggac tccaagcagg tatgtgtcca atacatgacg gacaccaaca
      301 tgctgttcct gggcagtctc attgtggcca cggctgtgga acgttgggaa cttcataaga
      361 ggattgctct gagaatgcta ctctttgtgg ggaccaagcc ttcacggctg atgctgggct
      421 tcatgttcgt cacagccttc ctgtccatgt ggatcagcaa tactgccacc acggccatga
      481 tgatacccat tgtggaggcc atgctggagc aaatggtagc cacaaatgta gcggtggatg
      541 ccagccagag gacaatggaa ctgttggaca agaacaaggc cagcgaattg ccaggaagcc
      601 aggtggtatt tgaagacccc agtgtgcaga agcaggagga tgaagaaaca aagaatatgt
      661 acaaggctat gaacctatgt gtgtgctacg cagccagcat cgggggtaca gccaccttga
      721 ccgggacggg acccaacgtg gtgctcctgg gccagatgca ggaattgttt cctgacagta
      781 aagacgtcat gaactttgca tcttggtttg catttgccct cccaaacatg cttttgatgc
      841 tggtgatggc ctggctgtgg ctcctgtgtt tttacatgag acccaattta aaaaaaactt
      901 gcatctgctg tgggaggaag aagaaggaca cggagaagat tgcctccaag gtgctgtatg
      961 aggagtacag gaagctgggg cccttgagct atgctgaatg caacgtgctc ttttgcttcg
     1021 gcctgctcat catcctgtgg ttctcccgag accccggctt catgcctggc tggctgtcca
     1081 tcgcctggat cgagggaaat accaagcatg tcacggacgc cacagtggcc atctttgtgg
     1141 ccattttgct tttcatcgta ccctcacaaa agcccaagtt caatttcagc cgccagactg
     1201 aggaagaaag gaaaactccc ttctaccccc cgccactgct gaattggaaa gtcacccaag
     1261 agaaagtgcc ctggggcatt gtgctgctcc tggggggagg atttgctatg gccaaaggat
     1321 gtgagacttc agggctctct gagtggatgg cgagacagat ggagcccttg agctcagtga
     1381 gacctgctat tattaccttg atcttgtcct gtattgttgc aatgaccaca gagtgcacga
     1441 gtaacgtggc cactactacc ctgttcctgc ctatctttgc ctccatggct cgttccatcg
     1501 gcatccatcc actgtatgtc atgattccct gcaccttgag tgcgtcactt gccttcatgt
     1561 tgcctgtggc caccccacct aacgccatcg tgtttgccta cggacacctc aaagttattg
     1621 acatggtaaa aacaggattg gtaatgaaca tccttggaat tgcatctgtg tttctgtcag
     1681 tcaacacctg gggacgggct gtgtttaact tggataaatt ccctgactgg gcaaatttga
     1741 cacatattaa cacttaggag aaccacaaga gcacaggctt gtcccccaac cctttcgagg
     1801 actgcgaacc ttctggcaca ccttgcacag agcactggtg ctcatacccc agtgtgaccc
     1861 aatgatgtca acaccccaag aagatctaac caactagcca cctcttcctc caggctcagg
     1921 ttcagagatg gcaatgggcg atgggaagat aggctcagaa gggaaaggaa cctttgagag
     1981 gtcgtgaggc ccatcttccc taggaccctt ccatctcacc tgggcaggaa acagagggac
     2041 tggggctcaa gtcctgtacc acgtggcttt gaaagacttc tgactccatg ctgggctcta
     2101 gttctcacat gcctgttccc acggtctcca catggggatc agatgaccag gagacagccc
     2161 ctgtgcctct tctggatgtt cccagatcac catctctatc accacgaagg aacttcctct
     2221 ccaggacaga actctgatct tgaacacttt ccactgccag agttagagtg gaaatcacgg
     2281 ccccctgaag actttgactc tacatggtgc catctccaac cactgggcaa cctgaggtcc
     2341 taacattgag gccttcctgc tcacccttgg ctgacctgtt ccctacttgc cttgtctctt
     2401 attagttaac agtttgaggc cccttcccag ctccccagtg agacttcatc aactcctaga
     2461 tgctcctggc tgaggctccc cagaaagtcc ctgtttgatt gttctgggga tgctcatcct
     2521 gccagcctgg agcagctggg tcatacatca gggatggaca atggtgtctc tttaggggat
     2581 ggtgttaaag tgggatacct aagccttcct tcctttggct ggatccagag cagattcagc
     2641 agctcgttta taagggctgg gccaccacag ttggtcctgt tggactcttg agctcctcca
     2701 gaaggccttt tccttgctgt ctgtgcactg tgggcaagcc tggtagcaac cgggcatggt
     2761 tgagatgagc gatgcttgct ggtgtctgag cggacagacc ctgccagagt aagctgacta
     2821 ggtagagtgt ccatgggaac ccatgggacc actcacatga aagggagaca gaagaggaag
     2881 ctctcccttg tccttcaggg atgctctctt ccttgcttaa tttgctctga aaagaagcat
     2941 gagtggggag ataagatccg tggatgtcat tttatttttc caggcagaag acagtatgag
     3001 gacccaagga gtccccatca aagaccaagt atgtgtctgg ctccttggga gggatggctc
     3061 ctgaccatac tgtcgaaggc ttgctcttgt caaatactct gtctgctatg gaaagttcca
     3121 gtgtgctgac tggtctgtga tttcgtgcct tgtgaaggag acagagggag gcagatgaat
     3181 aaacagttgc tctctgtcca cctcc
//
