LOCUS       NM_001106416            2996 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus S-phase kinase associated protein 2 (Skp2), mRNA.
ACCESSION   NM_001106416 XM_001057222 XM_226817
VERSION     NM_001106416.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Liu B, Wang J and Ren Z.
  TITLE     SKP2-Promoted Ubiquitination of FOXO3 Promotes the Development of
            Asthma
  JOURNAL   J Immunol 206 (10), 2366-2375 (2021)
   PUBMED   33837090
  REMARK    GeneRIF: SKP2-Promoted Ubiquitination of FOXO3 Promotes the
            Development of Asthma.
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Ren S, Xing Y, Wang C, Jiang F, Liu G, Li Z, Jiang T, Zhu Y and
            Piao D.
  TITLE     Fraxetin inhibits the growth of colon adenocarcinoma cells via the
            Janus kinase 2/signal transducer and activator of transcription 3
            signalling pathway
  JOURNAL   Int J Biochem Cell Biol 125, 105777 (2020)
   PUBMED   32504672
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Wang HH, Lee YN, Su CH, Shu KT, Liu WT, Hsieh CL, Yeh HI and Wu YJ.
  TITLE     S-Phase Kinase-associated Protein-2 Rejuvenates Senescent
            Endothelial Progenitor Cells and Induces Angiogenesis in Vivo
  JOURNAL   Sci Rep 10 (1), 6646 (2020)
   PUBMED   32313103
  REMARK    GeneRIF: S-Phase Kinase-associated Protein-2 Rejuvenates Senescent
            Endothelial Progenitor Cells and Induces Angiogenesis in Vivo.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Xue B, Yang D, Wang J, Xu Y, Wang X, Qin Y, Tian R, Chen S, Xie Q,
            Liu N and Zhu H.
  TITLE     ISG12a Restricts Hepatitis C Virus Infection through the
            Ubiquitination-Dependent Degradation Pathway
  JOURNAL   J Virol 90 (15), 6832-6845 (2016)
   PUBMED   27194766
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2996)
  AUTHORS   Del Debbio CB, Mir Q, Parameswaran S, Mathews S, Xia X, Zheng L,
            Neville AJ and Ahmad I.
  TITLE     Notch Signaling Activates Stem Cell Properties of Muller Glia
            through Transcriptional Regulation and Skp2-mediated Degradation of
            p27Kip1
  JOURNAL   PLoS One 11 (3), e0152025 (2016)
   PUBMED   27011052
  REMARK    GeneRIF: Notch signaling may facilitate re-entry of Muller Glia
            into the cell cycle by inhibiting p27Kip1 expression both
            transcriptionally and post-translationally, mediated by Skp2
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2996)
  AUTHORS   Lahav-Baratz S, Ben-Izhak O, Sabo E, Ben-Eliezer S, Lavie O, Ishai
            D, Ciechanover A and Dirnfeld M.
  TITLE     Decreased level of the cell cycle regulator p27 and increased level
            of its ubiquitin ligase Skp2 in endometrial carcinoma but not in
            normal secretory or in hyperstimulated endometrium
  JOURNAL   Mol Hum Reprod 10 (8), 567-572 (2004)
   PUBMED   15220466
REFERENCE   7  (bases 1 to 2996)
  AUTHORS   Shim EH, Johnson L, Noh HL, Kim YJ, Sun H, Zeiss C and Zhang H.
  TITLE     Expression of the F-box protein SKP2 induces hyperplasia,
            dysplasia, and low-grade carcinoma in the mouse prostate
  JOURNAL   Cancer Res 63 (7), 1583-1588 (2003)
   PUBMED   12670908
REFERENCE   8  (bases 1 to 2996)
  AUTHORS   Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T,
            Terasaki T, Horii A, Takahashi T, Hirohashi S and Inazawa J.
  TITLE     A novel target gene, SKP2, within the 5p13 amplicon that is
            frequently detected in small cell lung cancers
  JOURNAL   Am J Pathol 161 (1), 207-216 (2002)
   PUBMED   12107105
REFERENCE   9  (bases 1 to 2996)
  AUTHORS   Carrano AC and Pagano M.
  TITLE     Role of the F-box protein Skp2 in adhesion-dependent cell cycle
            progression
  JOURNAL   J Cell Biol 153 (7), 1381-1390 (2001)
   PUBMED   11425869
REFERENCE   10 (bases 1 to 2996)
  AUTHORS   Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I,
            Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N,
            Kitagawa M, Nakayama K and Hatakeyama S.
  TITLE     Targeted disruption of Skp2 results in accumulation of cyclin E and
            p27(Kip1), polyploidy and centrosome overduplication
  JOURNAL   EMBO J 19 (9), 2069-2081 (2000)
   PUBMED   10790373
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166459.1.
            
            On May 7, 2008 this sequence version replaced NM_001106416.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166459.1, SRR8487227.344228.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..2996
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /note="S-phase kinase associated protein 2"
                     /db_xref="GeneID:294790"
                     /db_xref="RGD:1562456"
     exon            1..95
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1359
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /note="S-phase kinase-associated protein 2 (p45); S-phase
                     kinase-associated protein 2, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="S-phase kinase-associated protein 2"
                     /protein_id="NP_001099886.1"
                     /db_xref="GeneID:294790"
                     /db_xref="RGD:1562456"
                     /translation="MHRKHLQEIPDQSSNVTTSFTWGWDSSKTSELLSGMGVSALEKE
                     EVDSENIPHGLLSNLGHPQSPPRKRLKSKGSDKDFVIIRRPKLNRENFPGVSWDSLPD
                     ELLLGIFSCLCLPELLRVSGVCKRWYRLSLDESLWQSLDLAGKNLHPDVTVRLLSRGV
                     VAFRCPRSFMEQPLGESFSSFRVQHMDLSNSVINVSNLHGILSECSKLQNLSLEGLQL
                     SDPIVTTLAQNENLVRLNLCGCSGFSESAVATLLSSCSRLDELNLSWCFDFTEKHVQA
                     AVAHLPDTLTQLNLSGYRKNLQKTDLCTLIKRCPNLVRLDLSDSIMLKNDCFPEFFQL
                     NYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLREALPRLQINCAY
                     FTSIARPTMDNKKNPEIWGIKCRLTLQKPSL"
     exon            96..367
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /inference="alignment:Splign:2.1.0"
     exon            368..479
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /inference="alignment:Splign:2.1.0"
     exon            480..623
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /inference="alignment:Splign:2.1.0"
     exon            624..758
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /inference="alignment:Splign:2.1.0"
     exon            759..857
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /inference="alignment:Splign:2.1.0"
     exon            858..988
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1040
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1148
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..2972
                     /gene="Skp2"
                     /gene_synonym="RGD1562456"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaagcagcg ccctagaacg ggagtctgga aggcaggcag ctcttcaatt aattgaagca
       61 ttcaaaactc cttaatcagt ggacgccatg cataggaagc accttcagga gattccggac
      121 cagagtagca acgtcaccac cagcttcacg tggggatggg attccagcaa gacttctgaa
      181 ctgctgtcag gcatgggtgt ctctgccttg gagaaggagg aggtggacag tgagaacatc
      241 ccacatggac tgctctcaaa cctcggccac ccccagagcc ctccaaggaa aaggctaaag
      301 agcaaaggga gtgacaaaga ctttgtgatc attcgtcggc ctaagctcaa tcgagagaac
      361 tttccaggtg tttcctggga ctcccttcca gatgagctgc tcctgggaat cttttcctgt
      421 ctgtgcctcc ctgagctttt gagagtctct ggagtttgca agaggtggta ccgcctctcg
      481 ctcgatgagt ctctctggca gtccctagac ctcgcaggca aaaatctgca cccagacgtg
      541 acagtgcgcc tgctctctcg aggagtcgtg gccttccgct gcccacggtc gtttatggag
      601 cagccactgg gcgaaagctt cagctctttc cgtgtacagc acatggacct gtcgaactca
      661 gttataaatg tgtcaaacct ccacgggatt ctgtccgagt gctccaagct gcagaatctg
      721 agtctggaag gcctgcagct ttcagatccc attgtcacta ctcttgcgca gaatgaaaac
      781 ttggtgcgac tgaacctttg tgggtgctct ggattttctg agtctgccgt ggccaccctg
      841 ctgagcagct gctccagact ggatgaactg aacctctcct ggtgctttga cttcactgag
      901 aagcatgtgc aagcggccgt ggcacattta ccagatacgc tcacccagct gaacctcagc
      961 ggctaccgaa agaacctcca gaaaacagat ctttgtaccc taattaaacg atgccccaac
     1021 ctcgtccgcc tcgacttaag tgacagtatc atgctgaaga atgactgctt tccagaattt
     1081 tttcaactca actacctcca acacctctcg ctcagccggt gctacgatat aatacctgag
     1141 acgctacttg aactcggaga aatccccaca ctaaaaacac tacaagtttt tgggatcgtg
     1201 ccagacggga cccttcagct actgagagaa gctcttcctc gcctgcagat taattgtgcc
     1261 tatttcacct ccattgcaag gccaactatg gacaacaaga agaacccgga gatttggggt
     1321 atcaaatgcc gactgaccct gcaaaagccc agtttatgaa gtgcttaccg cgaggctgtg
     1381 tctcctcctc ctctgaaagg aggacacagg cagcagatcc atgtgctgga gaccttggtt
     1441 actcttcctg ttggttctgc cttcgacttc acattacacg tatgttaggg aaccattaga
     1501 gagggacagc caccaagtgt tactttttca gaaacagagc tgtttctggc agtgctgtgc
     1561 cctaagggcc taagcgttag gtctttggaa atttttaggt gagcctatta tttcacaatg
     1621 ctttttaaag caaaatttga gccaactctt ctaagtgccc ttctgattaa gtctatttag
     1681 aatcgaggtt tttaaagtac ccctggctaa cagtcttcat ggtgtttgtc attttatcta
     1741 tttaattact cagtatttta taaaacttga ctttgaagaa taagctatat gtatggtgag
     1801 ctggacagaa agcaacagag gctggtagcg ttggaggtgg tcttttctgg gaattaacac
     1861 atttcagctt cgtgtgcagt atgaggttag cttcacagag aggagcgcag tcctgcgtgg
     1921 tgtaccgtaa actctaagtg agaaaagaca cagacacaca caaccagagc aggagactag
     1981 gactggtgca ggatttgaaa cctcaaaggc tgttcgcgaa aaccgggtta atatgaagta
     2041 tcctttgctg tttttaggag ctatgctatg tttgcaggat cttaaattag gtaaggaaac
     2101 cctactcgtg tgctttttaa actttataat caatgtatgt tacaatctat gtgggttgtt
     2161 tagcttttta aaatgacttg ctttgtttta ggaatgcgac attctagtca gcactctgag
     2221 aagccggata gaattctgag ctgatcgggc atgctgatcg ttcgttgggt gctgcagtta
     2281 tttttatatt actctgaaat caaggacttg aaattctttt cagtgatctt ttacagtgat
     2341 tgcttgaaac tgcccattag gttactggac ctaaagttgt taggtagagc agatttctgt
     2401 ccatcagaaa cgcacaggaa gcgtgggcag gtgcagcctc agagcgggta gcacggctta
     2461 cacttcacac gggtcctgaa gaatcactgg gcattaaacc tttggataac agatgtgtct
     2521 ttttagcact tgatacacag aagcaaaagg atcaaattgt gtttcttaga aaatgaaaga
     2581 aaaaattaag gcagttacct ctagagtatt tcagagctgt aatccatttc tattaacctc
     2641 ttcttcaaaa actgttagtt aaccacgtga agtgcctcat ctgctcagac ctacagaacg
     2701 ttttaagtgt cacacaagaa tggtcatgct tcaattccct agtagttaag agtgctaact
     2761 actacttgaa actattgttt acacattagt gatgggctga tggcggactc tggttggacc
     2821 ctgccctcca ggtgccctca gtcagtacct gctcttcctt acgcaagtcc agctgggagc
     2881 tattttgcca acatgtcgca gcaatctgta tttttgtatg tgatttttac ttttatagac
     2941 tgattttaaa ataaagtaca tttttataag aaaaaaaaaa aaaaaaaaaa aaaaaa
//
