LOCUS       NM_001013144            5003 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus solute carrier family 12 member 7 (Slc12a7),
            mRNA.
ACCESSION   NM_001013144 XM_217744
VERSION     NM_001013144.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5003)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   2  (bases 1 to 5003)
  AUTHORS   de Los Heros,P., Alessi,D.R., Gourlay,R., Campbell,D.G., Deak,M.,
            Macartney,T.J., Kahle,K.T. and Zhang,J.
  TITLE     The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and
            inhibit the K+-Cl- co-transporters
  JOURNAL   Biochem J 458 (3), 559-573 (2014)
   PUBMED   24393035
REFERENCE   3  (bases 1 to 5003)
  AUTHORS   Melo,Z., Cruz-Rangel,S., Bautista,R., Vazquez,N.,
            Castaneda-Bueno,M., Mount,D.B., Pasantes-Morales,H., Mercado,A. and
            Gamba,G.
  TITLE     Molecular evidence for a role for K(+)-Cl(-) cotransporters in the
            kidney
  JOURNAL   Am J Physiol Renal Physiol 305 (10), F1402-F1411 (2013)
   PUBMED   24089410
  REMARK    GeneRIF: Data are consistent with a role for KCC4 in salt
            reabsorption of the thick ascending loop of Henle's loop and acid
            secretion of the collecting duct.
REFERENCE   4  (bases 1 to 5003)
  AUTHORS   Weng,T.Y., Chiu,W.T., Liu,H.S., Cheng,H.C., Shen,M.R., Mount,D.B.
            and Chou,C.Y.
  TITLE     Glycosylation regulates the function and membrane localization of
            KCC4
  JOURNAL   Biochim Biophys Acta 1833 (5), 1133-1146 (2013)
   PUBMED   23376777
REFERENCE   5  (bases 1 to 5003)
  AUTHORS   Weinstein,A.M.
  TITLE     A mathematical model of rat ascending Henle limb. I. Cotransporter
            function
  JOURNAL   Am J Physiol Renal Physiol 298 (3), F512-F524 (2010)
   PUBMED   19923415
  REMARK    GeneRIF: Kinetic models of Na+-K+-2Cl- costransporter (NKCC2) and
            K+-Cl- cotransporter (KCC4), two of the key cotransporters of the
            Henle limb, are fashioned with inclusion of terms representing
            binding and transport of NH4+.
REFERENCE   6  (bases 1 to 5003)
  AUTHORS   Belenky,M.A., Sollars,P.J., Mount,D.B., Alper,S.L., Yarom,Y. and
            Pickard,G.E.
  TITLE     Cell-type specific distribution of chloride transporters in the rat
            suprachiasmatic nucleus
  JOURNAL   Neuroscience 165 (4), 1519-1537 (2010)
   PUBMED   19932740
REFERENCE   7  (bases 1 to 5003)
  AUTHORS   Fujii,T., Takahashi,Y., Ikari,A., Morii,M., Tabuchi,Y., Tsukada,K.,
            Takeguchi,N. and Sakai,H.
  TITLE     Functional association between K+-Cl- cotransporter-4 and
            H+,K+-ATPase in the apical canalicular membrane of gastric parietal
            cells
  JOURNAL   J Biol Chem 284 (1), 619-629 (2009)
   PUBMED   18984587
  REMARK    GeneRIF: KCC4 and H+,K+-ATPase are the main machineries for basal
            HCl secretion in the apical canalicular membrane of the resting
            parietal cell. They also may contribute in part to massive acid
            secretion in the stimulated state.
REFERENCE   8  (bases 1 to 5003)
  AUTHORS   Le Rouzic,P., Ivanov,T.R., Stanley,P.J., Baudoin,F.M., Chan,F.,
            Pinteaux,E., Brown,P.D. and Luckman,S.M.
  TITLE     KCC3 and KCC4 expression in rat adult forebrain
  JOURNAL   Brain Res 1110 (1), 39-45 (2006)
   PUBMED   16872584
  REMARK    GeneRIF: In the rat brain, KCC4 express in the choroid plexus and
            the suprachiasmatic nucleus of the hypothalamus.
REFERENCE   9  (bases 1 to 5003)
  AUTHORS   Davies,S.L., Roussa,E., Le Rouzic,P., Thevenod,F., Alper,S.L.,
            Best,L. and Brown,P.D.
  TITLE     Expression of K+-Cl- cotransporters in the alpha-cells of rat
            endocrine pancreas
  JOURNAL   Biochim Biophys Acta 1667 (1), 7-14 (2004)
   PUBMED   15533301
  REMARK    GeneRIF: distribution of KCC1, KCC3a, KCC3b, KCC4, and KCC2 protein
            and mrna in pancreatic alpha-cells and beta-cells; KCC's make a
            significant contribution to volume homeostasis only in alpha-cells
REFERENCE   10 (bases 1 to 5003)
  AUTHORS   Bergeron,M.J., Gagnon,E., Wallendorff,B., Lapointe,J.Y. and
            Isenring,P.
  TITLE     Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters
  JOURNAL   Am J Physiol Renal Physiol 285 (1), F68-F78 (2003)
   PUBMED   12657561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 13, 2010 this sequence version replaced NM_001013144.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            are predicted based on partial rat transcript alignments and on
            full-length homologous protein alignments with human NP_006589.2
            and mouse NP_035520.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2857602.1,
                                           SRR26360186.260175.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000001.1  31354454-31354625   c
            173-267             JAXUCZ010000001.1  31333380-31333474   c
            268-390             JAXUCZ010000001.1  31332837-31332959   c
            391-537             JAXUCZ010000001.1  31329373-31329519   c
            538-592             JAXUCZ010000001.1  31328086-31328140   c
            593-723             JAXUCZ010000001.1  31327300-31327430   c
            724-965             JAXUCZ010000001.1  31325821-31326062   c
            966-1177            JAXUCZ010000001.1  31324418-31324629   c
            1178-1345           JAXUCZ010000001.1  31323697-31323864   c
            1346-1444           JAXUCZ010000001.1  31323318-31323416   c
            1445-1502           JAXUCZ010000001.1  31322768-31322825   c
            1503-1677           JAXUCZ010000001.1  31321929-31322103   c
            1678-1796           JAXUCZ010000001.1  31321072-31321190   c
            1797-1895           JAXUCZ010000001.1  31320569-31320667   c
            1896-2015           JAXUCZ010000001.1  31319942-31320061   c
            2016-2120           JAXUCZ010000001.1  31319198-31319302   c
            2121-2289           JAXUCZ010000001.1  31318265-31318433   c
            2290-2485           JAXUCZ010000001.1  31313637-31313832   c
            2486-2655           JAXUCZ010000001.1  31313045-31313214   c
            2656-2787           JAXUCZ010000001.1  31312807-31312938   c
            2788-2895           JAXUCZ010000001.1  31310320-31310427   c
            2896-3074           JAXUCZ010000001.1  31307898-31308076   c
            3075-3208           JAXUCZ010000001.1  31304213-31304346   c
            3209-5003           JAXUCZ010000001.1  31301243-31303037   c
FEATURES             Location/Qualifiers
     source          1..5003
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..5003
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /note="solute carrier family 12 member 7"
                     /db_xref="GeneID:308069"
                     /db_xref="RGD:1359672"
     exon            1..172
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..3300
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /note="furosemide-sensitive KCl cotransporter 4; K-Cl
                     cotransporter 4; electroneutral potassium-chloride
                     cotransporter 4; K-Cl cotransporter KCC4; solute carrier
                     family 12 (potassium/chloride transporters), member 7;
                     solute carrier family 12 (potassium/chloride transporter),
                     member 7"
                     /codon_start=1
                     /product="solute carrier family 12 member 7"
                     /protein_id="NP_001013162.2"
                     /db_xref="GeneID:308069"
                     /db_xref="RGD:1359672"
                     /translation="MPTNFTVVPVEARADGAGDEAAERTEEPGSPESADPACPTPGDG
                     NPRENSPFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEH
                     EEDEDSRRREIKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVLESFLIVAMC
                     CTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYIL
                     GTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVVFVGVKYVNKL
                     ALVFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNFDTCAKMQVVSNGTV
                     TTALWRLFCNGSSLGASCDEYFVQNNVTEIQGIPGVASGVFLDNLWSTYSDKGAFVEK
                     KGVSSVPVSEESRPGGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKS
                     IPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIV
                     IGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALICE
                     TGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMS
                     LCLALMFICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEH
                     GPPHTKNWRPQVLVMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHV
                     EAQRAEENIRSLMSAEKMKGFCQLVVSSNLRDGASHLIQSAGLGGMKHNTVLMAWPEA
                     WKQADNPFSWKNFVDTVRDTTAAHQALLVAKNIDLFPQNQERFSDGNIDVWWIVHDGG
                     MLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMV
                     ENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREAQLIHDRNTASHTVATARTEAPP
                     TPDKVQMTWTKEKLIAEKHRNKDTGTSGFKDLFSLKPDQSNVRRMHTAVKLNGVVLNK
                     SQDAQLVLLNMPGPPKSRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS"
     exon            173..267
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            268..390
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            391..537
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            538..592
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            593..723
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            724..965
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1177
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1345
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1444
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1502
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1677
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1796
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1895
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2015
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2120
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2289
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2485
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2655
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2787
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2895
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3074
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3208
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..5003
                     /gene="Slc12a7"
                     /gene_synonym="Kcc4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccggggc agcgtgtggc tgcgagggac gcagagtcta acggagccat gcccacgaac
       61 tttacggtgg tgccggtgga ggcgcgcgcc gacggcgccg gggacgaagc tgctgagcgc
      121 acggaagaac ccgggtctcc cgagagcgcg gatcctgcct gccctacgcc gggagatgga
      181 aaccccaggg agaacagccc attcatcaat aatgtggagg tggaaagaga gagctacttc
      241 gaggggaaga acatggcgct ttttgaggaa gagatggaca gcaaccccat ggtatcatca
      301 ctgctgaaca agctggccaa ctataccaac ctgagccagg gtgtggtaga gcatgaggaa
      361 gatgaggaca gccggaggcg ggagatcaag gccccacgca tgggcacctt catcggagtc
      421 tacctaccgt gcctgcagaa catcttgggt gtaatccttt tcctgcgcct gacctggatt
      481 gtgggggcgg ctggcgttct ggagtccttc ctcatcgtgg ccatgtgctg cacctgtaca
      541 atgctgacag ccatctccat gagtgccatc gctaccaacg gtgtggtccc agcgggaggc
      601 tcatactaca tgatctcccg ttcgctgggg cctgagtttg gaggggctgt tggcctctgc
      661 ttctacttgg gcacaacgtt cgcaggcgcc atgtacatcc tgggaaccat cgagatcttc
      721 ctgacctaca tctctccaag tgcagccatc ttccaggcag agacagcaga cggcgaggcg
      781 gccgcgctgc tgaacaacat gcgtgtgtat ggcagctgcg cactggcgct catggccgtg
      841 gtggtcttcg tcggagtcaa atatgtcaac aagctggccc tggtcttctt agcctgtgtt
      901 gtgctttcta tcctggccat ctatgctggt gtcatcaaga cagccttcgc cccacctgac
      961 atcccggtct gccttctagg gaaccgcacg ctggcgaatc gcaactttga tacctgtgcc
     1021 aaaatgcagg ttgtcagcaa tggcacagtc accaccgcgc tctggcgcct cttctgcaac
     1081 ggctccagct tgggtgcctc ctgcgatgag tactttgtgc agaacaatgt cactgagatc
     1141 cagggcattc ctggtgtggc cagtggtgtc ttcctggata acctgtggag cacgtattcg
     1201 gacaaggggg catttgtgga aaagaagggc gtgtcctcgg tgcctgtgtc cgaggagagc
     1261 cggcctggtg gattgccata tgtcctcaca gacatcatga cctacttcac catgctagtc
     1321 ggcatctact tcccctccgt aacggggatc atggcaggat ccaaccgctc cggggacctc
     1381 aaagatgccc agaagtccat cccaacaggg accattctgg ccattgtgac tacatctttc
     1441 atttatcttt cctgcattgt gctgtttggg gcctgcatcg agggtgtagt cttgcgagat
     1501 aagtttgggg aggccctgca agggaacttg gtcattggca tgctggcttg gccatctccc
     1561 tgggtcatcg tgattggctc cttcttctcc acctgtggtg ctggcctgca gagcctaact
     1621 ggggcacccc gcctgctgca ggccattgca cgcgacggca tcatcccctt cctgcaggtg
     1681 tttggccatg gaaaggccaa cggggagccc acgtgggccc tgctgctcac ggccctcatc
     1741 tgtgagaccg gcatcctcat cgcctccctg gacagcgtgg ctcccatcct gtccatgttc
     1801 ttcctcatgt gctacatgtt cgtcaacctg gcctgtgctg ttcagaccct gctgcgcaca
     1861 cccaactggc gtccacgttt caagttctac cactggaccc tctccttcct tgggatgagt
     1921 ctctgccttg cgctcatgtt catctgctcc tggtactacg ccctcttcgc catgctcatc
     1981 gcgggctgca tctacaagta catcgagtac cgaggggctg agaaggagtg gggggatggc
     2041 atcaggggcc tgtcactgaa tgctgcccgc tatgccctgc tgcgtgtgga acatgggccc
     2101 ccacatacca agaactggag gccccaggta ttggtgatgc tgaacctgga ctctgagcag
     2161 tgtgtaaagc acccccgcct gctgtccttc acctctcagc tgaaggctgg caagggcctg
     2221 accatcgtgg gatctgtgct ggagggcacc tacttagaca agcatgtgga ggcccagcgg
     2281 gctgaggaga atatccggtc tctgatgagt gcagagaaga tgaaaggctt ctgccagctg
     2341 gtggtgtcgt ccaacctgcg agacggtgca tcccacttga tccagtcagc tggccttggt
     2401 ggcatgaagc acaacactgt cctcatggcc tggccagagg cttggaagca ggcagataac
     2461 cctttctcct ggaagaactt tgtggacact gtccgtgaca ctacagcagc acatcaggca
     2521 ctgttggtgg ccaagaacat cgacttgttc ccgcagaacc aggagcgctt cagcgacggc
     2581 aacatcgatg tgtggtggat cgtgcacgat ggggggatgc tcatgcttct gccgttcctg
     2641 ctgcgccagc acaaggtgtg gcgaaagtgc cggatgcgca tcttcacggt cgcccaggtg
     2701 gacgataaca gcatccagat gaagaaggac ctgcagatgt tcctgtacca tctcaggatc
     2761 agcgccgagg tggaggtggt agagatggtt gaaaatgaca tttctgcatt cacctatgag
     2821 aagacgctaa tgatggagca gaggtcacag atgctgaaac agatgcagtt gtcaaagaat
     2881 gagcgggaga gagaggccca gctgattcac gacaggaaca ctgcatccca caccgtagca
     2941 acggctagaa ctgaagcccc accaacacct gacaaagtgc agatgacatg gacgaaagag
     3001 aaactcattg cagagaaaca caggaacaag gacaccggca catcaggctt caaagacctt
     3061 ttcagcctaa agccggacca gtccaacgtc agaaggatgc atactgctgt gaagctcaat
     3121 ggtgtggttc tcaacaagtc ccaggatgct caactcgtcc tgctgaatat gccaggcccc
     3181 ccaaaaagtc ggcagggcga cgagaactac atggaatttc ttgaggtctt gaccgaaggg
     3241 ctgaacaggg tcctcctggt caggggtggt ggccgggaag tcatcaccat ctactcctaa
     3301 cacctgaagc ctggacacac atggatgggg tcaggacttc gcgagctgcc tgtgaccagg
     3361 ctggggctca ccaggtgctg ctgactgatg gcctacccta gcacctgttg cctggccaac
     3421 caagatgttg cagtgatcct ggtcaccctg acacacatgg cttcccacag acataatact
     3481 ccgtaggctt cctccaagca gaggatgcta catggggagt atctagagct gttctgacag
     3541 gaatggctcc ttaacattgt cgtgggcaac ggtaggtata cccaggggat ctggggcagc
     3601 tctggcgcct ctgtaccttt cacgaacctg acagatgaac cagaacacgt gaacaagcac
     3661 acagttcctt ggggctagaa tgtcactgag cggttctcca ttggcttctg ccttcttcgt
     3721 tccttggagc atccctgatg tgctttctgt acagtaggca cactgaggac tgttcaccct
     3781 cacgcacacc tcacctcctt atttcctccc cgctctcctc agacacggct cagggtacca
     3841 ctggaaagtg acatagtgtt tacaggatag gagtgggtca ccattagagc cggtggtgcc
     3901 tgccagctct gttcccatct gagttgatgc cctaggagct cctgcagaga gaacctttgt
     3961 tctgcagggc tctctgcagt gagcccgcgt tctcttctca cgggaactca gtcactttac
     4021 ttcataagca ctgagctggg acctcaagcg ggtgactacc gggagccaca gtgtgacaaa
     4081 cagcaggaac actgagaact ctgcacatag tccatgatga cagcaaggca ccttccagag
     4141 tgtgaaccat gcacacagct tcacatatga catgccgtcc catccctcac cctcctggag
     4201 agaacagcca ggcccagccc agtaccctcg gcatcggcag ccacagccct gggtctttct
     4261 ggctgagtct cttgtctcct gctgtggagc cttgctcagc cggggccatg ggcgcctctg
     4321 cactttctaa ggagctgaca gatgatttgc actttaccct tgggcattct gttctgtagg
     4381 tcatggtttg ttcacaggct gtgggcaaca gcagtgatcc gttcctcaca ttgtgtgtgg
     4441 catatttatt tatttaaccc tccctgggga agcttgatag agatagcttc tgtgtggatg
     4501 ccccgtgctg ccaggctctg ggcatctctg gcttcctccg agagaatcaa ccccgtccac
     4561 actcacgacg ttctggttag ggtagaagcc aagtttgcac ctgcacagtt tcttcagact
     4621 ttgttaggca gccagaggta ggcttgccaa gtaactgctg cccggtgtgt gtccccatca
     4681 gggtagtgat ttccacacct gcttttgact cagcactgga cttggctcag actcctgagc
     4741 cctcgatgtc tagagcagag caggtggggc gctgctccca gctgtcagga atgccttggg
     4801 caggtggccc tttcaggttc tgggtcactg cttacaagag ctgcctgtca agagtgtcca
     4861 gcctccttat ctcgcagact ccgtgttcct ggtaactgtg gccattcaga tcagtttcat
     4921 gttttccttt ttataggctt ttgcctttgt atgactttgt tagtagaaga gtaaagttct
     4981 ataaaatata aatgtttaag gaa
//
