LOCUS       NM_001372077            3619 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus SIX homeobox 5 (Six5), mRNA.
ACCESSION   NM_001372077 XM_003748780 XM_003753221
VERSION     NM_001372077.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3619)
  AUTHORS   Yajima,H., Motohashi,N., Ono,Y., Sato,S., Ikeda,K., Masuda,S.,
            Yada,E., Kanesaki,H., Miyagoe-Suzuki,Y., Takeda,S. and Kawakami,K.
  TITLE     Six family genes control the proliferation and differentiation of
            muscle satellite cells
  JOURNAL   Exp Cell Res 316 (17), 2932-2944 (2010)
   PUBMED   20696153
REFERENCE   2  (bases 1 to 3619)
  AUTHORS   Sarkar,P.S., Paul,S., Han,J. and Reddy,S.
  TITLE     Six5 is required for spermatogenic cell survival and spermiogenesis
  JOURNAL   Hum Mol Genet 13 (14), 1421-1431 (2004)
   PUBMED   15163633
REFERENCE   3  (bases 1 to 3619)
  AUTHORS   Himeda,C.L., Ranish,J.A., Angello,J.C., Maire,P., Aebersold,R. and
            Hauschka,S.D.
  TITLE     Quantitative proteomic identification of six4 as the trex-binding
            factor in the muscle creatine kinase enhancer
  JOURNAL   Mol Cell Biol 24 (5), 2132-2143 (2004)
   PUBMED   14966291
REFERENCE   4  (bases 1 to 3619)
  AUTHORS   Sarkar,P.S., Appukuttan,B., Han,J., Ito,Y., Ai,C., Tsai,W.,
            Chai,Y., Stout,J.T. and Reddy,S.
  TITLE     Heterozygous loss of Six5 in mice is sufficient to cause ocular
            cataracts
  JOURNAL   Nat Genet 25 (1), 110-114 (2000)
   PUBMED   10802668
REFERENCE   5  (bases 1 to 3619)
  AUTHORS   Klesert,T.R., Cho,D.H., Clark,J.I., Maylie,J., Adelman,J.,
            Snider,L., Yuen,E.C., Soriano,P. and Tapscott,S.J.
  TITLE     Mice deficient in Six5 develop cataracts: implications for myotonic
            dystrophy
  JOURNAL   Nat Genet 25 (1), 105-109 (2000)
   PUBMED   10802667
REFERENCE   6  (bases 1 to 3619)
  AUTHORS   Ohto,H., Kamada,S., Tago,K., Tominaga,S.I., Ozaki,H., Sato,S. and
            Kawakami,K.
  TITLE     Cooperation of six and eya in activation of their target genes
            through nuclear translocation of Eya
  JOURNAL   Mol Cell Biol 19 (10), 6815-6824 (1999)
   PUBMED   10490620
REFERENCE   7  (bases 1 to 3619)
  AUTHORS   Kawakami,K., Ohto,H., Takizawa,T. and Saito,T.
  TITLE     Identification and expression of six family genes in mouse retina
  JOURNAL   FEBS Lett 393 (2-3), 259-263 (1996)
   PUBMED   8814301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Aug 7, 2019 this sequence version replaced
            XM_003748780.4, XM_003753221.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.1691.1,
                                           SRR26643295.1189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-804               JAXUCZ010000001.1  87869406-87870209
            805-1598            JAXUCZ010000001.1  87870982-87871775
            1599-3619           JAXUCZ010000001.1  87871909-87873929
FEATURES             Location/Qualifiers
     source          1..3619
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3619
                     /gene="Six5"
                     /note="SIX homeobox 5"
                     /db_xref="GeneID:308406"
                     /db_xref="RGD:1305040"
     exon            1..804
                     /gene="Six5"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2188
                     /gene="Six5"
                     /note="sine oculis-related homeobox 5 homolog"
                     /codon_start=1
                     /product="homeobox protein SIX5"
                     /protein_id="NP_001359006.1"
                     /db_xref="GeneID:308406"
                     /db_xref="RGD:1305040"
                     /translation="MATSPAEPSAGPAAQGEAAAATEEEEEEARQLLQTLQAAEGEAA
                     AAGAGEGAAADSGSPSGPGSPRETGTEAPTGLRFSPEQVACVCEALLQAGHAGRLSRF
                     LGALPPAERLRGSDPVLRARALVAFQRGEYAELYQLLESRPFPAAHHAFLQDLYLRAR
                     YHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYP
                     TPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGTGGGAPCKSESDGNPTTEDESSRSP
                     EDLERGVASVAAEAPTQSSIFLAGATPSATCPASSSILVNGSFLAASSPPAVLLNGSP
                     VIINSLTLGEGSSLGPLLLTGGGGTPQPQPSPQGVSETKTSLVLDPQTGEVRLDEAQS
                     EAPEAKGVHGTTPGEEIPGTLPQVVPGPPPASTFPLTPGAVPSVAAPQVVPLSPSSGY
                     PTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAATAGPTNVHLIN
                     SSVGVTALQLPSSATPGNLLLANPVSGSPIVTGVAVQQGRILLTATFPTRMLVSQVLP
                     PAPSLALPLKQEPAITVPEGALPVGPSPTLPEGHTLGPVSTQPLPPAPAVTSATSLPF
                     SPDSSGLLSSFSAPLPEGLMLSPAAVPVWPAGLELSTGVEGLGTQATHTVLRLPDPDH
                     QGLLLGATAGTEVDEGLEAEAKVLTQLQSVPVEEPLEL"
     exon            805..1598
                     /gene="Six5"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..3619
                     /gene="Six5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggaacttc ccaaagttgc caaacatggc tacctcgcct gccgagccga gcgcggggcc
       61 ggcggctcag ggggaggcgg cggcggcgac cgaggaagag gaggaagaag cgcgccagct
      121 tctgcagact cttcaggcag ccgaggggga ggcggcggcg gccggggcgg gagagggggc
      181 ggcggcggat tctgggtccc cgagcggccc agggtctcca cgcgagaccg ggaccgaggc
      241 gcccactggc cttcgcttct cgcccgagca ggtggcatgc gtgtgcgagg cgctgctgca
      301 ggcgggccac gccggccgct tgagccgctt cctgggcgcg ctgcccccgg ccgagcgtct
      361 acgtggcagc gatccggtgc tgcgcgcgcg ggccctagtg gccttccagc ggggtgaata
      421 tgccgagctc taccagctcc ttgagagccg ccctttcccc gccgcccacc acgccttcct
      481 gcaggacctc tacctgcgcg cgcgctacca cgaggccgag cgggcccgtg gccgtgcgct
      541 gggcgcggtg gacaaatacc ggctgcgcaa gaagttccct ctgcccaaga ccatctggga
      601 tggcgaggag acggtctatt gcttcaagga gcgctcgcga gcagcgctca aggcctgcta
      661 ccgcggcaac cgctatccca cgccagacga gaagcgccgc ctggccacgc tcaccggcct
      721 ctcacttaca caggtcagca actggttcaa gaaccggcga cagcgcgacc gtactgggac
      781 cggcggtgga gcgccctgca aaagcgagtc tgacgggaac cccactacgg aggatgagtc
      841 cagccgcagt ccggaggacc tggagagggg tgtggcctcc gtggctgctg aggctcccac
      901 ccagagttcc atcttcctgg caggggccac cccttctgcc acatgccctg cctcctcttc
      961 tatcctagtg aacgggagct tcctggcagc cagcagtccc ccagcagtgc tcctcaatgg
     1021 cagcccagtc atcatcaata gcttgaccct aggagagggc tccagcttgg ggcctctgct
     1081 actcacaggg ggagggggta cccctcaacc acagcccagt ccccaagggg tcagtgagac
     1141 caagacttcc ctggtcctgg accctcagac aggagaggtt cgactggatg aggctcagtc
     1201 tgaggcccct gaggccaaag gggttcatgg aactactcct ggagaggaaa tcccaggaac
     1261 cctgccccaa gtagtcccag gccccccacc tgcctccacc ttccctttga cccccggagc
     1321 tgtgccctct gtggctgctc ctcaggttgt accactctcc ccttcttctg ggtacccaac
     1381 aggcctgagc cccacctccc cactgctgaa cttgccccag gtggtgccca cctctcaggt
     1441 ggtaaccctg cctcaggctg tgggacctct ccagctgtta gcagctggac caggcagtcc
     1501 tgtgaaggtg gcagctacag cagggcctac caatgtgcac ctgataaact ctagtgtggg
     1561 agtgactgcg ctgcaacttc cctcatccgc tactccagga aacttgctcc tggccaaccc
     1621 tgtgtctggc agccccattg tcactggggt agctgtgcag cagggcagga tcctcctcac
     1681 ggccaccttc cccacccgca tgctcgtctc ccaggtcctg cctcctgctc ccagtctagc
     1741 cctgcccctg aagcaagagc cagctatcac agtgcctgaa ggagccctcc cagtgggccc
     1801 cagccccacc ctcccagagg gtcacactct ggggccagtc tctactcagc cactgccacc
     1861 tgctcctgct gtcacctctg ccaccagcct gcctttctcc ccagactcct ctggcctgct
     1921 ttccagcttc tcagcacccc tacctgaagg tctgatgctg tcacctgcgg ctgtgccagt
     1981 ttggccagca gggctggaac tgagcacagg agtagagggg ctggggacac aggccaccca
     2041 tactgtgctg aggctaccag accctgacca ccaggggctg ctcctggggg ccacagcagg
     2101 gactgaggtt gacgagggcc tagaagctga ggccaaggtc ctgacccagc tgcagtccgt
     2161 gcctgtggag gagcccttgg aactgtaact gcctggattt aaccacttct cctgacaatg
     2221 gtgtcaaggt gctaagacag gaggaaccct cagtaaagtg gctgcagtct gaagtcccac
     2281 actacgccct cctacctgga tgagctacaa gcattggagg agccagagag accaccacag
     2341 gtcagggcac tgtccctctc ctgatgacag atcttgttct agtcctctcc ttgctctgcc
     2401 tgcccaatgt gtgtgggctc taggggcctt gacttgggct gtgccctcct ctacctagta
     2461 ctagtaagag aaggctctgc caagtggctg atttccagcc agcaccctca gtataacact
     2521 attgatggcc ccactgatac cccattccca aaatttcctg agagaccagg gttgcccaga
     2581 gacagccctt cctgttgagg gtctggtggg tgcacaggcc tttcccctgc ttccctggac
     2641 ttgagcccca ggatccagcc ccagaccaaa gatttccctg tcccctgggg caatcctgac
     2701 ccctttgtct agtttgtatt gtaaatcttt atttttctag gacatgttat gcctcctcca
     2761 tttcaattaa agtcaagtta acagacaaca gagctattga gggtaagagt cacccgacaa
     2821 acaacccacc caggagagaa ctggggacaa agcccagcca gaggctgtgg cttgtttttc
     2881 ttgagatggg aatcatgttc tatatagccc aggttggtct cagatcccat cttcctgctt
     2941 tagcttcctg aatgttggaa ttataaacat gggtcactat gtctcaagac tggattactg
     3001 aggtaaaggg tttaagttca gacctgtagg ctctgggggg ttttcaaagt gaagaagcaa
     3061 acggcttctg gatttgatgt ggaaagcaca ccatggccaa gagatcctgg acacaacatt
     3121 ccttctcccc tgttggtaaa aggggtttca cttcatttta catagagcag ggaaggacgc
     3181 tgtgaggtga ggccatgtgg ttctggggca gaggggagct ctgcatttca tctagggccc
     3241 ccaccctata agaacagatg taggggggct attgggtagg gctgtgcaca ggcagaacac
     3301 agagccttgg gtcagtcaat acatttcctc tctagtgctg aagctggggg gctgggaagg
     3361 ggagccatag cagggcctga agctcagggg agacaaatgt tagaggacct gggaactaag
     3421 taggtggcag agcccagcag ggactgcctc ttactcgcag tgaggggtgg gcagtgaggt
     3481 gaggcccaaa gacacttggg ccttctcagc cagcagctga tagaagggtt tgggggtctc
     3541 cccatcgtcg tcctcactgc tggagctttc ctgcttcaca attcggttgt gctgccggct
     3601 gaacctgcgt gccttagtg
//
