LOCUS       NM_053759               3188 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus SIX homeobox 1 (Six1), mRNA.
ACCESSION   NM_053759 XM_001080688 XM_343079
VERSION     NM_053759.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3188)
  AUTHORS   Zhang,J., Mei,Z., Yao,W., Zhao,C., Wu,S. and Ouyang,J.
  TITLE     SIX1 induced HULC modulates neuropathic pain and Schwann cell
            oxidative stress after sciatic nerve injury
  JOURNAL   Gene 882, 147655 (2023)
   PUBMED   37479098
  REMARK    GeneRIF: SIX1 induced HULC modulates neuropathic pain and Schwann
            cell oxidative stress after sciatic nerve injury.
REFERENCE   2  (bases 1 to 3188)
  AUTHORS   Zhan,H., Chen,H., Tang,Z., Liu,S., Xie,K. and Wang,H.
  TITLE     SIX1 attenuates inflammation and rheumatoid arthritis by silencing
            MyD88-dependent TLR1/2 signaling
  JOURNAL   Int Immunopharmacol 106, 108613 (2022)
   PUBMED   35180623
  REMARK    GeneRIF: SIX1 attenuates inflammation and rheumatoid arthritis by
            silencing MyD88-dependent TLR1/2 signaling.
REFERENCE   3  (bases 1 to 3188)
  AUTHORS   Brunmeir,R., Wu,J., Peng,X., Kim,S.Y., Julien,S.G., Zhang,Q.,
            Xie,W. and Xu,F.
  TITLE     Comparative Transcriptomic and Epigenomic Analyses Reveal New
            Regulators of Murine Brown Adipogenesis
  JOURNAL   PLoS Genet 12 (12), e1006474 (2016)
   PUBMED   27923061
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3188)
  AUTHORS   Williams,T., Hundertmark,M., Nordbeck,P., Voll,S., Arias-Loza,P.A.,
            Oppelt,D., Muhlfelder,M., Schraut,S., Elsner,I., Czolbe,M.,
            Seidlmayer,L., Heinze,B., Hahner,S., Heinze,K., Schonberger,J.,
            Jakob,P. and Ritter,O.
  TITLE     Eya4 Induces Hypertrophy via Regulation of p27kip1
  JOURNAL   Circ Cardiovasc Genet 8 (6), 752-764 (2015)
   PUBMED   26499333
REFERENCE   5  (bases 1 to 3188)
  AUTHORS   Wegert,J., Ishaque,N., Vardapour,R., Georg,C., Gu,Z., Bieg,M.,
            Ziegler,B., Bausenwein,S., Nourkami,N., Ludwig,N., Keller,A.,
            Grimm,C., Kneitz,S., Williams,R.D., Chagtai,T., Pritchard-Jones,K.,
            van Sluis,P., Volckmann,R., Koster,J., Versteeg,R., Acha,T.,
            O'Sullivan,M.J., Bode,P.K., Niggli,F., Tytgat,G.A., van
            Tinteren,H., van den Heuvel-Eibrink,M.M., Meese,E., Vokuhl,C.,
            Leuschner,I., Graf,N., Eils,R., Pfister,S.M., Kool,M. and
            Gessler,M.
  TITLE     Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA
            microprocessor complex underlie high-risk blastemal type Wilms
            tumors
  JOURNAL   Cancer Cell 27 (2), 298-311 (2015)
   PUBMED   25670083
REFERENCE   6  (bases 1 to 3188)
  AUTHORS   Zheng,W., Huang,L., Wei,Z.B., Silvius,D., Tang,B. and Xu,P.X.
  TITLE     The role of Six1 in mammalian auditory system development
  JOURNAL   Development 130 (17), 3989-4000 (2003)
   PUBMED   12874121
REFERENCE   7  (bases 1 to 3188)
  AUTHORS   Xu,P.X., Zheng,W., Huang,L., Maire,P., Laclef,C. and Silvius,D.
  TITLE     Six1 is required for the early organogenesis of mammalian kidney
  JOURNAL   Development 130 (14), 3085-3094 (2003)
   PUBMED   12783782
REFERENCE   8  (bases 1 to 3188)
  AUTHORS   Laclef,C., Souil,E., Demignon,J. and Maire,P.
  TITLE     Thymus, kidney and craniofacial abnormalities in Six 1 deficient
            mice
  JOURNAL   Mech Dev 120 (6), 669-679 (2003)
   PUBMED   12834866
REFERENCE   9  (bases 1 to 3188)
  AUTHORS   Spitz,F., Demignon,J., Porteu,A., Kahn,A., Concordet,J.P.,
            Daegelen,D. and Maire,P.
  TITLE     Expression of myogenin during embryogenesis is controlled by
            Six/sine oculis homeoproteins through a conserved MEF3 binding site
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14220-14225 (1998)
   PUBMED   9826681
REFERENCE   10 (bases 1 to 3188)
  AUTHORS   Ford,H.L., Kabingu,E.N., Bump,E.A., Mutter,G.L. and Pardee,A.B.
  TITLE     Abrogation of the G2 cell cycle checkpoint associated with
            overexpression of HSIX1: a possible mechanism of breast
            carcinogenesis
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12608-12613 (1998)
   PUBMED   9770533
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On or before Oct 25, 2008 this sequence version replaced
            XM_001080688.1, XM_343079.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.35988.1,
                                           SRR26643297.22847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676789 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1175              JAXUCZ010000006.1  97486679-97487853   c
            1176-3188           JAXUCZ010000006.1  97482617-97484629   c
FEATURES             Location/Qualifiers
     source          1..3188
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3188
                     /gene="Six1"
                     /note="SIX homeobox 1"
                     /db_xref="GeneID:114634"
                     /db_xref="RGD:620906"
     exon            1..1175
                     /gene="Six1"
                     /inference="alignment:Splign:2.1.0"
     CDS             616..1470
                     /gene="Six1"
                     /note="sine oculis-related homeobox 1 homolog; sine oculis
                     homeobox homolog 1"
                     /codon_start=1
                     /product="homeobox protein SIX1"
                     /protein_id="NP_446211.1"
                     /db_xref="GeneID:114634"
                     /db_xref="RGD:620906"
                     /translation="MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLH
                     KNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRP
                     LGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEA
                     TGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEE
                     EFSPPQSPDQNSVLLLQSNMGHARSSNYSLPGLTASQPSHGLQAHQHQLQDSLLGPLT
                     SSLVDLGS"
     exon            1176..3188
                     /gene="Six1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagaagtgt gagattccct ttaggtgaca ccgaagaggg cgccgcttcc ctaggtccgg
       61 acttggtcac caccctcttc agcaccctag ttccctcccc ctcccgaccc cacctcactt
      121 cccacctctc caggtccttc tcctcccacc actccttatc ccagggctcg gcagcttcgc
      181 cctccccacg cggggcggca cgctggcgcg gctttgctgc ccgtccgggc ggcgcacagg
      241 ctggccagct tcggataggc gccgctcaca gccaatcaga gtgccgggga ctctgcgcgc
      301 tttaaggccg cagcggggag aacagaaacc aagttccccg gcaaccagca gcatccaccc
      361 ggcggccggc aggcaggagc cagcgaggcc cggaaggctg tagagtgcgc cagccactcg
      421 gagtctagcg cacccctact tcgttttcct tcgcctccta cccgccaagg tccgactggt
      481 ttcttcgcct gcgccaagcc tagggagggg gttaggagca gccgcgcccc cctccccgcg
      541 gcagccgccc cctgctctcc cagctctgct cgctgccgcg tgcgcccggg ccggtgcgcc
      601 ccggcagcgc cagccatgtc gatgctgccg tcgtttggtt ttactcaaga gcaagtggcg
      661 tgcgtgtgcg aggttctgca gcaaggaggg aacctggaac gcctgggcag gttcttgtgg
      721 tcgttgcccg cctgcgatca cctgcacaag aacgagagcg tgctcaaggc caaggcggtg
      781 gtcgccttcc accgcggcaa cttccgcgag ctctacaaga tcctggagag ccaccagttc
      841 tcgcctcaca accatcccaa attgcagcag ctgtggctga aagcgcacta cgtggaggcc
      901 gagaaacttc gcggccgacc cctgggtgcc gtgggcaaat atcgggtgcg ccgaaaattc
      961 ccgttgccgc gcaccatctg ggatggcgaa gagactagct actgttttaa ggagaagtct
     1021 cggggcgtgc tgagggagtg gtacgcgcac aacccctacc cctcgccgcg ggagaagcgg
     1081 gagctggccg aggctacggg cctcaccacc acccaggtca gcaactggtt taagaaccgg
     1141 aggcaaagag accgggccgc cgaggccaag gaaagggaga acaccgaaaa caataactcc
     1201 tcctccaaca agcagaatca actctctcct ctggaagggg gcaagccgct catgtccagc
     1261 tcagaagagg aattctcacc tccccaaagt ccagaccaga actcggtcct cctgctccag
     1321 agcaatatgg gccatgccag gagctcaaac tattctcttc cgggcctaac ggcctcacag
     1381 cccagccatg gcctgcaggc tcatcagcac cagctccagg actctctgct gggcccgctc
     1441 acctccagtc tggtggactt gggttcctaa gtgggggaga tactggggcc ttgaagggat
     1501 gaccggagca gcaaccaacc gcagcatcta gggacacttg tacatagaag ccaggggcaa
     1561 ttctgcagct tgattctggg gttctttgcg cagaaagcaa ccacaggctt tcacaattgt
     1621 ctttttaaaa attacagtcg acagtgatct cagttgagcc tactctccct cttctcttcg
     1681 gctcttaata ccctcgcatc gcatttcccc tctcactaaa aggtcaggaa acaacaaaaa
     1741 cacccaggct tggttctggg caacccaggt atccttttca gtagtccctt cttccatgtc
     1801 ttcctccccc tctccctcct cctcctcttt gtcttctttt aatgaacaga gattacaaat
     1861 caactggatt ttaattattt tcttttaatt tatttatgga gaaacggttt agggaagagg
     1921 aaaaggaaat gaagagaaag agagagagac atatcaaaat aatgaaaaca agaaacctcc
     1981 agtctgagag gaactggctg ccttcttaag atgaatagga aaaatataat cataatggtt
     2041 ttttgatggg aagattaagt ttacattttt catatttagt gttaaataat tttacgtagg
     2101 ttaaaataaa agagcagtat tagtgaggga aacaagtgcc taaatgtctt catgctctct
     2161 atgtgaggcg gttagagtag aagcgatgtt agtaacgcaa caaactattt ttgtcaattt
     2221 taatgggggt tttggtgatt gttttcttgt tttttttttt ttatgacaaa ctccaaatgt
     2281 gtaccaatgg ggggagggga gggaaccact ttcctaaatg tcatcacttc ttcctcagaa
     2341 actttcctac ctgtaggctg cctctgtcta ctcctagttt ctacgtgaca gagggtgcca
     2401 accaacctgg caacctggta tttgttacta aaacggcatg tgtttttagg tttcatttct
     2461 attgtaccta aaccagtcta aattaaaact cagtagacca gcaggagttt gattctgttt
     2521 ctgaaaggtg agttatgtat tgctgtcatt gggcctattt aaaaacaagt tttcttgctt
     2581 tcttagtggt agtcatgaat tgcagggtat ttttgaagtc tatcacctga agccaagaat
     2641 agtggctagg ttaatgctat gatgaaagaa aagaaattta gccttgggta tttatttatt
     2701 tttttttgtt atttagaaat gcagtcttgt ttaccactgt ttcttctcca cagccttcgt
     2761 atgttggctc agctctcttg tgttagcaac ttatgaaaag actgtgaaag caaacgtaat
     2821 ttatctgttt ttttttaagg gaactcgaac cagaatttaa aattatgaat tgatttgtac
     2881 aaataaaaaa gcaggccatc ggaaactctt ttgtcagata gtgtccagga aaacaaatct
     2941 cagtacatga aggctccatg ttctttttgc ctggggcaaa atgatgtatc ttctgtattt
     3001 agcttttaag actagtgaaa caaatggcat tatttattaa aattctactc agaataacag
     3061 gattggcttg ttcgtgcttt gtaaaatatt gttccccagg gagagttttt ttttctgaca
     3121 tgacagtttc ataattttga tttttcctca tctataagtg tcaatattaa tatatttctt
     3181 acctttcc
//
