LOCUS       NM_001398590            6724 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SKI-like proto-oncogene (Skil), transcript
            variant 1, mRNA.
ACCESSION   NM_001398590 XM_006232237
VERSION     NM_001398590.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6724)
  AUTHORS   Chi,C., Liang,X., Cui,T., Gao,X., Liu,R. and Yin,C.
  TITLE     SKIL/SnoN attenuates TGF-beta1/SMAD signaling-dependent collagen
            synthesis in hepatic fibrosis
  JOURNAL   Biomol Biomed 23 (6), 1014-1025 (2023)
   PUBMED   37389959
  REMARK    GeneRIF: SKIL/SnoN attenuates TGF-beta1/SMAD signaling-dependent
            collagen synthesis in hepatic fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6724)
  AUTHORS   Wang,Y., Liu,L., Peng,W., Liu,H., Liang,L., Zhang,X., Mao,Y.,
            Zhou,X., Shi,M., Xiao,Y., Zhang,F., Zhang,Y., Liu,L., Yan,R. and
            Guo,B.
  TITLE     Ski-related novel protein suppresses the development of diabetic
            nephropathy by modulating transforming growth factor-beta signaling
            and microRNA-21 expression
  JOURNAL   J Cell Physiol 234 (10), 17925-17936 (2019)
   PUBMED   30847937
  REMARK    GeneRIF: Ski-related novel protein suppresses the development of
            diabetic nephropathy by modulating kidney transforming growth
            factor-beta signaling and microRNA-21 expression.
REFERENCE   3  (bases 1 to 6724)
  AUTHORS   Wang,Y., Mao,Y., Zhang,X., Liu,H., Peng,W., Liang,L., Shi,M.,
            Xiao,Y., Zhang,Y., Zhang,F., Yan,R. and Guo,B.
  TITLE     TAK1 may promote the development of diabetic nephropathy by
            reducing the stability of SnoN protein
  JOURNAL   Life Sci 228, 1-10 (2019)
   PUBMED   31028803
  REMARK    GeneRIF: TAK1 mediated the phosphorylation of Ski-related novel
            protein N (SnoN), resulting in SnoN ubiquitination and eventual
            degradation, which enhanced EMT and extracellular matrix deposition
            to promote renal fibrosis during diabetic nephropathy.
REFERENCE   4  (bases 1 to 6724)
  AUTHORS   Chi,C., Liu,X.Y., Hou,F., Yu,X.Z., Li,C.Y., Cui,L.J., Liu,R.X. and
            Yin,C.H.
  TITLE     Herbal compound 861 prevents hepatic fibrosis by inhibiting the
            TGF-beta1/Smad/SnoN pathway in bile duct-ligated rats
  JOURNAL   BMC Complement Altern Med 18 (1), 52 (2018)
   PUBMED   29402324
  REMARK    GeneRIF: Studied the effects of herbal compound 861 on transforming
            growth factor beta1 (TGF-beta1)/Sma and Mad-related proteins
            (Smad)/Ski-related novel protein N (SnoN) signal pathway in a rat
            hepatic fibrosis disease model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6724)
  AUTHORS   Wang,Y., Xiao,Y., Li,S., Shi,L., Liu,L., Zhang,Y., Shi,M. and
            Guo,B.
  TITLE     BMP-7 enhances SnoN mRNA expression in renal tubular epithelial
            cells under high-glucose conditions
  JOURNAL   Mol Med Rep 16 (3), 3308-3314 (2017)
   PUBMED   28765970
  REMARK    GeneRIF: BMP7 may ameliorate diabetic nephropathy and renal
            fibrosis via increasing the expression of SnoN mRNA and protein in
            renal tubular epithelial cells, rather than directly inhibiting the
            degradation of SnoN by E3 ubiquitin ligase.
REFERENCE   6  (bases 1 to 6724)
  AUTHORS   He,J., Tegen,S.B., Krawitz,A.R., Martin,G.S. and Luo,K.
  TITLE     The transforming activity of Ski and SnoN is dependent on their
            ability to repress the activity of Smad proteins
  JOURNAL   J Biol Chem 278 (33), 30540-30547 (2003)
   PUBMED   12764135
REFERENCE   7  (bases 1 to 6724)
  AUTHORS   Pearson-White,S. and McDuffie,M.
  TITLE     Defective T-cell activation is associated with augmented
            transforming growth factor Beta sensitivity in mice with mutations
            in the Sno gene
  JOURNAL   Mol Cell Biol 23 (15), 5446-5459 (2003)
   PUBMED   12861029
REFERENCE   8  (bases 1 to 6724)
  AUTHORS   Shinagawa,T., Dong,H.D., Xu,M., Maekawa,T. and Ishii,S.
  TITLE     The sno gene, which encodes a component of the histone deacetylase
            complex, acts as a tumor suppressor in mice
  JOURNAL   EMBO J 19 (10), 2280-2291 (2000)
   PUBMED   10811619
REFERENCE   9  (bases 1 to 6724)
  AUTHORS   Stroschein,S.L., Wang,W., Zhou,S., Zhou,Q. and Luo,K.
  TITLE     Negative feedback regulation of TGF-beta signaling by the SnoN
            oncoprotein
  JOURNAL   Science 286 (5440), 771-774 (1999)
   PUBMED   10531062
REFERENCE   10 (bases 1 to 6724)
  AUTHORS   Nagase,T., Nomura,N. and Ishii,S.
  TITLE     Complex formation between proteins encoded by the ski gene family
  JOURNAL   J Biol Chem 268 (18), 13710-13716 (1993)
   PUBMED   8514802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 20, 2021 this sequence version replaced XM_006232237.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.9162.1,
                                           SRR26360176.1581728.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000002.1  114203525-114203572 c
            49-1811             JAXUCZ010000002.1  114200209-114201971 c
            1812-1909           JAXUCZ010000002.1  114186487-114186584 c
            1910-2142           JAXUCZ010000002.1  114184573-114184805 c
            2143-2372           JAXUCZ010000002.1  114181118-114181347 c
            2373-2597           JAXUCZ010000002.1  114180537-114180761 c
            2598-6724           JAXUCZ010000002.1  114175534-114179660 c
FEATURES             Location/Qualifiers
     source          1..6724
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..6724
                     /gene="Skil"
                     /gene_synonym="Skir; Sno"
                     /note="SKI-like proto-oncogene"
                     /db_xref="GeneID:114208"
                     /db_xref="RGD:621399"
     exon            1..48
                     /gene="Skil"
                     /gene_synonym="Skir; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            49..1811
                     /gene="Skil"
                     /gene_synonym="Skir; Sno"
                     /inference="alignment:Splign:2.1.0"
     CDS             723..2756
                     /gene="Skil"
                     /gene_synonym="Skir; Sno"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ski-like protein; ski/sno related; SKI-like oncogene"
                     /codon_start=1
                     /product="ski-like protein isoform 1"
                     /protein_id="NP_001385519.1"
                     /db_xref="GeneID:114208"
                     /db_xref="RGD:621399"
                     /translation="MENLQSNFSLVQGSNKKLSGMEDDGSPPVKKMMTDIHANGKTLT
                     QVKKEHLDDYGDASVEPDGEHAKRNCPSLPETLNLNPSLKHTLAQFHLSSQSSLGGPA
                     AFSARYSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEK
                     RLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLI
                     TLTDAQRLCNALLRPRTFPQNGSILPAKSSWAQLKETGSAFEVEHECLGKCQGLFAPQ
                     FYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLG
                     TPEEKKLKIILEEMKEKFSMRNGKRIQSKTDTPSGMELPPWYPVIKQEGDHGPQTHSF
                     LHPSYYLYMCDKVVAPNVSLASAASQSKAVTKAETSKSISKQSEKPHDSSKRQKTVSY
                     PDVSLEEQEKMDLKTSRELYSCLDSSVSNNSTSKKKCESTICDLVRDTDKQGSGASSP
                     LVVRDVTCEDDKGKIVEDVMRTYVRQQEKLSSILQKKQQLQMEVEMLSSSKAMKELTE
                     EQQNLQKELESLQNEHAQRMEEFYIEQRDLEKKLEQVMKQKCTCDSNVEKDKEAEYAA
                     QLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQIVKSSKTAKE"
     exon            1812..1909
                     /gene="Skil"
                     /gene_synonym="Skir; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2142
                     /gene="Skil"
                     /gene_synonym="Skir; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2372
                     /gene="Skil"
                     /gene_synonym="Skir; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2597
                     /gene="Skil"
                     /gene_synonym="Skir; Sno"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..6724
                     /gene="Skil"
                     /gene_synonym="Skir; Sno"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcgaagg cggcgggcga gcgacggcga cggcgacggc gggcacagat caattaaaag
       61 aagaatgaac tgtaatccct gaagataaac tgggcagctt ttttacttag tgtatgtata
      121 ttgctaatta taaaagttca ggtggagcca ggctcctgct gtgtggagat ttagacaagt
      181 cttcagtttg tcagcacaga gccacagacc accattttca gtgaggatac ctgcctcttc
      241 ttttttggtg ttcttggcaa aaactaaaac cattgcatca ttgtaactcg tgtttgggtg
      301 tagtttcagg atacagtcat ggcataaact ttccacatgc tttgcttaaa gaacaaaacc
      361 aaccaaactc aaccactata ccaaactttg gacttcttga actgaggaat tagctttatt
      421 ttaacataaa tagctgaagt gctcaagaaa acaagacttt tctcaggggt gtgctgacaa
      481 ttataccctt tgttattaga agcgaattga gaagttttgt agtattttca gttacatcct
      541 gagaaacggc tgaaccgaaa cagagttgta caatctattg agcaagaaaa ttcatctttg
      601 gaaactaaac atttctaagt gagtcacaag tatttgtata cgttgccttt ttctcttcaa
      661 attaggaact gagaacaaca tgccaattga agacttaatt atttaaaaac accggtgtgg
      721 ccatggaaaa cctgcagtct aatttctcct tagttcaggg ttcaaataaa aagctgagcg
      781 ggatggagga tgatggcagt cctcccgtga aaaaaatgat gacagacatt catgccaatg
      841 ggaaaacgct gacccaggtg aagaaggagc atttggacga ctacggagat gcgtcagtgg
      901 aaccagatgg cgagcacgcc aagcgcaact gtccttctct acctgaaact ttaaatttaa
      961 accccagtct gaaacacaca ctggcacaat tccatttaag tagtcagagc tctttgggtg
     1021 gaccagcagc tttttctgct cgatattccc aagaaagcat gtcaccgact gtgttcctgc
     1081 ctcttccgtc tcctcaggtt cttcctggtc ctcttcttat tccttctgat agctccacag
     1141 agctcactca gactgttttg gaaggggagt ctatttcttg ttttcaagtc ggaggagaaa
     1201 agagactgtg tttgccccaa gtcttaaatt ctgttctccg agaattttca ctccagcaaa
     1261 taaacacagt atgcgatgag ctctacatct attgttcaag gtgtacttca gaccagcttc
     1321 atatcttaaa ggtcttaggt atacttccat tcaatgcccc ctcctgtggg ctgatcacgt
     1381 tgactgacgc acagagactc tgtaatgctt tactgaggcc acgaactttt cctcaaaatg
     1441 gtagcatact tcctgctaaa agctcttggg cccagctgaa ggagactggc agtgcctttg
     1501 aagtggaaca tgagtgcttg ggcaaatgtc agggtctctt tgcacctcag ttttatgttc
     1561 agcccgatgc tccctgtatc cagtgtctgg agtgctgtgg aatgtttgct cctcagacat
     1621 tcgtcatgca ttcacacaga tcccctgaca agagaacttg ccattggggc tttgagtcag
     1681 ccaagtggca ctgttacctt catgtgaacc aaaaatacct agggacaccc gaagaaaaga
     1741 aactgaagat aattttagag gaaatgaagg agaagtttag catgagaaat ggaaagagaa
     1801 tccaatcaaa gacagatacg ccttcgggaa tggaattgcc accatggtat cctgttataa
     1861 aacaggaagg tgaccacggt cctcagaccc attcattttt acaccccagc tactacttgt
     1921 acatgtgtga caaagtggtt gcaccgaatg tgtcgctcgc ctctgctgcg tcccagtcta
     1981 aagcggtcac caaggcagag acaagtaagt ccatctccaa acagtcagaa aagcctcatg
     2041 atagtagtaa gcgccaaaag acagtgtctt acccagacgt ctcacttgag gagcaggaga
     2101 aaatggattt aaaaaccagt agagaattat acagttgttt agattcatcg gtctcaaata
     2161 attctacaag taaaaagaaa tgtgaatcta ccatttgcga cttagtgaga gacacagaca
     2221 agcagggttc tggagcctcc tctccactcg tggtccgaga tgttacttgt gaagatgaca
     2281 aggggaagat cgtggaagac gtgatgagaa cctatgtgag acagcaggag aagctgagct
     2341 caattctaca gaagaagcag cagttgcaga tggaagtgga gatgctgagc agttcaaagg
     2401 cgatgaagga gctcactgaa gagcagcaga atctacagaa agagcttgag tctttgcaga
     2461 atgagcatgc tcagaggatg gaggaatttt atattgagca gagagactta gagaagaagt
     2521 tggagcaggt gatgaagcag aagtgcacct gtgactcaaa cgtagagaaa gacaaagagg
     2581 ctgaatacgc agcccagctg gcagaactga ggcaaagact agaccatgct gaggccgaca
     2641 ggcaagaact gcaagatgaa ctgagacagg agcgggaggc gaggcagaag ctagagatga
     2701 tgataaagga actgaagctg cagatcgtga agtcgtccaa gaccgccaag gagtaagcgg
     2761 aagaggagac gcgcctgtgt ttggttggca ggacttcatg tttgtcactt gctttgaaaa
     2821 ttgaattcta acatcttact tgcatgaagg tagctaggca ttctgttcat ttatagggca
     2881 gcaaaagtga agattatata ttaatacaga ttttttccat ttccaaatga atgaaaatgt
     2941 atgctccttt gtactttttc cagttggctt ggtaataata acctatgtag tttgaaccgt
     3001 aggcagtctg cctgtatttc taacagttac actttccaaa gcagcatcct gtggtgggaa
     3061 gtacctgtgt cagctttctt atgcattgct tcaggctcga ccgaccgtag atatacaggt
     3121 aatgtttatg atacaaagct actcactctg gagccttctc attacagaat ctcttgactt
     3181 ttatacaccc agcctgttgt tactttgttc aggttgcaga atgagtttcc tctggtttcc
     3241 tcctagagga gttttcctga tgaaatgcta gtagcacctc cccgacatac agcgggtggg
     3301 tggggcacac tttgctgtgc tctgatggta cacacaagaa gcagttgtaa tttgtctttc
     3361 tgtttaagag tgaccatagc tagatatgtg tgtgtgactt cagaaaatta aaatgctttc
     3421 cgaacttttc ctgttaatag aggtgtgaag tactcattca tgtgcatgag gaaagtggat
     3481 tccacggacg cacaccgctt cctatgtaac tcacaatgct ctgtacagtt tttatatgta
     3541 gtcttacaaa ggtcttatga aatttatata atggattttt tcttttaaat tataaaatac
     3601 taaatatctt aaatattgtt ttggactttt gtatgtttaa atgttatctt aaaacttgca
     3661 caaatggacc atgatgactc tttgatctta aaatcaggaa tttacagtca gctaagaaaa
     3721 tgtgataggt taataatcca cagtgggagt atctgctagg agcaggaatt gtagatgaca
     3781 tgaattccgt gatttgagga agggcagcct ctgcactttt ctttgttttt gttttttgca
     3841 catgaagtct gacattttta ccatcgaatt tcacattact agatggttgg cttgggattt
     3901 actaggggaa attcttagca actttgtact ttgttgtttt tgttctgttt ggtctccagc
     3961 ttgcagagac cctcttgcct ctgtctccca agtgttgggt tggcaggatg agccccacca
     4021 ccgctggccc tgtgcagttc ttttgggatg tccctgaaag cagctgtggc attatcttct
     4081 gtttcatgtg tcccgagctg tctcatggta ctacatgcag tgacctgaga tctgcgttaa
     4141 ggaataactt aggagaaacg gctgtcactg tcctccccgc tgtgagacac cagagttatc
     4201 acacctgtta tggtcatact ttgtgttatg atactgatgt ctaaggcaat ttttctactt
     4261 tccaaaaggg agtttgtttc ctaaatatat tgtgacctaa atgtggtttt attctgctat
     4321 gttctataat ttatgtattg acttttgtaa cctccttggg agaaacatgt taagtggcac
     4381 agggaccata tatgtcattt tatttagctc tggagaagga aaccacaggc gtttgtaaaa
     4441 tagcattagc ttagatgtca gttcattgtg cttggctgtg tgggaggcag actcaaggac
     4501 ttgcaccatt tatttttctg acagaagtgt tctgcttatg tgctgcttag taagtgtgat
     4561 ttttctagtc ttgatgaaac ttgcctcgtg acattgttga gcgtagtctt cactttccag
     4621 aagatgaaat gatgtgccat cattttctgt ctaaacttcc tttaaagtaa tttttaatca
     4681 gctgtaaata tcatatctcc tactgttgaa agtaacttta atttacattg caccatatag
     4741 cttgaaaacc aactttgaaa ttctgtactc ctccacaagt gacctctgct aaaataccca
     4801 taggaagctt actttgtgca tgcttgcttt gtgtgctggt tgctgtctta aggtttgctt
     4861 tggtgttagg tctcgtgtgc tgtgccaagt tcactgggca agcagatttc ccttcggagt
     4921 ccatcctctg tttaggggga aatgagacca tttactctga aaagctgtgt ttaggagtgg
     4981 aagacacagg cgttagcttt tatactgagt gaagagtgat gcttgctctg gatggttttt
     5041 ctctatggtc cacactgagg actttgtacc acgtgtgtaa aggtattaag tgtggaagct
     5101 cctgctgccg tcaagcaggc tttaaacaaa ccacagctga gacccagcac tgagagattc
     5161 taccaacaac ttaggcttgg ttcgggcttt accatttttg aagtttagtc tttcgcttat
     5221 atctcttgtg ttttggaaat aaggatgttt tatgcttctt gagctaattt tataacatat
     5281 ttaatatata agctgtttat atgtaaaatc ttttgtacag gggtgggaag gagtaatgaa
     5341 aaaactgatt tgtacatagt gaattataaa gcagaccgaa gtcggtgaaa cagtgagtaa
     5401 cctcattgtt tgcaggctcc ctgcatccct ccagagtccg ccagaacact ggttagtgtc
     5461 tgtgtctgtg gctcctgtct gcagaaaagc aaaatgaaaa ggaagcacaa gtaataagaa
     5521 acgtgcccga ggtatttccc tagcaagagc tgcacagcta gtcctgaggg ttttcatcca
     5581 cttctgaaag gtctgcccac catgctatgc tttgagtgag tagggaagga tgcttgtttt
     5641 cacttgtccg ttatgcattt aacctttagg gcaggacatt acaaactgac gacagattgt
     5701 gtccatgctg tacccctgct cctgaacttg gatctacttg ttaatggttt catggaagca
     5761 atcagcaata tgtgatatga actgctgcat tacttattat actcgtggaa ctgagatatt
     5821 taaacagagc ttaacttttt ttttctagtg taaaatactt aagcgtttcc actattggaa
     5881 gaaaagcata tatgggtatt ttgtattgta acttgtttaa aaggacagtc ttttttaatc
     5941 ttcccactta aatgctttta aaatatgtaa tacaatttga agcttgttta gaaatagaat
     6001 taaatgtctt atatagtgct actgttttgg aattagaaag tgatcaaata caaaacattt
     6061 taaaattaag cccagaaaac aaaatagtgt ttaaagttag tttagtataa aagaaattta
     6121 taagattttt tcttcaatat aagatacctc acttgaaaat aaagaaagca cagcacatta
     6181 aagtaattct catgagaaca ccccattaga ataattgcta aatctaggac accttttgag
     6241 ttgtgagttt gtgatacatg tagtcaccat tagcttttct gctggaagga cttcccgtag
     6301 taattttaag gcagtgtaat agttcaatta ccccacagtt tctaacctgg gaaggcagta
     6361 tgtgaatggt cccttctgca actacggaaa cacattagct acattgagca taactcgatt
     6421 gataattttg ccagtgcata tagttttatg attaaaattg ctgtggttgg ttgcattaca
     6481 cgacacacaa aactgtcctc tacctcacat gaaataaata ttttatatgg ttttactaaa
     6541 aaaaatgact catctatctg gttacttagt ttacaaattt tggattatat ttattgaaac
     6601 atgacatact gtgctcttag cttatacctc aatcgtattt tgtgctgttt gccattttca
     6661 tgccttgtat ataacttgta tagattggat gatattccca ataaacactt ttaatgccaa
     6721 tgaa
//
