LOCUS       NM_017047               1664 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus solute carrier family 10 member 1 (Slc10a1),
            mRNA.
ACCESSION   NM_017047
VERSION     NM_017047.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1664)
  AUTHORS   Asami,J., Kimura,K.T., Fujita-Fujiharu,Y., Ishida,H., Zhang,Z.,
            Nomura,Y., Liu,K., Uemura,T., Sato,Y., Ono,M., Yamamoto,M.,
            Noda,T., Shigematsu,H., Drew,D., Iwata,S., Shimizu,T., Nomura,N.
            and Ohto,U.
  TITLE     Structure of the bile acid transporter and HBV receptor NTCP
  JOURNAL   Nature 606 (7916), 1021-1026 (2022)
   PUBMED   35580629
  REMARK    GeneRIF: Structure of the bile acid transporter and HBV receptor
            NTCP.
REFERENCE   2  (bases 1 to 1664)
  AUTHORS   Mayer,P.G.K., Qvartskhava,N., Sommerfeld,A., Gorg,B. and
            Haussinger,D.
  TITLE     Regulation of Plasma Membrane Localization of the Na-Taurocholate
            Co-Transporting Polypeptide by Glycochenodeoxycholate and
            Tauroursodeoxycholate
  JOURNAL   Cell Physiol Biochem 52 (6), 1427-1445 (2019)
   PUBMED   31088037
  REMARK    GeneRIF: The present study suggests that glycochenodeoxycholate
            triggers the retrieval of Ntcp from the basolateral membrane into
            the cytosol through an oxidative stress-dependent activation of
            Fyn.
REFERENCE   3  (bases 1 to 1664)
  AUTHORS   Huo,X.K., Liu,J., Yu,Z.L., Wang,Y.F., Wang,C., Tian,X.G., Ning,J.,
            Feng,L., Sun,C.P., Zhang,B.J. and Ma,X.C.
  TITLE     Alisma orientale extract exerts the reversing cholestasis effect by
            activation of farnesoid X receptor
  JOURNAL   Phytomedicine 42, 34-42 (2018)
   PUBMED   29655695
REFERENCE   4  (bases 1 to 1664)
  AUTHORS   Tian,J., Zhu,J., Yi,Y., Li,C., Zhang,Y., Zhao,Y., Pan,C., Xiang,S.,
            Li,X., Li,G., Newman,J.W., Feng,X., Liu,J., Han,J., Wang,L.,
            Gao,Y., La Frano,M.R. and Liang,A.
  TITLE     Dose-related liver injury of Geniposide associated with the
            alteration in bile acid synthesis and transportation
  JOURNAL   Sci Rep 7 (1), 8938 (2017)
   PUBMED   28827769
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1664)
  AUTHORS   Xu,W., Lu,C., Yao,L., Zhang,F., Shao,J. and Zheng,S.
  TITLE     Dihydroartemisinin protects against alcoholic liver injury through
            alleviating hepatocyte steatosis in a farnesoid X
            receptor-dependent manner
  JOURNAL   Toxicol Appl Pharmacol 315, 23-34 (2017)
   PUBMED   27939985
REFERENCE   6  (bases 1 to 1664)
  AUTHORS   Webster,C.R., Srinivasulu,U., Ananthanarayanan,M., Suchy,F.J. and
            Anwer,M.S.
  TITLE     Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated
            Na+/taurocholate cotransport and Ntcp translocation
  JOURNAL   J Biol Chem 277 (32), 28578-28583 (2002)
   PUBMED   12034724
  REMARK    GeneRIF: translocation requires activation of protein kinase B
REFERENCE   7  (bases 1 to 1664)
  AUTHORS   Tygstrup,N., Bangert,K., Ott,P. and Bisgaard,H.C.
  TITLE     Messenger RNA profiles in liver injury and stress: a comparison of
            lethal and nonlethal rat models
  JOURNAL   Biochem Biophys Res Commun 290 (1), 518-525 (2002)
   PUBMED   11779202
REFERENCE   8  (bases 1 to 1664)
  AUTHORS   Shih,D.Q., Bussen,M., Sehayek,E., Ananthanarayanan,M.,
            Shneider,B.L., Suchy,F.J., Shefer,S., Bollileni,J.S.,
            Gonzalez,F.J., Breslow,J.L. and Stoffel,M.
  TITLE     Hepatocyte nuclear factor-1alpha is an essential regulator of bile
            acid and plasma cholesterol metabolism
  JOURNAL   Nat Genet 27 (4), 375-382 (2001)
   PUBMED   11279518
REFERENCE   9  (bases 1 to 1664)
  AUTHORS   Karpen,S.J., Sun,A.Q., Kudish,B., Hagenbuch,B., Meier,P.J.,
            Ananthanarayanan,M. and Suchy,F.J.
  TITLE     Multiple factors regulate the rat liver basolateral
            sodium-dependent bile acid cotransporter gene promoter
  JOURNAL   J Biol Chem 271 (25), 15211-15221 (1996)
   PUBMED   8662994
REFERENCE   10 (bases 1 to 1664)
  AUTHORS   Hagenbuch,B., Stieger,B., Foguet,M., Lubbert,H. and Meier,P.J.
  TITLE     Functional expression cloning and characterization of the
            hepatocyte Na+/bile acid cotransport system
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10629-10633 (1991)
   PUBMED   1961729
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017047.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M77479.1, BC091152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               JAXUCZ010000006.1  106357468-106357944 c
            478-688             JAXUCZ010000006.1  106350391-106350601 c
            689-867             JAXUCZ010000006.1  106348153-106348331 c
            868-1064            JAXUCZ010000006.1  106346327-106346523 c
            1065-1664           JAXUCZ010000006.1  106344319-106344918 c
FEATURES             Location/Qualifiers
     source          1..1664
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1664
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp; Ntcp1; SBACT"
                     /note="solute carrier family 10 member 1"
                     /db_xref="GeneID:24777"
                     /db_xref="RGD:3681"
     exon            1..477
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp; Ntcp1; SBACT"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1210
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp; Ntcp1; SBACT"
                     /note="sodium/bile acid cotransporter; sodium-dependent
                     bile acid cotransporter; sodium/taurocholate
                     cotransporting polypeptide; Na(+)/bile acid cotransporter;
                     Na(+)/taurocholate transport protein; sodium-dependent
                     taurocholate cotransporting polypeptide; NA-dependent
                     cholate transporting protein; solute carrier family 10
                     (sodium/bile acid cotransporter family), member 1; solute
                     carrier family 10 (sodium/bile acid cotransporter), member
                     1"
                     /codon_start=1
                     /product="hepatic sodium/bile acid cotransporter"
                     /protein_id="NP_058743.1"
                     /db_xref="GeneID:24777"
                     /db_xref="RGD:3681"
                     /translation="MEVHNVSAPFNFSLPPGFGHRATDKALSIILVLMLLLIMLSLGC
                     TMEFSKIKAHLWKPKGVIVALVAQFGIMPLAAFLLGKIFHLSNIEALAILICGCSPGG
                     NLSNLFTLAMKGDMNLSIVMTTCSSFSALGMMPLLLYVYSKGIYDGDLKDKVPYKGIM
                     ISLVIVLIPCTIGIVLKSKRPHYVPYILKGGMIITFLLSVAVTALSVINVGNSIMFVM
                     TPHLLATSSLMPFSGFLMGYILSALFQLNPSCRRTISMETGFQNIQLCSTILNVTFPP
                     EVIGPLFFFPLLYMIFQLAEGLLIIIIFRCYEKIKPPKDQTKITYKAAATEDATPAAL
                     EKGTHNGNIPPLQPGPSPNGLNSGQMAN"
     exon            478..688
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp; Ntcp1; SBACT"
                     /inference="alignment:Splign:2.1.0"
     exon            689..867
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp; Ntcp1; SBACT"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1064
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp; Ntcp1; SBACT"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1664
                     /gene="Slc10a1"
                     /gene_synonym="Ntcp; Ntcp1; SBACT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccacatt ttgtccacaa actctgtcct gaaaggggac tgactgaaga aaacatccag
       61 caagctctgg gcaaggaagg acagcagcag agagcgaggg ccgtgttcgc tgtgccagag
      121 gatggaggtg cacaacgtat cagccccttt caatttctcc ctgccgcctg gctttggcca
      181 ccgggccaca gacaaggcgc ttagcatcat cctggtgtta atgttgctgc ttatcatgct
      241 ctcactgggc tgcaccatgg aattcagcaa gatcaaggct cacttgtgga agcccaaagg
      301 ggtgatcgtt gccttggtgg cccagtttgg catcatgccc ctcgctgctt ttcttctcgg
      361 caagatcttt cacctgagca acattgaagc tctggccatc ctcatctgtg gctgctctcc
      421 cggggggaac ttgtccaacc tcttcaccct ggccatgaag ggggacatga acctcagcat
      481 cgtgatgacc acctgctcca gcttcagtgc cttgggcatg atgccactcc tcttatacgt
      541 ctacagcaaa ggcatctacg atggagacct taaggacaag gtgccctaca aaggcattat
      601 gatatcacta gtcatagttc tcattccttg caccataggg atcgtcctca agtccaaaag
      661 gccacactat gtaccctaca tccttaaggg aggcatgatc atcaccttcc tcctctctgt
      721 ggctgtcaca gccctctctg tcatcaatgt gggcaacagc atcatgttcg tcatgacacc
      781 acacttactg gctacctcct ccctgatgcc cttctctggc tttctgatgg gttacattct
      841 ctctgctctc ttccaactca atccaagctg cagacgcacc atcagcatgg aaacaggatt
      901 ccaaaacatt caactctgtt ctaccatcct caatgtgacc ttcccccctg aagtcattgg
      961 gccacttttc ttctttcctc tcctctacat gattttccag cttgcagaag gacttctcat
     1021 catcattatc ttccggtgct atgagaaaat caagcctcca aaggaccaaa caaaaattac
     1081 ctacaaagct gctgcaactg aggatgctac tccagcagct ctggaaaaag gtacccacaa
     1141 tgggaatatt cctcctctcc aacctggtcc ttcccctaat ggcctgaatt ctggtcagat
     1201 ggcaaattag aatgtgaaac ttcgaagcag caagaaaagg aacgaacgtc gacgttgccg
     1261 gaatgtttgt ctagcacttc gggcaaacca tcagaaccat ggagccatga actgagacag
     1321 aagggcatct atctatccag taactgtaac ccataccaat ttgctttttg tttaaatttt
     1381 ctatttaaaa gataaacaag aattaggcaa aaatgttcct gcctataatc ccgatgctca
     1441 gaaactcaag atcaacctta agtatacaaa acaagactgt ctcaagaaac caaaaacact
     1501 tttcagtggc tatgaactct atgaaagctg aaccaaacag cttcatctga taaacattaa
     1561 cttcactatt tccaaacttt ccagtaagca ggtgttttgt tcattaaaca tccacaacct
     1621 gcttcatgtt actcaaaatg aaataaagtg caactcctag ttct
//
