LOCUS       NM_001106739            5980 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus SIX homeobox 4 (Six4), transcript variant 3,
            mRNA.
ACCESSION   NM_001106739 XM_001080700 XM_234292
VERSION     NM_001106739.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5980)
  AUTHORS   Fujimoto,Y., Tanaka,S.S., Yamaguchi,Y.L., Kobayashi,H., Kuroki,S.,
            Tachibana,M., Shinomura,M., Kanai,Y., Morohashi,K., Kawakami,K. and
            Nishinakamura,R.
  TITLE     Homeoproteins Six1 and Six4 regulate male sex determination and
            mouse gonadal development
  JOURNAL   Dev Cell 26 (4), 416-430 (2013)
   PUBMED   23987514
REFERENCE   2  (bases 1 to 5980)
  AUTHORS   Suzuki,Y., Ikeda,K. and Kawakami,K.
  TITLE     Development of gustatory papillae in the absence of Six1 and Six4
  JOURNAL   J Anat 219 (6), 710-721 (2011)
   PUBMED   21978088
REFERENCE   3  (bases 1 to 5980)
  AUTHORS   Richard,A.F., Demignon,J., Sakakibara,I., Pujol,J., Favier,M.,
            Strochlic,L., Le Grand,F., Sgarioto,N., Guernec,A., Schmitt,A.,
            Cagnard,N., Huang,R., Legay,C., Guillet-Deniau,I. and Maire,P.
  TITLE     Genesis of muscle fiber-type diversity during mouse embryogenesis
            relies on Six1 and Six4 gene expression
  JOURNAL   Dev Biol 359 (2), 303-320 (2011)
   PUBMED   21884692
REFERENCE   4  (bases 1 to 5980)
  AUTHORS   Yajima,H., Motohashi,N., Ono,Y., Sato,S., Ikeda,K., Masuda,S.,
            Yada,E., Kanesaki,H., Miyagoe-Suzuki,Y., Takeda,S. and Kawakami,K.
  TITLE     Six family genes control the proliferation and differentiation of
            muscle satellite cells
  JOURNAL   Exp Cell Res 316 (17), 2932-2944 (2010)
   PUBMED   20696153
REFERENCE   5  (bases 1 to 5980)
  AUTHORS   He,G., Tavella,S., Hanley,K.P., Self,M., Oliver,G., Grifone,R.,
            Hanley,N., Ward,C. and Bobola,N.
  TITLE     Inactivation of Six2 in mouse identifies a novel genetic mechanism
            controlling development and growth of the cranial base
  JOURNAL   Dev Biol 344 (2), 720-730 (2010)
   PUBMED   20515681
REFERENCE   6  (bases 1 to 5980)
  AUTHORS   Himeda,C.L., Ranish,J.A., Angello,J.C., Maire,P., Aebersold,R. and
            Hauschka,S.D.
  TITLE     Quantitative proteomic identification of six4 as the trex-binding
            factor in the muscle creatine kinase enhancer
  JOURNAL   Mol Cell Biol 24 (5), 2132-2143 (2004)
   PUBMED   14966291
REFERENCE   7  (bases 1 to 5980)
  AUTHORS   Ohto,H., Kamada,S., Tago,K., Tominaga,S.I., Ozaki,H., Sato,S. and
            Kawakami,K.
  TITLE     Cooperation of six and eya in activation of their target genes
            through nuclear translocation of Eya
  JOURNAL   Mol Cell Biol 19 (10), 6815-6824 (1999)
   PUBMED   10490620
REFERENCE   8  (bases 1 to 5980)
  AUTHORS   Niiya,A., Ohto,H., Kawakami,K. and Araki,M.
  TITLE     Localization of Six4/AREC3 in the developing mouse retina;
            implications in mammalian retinal development
  JOURNAL   Exp Eye Res 67 (6), 699-707 (1998)
   PUBMED   9990334
REFERENCE   9  (bases 1 to 5980)
  AUTHORS   Spitz,F., Demignon,J., Porteu,A., Kahn,A., Concordet,J.P.,
            Daegelen,D. and Maire,P.
  TITLE     Expression of myogenin during embryogenesis is controlled by
            Six/sine oculis homeoproteins through a conserved MEF3 binding site
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14220-14225 (1998)
   PUBMED   9826681
REFERENCE   10 (bases 1 to 5980)
  AUTHORS   Kawakami,K., Ohto,H., Takizawa,T. and Saito,T.
  TITLE     Identification and expression of six family genes in mouse retina
  JOURNAL   FEBS Lett 393 (2-3), 259-263 (1996)
   PUBMED   8814301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 14, 2022 this sequence version replaced NM_001106739.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760386, SAMEA5760393
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000006.1  97551809-97551872   c
            65-139              JAXUCZ010000006.1  97551528-97551602   c
            140-693             JAXUCZ010000006.1  97550788-97551341   c
            694-1382            JAXUCZ010000006.1  97547358-97548046   c
            1383-5980           JAXUCZ010000006.1  97538202-97542799   c
FEATURES             Location/Qualifiers
     source          1..5980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..5980
                     /gene="Six4"
                     /note="SIX homeobox 4"
                     /db_xref="GeneID:299138"
                     /db_xref="RGD:1306726"
     exon            1..64
                     /gene="Six4"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2179
                     /gene="Six4"
                     /note="isoform 3 is encoded by transcript variant 3; sine
                     oculis-related homeobox 4 homolog; homeobox protein SIX4"
                     /codon_start=1
                     /product="homeobox protein SIX4 isoform 3"
                     /protein_id="NP_001100209.1"
                     /db_xref="GeneID:299138"
                     /db_xref="RGD:1306726"
                     /translation="MIASAADIKQENGMESASEGQEAHREPPLAFSPDHVACVCEALQ
                     QGGNLDRLARFLWSLPQSDLLRGNESLLKARALVAFHQGIYPELYSILESHSFESANH
                     PLLQQLWYKARYTEAERARGRPLGAVDKYRLRRKFPLPRTIWDGEETVYCFKEKSRNA
                     LKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKNRRQRDRNPSETQSKSESDGNPS
                     TEDESSKGHEDLSPHPLSGASDGVTNLSLSSHMEPVYMQQIGNAKISLSSSGVLLNGS
                     LVPASTSPVFLNGNSFIQGHNGVILNGLNVGNTQTVSLNPPKMSSNTVGNGIAMTDIL
                     GSTSQDVKEFKVLQSSAVNSAATTSYSPSAPVSFPGLIPCTEVKREGVQTVASQDGGS
                     VVTFTTPVQINQYGIVQIPNSGANGQFLNGSIGFSPLQLPPVSVSASQGHLSVTPSTS
                     DGSTFTSESATVQHGKLFLSPLTPSAVVYTVPNSGQTVGAVKQEGLERGLVFSQLMPV
                     NHNAQVNANLSSENLSGSGLHPLTSSLVNVSAAHGFSLTPSTLLNPAELNPDLAESQP
                     VSAPVASKCTVTSVSNTNYATLQNCSLIPGPDLLSVPMTQAALGEIVPTAEEQVSHAS
                     PAVHQDFVREQRLVLQSVANLKENFLQNSENKTTNNLMMLDSKSKYVLDGMVEPGCED
                     LGTDKKELAKLQTVQLDEDMQDL"
     exon            65..139
                     /gene="Six4"
                     /inference="alignment:Splign:2.1.0"
     exon            140..693
                     /gene="Six4"
                     /inference="alignment:Splign:2.1.0"
     exon            694..1382
                     /gene="Six4"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..5980
                     /gene="Six4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgggggaa cggcagaaag cagctatccg tttacactac tttgctctag cagctatctt
       61 aatgattgca agtgcggcgg acatcaagca ggagaatggg atggaaagcg cctcggaagg
      121 acaggaggcg caccgagaac ccccgctggc cttctcgccg gaccatgtcg cctgcgtgtg
      181 cgaggcgttg cagcaggggg gcaacctgga ccgcctggcc cggttccttt ggtccctgcc
      241 ccagagcgac ctgctacgtg gcaacgagag cctgctgaag gcgcgagcgc tcgtggcctt
      301 ccaccagggc atctaccctg agttgtacag catcctcgag agccacagct tcgagtcggc
      361 caaccatccg ctgctgcagc agctctggta caaggcgcgc tacaccgagg ccgagcgagc
      421 gcgcggccgg ccgctgggcg ccgtggacaa gtaccggctg cgcaggaaat tccccttgcc
      481 ccgcaccatc tgggacggcg aggagacggt gtattgtttc aaggagaagt cgcgcaacgc
      541 gcttaaggag ctctacaagc agaatcgcta cccctcgccc gccgagaagc ggcacctggc
      601 caagatcact ggcctctccc tcacccaggt cagcaactgg ttcaagaacc ggcggcagcg
      661 cgaccgaaac ccctccgaga cccagtccaa aagcgaatca gatggcaacc ccagcactga
      721 agacgaatcc agcaagggac atgaggattt gtctcctcat ccactttcag gcgcatctga
      781 tggcgtcacc aacctcagcc tttctagcca catggagcca gtatatatgc aacaaattgg
      841 aaatgctaag atatcattaa gctcgtctgg agttttgctg aatggaagct tggtacccgc
      901 aagtacttca cccgtcttcc ttaatggcaa ttcttttatt cagggacaca atggagttat
      961 ccttaatgga ctgaatgtgg gaaatacaca gacagtgtca ctgaacccac ccaaaatgtc
     1021 ttcaaacact gtgggcaatg gcatagccat gacagacatc ctgggatcta cctcacagga
     1081 tgtgaaagaa ttcaaagtcc tccagagttc tgctgtgaac tcagcagcca ccacctccta
     1141 cagccctagt gcccctgtgt cattcccagg gctgataccc tgtactgaag tgaaaagaga
     1201 aggcgttcag acagtggcct cccaggatgg cggctctgta gtgactttta ctacaccagt
     1261 gcaaattaac cagtatggca ttgtccagat ccctaattct ggagcaaatg gccagttcct
     1321 taatgggagc attggattct ctccactgca gctgcctcct gtctcagtat cagcttcaca
     1381 aggtcatctt tcggtgactc caagcacttc ggatggaagc acatttacaa gtgagtcggc
     1441 cacagtccag catggtaaac ttttcctgag ccctcttacc cccagtgcag tggtatacac
     1501 tgtacctaat tcaggccaga ctgtaggagc tgtaaaacag gaaggcttag aaagaggcct
     1561 agtcttttct cagttgatgc ctgtcaatca caacgcacaa gtaaatgcaa acctgtcttc
     1621 ggaaaatctc tctgggagtg gcctccatcc tctgacctct tcgttggtta atgtgtccgc
     1681 cgcccacggt ttttccctaa ccccctctac actactaaat cccgctgagc taaaccccga
     1741 ccttgctgag agccagccag tgtctgcacc tgtggcaagc aaatgtactg tgacatctgt
     1801 cagcaacact aactacgcaa cccttcagaa ctgttccctt attcctggtc cagacctatt
     1861 gtccgtcccg atgacccagg ctgccctggg tgagatagtt cccacagccg aagagcaggt
     1921 gagccacgcc tcgccagcag tccaccagga ttttgtaaga gaacagcgct tggttctgca
     1981 atcagtcgct aacctgaaag agaacttctt acaaaattct gagaacaaaa caacaaacaa
     2041 cttaatgatg ttggactcga aatccaagta cgtcctggac ggcatggttg aacccggctg
     2101 tgaagacctg ggaacggaca aaaaagagct ggccaagctc caaactgtcc agttggatga
     2161 agatatgcaa gacttataag cctgattcac tccacacatc cccccacccc ttctctgcta
     2221 taacaggagc aaatcatttt ctttgtgaag ccccgaagat ggggcgcttc tactcattta
     2281 gaggaaaaca ctgtacttct gcgagcaagt gcgtttgggt tgagctgcat ggcgagcata
     2341 gttaaatata caggagtgga actgcattgc tgaagccttt ctggtcccat cgtgctcgct
     2401 ttgaaacaga tagggacaag gcaacaaatg aatgcatcaa accatcatct atcatttagt
     2461 cagcagttat aaatcttaag ggcgagacgg aacgtgatgg tatttcaaat ttaaaacgta
     2521 tacacctcac ttagaaaatt aaccgctcca ggctgttgga agctatgcag ttggtttttg
     2581 tttgtttact tttactccat gggcattgag atggttaaga agcaacggca ctctagacta
     2641 tcgtaagggt atatttttca aattatgtag cgtatatgtg tgtgtgttgg tgtgtgcata
     2701 cacacattgg tcgttttcag cattttgggg gaaaggcttg gttttaagtc tctacgtgtt
     2761 tccagatgtg attgctaatg gtcaaatgtg gcagagaaag tctgaaacgc cactacaatc
     2821 cggtacgaat gtaaatccag gtctgtaagc aagatctgag ttaagtacag taagttttta
     2881 tttataccgt gtatgtctct cttcaggctc tgtgaactga aaggaaggct gtcttcttac
     2941 tgtttaattt atatttattg tttgagcagg aataggacat ctttgtttcc aaacgaggtt
     3001 ttgctttttt gttttttgta attgttatca agagtctatt aaggtcaacg tcaacactga
     3061 aacagtaact gttgaccccc agtactggaa cttggctact tctcctcaca accgtcttac
     3121 tttggcaact ttgattcctt taaatctgtt ttatatagac tcctatgtgc ctttttacct
     3181 tgtggccttt ttattactag taaggtacag aagcgtcaac aggagtgttg atggttcttt
     3241 tgtgccgtca aacagggttc agtttaccac acagaactcc tttatacagg acatctgctt
     3301 cactaaatat catgtgtaag gtttctcctg caagtggatg acagatattg ttgatgcttc
     3361 tcatcacaat gaaagtaaaa aattatagaa gaccatgaaa cagcaattct tcaggctatg
     3421 aaaacaatcc tttttgttct gttttggttt taggtttttt tgagaaagag tttctcagtt
     3481 taacagagaa actgttactg actgtcctgg aactcacttt ctagaccagg ctggccttga
     3541 attcacagag atccacctgc ctctgccccc caagtgctgg gattccactg cccaacttga
     3601 aaacaaccat tttaaagtaa acaaaatata tgtaaattgt actaatcaaa atctgtccaa
     3661 ttgaagcttc attcctactg ttttgaattt ggttggtata cggtaacaca tgactgttgc
     3721 ctgtcctatt taatcaagta aacccttcag gtttctgtgg aaaagtctct tgtatgataa
     3781 cgttgtgagc tgagtttaaa agttttagcg ggactctgca tccacaatat aacaatgcaa
     3841 tggcttcgtg ccgttagtcc aggcatctct gatttcagaa agtaagaagg caatcttttc
     3901 taaggtgacg tttcagttgt taagctgaaa aagacagtgc cacaccttgc tttccttaag
     3961 atgttgggag ggactgctcg gtttctagct aacatactca tcggctgagc ttctcaaata
     4021 aggctcactt tagcatttat tgctactata aagggaactt tcagtcaaga taaagagccc
     4081 tatgcagaat tctgtgccca tcattttggt aaagattcta gatcccattt ttgtgaaatt
     4141 actgaatgtc cctcaaatgc tgaaatacga aatttgggcc agaggctgtt tgttttggga
     4201 gcttttattt tttttcacat agccggttgc ttcagtgtgg ttttccactc tgacactact
     4261 tacacagctc ggctgccccc atctccctcc cagttatgta ctgatcatat taatgtgatt
     4321 agcttcatgg ttttgtagta tagtttacat aaaaatgata ttttttcact agatagctgc
     4381 aggtatcaag aggtcattat tttaaaatac ctgtctggta agggaagtgg gaaagtcaaa
     4441 acgttatata aggtgtgtgg gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgatgga
     4501 aaacttccac acaactgaca aaagtatctc ttttattccg agttcttcct ctttttctcc
     4561 ctatgagaaa gaaaagatag cacaaaacta agtacttacc taggaaatgt attcatattc
     4621 cgacatgatg agcttctagc cctacaaaca ccccaggtag ctatataacc caccaggtag
     4681 gaatcagtgc acattagaag aacttagtgt tcttttctct tctttcagta gaataagggc
     4741 cagttgatat gcagcccgtg tctgtgtgga tggaatccga taaaccctgt gatctccttg
     4801 cacagaattg caaatgactc ccccctcccc caacaccaag gcccagcctc agagcccttg
     4861 gagtttatgt ggcagaatat ctgtcttaca taaaccaatg cttgaagatg ctgcaaagga
     4921 ccctctagcg attcctgagg aggaatcaga ctagaggtca ataactccct ttaaacccaa
     4981 cccctgctgc tggctgtgag attttctggt gccagcttat ctatgcactc tgtagccaga
     5041 attggcattc agctcttagt tacatctaat agagaggaca gcttagcatt caaagaagat
     5101 ccccccccca aaaaaaaaca agcaagtacc tgtgttgtac tgcataaata tctcatgtag
     5161 attcatagtg aagacttaat acgtgttctg gagcctttct tgtgttgtga aaggcaagta
     5221 gatgttgtag ccataggttt ttttctgttt ctgttttttt tttttaaatc catagttgaa
     5281 ttgcacaatg cccttaactc tctgtatgta cccttgttgt tctgcatgtt aaagctggaa
     5341 ttattgggca tgtatggcag gctatcctgc tgcatcctca atatgtggac attagtacat
     5401 aaactcgagt ccttcatcct ctaaaatgtt tttgacagat catctcataa aaataattca
     5461 ggaaatctgt agggaaagta gttatgtttt acaagagcca tttcaaagtc ttcctaaaac
     5521 ttggatgata gaacctaatg tttattttgt gtctaatcga gacatttcaa tttcattaga
     5581 tgttaccacg tttttattaa ttcaaattat atcgcatgtg actcttttga ctttcagggt
     5641 ttctcaaaaa aaaatgtatc attttgttgc atgtactgta tgttcagagg caatcagttg
     5701 tatactcaat atggttttac tgtgccttac atgaagagaa actatacaga atgtatgaca
     5761 tggggtggga aacagcctct actgcactgt taggcgacag cacacagcat gtcccagaac
     5821 atttctgtgt ttaattaccc aaccaaagag atctaaagta tgtatgttgt actgtaatgg
     5881 gggttaggcc tggacaattt aagtgtttta tttgttttct gaaatgatgt gaacttattt
     5941 ttctaaacac tatgctaaat aaactttata tttatacata
//
