LOCUS       NM_173311               1551 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus src kinase associated phosphoprotein 1 (Skap1),
            mRNA.
ACCESSION   NM_173311
VERSION     NM_173311.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1551)
  AUTHORS   Cao,D., Su,Z., Wang,W., Wu,H., Liu,X., Akram,S., Qin,B., Zhou,J.,
            Zhuang,X., Adams,G., Jin,C., Wang,X., Liu,L., Hill,D.L., Wang,D.,
            Ding,X. and Yao,X.
  TITLE     Signaling Scaffold Protein IQGAP1 Interacts with Microtubule
            Plus-end Tracking Protein SKAP and Links Dynamic Microtubule
            Plus-end to Steer Cell Migration
  JOURNAL   J Biol Chem 290 (39), 23766-23780 (2015)
   PUBMED   26242911
REFERENCE   2  (bases 1 to 1551)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   3  (bases 1 to 1551)
  AUTHORS   Menasche,G., Kliche,S., Chen,E.J., Stradal,T.E., Schraven,B. and
            Koretzky,G.
  TITLE     RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating
            T-cell-receptor-mediated integrin activation
  JOURNAL   Mol Cell Biol 27 (11), 4070-4081 (2007)
   PUBMED   17403904
REFERENCE   4  (bases 1 to 1551)
  AUTHORS   Fujii,Y., Wakahara,S., Nakao,T., Hara,T., Ohtake,H., Komurasaki,T.,
            Kitamura,K., Tatsuno,A., Fujiwara,N., Hozumi,N., Ra,C., Kitamura,D.
            and Goitsuka,R.
  TITLE     Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor
            complex in mast cells
  JOURNAL   FEBS Lett 540 (1-3), 111-116 (2003)
   PUBMED   12681493
REFERENCE   5  (bases 1 to 1551)
  AUTHORS   Wang,H., Moon,E.Y., Azouz,A., Wu,X., Smith,A., Schneider,H.,
            Hogg,N. and Rudd,C.E.
  TITLE     SKAP-55 regulates integrin adhesion and formation of T cell-APC
            conjugates
  JOURNAL   Nat Immunol 4 (4), 366-374 (2003)
   PUBMED   12652296
REFERENCE   6  (bases 1 to 1551)
  AUTHORS   Wu,L., Fu,J. and Shen,S.H.
  TITLE     SKAP55 coupled with CD45 positively regulates T-cell
            receptor-mediated gene transcription
  JOURNAL   Mol Cell Biol 22 (8), 2673-2686 (2002)
   PUBMED   11909961
REFERENCE   7  (bases 1 to 1551)
  AUTHORS   Marie-Cardine,A., Bruyns,E., Eckerskorn,C., Kirchgessner,H.,
            Meuer,S.C. and Schraven,B.
  TITLE     Molecular cloning of SKAP55, a novel protein that associates with
            the protein tyrosine kinase p59fyn in human T-lymphocytes
  JOURNAL   J Biol Chem 272 (26), 16077-16080 (1997)
   PUBMED   9195899
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097931.1.
            
            On Jun 12, 2005 this sequence version replaced NM_173311.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1551
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26-q31"
     gene            1..1551
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /note="src kinase associated phosphoprotein 1"
                     /db_xref="GeneID:286975"
                     /db_xref="RGD:708436"
     exon            1..144
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1163
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /note="pp55; SKAP-55; SKAP55 adapter protein; src
                     family-associated phosphoprotein 1; src kinase-associated
                     phosphoprotein of 55 kDa; SKAP55 adaptor protein"
                     /codon_start=1
                     /product="src kinase-associated phosphoprotein 1"
                     /protein_id="NP_775433.2"
                     /db_xref="GeneID:286975"
                     /db_xref="RGD:708436"
                     /translation="MQAIALPEEICWLLEDAEDFLAEGLQNENLSPGAQDQRDHILRG
                     FQQIKSRYCWDFQPQGDDLGQDGSDENLSGTHGPALASDASFWSDYQEEGIDDIIRGA
                     QELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVISRGLFLYYANEKSKQPKGTFLIKGY
                     NVRMAPHLRKDSKKDSCFELTSQDRRSYEFTAFSPAEARDWVDQISFLLKDLSSLTIP
                     FEEEEEEEEEDKEQEEMYNDIDGFDSARSGSQGRAMALPEPLDKEEDVYEVLPDEDDL
                     EEDACGAHRRRVDYADYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELN
                     SIIGIVPKDYLTTAFEMEGR"
     exon            145..250
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     exon            251..276
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     exon            277..378
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     exon            379..456
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     exon            457..540
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     exon            541..665
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     exon            666..729
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     exon            730..912
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     exon            913..960
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1061
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1170
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1523
                     /gene="Skap1"
                     /gene_synonym="Scap1; Skap55"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggggtgc agctcgcctc cttctgcctg ccgccgtcaa aacaggcctc gtgtcccttg
       61 tccctccttc tgctgtggcc accctctcgc cgtgccaaat gcaggccatc gccctcccgg
      121 aggagatctg ttggctcctg gaagatgctg aagactttct ggcggaaggc ttgcagaatg
      181 agaaccttag tcctggggca caggatcaga gagaccacat tctccggggt ttccagcaaa
      241 tcaaatccag gtactgttgg gattttcagc cccaaggaga cgaccttggc caagacggct
      301 ctgatgaaaa tctgagtggg acacacggcc cagccctcgc atcagatgca tccttttggt
      361 cagattatca ggaggaggga atagacgaca tcatcagagg ggctcaagag ctggataacg
      421 tcatcaaaca aggatacctg gagaagaaaa gcaaagatca tagcttcttt gggtcggagt
      481 ggcagaagcg atggtgtgtt atcagcagag ggctcttcct ctactatgct aatgagaaaa
      541 gcaagcagcc caaaggaacc ttcctcatta agggatacaa cgtccggatg gcccctcacc
      601 tgcggaaaga ctccaagaaa gactcctgct ttgaactgac ctcccaggat aggcgcagct
      661 atgagttcac agcttttagt ccagctgaag ccagagactg ggtggatcaa ataagtttct
      721 tgttaaaaga tcttagctcc ttgaccattc ccttcgaaga ggaggaggag gaggaagagg
      781 aagacaaaga acaggaagaa atgtacaatg acattgatgg ctttgactcc gcaaggtccg
      841 gctcccaggg cagagccatg gccttgcctg agcctctgga caaagaggag gacgtttacg
      901 aagtcctacc agatgaagat gatctagaag aggatgcatg tggcgctcat cggcggcgag
      961 tggactatgc cgattattac cagggcctct gggattgcca tggtgaccag ccagatgaac
     1021 tgtccttcca acgaggtgac ctcatccgca ttctgagcaa ggagtacaac atgtacggct
     1081 ggtgggtagg agaactgaac agcatcattg ggattgttcc aaaggactac ctcaccaccg
     1141 cctttgaaat ggaaggaaga tgaagcccag gggacatatt cttctctcaa tcctactttg
     1201 aggaagaaac agatcatcag aaactcccac tccctgctgg ggccatgaat tcttctctcc
     1261 gctgaatgga gccaaaactc tgctgcttca tgtgacttta agccactaat agacaagtag
     1321 gaagaggaca ggtcatcaaa catgttcctc aagcagccag cttctagctt atcacccctc
     1381 ccatgtcctc acacccataa gccttttcta caagcctgct acaaagaaga cagcaaggaa
     1441 ggaaatcatg ggaggaagaa gttactggtg ggctgtgact tgcaaagcac aaataaagtt
     1501 tggatttgtt tctttgcctt gtaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
