LOCUS       NM_001414919            6372 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SIX homeobox 4 (Six4), transcript variant 1,
            mRNA.
ACCESSION   NM_001414919 XM_006240207
VERSION     NM_001414919.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6372)
  AUTHORS   Fujimoto,Y., Tanaka,S.S., Yamaguchi,Y.L., Kobayashi,H., Kuroki,S.,
            Tachibana,M., Shinomura,M., Kanai,Y., Morohashi,K., Kawakami,K. and
            Nishinakamura,R.
  TITLE     Homeoproteins Six1 and Six4 regulate male sex determination and
            mouse gonadal development
  JOURNAL   Dev Cell 26 (4), 416-430 (2013)
   PUBMED   23987514
REFERENCE   2  (bases 1 to 6372)
  AUTHORS   Suzuki,Y., Ikeda,K. and Kawakami,K.
  TITLE     Development of gustatory papillae in the absence of Six1 and Six4
  JOURNAL   J Anat 219 (6), 710-721 (2011)
   PUBMED   21978088
REFERENCE   3  (bases 1 to 6372)
  AUTHORS   Richard,A.F., Demignon,J., Sakakibara,I., Pujol,J., Favier,M.,
            Strochlic,L., Le Grand,F., Sgarioto,N., Guernec,A., Schmitt,A.,
            Cagnard,N., Huang,R., Legay,C., Guillet-Deniau,I. and Maire,P.
  TITLE     Genesis of muscle fiber-type diversity during mouse embryogenesis
            relies on Six1 and Six4 gene expression
  JOURNAL   Dev Biol 359 (2), 303-320 (2011)
   PUBMED   21884692
REFERENCE   4  (bases 1 to 6372)
  AUTHORS   Yajima,H., Motohashi,N., Ono,Y., Sato,S., Ikeda,K., Masuda,S.,
            Yada,E., Kanesaki,H., Miyagoe-Suzuki,Y., Takeda,S. and Kawakami,K.
  TITLE     Six family genes control the proliferation and differentiation of
            muscle satellite cells
  JOURNAL   Exp Cell Res 316 (17), 2932-2944 (2010)
   PUBMED   20696153
REFERENCE   5  (bases 1 to 6372)
  AUTHORS   He,G., Tavella,S., Hanley,K.P., Self,M., Oliver,G., Grifone,R.,
            Hanley,N., Ward,C. and Bobola,N.
  TITLE     Inactivation of Six2 in mouse identifies a novel genetic mechanism
            controlling development and growth of the cranial base
  JOURNAL   Dev Biol 344 (2), 720-730 (2010)
   PUBMED   20515681
REFERENCE   6  (bases 1 to 6372)
  AUTHORS   Himeda,C.L., Ranish,J.A., Angello,J.C., Maire,P., Aebersold,R. and
            Hauschka,S.D.
  TITLE     Quantitative proteomic identification of six4 as the trex-binding
            factor in the muscle creatine kinase enhancer
  JOURNAL   Mol Cell Biol 24 (5), 2132-2143 (2004)
   PUBMED   14966291
REFERENCE   7  (bases 1 to 6372)
  AUTHORS   Ohto,H., Kamada,S., Tago,K., Tominaga,S.I., Ozaki,H., Sato,S. and
            Kawakami,K.
  TITLE     Cooperation of six and eya in activation of their target genes
            through nuclear translocation of Eya
  JOURNAL   Mol Cell Biol 19 (10), 6815-6824 (1999)
   PUBMED   10490620
REFERENCE   8  (bases 1 to 6372)
  AUTHORS   Niiya,A., Ohto,H., Kawakami,K. and Araki,M.
  TITLE     Localization of Six4/AREC3 in the developing mouse retina;
            implications in mammalian retinal development
  JOURNAL   Exp Eye Res 67 (6), 699-707 (1998)
   PUBMED   9990334
REFERENCE   9  (bases 1 to 6372)
  AUTHORS   Spitz,F., Demignon,J., Porteu,A., Kahn,A., Concordet,J.P.,
            Daegelen,D. and Maire,P.
  TITLE     Expression of myogenin during embryogenesis is controlled by
            Six/sine oculis homeoproteins through a conserved MEF3 binding site
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14220-14225 (1998)
   PUBMED   9826681
REFERENCE   10 (bases 1 to 6372)
  AUTHORS   Kawakami,K., Ohto,H., Takizawa,T. and Saito,T.
  TITLE     Identification and expression of six family genes in mouse retina
  JOURNAL   FEBS Lett 393 (2-3), 259-263 (1996)
   PUBMED   8814301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 14, 2022 this sequence version replaced XM_006240207.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2654186.1,
                                           SRR26643296.17975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1085              JAXUCZ010000006.1  97550788-97551872   c
            1086-1774           JAXUCZ010000006.1  97547358-97548046   c
            1775-6372           JAXUCZ010000006.1  97538202-97542799   c
FEATURES             Location/Qualifiers
     source          1..6372
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..6372
                     /gene="Six4"
                     /note="SIX homeobox 4"
                     /db_xref="GeneID:299138"
                     /db_xref="RGD:1306726"
     exon            1..1085
                     /gene="Six4"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2571
                     /gene="Six4"
                     /note="isoform 1 is encoded by transcript variant 1; sine
                     oculis-related homeobox 4 homolog; homeobox protein SIX4"
                     /codon_start=1
                     /product="homeobox protein SIX4 isoform 1"
                     /protein_id="NP_001401848.1"
                     /db_xref="GeneID:299138"
                     /db_xref="RGD:1306726"
                     /translation="MSSSSPTGQIASAADIKQENGMESASEGQEAHREVAGGAAAGLS
                     PPAPAPFPLEPGDAAAASRVSREEGAAAAGAADQVQLHSELLGRHQHAATAQPPLAFS
                     PDHVACVCEALQQGGNLDRLARFLWSLPQSDLLRGNESLLKARALVAFHQGIYPELYS
                     ILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPRTIWDGEE
                     TVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNPSE
                     TQSKSESDGNPSTEDESSKGHEDLSPHPLSGASDGVTNLSLSSHMEPVYMQQIGNAKI
                     SLSSSGVLLNGSLVPASTSPVFLNGNSFIQGHNGVILNGLNVGNTQTVSLNPPKMSSN
                     TVGNGIAMTDILGSTSQDVKEFKVLQSSAVNSAATTSYSPSAPVSFPGLIPCTEVKRE
                     GVQTVASQDGGSVVTFTTPVQINQYGIVQIPNSGANGQFLNGSIGFSPLQLPPVSVSA
                     SQGHLSVTPSTSDGSTFTSESATVQHGKLFLSPLTPSAVVYTVPNSGQTVGAVKQEGL
                     ERGLVFSQLMPVNHNAQVNANLSSENLSGSGLHPLTSSLVNVSAAHGFSLTPSTLLNP
                     AELNPDLAESQPVSAPVASKCTVTSVSNTNYATLQNCSLIPGPDLLSVPMTQAALGEI
                     VPTAEEQVSHASPAVHQDFVREQRLVLQSVANLKENFLQNSENKTTNNLMMLDSKSKY
                     VLDGMVEPGCEDLGTDKKELAKLQTVQLDEDMQDL"
     exon            1086..1774
                     /gene="Six4"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..6372
                     /gene="Six4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgggggaa cggcagaaag cagctatccg tttacactac tttgctctag cagctatctt
       61 aatggtgact gcgtggcctg ggggaaacct gatcggccag atccagccga aaccgggagg
      121 gagggagtgg gctttccgga ggggggaggg ggagggagac gaagaaggag gagtaagaga
      181 gggggaaaga aagaggaaaa gagtgcgagg gagtgaggga gggaggaaaa taaacaacaa
      241 aaaatgtcct cttcctcccc caccgggcag attgcaagtg cggcggacat caagcaggag
      301 aatgggatgg aaagcgcctc ggaaggacag gaggcgcacc gagaagtggc ggggggcgcg
      361 gcggctgggc tgagcccccc ggctccagct cctttccccc tggagccggg ggacgccgcg
      421 gctgcctcca gggtaagccg ggaggaaggg gcagcggcgg ccggagcggc agatcaggta
      481 caactccact cggaacttct gggcaggcac cagcacgcag ccaccgcgca gcccccgctg
      541 gccttctcgc cggaccatgt cgcctgcgtg tgcgaggcgt tgcagcaggg gggcaacctg
      601 gaccgcctgg cccggttcct ttggtccctg ccccagagcg acctgctacg tggcaacgag
      661 agcctgctga aggcgcgagc gctcgtggcc ttccaccagg gcatctaccc tgagttgtac
      721 agcatcctcg agagccacag cttcgagtcg gccaaccatc cgctgctgca gcagctctgg
      781 tacaaggcgc gctacaccga ggccgagcga gcgcgcggcc ggccgctggg cgccgtggac
      841 aagtaccggc tgcgcaggaa attccccttg ccccgcacca tctgggacgg cgaggagacg
      901 gtgtattgtt tcaaggagaa gtcgcgcaac gcgcttaagg agctctacaa gcagaatcgc
      961 tacccctcgc ccgccgagaa gcggcacctg gccaagatca ctggcctctc cctcacccag
     1021 gtcagcaact ggttcaagaa ccggcggcag cgcgaccgaa acccctccga gacccagtcc
     1081 aaaagcgaat cagatggcaa ccccagcact gaagacgaat ccagcaaggg acatgaggat
     1141 ttgtctcctc atccactttc aggcgcatct gatggcgtca ccaacctcag cctttctagc
     1201 cacatggagc cagtatatat gcaacaaatt ggaaatgcta agatatcatt aagctcgtct
     1261 ggagttttgc tgaatggaag cttggtaccc gcaagtactt cacccgtctt ccttaatggc
     1321 aattctttta ttcagggaca caatggagtt atccttaatg gactgaatgt gggaaataca
     1381 cagacagtgt cactgaaccc acccaaaatg tcttcaaaca ctgtgggcaa tggcatagcc
     1441 atgacagaca tcctgggatc tacctcacag gatgtgaaag aattcaaagt cctccagagt
     1501 tctgctgtga actcagcagc caccacctcc tacagcccta gtgcccctgt gtcattccca
     1561 gggctgatac cctgtactga agtgaaaaga gaaggcgttc agacagtggc ctcccaggat
     1621 ggcggctctg tagtgacttt tactacacca gtgcaaatta accagtatgg cattgtccag
     1681 atccctaatt ctggagcaaa tggccagttc cttaatggga gcattggatt ctctccactg
     1741 cagctgcctc ctgtctcagt atcagcttca caaggtcatc tttcggtgac tccaagcact
     1801 tcggatggaa gcacatttac aagtgagtcg gccacagtcc agcatggtaa acttttcctg
     1861 agccctctta cccccagtgc agtggtatac actgtaccta attcaggcca gactgtagga
     1921 gctgtaaaac aggaaggctt agaaagaggc ctagtctttt ctcagttgat gcctgtcaat
     1981 cacaacgcac aagtaaatgc aaacctgtct tcggaaaatc tctctgggag tggcctccat
     2041 cctctgacct cttcgttggt taatgtgtcc gccgcccacg gtttttccct aaccccctct
     2101 acactactaa atcccgctga gctaaacccc gaccttgctg agagccagcc agtgtctgca
     2161 cctgtggcaa gcaaatgtac tgtgacatct gtcagcaaca ctaactacgc aacccttcag
     2221 aactgttccc ttattcctgg tccagaccta ttgtccgtcc cgatgaccca ggctgccctg
     2281 ggtgagatag ttcccacagc cgaagagcag gtgagccacg cctcgccagc agtccaccag
     2341 gattttgtaa gagaacagcg cttggttctg caatcagtcg ctaacctgaa agagaacttc
     2401 ttacaaaatt ctgagaacaa aacaacaaac aacttaatga tgttggactc gaaatccaag
     2461 tacgtcctgg acggcatggt tgaacccggc tgtgaagacc tgggaacgga caaaaaagag
     2521 ctggccaagc tccaaactgt ccagttggat gaagatatgc aagacttata agcctgattc
     2581 actccacaca tccccccacc ccttctctgc tataacagga gcaaatcatt ttctttgtga
     2641 agccccgaag atggggcgct tctactcatt tagaggaaaa cactgtactt ctgcgagcaa
     2701 gtgcgtttgg gttgagctgc atggcgagca tagttaaata tacaggagtg gaactgcatt
     2761 gctgaagcct ttctggtccc atcgtgctcg ctttgaaaca gatagggaca aggcaacaaa
     2821 tgaatgcatc aaaccatcat ctatcattta gtcagcagtt ataaatctta agggcgagac
     2881 ggaacgtgat ggtatttcaa atttaaaacg tatacacctc acttagaaaa ttaaccgctc
     2941 caggctgttg gaagctatgc agttggtttt tgtttgttta cttttactcc atgggcattg
     3001 agatggttaa gaagcaacgg cactctagac tatcgtaagg gtatattttt caaattatgt
     3061 agcgtatatg tgtgtgtgtt ggtgtgtgca tacacacatt ggtcgttttc agcattttgg
     3121 gggaaaggct tggttttaag tctctacgtg tttccagatg tgattgctaa tggtcaaatg
     3181 tggcagagaa agtctgaaac gccactacaa tccggtacga atgtaaatcc aggtctgtaa
     3241 gcaagatctg agttaagtac agtaagtttt tatttatacc gtgtatgtct ctcttcaggc
     3301 tctgtgaact gaaaggaagg ctgtcttctt actgtttaat ttatatttat tgtttgagca
     3361 ggaataggac atctttgttt ccaaacgagg ttttgctttt ttgttttttg taattgttat
     3421 caagagtcta ttaaggtcaa cgtcaacact gaaacagtaa ctgttgaccc ccagtactgg
     3481 aacttggcta cttctcctca caaccgtctt actttggcaa ctttgattcc tttaaatctg
     3541 ttttatatag actcctatgt gcctttttac cttgtggcct ttttattact agtaaggtac
     3601 agaagcgtca acaggagtgt tgatggttct tttgtgccgt caaacagggt tcagtttacc
     3661 acacagaact cctttataca ggacatctgc ttcactaaat atcatgtgta aggtttctcc
     3721 tgcaagtgga tgacagatat tgttgatgct tctcatcaca atgaaagtaa aaaattatag
     3781 aagaccatga aacagcaatt cttcaggcta tgaaaacaat cctttttgtt ctgttttggt
     3841 tttaggtttt tttgagaaag agtttctcag tttaacagag aaactgttac tgactgtcct
     3901 ggaactcact ttctagacca ggctggcctt gaattcacag agatccacct gcctctgccc
     3961 cccaagtgct gggattccac tgcccaactt gaaaacaacc attttaaagt aaacaaaata
     4021 tatgtaaatt gtactaatca aaatctgtcc aattgaagct tcattcctac tgttttgaat
     4081 ttggttggta tacggtaaca catgactgtt gcctgtccta tttaatcaag taaacccttc
     4141 aggtttctgt ggaaaagtct cttgtatgat aacgttgtga gctgagttta aaagttttag
     4201 cgggactctg catccacaat ataacaatgc aatggcttcg tgccgttagt ccaggcatct
     4261 ctgatttcag aaagtaagaa ggcaatcttt tctaaggtga cgtttcagtt gttaagctga
     4321 aaaagacagt gccacacctt gctttcctta agatgttggg agggactgct cggtttctag
     4381 ctaacatact catcggctga gcttctcaaa taaggctcac tttagcattt attgctacta
     4441 taaagggaac tttcagtcaa gataaagagc cctatgcaga attctgtgcc catcattttg
     4501 gtaaagattc tagatcccat ttttgtgaaa ttactgaatg tccctcaaat gctgaaatac
     4561 gaaatttggg ccagaggctg tttgttttgg gagcttttat tttttttcac atagccggtt
     4621 gcttcagtgt ggttttccac tctgacacta cttacacagc tcggctgccc ccatctccct
     4681 cccagttatg tactgatcat attaatgtga ttagcttcat ggttttgtag tatagtttac
     4741 ataaaaatga tattttttca ctagatagct gcaggtatca agaggtcatt attttaaaat
     4801 acctgtctgg taagggaagt gggaaagtca aaacgttata taaggtgtgt gggtgtgtgt
     4861 gtgtgtgtgt gtgtgtgtgt gtgtgtgatg gaaaacttcc acacaactga caaaagtatc
     4921 tcttttattc cgagttcttc ctctttttct ccctatgaga aagaaaagat agcacaaaac
     4981 taagtactta cctaggaaat gtattcatat tccgacatga tgagcttcta gccctacaaa
     5041 caccccaggt agctatataa cccaccaggt aggaatcagt gcacattaga agaacttagt
     5101 gttcttttct cttctttcag tagaataagg gccagttgat atgcagcccg tgtctgtgtg
     5161 gatggaatcc gataaaccct gtgatctcct tgcacagaat tgcaaatgac tcccccctcc
     5221 cccaacacca aggcccagcc tcagagccct tggagtttat gtggcagaat atctgtctta
     5281 cataaaccaa tgcttgaaga tgctgcaaag gaccctctag cgattcctga ggaggaatca
     5341 gactagaggt caataactcc ctttaaaccc aacccctgct gctggctgtg agattttctg
     5401 gtgccagctt atctatgcac tctgtagcca gaattggcat tcagctctta gttacatcta
     5461 atagagagga cagcttagca ttcaaagaag atcccccccc caaaaaaaaa caagcaagta
     5521 cctgtgttgt actgcataaa tatctcatgt agattcatag tgaagactta atacgtgttc
     5581 tggagccttt cttgtgttgt gaaaggcaag tagatgttgt agccataggt ttttttctgt
     5641 ttctgttttt tttttttaaa tccatagttg aattgcacaa tgcccttaac tctctgtatg
     5701 tacccttgtt gttctgcatg ttaaagctgg aattattggg catgtatggc aggctatcct
     5761 gctgcatcct caatatgtgg acattagtac ataaactcga gtccttcatc ctctaaaatg
     5821 tttttgacag atcatctcat aaaaataatt caggaaatct gtagggaaag tagttatgtt
     5881 ttacaagagc catttcaaag tcttcctaaa acttggatga tagaacctaa tgtttatttt
     5941 gtgtctaatc gagacatttc aatttcatta gatgttacca cgtttttatt aattcaaatt
     6001 atatcgcatg tgactctttt gactttcagg gtttctcaaa aaaaaatgta tcattttgtt
     6061 gcatgtactg tatgttcaga ggcaatcagt tgtatactca atatggtttt actgtgcctt
     6121 acatgaagag aaactataca gaatgtatga catggggtgg gaaacagcct ctactgcact
     6181 gttaggcgac agcacacagc atgtcccaga acatttctgt gtttaattac ccaaccaaag
     6241 agatctaaag tatgtatgtt gtactgtaat gggggttagg cctggacaat ttaagtgttt
     6301 tatttgtttt ctgaaatgat gtgaacttat ttttctaaac actatgctaa ataaacttta
     6361 tatttataca ta
//
