LOCUS       NM_022866               3206 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 13 member 3 (Slc13a3),
            mRNA.
ACCESSION   NM_022866
VERSION     NM_022866.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3206)
  AUTHORS   Dewulf,J.P., Wiame,E., Dorboz,I., Elmaleh-Berges,M., Imbard,A.,
            Dumitriu,D., Rak,M., Bourillon,A., Helaers,R., Malla,A.,
            Renaldo,F., Boespflug-Tanguy,O., Vincent,M.F., Benoist,J.F.,
            Wevers,R.A., Schlessinger,A., Van Schaftingen,E., Nassogne,M.C. and
            Schiff,M.
  TITLE     SLC13A3 variants cause acute reversible leukoencephalopathy and
            alpha-ketoglutarate accumulation
  JOURNAL   Ann Neurol 85 (3), 385-395 (2019)
   PUBMED   30635937
REFERENCE   2  (bases 1 to 3206)
  AUTHORS   Breljak,D., Ljubojevic,M., Hagos,Y., Micek,V., Balen Eror,D.,
            Vrhovac Madunic,I., Brzica,H., Karaica,D., Radovic,N., Kraus,O.,
            Anzai,N., Koepsell,H., Burckhardt,G., Burckhardt,B.C. and
            Sabolic,I.
  TITLE     Distribution of organic anion transporters NaDC3 and OAT1-3 along
            the human nephron
  JOURNAL   Am J Physiol Renal Physiol 311 (1), F227-F238 (2016)
   PUBMED   27053689
REFERENCE   3  (bases 1 to 3206)
  AUTHORS   Schorbach,L., Krick,W., Burckhardt,G. and Burckhardt,B.C.
  TITLE     Glutathione is a low-affinity substrate of the human
            sodium-dependent dicarboxylate transporter
  JOURNAL   Nephron Physiol 124 (1-2), 1-5 (2013)
   PUBMED   24247155
REFERENCE   4  (bases 1 to 3206)
  AUTHORS   Brauburger,K., Burckhardt,G. and Burckhardt,B.C.
  TITLE     The sodium-dependent di- and tricarboxylate transporter, NaCT, is
            not responsible for the uptake of D-, L-2-hydroxyglutarate and
            3-hydroxyglutarate into neurons
  JOURNAL   J Inherit Metab Dis 34 (2), 477-482 (2011)
   PUBMED   21264516
REFERENCE   5  (bases 1 to 3206)
  AUTHORS   Liu,W., Hong,Q., Bai,X.Y., Fu,B., Xie,Y., Zhang,X., Li,J., Shi,S.,
            Lv,Y., Sun,X. and Chen,X.
  TITLE     High-affinity Na(+)-dependent dicarboxylate cotransporter promotes
            cellular senescence by inhibiting SIRT1
  JOURNAL   Mech Ageing Dev 131 (10), 601-613 (2010)
   PUBMED   20813124
  REMARK    GeneRIF: NaDC3 promotes cellular senescence probably by inhibiting
            NAD(+)-dependent SIRT1.
REFERENCE   6  (bases 1 to 3206)
  AUTHORS   Inoue,K., Zhuang,L., Maddox,D.M., Smith,S.B. and Ganapathy,V.
  TITLE     Structure, function, and expression pattern of a novel
            sodium-coupled citrate transporter (NaCT) cloned from mammalian
            brain
  JOURNAL   J Biol Chem 277 (42), 39469-39476 (2002)
   PUBMED   12177002
REFERENCE   7  (bases 1 to 3206)
  AUTHORS   Pajor,A.M., Gangula,R. and Yao,X.
  TITLE     Cloning and functional characterization of a high-affinity
            Na(+)/dicarboxylate cotransporter from mouse brain
  JOURNAL   Am J Physiol Cell Physiol 280 (5), C1215-C1223 (2001)
   PUBMED   11287335
REFERENCE   8  (bases 1 to 3206)
  AUTHORS   Huang,W., Wang,H., Kekuda,R., Fei,Y.J., Friedrich,A., Wang,J.,
            Conway,S.J., Cameron,R.S., Leibach,F.H. and Ganapathy,V.
  TITLE     Transport of N-acetylaspartate by the Na(+)-dependent high-affinity
            dicarboxylate transporter NaDC3 and its relevance to the expression
            of the transporter in the brain
  JOURNAL   J Pharmacol Exp Ther 295 (1), 392-403 (2000)
   PUBMED   10992006
REFERENCE   9  (bases 1 to 3206)
  AUTHORS   Chen,X., Tsukaguchi,H., Chen,X.Z., Berger,U.V. and Hediger,M.A.
  TITLE     Molecular and functional analysis of SDCT2, a novel rat
            sodium-dependent dicarboxylate transporter
  JOURNAL   J Clin Invest 103 (8), 1159-1168 (1999)
   PUBMED   10207168
REFERENCE   10 (bases 1 to 3206)
  AUTHORS   Kekuda,R., Wang,H., Huang,W., Pajor,A.M., Leibach,F.H., Devoe,L.D.,
            Prasad,P.D. and Ganapathy,V.
  TITLE     Primary structure and functional characteristics of a mammalian
            sodium-coupled high affinity dicarboxylate transporter
  JOURNAL   J Biol Chem 274 (6), 3422-3429 (1999)
   PUBMED   9920886
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129094.1.
            
            On Dec 8, 2007 this sequence version replaced NM_022866.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129094.1, AF081825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3206
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3206
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /note="solute carrier family 13 member 3"
                     /db_xref="GeneID:64846"
                     /db_xref="RGD:628786"
     exon            1..139
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1831
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /note="naDC-3; rNaDC3; sodium-dependent high-affinity
                     dicarboxylate transporter 2; Na(+)-coupled carboxylate
                     transporter 3; sodium-dependent high-affinity
                     dicarboxylate transporter 3; solute carrier family 13
                     (sodium-dependent dicarboxylate transporter), member 3"
                     /codon_start=1
                     /product="Na(+)/dicarboxylate cotransporter 3"
                     /protein_id="NP_074057.2"
                     /db_xref="GeneID:64846"
                     /db_xref="RGD:628786"
                     /translation="MAALAALAKKVWSARRLLVLLLVPLALLPILFALPPKEGRCLYV
                     ILLMAVYWCTEALPLSVTALLPIILFPFMGILPSSKVCPQYFLDTNFLFLSGLIMASA
                     IEERNLHRRIALKVLMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIASAILK
                     SLFGQRDARKDLPREGEDSTAAVRGNGLRTVPTEMQFLASSEGGHAEDVEAPLELPDD
                     SKEEEHRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSW
                     FIFAFPLMLLFLLVGWLWISFLYGGMSWRGWRKKNSKLRDVAEDKAKAVIQEEFQNLG
                     PIKFAEQAVFILFCLFAILLFSRDPKFIPGWASLFAPGFVSDAVTGVAIVTILFFFPS
                     QKPSLKWWFDFKAPNSETEPLLSWKKAQETVPWNIILLLGGGFAMAKGCEESGLSAWI
                     GGQLHPLEHVPPLLAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLHVHPLYLM
                     IPGTVSCSYAFMLPVSTPPNSIAFSTGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQ
                     AIFQLGTFPDWANTHAANVTALPPALTNNTVQTL"
     exon            140..405
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            406..569
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            570..636
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            637..816
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            817..942
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1038
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1143
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1241
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1354
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1516
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1654
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..3179
                     /gene="Slc13a3"
                     /gene_synonym="NaC3; Nadc3; SDCT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgcccgg tctccggcga tcgcgcggat ggcggcgctg gcggcgctgg ccaagaaggt
       61 gtggagcgcg cggcgcctgc tggtgctgct gctggtgccg ctggctctgc tgcccattct
      121 cttcgccctg ccgcccaagg aaggccgttg cctgtatgtc atcttgctca tggcggtgta
      181 ttggtgcaca gaggccctgc ccctgtcagt gacggctctt ctgcccatca tcctcttccc
      241 cttcatgggt attctaccct ccagcaaggt ctgtccccag tacttcctcg acaccaactt
      301 cctcttcctc agcggcctga tcatggccag tgccattgag gaacggaact tgcaccggag
      361 aatcgccctc aaggtcctca tgctggttgg ggtccagcct gcaaggctca tcctggggat
      421 gatggtgacc acgtcattcc tgtctatgtg gctgagcaac acggcttcca ccgcaatgat
      481 gctgcccatc gccagtgcca tcctcaagag cctctttggc cagcgcgacg ctcggaagga
      541 ccttccccgg gaaggcgagg acagcacagc tgctgtgcgg ggaaatggac ttcgaacagt
      601 gcccacggag atgcagtttc tcgccagttc agaaggaggc cacgctgagg atgtagaggc
      661 cccactggag ttgcctgatg actccaagga ggaggaacat cgcaggaaca tctggaaggg
      721 cttcctcatt tccattccct actcagccag catcgggggc accgccaccc tcacaggcac
      781 agcccccaac ctcatcctgc tcggccagct caagagtttc tttccacagt gtgatgtggt
      841 aaattttggc tcctggttca tctttgcctt ccctctcatg ctgctgttcc tactggtggg
      901 ctggctctgg atctccttcc tctacggtgg aatgagctgg aggggctgga ggaagaagaa
      961 ctcgaagtta cgagacgttg cagaggataa ggctaaagct gtgattcagg aggagttcca
     1021 gaacctaggg cccatcaagt ttgctgaaca ggctgtcttc atcttgttct gcttgtttgc
     1081 catcctcctc ttctcccggg acccgaagtt tatccctggc tgggccagcc tcttcgcccc
     1141 tgggtttgtt tcagatgctg tcaccggtgt ggccattgtc accatcctgt tcttcttccc
     1201 ttcccagaag ccctcactca agtggtggtt tgacttcaaa gctcccaact cggagacaga
     1261 gcccctgctg agctggaaga aggcccagga gacagtgccc tggaatatca tccttctcct
     1321 gggaggtggc tttgccatgg ccaaaggctg tgaggagtcg gggctgtctg cgtggatcgg
     1381 tgggcagctg caccccctag agcatgttcc cccactgctg gctgtgctac tcatcactgt
     1441 ggtcatcgcc ttcttcacag agttcgccag caacacggcc accatcatca tcttcctgcc
     1501 tgtcctggca gagctggcca tccgactgca cgtgcacccc ttgtacctga tgatcccggg
     1561 cacggtcagc tgttcctacg ccttcatgct gccggtctcg acgcccccca actctattgc
     1621 cttctccact ggacacttgc tggtcaaaga catggtgcgg accggccttc tgatgaacct
     1681 gatgggtgtc ctgctgctca gcctggccat gaacacctgg gcacaggcca tcttccagct
     1741 gggcaccttc ccagactggg ccaacaccca cgctgccaat gtgaccgcac tgccacccgc
     1801 cttgaccaac aacacagttc aaaccctctg aacactgatg gggacttctt tttccggctg
     1861 ggcgttcctc ccagcgggtt gttgctgttg ttgctgctgg gatcctacaa gctgatcgag
     1921 taattcttcc ctgtaatctg ctaggaggct gccagccagg ttccctgggc cacaggctca
     1981 ctgtctgcag cgccttctct ttctttctca tgcatttcaa agctaactcc tgcacctgat
     2041 gcctgaggaa caggcttttc tcaccgagct ggtctgtggc cacggtgtgg ggaaagtcca
     2101 cttgagccac aagctgaaat ggcgaggctg aagtggtgtt tgttttgcaa cacctagggt
     2161 cgagggtatc gagacaggag gagctatgtg actgcaaagc tccagatgtt acagatgttc
     2221 acagctggct ggattctgcc ttttctgttt aaccatctcc cttgcagatg atacctggca
     2281 gctagaggtc ggcttccatt gcctgaggcg gagggagtac acaggtcttc ctggagtctc
     2341 tctgctgctt ccccaatctc gcaagcagca caccatgggg tttgaaaaac tccaactcac
     2401 acatctatcc aagatgcctg ggattctctt tttttcatct gattctctta ggaccaagct
     2461 ctaggtcagc cttgctcatt atccttctag ggccctcctg tctgtggccc tggggagggg
     2521 ctctgtggct gcagaccacc agctgttttt actctaacaa ctgggtttgg cctccccccc
     2581 ccccccgccc cacatgatca gtaagttcta tttgcaaagg ccacaatctt caggggtgag
     2641 agaaaaatct gaaagacgtg gagacctgtg agaaaaccag ggcaaagtat ctcaggccag
     2701 aagtgtgctg taacattgtg acattgtaac atcctgcaga tggagacccc acccccaccc
     2761 ccagtcccct tccaccagag gccgaagcct gaaagcagac agttgctgtc cttattccca
     2821 gtaaaagcct ctgatactct gcgaacagca cactgtgggg acagtgggca gctcggaact
     2881 cggctgacac cagaggtgga accatcactt cctccagagg gtggacatcc gaaggatgga
     2941 cactttctgt taaggcacaa gtgagtcaga gtattttccc agagctgggc tggagggggc
     3001 ctgagctgga agtgacactg taagactgag tcagcacccc ctgggtctgg atagtgggat
     3061 ccctcagggg acaaggacgg gcatacacag agaagaccat ggccttgtga ccacaggatt
     3121 catgatttct gatactgctg atccaatatg cgctcaaata aataaagact gttagtcaaa
     3181 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
