LOCUS       NM_031746               2438 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 13 member 2 (Slc13a2),
            mRNA.
ACCESSION   NM_031746
VERSION     NM_031746.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2438)
  AUTHORS   Campagno,R.V., Severin,M.J., Nosetto,E.C., Brandoni,A. and
            Torres,A.M.
  TITLE     Renal expression and urinary excretion of Na+/dicarboxylate
            cotransporter 1 (NaDC1) in obstructive nephropathy: a candidate
            biomarker for this pathology
  JOURNAL   Pflugers Arch 470 (12), 1777-1786 (2018)
   PUBMED   30140954
  REMARK    GeneRIF: The renal expression of NaDC1 was decreased in the mouse
            model of obstructive nephropathy. The urinary excretion of NaDC1
            increased after short times of ureteral obstruction.
REFERENCE   2  (bases 1 to 2438)
  AUTHORS   Hu,J., Shi,Y., Wang,C., Wan,H., Wu,D., Wang,H. and Peng,X.
  TITLE     Role of intestinal trefoil factor in protecting intestinal
            epithelial cells from burn-induced injury
  JOURNAL   Sci Rep 8 (1), 3201 (2018)
   PUBMED   29453360
  REMARK    GeneRIF: ITF can improve cytomorphosis ability for promoting cell
            migration with limited effect on cell proliferation, which can be
            enhanced with addition of mucin. The main mechanism of ITF in
            maintaining intestinal mucosal barrier may be attributed to
            acceleration of cell migration.
            Erratum:[Sci Rep. 2020 Jul 24;10(1):12741. doi:
            10.1038/s41598-020-69648-x.. PMID: 32704055]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2438)
  AUTHORS   Brandoni,A. and Torres,A.M.
  TITLE     Expression of renal Oat5 and NaDC1 transporters in rats with acute
            biliary obstruction
  JOURNAL   World J Gastroenterol 21 (29), 8817-8825 (2015)
   PUBMED   26269671
  REMARK    GeneRIF: Cholestasis induced by common bile duct ligation in the
            rat induces upregulation of NaDC1 in kidneys.
REFERENCE   4  (bases 1 to 2438)
  AUTHORS   Hering-Smith,K.S., Mao,W., Schiro,F.R., Coleman-Barnett,J.,
            Pajor,A.M. and Hamm,L.L.
  TITLE     Localization of the calcium-regulated citrate transport process in
            proximal tubule cells
  JOURNAL   Urolithiasis 42 (3), 209-219 (2014)
   PUBMED   24652587
  REMARK    GeneRIF: NaDC1 was predominantly located in discrete apical
            membrane or subapical areas in proximal kidney tubules.
REFERENCE   5  (bases 1 to 2438)
  AUTHORS   Komura,M., Fukuta,T., Genda,T., Hino,S., Aoe,S., Kawagishi,H. and
            Morita,T.
  TITLE     A short-term ingestion of fructo-oligosaccharides increases
            immunoglobulin A and mucin concentrations in the rat cecum, but the
            effects are attenuated with the prolonged ingestion
  JOURNAL   Biosci Biotechnol Biochem 78 (9), 1592-1602 (2014)
   PUBMED   25209509
  REMARK    GeneRIF: These findings may explain the
            fructo-oligosaccharides-induced early elevation of IgA and mucin
REFERENCE   6  (bases 1 to 2438)
  AUTHORS   Chen,X.Z., Shayakul,C., Berger,U.V., Tian,W. and Hediger,M.A.
  TITLE     Characterization of a rat Na+-dicarboxylate cotransporter
  JOURNAL   J Biol Chem 273 (33), 20972-20981 (1998)
   PUBMED   9694847
REFERENCE   7  (bases 1 to 2438)
  AUTHORS   Sekine,T., Cha,S.H., Hosoyamada,M., Kanai,Y., Watanabe,N.,
            Furuta,Y., Fukuda,K., Igarashi,T. and Endou,H.
  TITLE     Cloning, functional characterization, and localization of a rat
            renal Na+-dicarboxylate transporter
  JOURNAL   Am J Physiol 275 (2), F298-F305 (1998)
   PUBMED   9691021
REFERENCE   8  (bases 1 to 2438)
  AUTHORS   Sekine,T., Watanabe,N., Hosoyamada,M., Kanai,Y. and Endou,H.
  TITLE     Expression cloning and characterization of a novel multispecific
            organic anion transporter
  JOURNAL   J Biol Chem 272 (30), 18526-18529 (1997)
   PUBMED   9228014
REFERENCE   9  (bases 1 to 2438)
  AUTHORS   Khatri,I.A., Kovacs,S.V. and Forstner,J.F.
  TITLE     Cloning of the cDNA for a rat intestinal Na+/dicarboxylate
            cotransporter reveals partial sequence homology with a rat
            intestinal mucin
  JOURNAL   Biochim Biophys Acta 1309 (1-2), 58-62 (1996)
   PUBMED   8950177
REFERENCE   10 (bases 1 to 2438)
  AUTHORS   Khatri,I.A., Forstner,G.G. and Forstner,J.F.
  TITLE     Suggestive evidence for two different mucin genes in rat intestine
  JOURNAL   Biochem J 294 (Pt 2) (Pt 2), 391-399 (1993)
   PUBMED   8373354
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF058714.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF058714.1, AB001321.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2438
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..2438
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /note="solute carrier family 13 member 2"
                     /db_xref="GeneID:65202"
                     /db_xref="RGD:61920"
     exon            1..166
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1828
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /note="sodium-dependent dicarboxylate transporter; naDC-1;
                     intestinal sodium/dicarboxylate cotransporter;
                     Na(+)/dicarboxylate cotransporter 1; solute carrier family
                     13 (sodium-dependent dicarboxylate transporter), member 2"
                     /codon_start=1
                     /product="solute carrier family 13 member 2"
                     /protein_id="NP_113934.1"
                     /db_xref="GeneID:65202"
                     /db_xref="RGD:61920"
                     /translation="MATCWPALWAYRFYLIVLCLPIFLLPLPLIVQTKEAYCAYSIIL
                     MALLWCTEALPLAVTALFPIVLFPLMGIMDASEVCIEYFKDTNILFVGGLMVAIAVEH
                     WNLHKRIALQVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQ
                     GSKKDVEGGNNNPTFELQEECPQKEVTKLDNGQPVSAPSEPRTQKTQEHHRFSQGLSL
                     CICYSASIGGIATLTGTTPNLVLQGQVNSLFPQNGNVVNFASWFGFAFPTMIILLLLA
                     WLWLQVLFLGVNFRKNFGFGEGEEERKQAAFQVIKTQYRLLGPMSFAEKTVTVLFVLL
                     VVLWFTREPGFFPGWGDTVFANEKGQSMASDGTVAIFISLVMFIIPSKIPGLMQDPKK
                     PGKLKAPPAILTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTPLQHIP
                     PSATAVILCLLIAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAF
                     MLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITLSINSWSIPIFKLDTFPSW
                     AHSNTSQCLLNPSNSTVPGGL"
     exon            167..295
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..432
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..632
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..804
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..927
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1146
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1235
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1357
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1519
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1657
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..2430
                     /gene="Slc13a2"
                     /gene_synonym="mucin; Nadc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttccgtg cctcctggac gaggctgctc tggcagcctc agcccggaca ggttggtcca
       61 caccatggcc acctgctggc cggcactatg ggcttatcgc ttctacctga ttgtgctctg
      121 tctgcccatt ttcctgttgc ctctgccact cattgtccaa actaaggaag cctactgtgc
      181 ttactccatc atcctcatgg cactgctgtg gtgtaccgag gccctgccct tggctgtcac
      241 tgccctcttc cccatcgtcc tcttcccctt gatgggcatc atggatgcct ctgaggtctg
      301 catagagtac ttcaaggaca ccaacatatt gtttgtcggg gggctgatgg tggccattgc
      361 tgtagaacac tggaacctgc acaaacgcat tgccctccaa gtgcttctta tcatcggagt
      421 gcggcctgcc ctgctgcttc tgggcttcat gttggtcaca gccttcctct ccatgtggat
      481 tagcaacaca gccaccacag ccatgatggt acccatcggg catgcagtcc tggaacagct
      541 gcagggctcc aaaaaggacg tggagggagg caataataac cccacctttg agctccagga
      601 agaatgtccc cagaaggagg tgaccaagct tgataatgga caacctgtat ctgctccttc
      661 agagccaaga acacagaaga cccaagagca tcaccgcttc agccagggcc tgagtctctg
      721 catctgctac tcagccagca tcgggggcat tgccaccctg acgggtacca cgcccaacct
      781 ggtgctccaa ggccaggtca actcgctctt cccccaaaat ggcaatgtgg tgaactttgc
      841 ttcgtggttt ggtttcgcct tccccaccat gatcatcttg ctgctgctgg cttggctatg
      901 gctacaggtc ctcttcctgg gtgtcaactt ccggaagaac tttggctttg gggaagggga
      961 agaggaacga aagcaggctg ctttccaggt catcaagacc cagtacaggc tgctggggcc
     1021 catgagtttt gcagagaaga ctgtcactgt tctgtttgtc ctgctggtgg tgctctggtt
     1081 cacgagagag ccgggcttct tcccaggctg gggtgacaca gttttcgcca atgaaaaagg
     1141 gcaaagcatg gcgtcagatg ggacagtggc catcttcatc agcctggtta tgttcatcat
     1201 accctccaag atcccaggac taatgcagga ccccaaaaaa ccagggaagc tgaaggctcc
     1261 tcctgccatc ctcacctgga agacagtgaa cgataagatg ccctggaata tcgtgatctt
     1321 gctgggtggg ggctttgccc tggccaaagg cagtgagcaa tcaggtctgt ctgaatggct
     1381 gggagacaaa ctgaccccac tgcagcacat accgccatca gccactgcag tcatcctctg
     1441 ccttttgatc gccatcttca ctgagtgtac cagtaacgtg gccaccacta cgctatttct
     1501 acccatcctg gcctccatgg cacaagccat ctgtcttcac ccgctctacg tcatgctccc
     1561 ctgcaccctg gctgcctccc tggctttcat gctacctgtg gccactccac ccaacgccat
     1621 tgtattctcc tttggaggcc tcaaggtgtc tgatatggcc cgcgctggat tcctgctcaa
     1681 tatcatcgga gtgctggcta tcacattatc catcaacagc tggagtatcc ccatcttcaa
     1741 gctggacaca ttcccctcct gggcccactc caacacaagc cagtgccttc tcaatccgtc
     1801 taattccact gtaccaggag gcctctagac tacctacaac ccagctctgc tcaggaaaac
     1861 ccgccggtgc cactccttag agccaggaga gggcgcccca aacgccaagt cccgggccag
     1921 agatggagaa taggccggcg cacgcgcaat cgtgtactcg tgtgtctgcc tagatcctgt
     1981 gtgctctctc tccagtgaag aggaagatgc tcacgcctcc gtgtggagtg cgtggacgct
     2041 tgtgtgtggt atggcatgag gacttctcag tagttgtatg catggtaaca gcacctgcac
     2101 tctggctccc agctaggcct ccagatctct ttgcactgta tttattaaaa ctctgggcag
     2161 gaggcccctg ggagcaggaa ctccaaggtg cattaaaggc tgttcatttt cagtagaatc
     2221 cgggtgtttc ccggtgttca gggcctggaa gcagaggtcg cgcacccctg ccagaccgtt
     2281 tggagtgggc gcagccaccc agcaaagttg cagtgacttc accagcggct aattgggagt
     2341 tgccagtccc tgcgtgcctt tgggaaaacc ggcctccccg ttcccagagc actccctgga
     2401 catttacata aaaccctctg cccctgccaa aaaaaaaa
//
