LOCUS       NM_023990               2677 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SIX homeobox 3 (Six3), mRNA.
ACCESSION   NM_023990 XM_001059990
VERSION     NM_023990.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2677)
  AUTHORS   Dai,G., Li,Y., Zhang,M., Lu,P., Zhang,Y., Wang,H., Shi,L., Cao,M.,
            Shen,R. and Rui,Y.
  TITLE     The Regulation of the AMPK/mTOR Axis Mitigates Tendon
            Stem/Progenitor Cell Senescence and Delays Tendon Aging
  JOURNAL   Stem Cell Rev Rep 19 (5), 1492-1506 (2023)
   PUBMED   36917311
  REMARK    GeneRIF: The Regulation of the AMPK/mTOR Axis Mitigates Tendon
            Stem/Progenitor Cell Senescence and Delays Tendon Aging.
REFERENCE   2  (bases 1 to 2677)
  AUTHORS   Lavado,A. and Oliver,G.
  TITLE     Six3 is required for ependymal cell maturation
  JOURNAL   Development 138 (24), 5291-5300 (2011)
   PUBMED   22071110
REFERENCE   3  (bases 1 to 2677)
  AUTHORS   VanDunk,C., Hunter,L.A. and Gray,P.A.
  TITLE     Development, maturation, and necessity of transcription factors in
            the mouse suprachiasmatic nucleus
  JOURNAL   J Neurosci 31 (17), 6457-6467 (2011)
   PUBMED   21525287
REFERENCE   4  (bases 1 to 2677)
  AUTHORS   Liu,W., Lagutin,O., Swindell,E., Jamrich,M. and Oliver,G.
  TITLE     Neuroretina specification in mouse embryos requires Six3-mediated
            suppression of Wnt8b in the anterior neural plate
  JOURNAL   J Clin Invest 120 (10), 3568-3577 (2010)
   PUBMED   20890044
REFERENCE   5  (bases 1 to 2677)
  AUTHORS   Abe,Y., Oka,A., Mizuguchi,M., Igarashi,T., Ishikawa,S.,
            Aburatani,H., Yokoyama,S., Asahara,H., Nagao,K., Yamada,M. and
            Miyashita,T.
  TITLE     EYA4, deleted in a case with middle interhemispheric variant of
            holoprosencephaly, interacts with SIX3 both physically and
            functionally
  JOURNAL   Hum Mutat 30 (10), E946-E955 (2009)
   PUBMED   19606496
REFERENCE   6  (bases 1 to 2677)
  AUTHORS   Lagutin,O., Zhu,C.C., Furuta,Y., Rowitch,D.H., McMahon,A.P. and
            Oliver,G.
  TITLE     Six3 promotes the formation of ectopic optic vesicle-like
            structures in mouse embryos
  JOURNAL   Dev Dyn 221 (3), 342-349 (2001)
   PUBMED   11458394
REFERENCE   7  (bases 1 to 2677)
  AUTHORS   Lengler,J., Krausz,E., Tomarev,S., Prescott,A., Quinlan,R.A. and
            Graw,J.
  TITLE     Antagonistic action of Six3 and Prox1 at the gamma-crystallin
            promoter
  JOURNAL   Nucleic Acids Res 29 (2), 515-526 (2001)
   PUBMED   11139622
REFERENCE   8  (bases 1 to 2677)
  AUTHORS   Ohkura,N., Ohkubo,T., Maruyama,K., Tsukada,T. and Yamaguchi,K.
  TITLE     The orphan nuclear receptor NOR-1 interacts with the homeobox
            containing protein Six3
  JOURNAL   Dev Neurosci 23 (1), 17-24 (2001)
   PUBMED   11173923
REFERENCE   9  (bases 1 to 2677)
  AUTHORS   Wallis,D.E., Roessler,E., Hehr,U., Nanni,L., Wiltshire,T.,
            Richieri-Costa,A., Gillessen-Kaesbach,G., Zackai,E.H., Rommens,J.
            and Muenke,M.
  TITLE     Mutations in the homeodomain of the human SIX3 gene cause
            holoprosencephaly
  JOURNAL   Nat Genet 22 (2), 196-198 (1999)
   PUBMED   10369266
REFERENCE   10 (bases 1 to 2677)
  AUTHORS   Kawakami,K., Ohto,H., Takizawa,T. and Saito,T.
  TITLE     Identification and expression of six family genes in mouse retina
  JOURNAL   FEBS Lett 393 (2-3), 259-263 (1996)
   PUBMED   8814301
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 26, 2021 this sequence version replaced NM_023990.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB030833.1, SRR26360194.744058.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN12840121
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1176              JAXUCZ010000006.1  14795081-14796256   c
            1177-2677           JAXUCZ010000006.1  14791937-14793437   c
FEATURES             Location/Qualifiers
     source          1..2677
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..2677
                     /gene="Six3"
                     /note="SIX homeobox 3"
                     /db_xref="GeneID:78974"
                     /db_xref="RGD:620909"
     exon            1..1176
                     /gene="Six3"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..1369
                     /gene="Six3"
                     /note="sine oculis-related homeobox 3 homolog; sine oculis
                     homeobox homolog 3"
                     /codon_start=1
                     /product="homeobox protein SIX3"
                     /protein_id="NP_076480.1"
                     /db_xref="GeneID:78974"
                     /db_xref="RGD:620909"
                     /translation="MVFRSPLDLYSSHFLLPNFADSHHCSLLLASSGGGSGAGGGGGA
                     GGGGGGGGGNRAGGGGAGGAGGGGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCE
                     TLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENH
                     KFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCF
                     KERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQ
                     HQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSE
                     CDV"
     exon            1177..2677
                     /gene="Six3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaatcgctga atcttgactc ggcggtggtt ggctctcgct ctcctctctc tccctctccc
       61 tctccctctc cctctctctg cctcgggttc tctctctgcg cgcgcgcacc gggccgctct
      121 ccttcctccc tctctatgtg gctgcgcggg tgtgtgtgta tgtggatgtg tgtggggtgt
      181 gggtgtccct tacgtccttc ctcctccccc tccttctcct tctgctcccc cctcctttcc
      241 atctcctcct cccccctctt ctctccctcc tcctggtcct catcgcccct ctcctcctct
      301 tcctcccctc tctcttcctc tccctgaatt ttctcctctc ctctcaggtc agtccatggt
      361 attccgctcc cccctagacc tctattcctc ccacttcttg ttgccaaact tcgccgattc
      421 tcaccactgc tccctacttc tggcgagtag cggcggcggg agcggtgcgg gcggcggcgg
      481 cggcgcggga ggaggcggcg gcggcggcgg cgggaaccgt gcgggaggcg gcggtgctgg
      541 cggagcaggc ggcggcggcg gcggcggcgg cggcggctcc agggcccccc cggaagagtt
      601 gtccatgttc cagctgccca ccctcaactt ctcgccggag caggtggcca gcgtctgcga
      661 gacgctggag gagacgggcg acatcgagcg gctgggccgc ttcctctggt cgctgcccgt
      721 ggcccctggg gcgtgcgagg ccatcaacaa acacgagtcg atcctgcgcg cgcgcgccgt
      781 cgtcgccttc cacaccggca acttccgaga cctgtaccac atcctggaga atcacaagtt
      841 caccaaggag tctcacggca agctgcaggc catgtggctc gaggcgcact accaggaggc
      901 cgagaagctg cgcggccgcc ctctcggccc ggtggacaag taccgcgtgc gcaagaagtt
      961 ccctctgccg cgcaccatct gggatgggga gcagaagacc cattgcttca aggagcggac
     1021 tcggagcctg ctgcgggaat ggtacctgca ggatccctac cccaacccca gcaagaaacg
     1081 agaactggcg caggccaccg gcctcacccc cacacaagta ggcaactggt ttaagaaccg
     1141 gcgacagcgc gaccgcgcag cggcggccaa gaacaggctc cagcaccagg ccatcgggcc
     1201 gagcgggatg cgctcgctgg ccgagcccgg ctgccccacg cacggctcag cagagtcacc
     1261 gtccacggca gccagtccga ccaccagtgt gtccagcctg acggagcgcg cggacactgg
     1321 cacttctatc ctctcggtaa cctccagcga ctcggaatgt gatgtatgat agccaaggcc
     1381 gccctcctcc tccttcccct cctccccctc caccttcccc tcctcctcct agccctgctc
     1441 ctcttcctcc tcttctactc catccctaga acaaaccgaa atcaggatac acagccacac
     1501 acacacacac acacacacac acacaagtcc atacacactc ccaccccagc caaaaatata
     1561 tttaaaaaaa acaagaaaaa taaattaacc tcaaatcatc aacaaccccc caccacctac
     1621 caccaccacg gccaccccaa aggaccgcga cgccaacaga cagtcacaaa cgctgatgtt
     1681 gcgggcagaa agcataaaag aggtgacaat tgtatacttt ctaggacaag cacggcttct
     1741 ccttttggtt cccacggacc cggcacccca cctgcatgac gatttatttg tatctgggaa
     1801 aatattctct ctagtttaaa atgatttaaa gagtcgacta tacaaaaaaa cgccaccatc
     1861 gccgccgcga caagacgaca aaagcaaaca gacaaaaaga aaaaaaatct gacatctccg
     1921 ttctgaattt gttttttttt tttaaaggaa agaaagaaag gaaaaaaaaa actcctcgag
     1981 agaaatagca aatgtttctt ccttctgttg ctcttttctc ctttagccct atccatccat
     2041 ctatctatct atctatctat ctatctatct atctatctat ctatctatct ctgtttttta
     2101 agtccaagta ttggtcaaac aagatgcaat cctctgtttt tgttcagccg acaatcattt
     2161 tcttcgtaag cacctttttc tctccactct gtcactgcct gtgtgggtac tggttataaa
     2221 tgtggaaaaa gaatagttat gactgtaaca gatttttatt tttatttcaa aattttatat
     2281 gaattatgta tatcttaatg atcggtcatt ttcccagttt gtaatatatg tgtagaaatt
     2341 gcttgtatat gatacctgct tttctcctct cccttctctc tctctctcct ccctccttcc
     2401 ctgcccactc acctctttcc tttggggatt ctcggcgtcg acttggcagt cgaggcttga
     2461 cgaggtggcc agggttagag cgagagaggg accctgtcgc tagcaaaagc agagagtgag
     2521 accgtagtat tcttatgcaa aagctattca agttttccta gccgctttgg aggccccctt
     2581 cactcccgta gggcgctttt actgttatct taactgcgtg tttatctata tgtaaaaact
     2641 ttctaaagca aatacagtat tctccatttt cttatga
//
