LOCUS       NM_001394537             777 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SIVA1, apoptosis-inducing factor (Siva1), mRNA.
ACCESSION   NM_001394537 XM_006240645
VERSION     NM_001394537.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 777)
  AUTHORS   Yu,W., Gubkina,O., Mechawar,N., Elwell,D., Quirion,R. and
            Krantic,S.
  TITLE     Expression of apoptosis-inducing factor (AIF) in the aged rat brain
  JOURNAL   Neurobiol Aging 32 (1), 179-180 (2011)
   PUBMED   19251341
  REMARK    GeneRIF: This study demonistrated that AIF more abundantly
            expressed in striatum than in the other two brain regions.
REFERENCE   2  (bases 1 to 777)
  AUTHORS   Nestler,M., Martin,U., Hortschansky,P., Saluz,H.P., Henke,A. and
            Munder,T.
  TITLE     The zinc containing pro-apoptotic protein siva interacts with the
            peroxisomal membrane protein pmp22
  JOURNAL   Mol Cell Biochem 287 (1-2), 147-155 (2006)
   PUBMED   16683188
REFERENCE   3  (bases 1 to 777)
  AUTHORS   Gudi,R., Barkinge,J., Hawkins,S., Chu,F., Manicassamy,S., Sun,Z.,
            Duke-Cohan,J.S. and Prasad,K.V.
  TITLE     Siva-1 negatively regulates NF-kappaB activity: effect on T-cell
            receptor-mediated activation-induced cell death (AICD)
  JOURNAL   Oncogene 25 (24), 3458-3462 (2006)
   PUBMED   16491128
REFERENCE   4  (bases 1 to 777)
  AUTHORS   Py,B., Slomianny,C., Auberger,P., Petit,P.X. and Benichou,S.
  TITLE     Siva-1 and an alternative splice form lacking the death domain,
            Siva-2, similarly induce apoptosis in T lymphocytes via a
            caspase-dependent mitochondrial pathway
  JOURNAL   J Immunol 172 (7), 4008-4017 (2004)
   PUBMED   15034012
REFERENCE   5  (bases 1 to 777)
  AUTHORS   Chu,F., Borthakur,A., Sun,X., Barkinge,J., Gudi,R., Hawkins,S. and
            Prasad,K.V.
  TITLE     The Siva-1 putative amphipathic helical region (SAH) is sufficient
            to bind to BCL-XL and sensitize cells to UV radiation induced
            apoptosis
  JOURNAL   Apoptosis 9 (1), 83-95 (2004)
   PUBMED   14739602
REFERENCE   6  (bases 1 to 777)
  AUTHORS   Spinicelli,S., Nocentini,G., Ronchetti,S., Krausz,L.T.,
            Bianchini,R. and Riccardi,C.
  TITLE     GITR interacts with the pro-apoptotic protein Siva and induces
            apoptosis
  JOURNAL   Cell Death Differ 9 (12), 1382-1384 (2002)
   PUBMED   12478477
REFERENCE   7  (bases 1 to 777)
  AUTHORS   Xue,L., Chu,F., Cheng,Y., Sun,X., Borthakur,A., Ramarao,M.,
            Pandey,P., Wu,M., Schlossman,S.F. and Prasad,K.V.
  TITLE     Siva-1 binds to and inhibits BCL-X(L)-mediated protection against
            UV radiation-induced apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6925-6930 (2002)
   PUBMED   12011449
REFERENCE   8  (bases 1 to 777)
  AUTHORS   Henke,A., Nestler,M., Strunze,S., Saluz,H.P., Hortschansky,P.,
            Menzel,B., Martin,U., Zell,R., Stelzner,A. and Munder,T.
  TITLE     The apoptotic capability of coxsackievirus B3 is influenced by the
            efficient interaction between the capsid protein VP2 and the
            proapoptotic host protein Siva
  JOURNAL   Virology 289 (1), 15-22 (2001)
   PUBMED   11601913
REFERENCE   9  (bases 1 to 777)
  AUTHORS   Padanilam,B.J., Lewington,A.J. and Hammerman,M.R.
  TITLE     Expression of CD27 and ischemia/reperfusion-induced expression of
            its ligand Siva in rat kidneys
  JOURNAL   Kidney Int 54 (6), 1967-1975 (1998)
   PUBMED   9853261
REFERENCE   10 (bases 1 to 777)
  AUTHORS   Prasad,K.V., Ao,Z., Yoon,Y., Wu,M.X., Rizk,M., Jacquot,S. and
            Schlossman,S.F.
  TITLE     CD27, a member of the tumor necrosis factor receptor family,
            induces apoptosis and binds to Siva, a proapoptotic protein
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6346-6351 (1997)
   PUBMED   9177220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Apr 23, 2021 this sequence version replaced XM_006240645.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ782074.1, BQ200239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               JAXUCZ010000006.1  137526416-137526661
            247-441             JAXUCZ010000006.1  137528442-137528636
            442-598             JAXUCZ010000006.1  137529427-137529583
            599-777             JAXUCZ010000006.1  137530612-137530790
FEATURES             Location/Qualifiers
     source          1..777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..777
                     /gene="Siva1"
                     /gene_synonym="Siva"
                     /note="SIVA1, apoptosis-inducing factor"
                     /db_xref="GeneID:362791"
                     /db_xref="RGD:1561872"
     exon            1..246
                     /gene="Siva1"
                     /gene_synonym="Siva"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..662
                     /gene="Siva1"
                     /gene_synonym="Siva"
                     /note="CD27BP; CD27-binding protein"
                     /codon_start=1
                     /product="apoptosis regulatory protein Siva"
                     /protein_id="NP_001381466.1"
                     /db_xref="GeneID:362791"
                     /db_xref="RGD:1561872"
                     /translation="MPKRSCPFTDAAPLQLKVHVSPRELSHGVFAERYSREVFERTKQ
                     LLFQGAQAYRDHIWGEGCSINHLPEPLKPGLVGAPQAARGQMLIGPDGRLTRCQAQAS
                     EAGLPGAAPIACSSCVRSVDGKAVCSQCERALCGQCVYTCWGCGALACVLCGLADYAD
                     DDDGEKTLCTSCAMFEA"
     exon            247..441
                     /gene="Siva1"
                     /gene_synonym="Siva"
                     /inference="alignment:Splign:2.1.0"
     exon            442..598
                     /gene="Siva1"
                     /gene_synonym="Siva"
                     /inference="alignment:Splign:2.1.0"
     exon            599..777
                     /gene="Siva1"
                     /gene_synonym="Siva"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccagtctt tctccggcct atcgggagcc gcgccctcgt ccgctcgagc ctcagcagcg
       61 gtccgagtga gttgtgacgt gttcggcgcg ctgtgcgctg ctgtgggctg tgtctggtac
      121 ccgctatcat gcccaagcgg agctgcccgt tcacggatgc tgccccgctt caactcaaag
      181 tccacgtgag cccgagagag ctgagccacg gtgtgttcgc cgagcgctac tcgcgcgagg
      241 tcttcgaaag aaccaagcag ctccttttcc aaggggccca ggcctataga gatcacatct
      301 ggggtgaagg ttgttccatc aaccacctgc cggagccact caagcctggt ctggtgggag
      361 cccctcaagc tgcaagggga cagatgttga ttggacctga tggccgactg acacggtgcc
      421 aagctcaggc ctcggaagct ggccttcccg gggcagcacc cattgcttgt tcatcctgcg
      481 tgagatctgt ggatggaaag gcggtctgca gccagtgtga gcgggccctg tgtgggcagt
      541 gtgtgtacac ctgctggggc tgtggtgcct tggcctgtgt gctgtgtggc ctggcagact
      601 atgccgacga tgacgatggt gaaaagacgc tttgcaccag ctgcgccatg tttgaagcct
      661 gaagtggcca tggacagcac aagatgttca tactaaagag agagaaggtg gctttttata
      721 tgttatattt tataccccag gaacaagtga ataaacctct ttatatttgc acaagga
//
