LOCUS       NM_013173               4398 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus solute carrier family 11 member 2 (Slc11a2),
            transcript variant 1, mRNA.
ACCESSION   NM_013173
VERSION     NM_013173.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4398)
  AUTHORS   Liang,T., Yang,S.X., Qian,C., Du,L.D., Qian,Z.M., Yung,W.H. and
            Ke,Y.
  TITLE     HMGB1 Mediates Inflammation-Induced DMT1 Increase and Dopaminergic
            Neurodegeneration in the Early Stage of Parkinsonism
  JOURNAL   Mol Neurobiol 61 (4), 2006-2020 (2024)
   PUBMED   37833459
  REMARK    GeneRIF: HMGB1 Mediates Inflammation-Induced DMT1 Increase and
            Dopaminergic Neurodegeneration in the Early Stage of Parkinsonism.
REFERENCE   2  (bases 1 to 4398)
  AUTHORS   Irollo,E., Nash,B., Luchetta,J., Brandimarti,R. and Meucci,O.
  TITLE     The Endolysosomal Transporter DMT1 is Required for Morphine
            Regulation of Neuronal Ferritin Heavy Chain
  JOURNAL   J Neuroimmune Pharmacol 18 (3), 495-508 (2023)
   PUBMED   37661197
  REMARK    GeneRIF: The Endolysosomal Transporter DMT1 is Required for
            Morphine Regulation of Neuronal Ferritin Heavy Chain.
REFERENCE   3  (bases 1 to 4398)
  AUTHORS   Wolff,N.A., Garrick,M.D., Zhao,L., Garrick,L.M., Ghio,A.J. and
            Thevenod,F.
  TITLE     A role for divalent metal transporter (DMT1) in mitochondrial
            uptake of iron and manganese
  JOURNAL   Sci Rep 8 (1), 211 (2018)
   PUBMED   29317744
  REMARK    GeneRIF: DMT1 mediates mitochondrial Fe2+ and Mn2+ acquisition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4398)
  AUTHORS   Naito,Y., Sawada,H., Oboshi,M., Okuno,K., Yasumura,S., Okuhara,Y.,
            Eguchi,A., Nishimura,K., Soyama,Y., Asakura,M., Ishihara,M.,
            Tsujino,T. and Masuyama,T.
  TITLE     Altered expression of intestinal duodenal cytochrome b and divalent
            metal transporter 1 might be associated with cardio-renal anemia
            syndrome
  JOURNAL   Heart Vessels 32 (11), 1410-1414 (2017)
   PUBMED   28669019
  REMARK    GeneRIF: impaired intestinal expression of Dcyt-b and DMT-1 might
            be associated with the reduction of an iron uptake in CKD. Taken
            together, impaired these intestinal iron transporters may become a
            novel therapeutic target for cardio-renal anemia syndrome.
REFERENCE   5  (bases 1 to 4398)
  AUTHORS   Mackenzie,K., Foot,N.J., Anand,S., Dalton,H.E., Chaudhary,N.,
            Collins,B.M., Mathivanan,S. and Kumar,S.
  TITLE     Regulation of the divalent metal ion transporter via membrane
            budding
  JOURNAL   Cell Discov 2, 16011 (2016)
   PUBMED   27462458
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4398)
  AUTHORS   Fleming,M.D., Trenor,C.C. 3rd, Su,M.A., Foernzler,D., Beier,D.R.,
            Dietrich,W.F. and Andrews,N.C.
  TITLE     Microcytic anaemia mice have a mutation in Nramp2, a candidate iron
            transporter gene
  JOURNAL   Nat Genet 16 (4), 383-386 (1997)
   PUBMED   9241278
REFERENCE   7  (bases 1 to 4398)
  AUTHORS   Sassa,S. and Bernstein,S.E.
  TITLE     Studies of erythrocyte protoporphyrin in anemic mutant mice: use of
            a modified hematofluorometer for the detection of heterozygotes for
            hemolytic disease
  JOURNAL   Exp Hematol 6 (5), 479-487 (1978)
   PUBMED   658175
REFERENCE   8  (bases 1 to 4398)
  AUTHORS   Edwards,J.A. and Hoke,J.E.
  TITLE     Red cell iron uptake in hereditary microcytic anemia
  JOURNAL   Blood 46 (3), 381-388 (1975)
   PUBMED   807277
REFERENCE   9  (bases 1 to 4398)
  AUTHORS   Kreimer-Birnbaum,M., Bannerman,R.M., Russell,E.S. and
            Bernstein,S.E.
  TITLE     Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W
            v, ha-ha, nb-nb, mk-mk, f-f and sla-Y)
  JOURNAL   Comp Biochem Physiol A Comp Physiol 43 (1), 21-30 (1972)
   PUBMED   4404581
REFERENCE   10 (bases 1 to 4398)
  AUTHORS   Bannerman,R.M., Edwards,J.A., Kreimer-Birnbaum,M., McFarland,E. and
            Russell,E.S.
  TITLE     Hereditary microcytic anaemia in the mouse; studies in iron
            distribution and metabolism
  JOURNAL   Br J Haematol 23 (2), 235-245 (1972)
   PUBMED   5070129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF008439.1.
            
            On Aug 3, 2012 this sequence version replaced NM_013173.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF008439.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4398              AF008439.1         12-4409
FEATURES             Location/Qualifiers
     source          1..4398
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..4398
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /note="solute carrier family 11 member 2"
                     /db_xref="GeneID:25715"
                     /db_xref="RGD:3684"
     CDS             1..1779
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DMT-1; NRAMP 2; divalent cation transporter 1; natural
                     resistance-associated macrophage protein 2; solute carrier
                     family 11 (proton-coupled divalent metal ion
                     transporters), member 2; Solute carrier family 11 member 2
                     (natural resistance-associated macrophage protein 2);
                     divalent metal transporter 1; solute carrier family 11
                     (proton-coupled divalent metal ion transporter), member 2"
                     /codon_start=1
                     /product="natural resistance-associated macrophage protein
                     2 isoform 1"
                     /protein_id="NP_037305.2"
                     /db_xref="GeneID:25715"
                     /db_xref="RGD:3684"
                     /translation="MGKKQPRAAASAAPNCELKSYSKSTDPQVSTMVLDPEEKIPDDG
                     ASGDHGDSASLGAINPAYSNSSLPHSTGDSEEPFTTYFDEKIPIPEEEYSCFSFRKLW
                     AFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATIVGLLLQRLAARLGVVT
                     GLHLAEVCHRQYPKVPRIILWLMVELAIIGSDMQEVIGSAIAINLLSAGRVPLYGGVL
                     ITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLRGMFVPSC
                     SGCHTPQVEQAVGIVGAVIMPHNMYLHSALVKSRQVNRANKQEVREANKYFFIESCIA
                     LFVSFIINVFVVSVFAEAFFEKTNEQVVEVCRNSSSPHADLFPNDNSTLAVDIYKGGV
                     VLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVILTRSIA
                     IIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSEFSNGIGWR
                     IAGGILVLLVCSINMYFVVVYVQELGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGL
                     SFLDCGRSVSISKVLLSEDTSGGNTK"
     exon            1..55
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            56..127
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            128..276
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..402
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            403..522
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..629
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..700
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..768
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            769..924
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1083
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1170
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1290
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1440
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1514
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1668
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..4320
                     /gene="Slc11a2"
                     /gene_synonym="Dmt1; Nramp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggggaaga agcagccgag ggcagcagca agtgctgctc caaactgtga gctaaaatcc
       61 tattctaaga gcacagatcc tcaggtatct accatggtgt tggatcctga agaaaagatt
      121 ccagacgatg gtgcttctgg ggaccatgga gactcggcca gcctcggtgc catcaaccct
      181 gcttacagca actcttccct cccacattcc accggggatt ctgaggagcc cttcaccacc
      241 tactttgatg agaaaatccc cattcctgag gaggagtact cttgttttag tttccgtaaa
      301 ctctgggcct tcacaggacc tggttttctt atgagcattg cctacctgga tccaggaaac
      361 attgaatctg atttacagtc tggagcagtg gctggattta agttgctctg ggtgctcctg
      421 ctggccacta ttgtggggct gctgctccag cgtctcgcag ctcgactggg agtggtcacc
      481 ggcttgcacc ttgctgaagt gtgtcaccgt cagtatccca aggtcccacg gatcatcctg
      541 tggctaatgg tggagttggc aatcattggt tctgatatgc aggaagtcat tggctcagcc
      601 atcgccatca atctcctgtc tgccggaagg gttcccctgt atggtggagt cctcatcacc
      661 atcgcagata cttttgtatt tctctttttg gacaaatatg gcttgcggaa gctggaagca
      721 ttttttggct ttctcatcac tatcatggcc ctcacatttg gatatgagta tgttacagtg
      781 aaacccagcc aaagccaagt actcaggggc atgttcgtgc catcctgttc aggctgccac
      841 acccctcagg tggagcaggc ggtgggcatc gtgggagctg tgatcatgcc acacaacatg
      901 tacctgcact ctgccttagt caagtctaga caagtgaacc gggccaataa gcaggaagtt
      961 cgagaagcca ataagtactt cttcatcgag tcctgcattg cactctttgt ttccttcatc
     1021 atcaatgtct ttgtcgtctc cgtctttgct gaagcatttt ttgagaaaac caatgagcag
     1081 gtggttgagg tctgcagaaa tagcagcagc ccccatgctg acctctttcc taacgacaac
     1141 tctaccctgg ctgtggacat ctacaaaggg ggtgttgtgc ttggatgtta cttcgggcct
     1201 gcggccctct acatctgggc ggtggggatc ctggctgctg gacagagctc caccatgact
     1261 ggaacctatt ctggccagtt tgtcatggag ggattcctga acctaaaatg gtcgcgcttt
     1321 gcccgcgtga tcctgaccag gtctattgcc atcatcccta ccctgcttgt tgctgtcttc
     1381 caagatgtgg agcatctgac agggatgaat gatttcctga atgttctgca gagcctacag
     1441 ctcccctttg ccctcatccc tatcctcacc ttcacaagcc tgcggccagt gatgagtgag
     1501 ttctccaacg gaataggctg gaggatcgca ggcggcatct tggtccttct cgtctgctcc
     1561 atcaacatgt actttgtcgt ggtctacgtc caggagctag ggcatgtggc actgtatgtg
     1621 gtggctgcag tggttagcgt ggcttatctg ggctttgtgt tctacttggg ttggcagtgt
     1681 ttgattgcgt tgggcctgtc gttcctggac tgtgggcgct cggtaagcat ctctaaagtc
     1741 ctgctgagcg aagataccag cggtggcaat actaagtaaa cactgggtca gcctgtctgt
     1801 ctgtctttgc agggagccat cagagccagt gtgtttctat ggtttactgt gtgaacatag
     1861 ccacaagtat gtgccgttgc acagactgca tttagggacc aactgttagt tgggaaacac
     1921 tggggtgggt gtgtggtgtg tgtgtgtgtg ttgtttcctt ctgtctttgt caaatagcat
     1981 gctgctatta aatgcttggt ggcctaaaac tctgtgtagc ctaggctgcc ttcaaactta
     2041 cagcaatcct cctggctcag cctcctgggt gctgggattc caggcatgtc taccgctcct
     2101 ggctgtcacg agtgcttaca agatgactgg ttttgtcagg ggaggtctta ccctgtagca
     2161 ttaggcagca ccttgaaaag gtgagccttg agctgttttg aacactaaat tcctaaatag
     2221 ctgtccaagg ccatggctcg gttttagttc tgagaaaccc aaccagactg ttgtcatcat
     2281 ttgaattgca gaattagaga ccgctatttt tgagttcagg atttctgttt gtttggtgca
     2341 tttcattttg tttttcaaga caagggtttc ttccttgttg tcctggaact tactctgtag
     2401 accagcctgg ctttgaactc acagagatcc tcctgcctct gcctctgctt cccgactgct
     2461 aggattagag gcatacacca ccactgccct gctaagctca gagtttttta tttctacttt
     2521 ggaattcctc agtggaaaga aaggtagagc aggagagggg gtgtggtcaa gtgatggctc
     2581 ccctccaggt ccttgcaggt ttaccttaag gagtggagct tagcagggct tcatctgtag
     2641 tcctgaggct agtgacttcc ctgttaatag caagcatccc gatagtgttt catctcgagt
     2701 acacacagtc ctggaatctc cgccttcctc tcctgagaga gtgcggatgg caaaagacta
     2761 ctgtagcact tgtgaactgg ctcacagcaa atcccagagc tgaccgcact actcccgaaa
     2821 gtacccttca ccaaatcttg gctctgaccc accgctgttt catgcccaag ataactcaga
     2881 aggcaacctc aggagctctg gacccaaacc ttgcaaagtc agtagttgtc actgtgatgc
     2941 aaagtcctct ccctgcaagg tgggactagg ctgcctcctc acagcccttc cctcggagag
     3001 aaagcctctt gagaccaggc tgcggagctc tggagattca gcacgggact acagaactgc
     3061 tgctctcagt tcagccactt ctgtcctggc acgtgggaga catgattctg tcacatcaag
     3121 tcctgtctgt ttgctggaaa ggaataatac aagtttgtat aatcattgcc ttggtggcaa
     3181 caggagctac agtgacttcg aaggatgtcg tcctctttgc cgctttccca gttcgactgt
     3241 cccgacaaat gacctgcatt gtggtgccac tgtggcatta gtgctagcat ttcacacagt
     3301 cagaagctca gcctgcatag agtcctgtga ggcatgaagg gtaaatgcag tttcactcag
     3361 cctggttgac ctcagcccca cagctaacac aacacagtca ggccgcgggt ccctcactgc
     3421 ggcattctca acccctgggt tgccacccat ttgcagcccc tatatccaaa accatttaca
     3481 ttatgattta taacagtagc agcattagtt gtgaaatagc aaagatttta tggttggggg
     3541 ttaccaccac aaagggtcgc agcagcagga agtttgagaa ccctgcacca cagggtccat
     3601 ctcacacctg cctctgccac cattgttccc aaaactgact ggaaactgag cttttgaaac
     3661 tgtctcgatg tggtgcttga gggccagatt gacagtagca gaattactgg aatggatgct
     3721 ctagtgacat ctgcatttgt acaggggcgg ggttgggcgg ggcggggcgg ggttgggcag
     3781 ggtgtgttca gagtcactgt acttacagtc cagcccagag ctgctggcag tcatgcccag
     3841 gggtctgcct tgtgcgtgct agcaaggctg tgctgcagat ctcacttcct gccccagagt
     3901 tctgctgtag tatgttcgtt tacagtgata gacggttcca ttgtgtacga cggtctctga
     3961 ctctatgcct acagtattta cagtgtcaaa gattaaaagt gtcgcctgtc catttggccg
     4021 tcactgggaa acagtgcttc caacagtgct ctgtacgtaa cctgtaagca tttcaacccc
     4081 gccacgccag tgtggcctgg cgttacgttg gcgagccatc ttgtacgttc tcacttggtc
     4141 ctcgttcttc tgcgacctga aatagttgtt ccctctgctc tgggagctgg cggctgggga
     4201 acagcagcag cttgtcttgt aaggtcctgc caggagggca acaagtgact ataaggaggc
     4261 tgttagtgag cctctgacag cttgtgaact tgctgtaatt aaaacaaaaa cttccctgtt
     4321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4381 aaaaaaaaaa aaaaaaaa
//
