LOCUS       NM_001191908            1327 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SIX homeobox 2 (Six2), mRNA.
ACCESSION   NM_001191908 XM_345630
VERSION     NM_001191908.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1327)
  AUTHORS   Ribeiro,P.C., Lojudice,F.H., Fernandes-Charpiot,I.M.M.,
            Baptista,M.A.S.F., de Almeida Araujo,S., Mendes,G.E.F.,
            Sogayar,M.C., Abbud-Filho,M. and Caldas,H.C.
  TITLE     Therapeutic potential of human induced pluripotent stem cells and
            renal progenitor cells in experimental chronic kidney disease
  JOURNAL   Stem Cell Res Ther 11 (1), 530 (2020)
   PUBMED   33298161
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1327)
  AUTHORS   Bagherie-Lachidan,M., Reginensi,A., Pan,Q., Zaveri,H.P.,
            Scott,D.A., Blencowe,B.J., Helmbacher,F. and McNeill,H.
  TITLE     Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the
            nephron progenitor pool
  JOURNAL   Development 142 (15), 2564-2573 (2015)
   PUBMED   26116661
REFERENCE   3  (bases 1 to 1327)
  AUTHORS   Xu,J., Liu,H., Park,J.S., Lan,Y. and Jiang,R.
  TITLE     Osr1 acts downstream of and interacts synergistically with Six2 to
            maintain nephron progenitor cells during kidney organogenesis
  JOURNAL   Development 141 (7), 1442-1452 (2014)
   PUBMED   24598167
REFERENCE   4  (bases 1 to 1327)
  AUTHORS   Senanayake,U., Koller,K., Pichler,M., Leuschner,I., Strohmaier,H.,
            Hadler,U., Das,S., Hoefler,G. and Guertl,B.
  TITLE     The pluripotent renal stem cell regulator SIX2 is activated in
            renal neoplasms and influences cellular proliferation and migration
  JOURNAL   Hum Pathol 44 (3), 336-345 (2013)
   PUBMED   22995329
REFERENCE   5  (bases 1 to 1327)
  AUTHORS   Park,J.S., Ma,W., O'Brien,L.L., Chung,E., Guo,J.J., Cheng,J.G.,
            Valerius,M.T., McMahon,J.A., Wong,W.H. and McMahon,A.P.
  TITLE     Six2 and Wnt regulate self-renewal and commitment of nephron
            progenitors through shared gene regulatory networks
  JOURNAL   Dev Cell 23 (3), 637-651 (2012)
   PUBMED   22902740
REFERENCE   6  (bases 1 to 1327)
  AUTHORS   Purcell,P., Oliver,G., Mardon,G., Donner,A.L. and Maas,R.L.
  TITLE     Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and
            nasal placode induction
  JOURNAL   Gene Expr Patterns 6 (1), 110-118 (2005)
   PUBMED   16024294
REFERENCE   7  (bases 1 to 1327)
  AUTHORS   Kutejova,E., Engist,B., Mallo,M., Kanzler,B. and Bobola,N.
  TITLE     Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme
  JOURNAL   Development 132 (3), 469-478 (2005)
   PUBMED   15634706
REFERENCE   8  (bases 1 to 1327)
  AUTHORS   Brodbeck,S., Besenbeck,B. and Englert,C.
  TITLE     The transcription factor Six2 activates expression of the Gdnf gene
            as well as its own promoter
  JOURNAL   Mech Dev 121 (10), 1211-1222 (2004)
   PUBMED   15327782
REFERENCE   9  (bases 1 to 1327)
  AUTHORS   Donovan,M.J., Natoli,T.A., Sainio,K., Amstutz,A., Jaenisch,R.,
            Sariola,H. and Kreidberg,J.A.
  TITLE     Initial differentiation of the metanephric mesenchyme is
            independent of WT1 and the ureteric bud
  JOURNAL   Dev Genet 24 (3-4), 252-262 (1999)
   PUBMED   10322633
REFERENCE   10 (bases 1 to 1327)
  AUTHORS   Kawakami,K., Ohto,H., Takizawa,T. and Saito,T.
  TITLE     Identification and expression of six family genes in mouse retina
  JOURNAL   FEBS Lett 393 (2-3), 259-263 (1996)
   PUBMED   8814301
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jul 17, 2010 this sequence version replaced XM_345630.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1188877.1,
                                           SRR22582419.866522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               JAXUCZ010000006.1  14728058-14728617
            561-1327            JAXUCZ010000006.1  14730610-14731376
FEATURES             Location/Qualifiers
     source          1..1327
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1327
                     /gene="Six2"
                     /note="SIX homeobox 2"
                     /db_xref="GeneID:366542"
                     /db_xref="RGD:1310792"
     CDS             1..891
                     /gene="Six2"
                     /note="sine oculis-related homeobox 2 homolog"
                     /codon_start=1
                     /product="homeobox protein SIX2"
                     /protein_id="NP_001178837.1"
                     /db_xref="GeneID:366542"
                     /db_xref="RGD:1310792"
                     /translation="MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLH
                     KNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRP
                     LGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEA
                     TGLTTTQVSNWFKNRRQRDRAAEAKERENSENSNSSSHNPLASSLNGSGKSVLGSSED
                     EKTPSGTPDHSSSSPALLLSPPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHH
                     HSLQDSILNPMSANLVDLGS"
     exon            1..560
                     /gene="Six2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..1327
                     /gene="Six2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtccatgc tgcccacctt cggcttcacg caggagcaag tggcgtgcgt gtgcgaggtg
       61 ctgcagcagg gcggcaacat cgagcggcta ggtcgcttcc tgtggtcgct gcctgcctgc
      121 gagcacctcc acaagaatga aagcgtgctc aaggccaagg ccgtggtggc ctttcaccgg
      181 ggcaacttcc gcgagctcta caaaatcctg gagagccacc agttctcgcc gcacaaccac
      241 gccaagctgc agcagctgtg gctcaaggcg cactacatcg aggcggagaa gctgcgcggc
      301 cggcccctgg gcgccgtggg caagtaccgc gtgcggcgca agttcccgct gccccgctcc
      361 atctgggacg gcgaggagac cagctactgc ttcaaggaga agagccgcag cgtgctgcgc
      421 gagtggtatg cgcacaaccc ttacccgtcg ccgcgggaga agcgcgagct ggccgaggcc
      481 accggcctca ccaccacgca ggtcagcaac tggttcaaaa accggcggca gcgcgacagg
      541 gcggcggagg ccaaggaaag ggagaacagc gagaactcca attccagtag ccacaacccg
      601 ctggcttcct cgctcaatgg cagcggcaag tcggtgctag gcagttccga ggacgagaag
      661 acgccgtcgg ggactccaga ccactcgtca tccagtcccg cactgttgct cagcccgccg
      721 ccgccccctg ggttgccttc cctacacagc ctgggccacc ctccgggccc gagcgcagtg
      781 cccgtgccag tgcccggtgg aggcggcgcg gatccactgc agcatcacca cagcctgcag
      841 gactccatac tcaaccccat gtcggccaac cttgtggacc taggctccta gagctctgct
      901 cgcctcccgg cgcttgcttt ccgtgcttgg tgcggggact tgagaggcgg tgtgggaggg
      961 cggtagattg gagtctggac cgggtactgg aagactgccc tgccacgctg gagcggcaga
     1021 accggcggcg ggacaaagtg gacaatggtc tgctcggggt cctttgcggg attcattctc
     1081 aagttgcttt tgagatcctt tggaggccag ggacctagtc ttgaactggg caagggaata
     1141 aattataaac gaccaccacc ccttttaaaa tctcttccct ttctcttgct cttttctttc
     1201 ctccattttc ccttcgggtt tcttatgtct cctcttttca tttttttctc tctgcctctt
     1261 tttgcttttc tttttcccct ttatacattt ctggatctct ctctctctct ctctctctct
     1321 ctctctc
//
