LOCUS       NM_001024344            1229 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus signaling threshold regulating transmembrane
            adaptor 1 (Sit1), mRNA.
ACCESSION   NM_001024344 XM_575810
VERSION     NM_001024344.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1229)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   2  (bases 1 to 1229)
  AUTHORS   Tedoldi,S., Paterson,J.C., Hansmann,M.L., Natkunam,Y., Rudiger,T.,
            Angelisova,P., Du,M.Q., Roberton,H., Roncador,G., Sanchez,L.,
            Pozzobon,M., Masir,N., Barry,R., Pileri,S., Mason,D.Y.,
            Marafioti,T. and Horejsi,V.
  TITLE     Transmembrane adaptor molecules: a new category of lymphoid-cell
            markers
  JOURNAL   Blood 107 (1), 213-221 (2006)
   PUBMED   16160011
REFERENCE   3  (bases 1 to 1229)
  AUTHORS   Kirchgessner,H., Dietrich,J., Scherer,J., Isomaki,P., Korinek,V.,
            Hilgert,I., Bruyns,E., Leo,A., Cope,A.P. and Schraven,B.
  TITLE     The transmembrane adaptor protein TRIM regulates T cell receptor
            (TCR) expression and TCR-mediated signaling via an association with
            the TCR zeta chain
  JOURNAL   J Exp Med 193 (11), 1269-1284 (2001)
   PUBMED   11390434
REFERENCE   4  (bases 1 to 1229)
  AUTHORS   Marie-Cardine,A., Kirchgessner,H., Bruyns,E., Shevchenko,A.,
            Mann,M., Autschbach,F., Ratnofsky,S., Meuer,S. and Schraven,B.
  TITLE     SHP2-interacting transmembrane adaptor protein (SIT), a novel
            disulfide-linked dimer regulating human T cell activation
  JOURNAL   J Exp Med 189 (8), 1181-1194 (1999)
   PUBMED   10209036
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088199.1.
            
            On May 27, 2005 this sequence version replaced XM_575810.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088199.1, CV074832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680428
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1229
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1229
                     /gene="Sit1"
                     /note="signaling threshold regulating transmembrane
                     adaptor 1"
                     /db_xref="GeneID:500449"
                     /db_xref="RGD:1559919"
     exon            1..157
                     /gene="Sit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..651
                     /gene="Sit1"
                     /note="suppression-inducing transmembrane adapter 1;
                     SHP2-interacting transmembrane adapter protein;
                     suppression inducing transmembrane adaptor 1"
                     /codon_start=1
                     /product="signaling threshold-regulating transmembrane
                     adapter 1"
                     /protein_id="NP_001019515.1"
                     /db_xref="GeneID:500449"
                     /db_xref="RGD:1559919"
                     /translation="MSRENNCTTADLAWGIPSITQAWGLWALFGVVTMLLLISLAALL
                     SQWTRGRRRTQEEQGPPSGRSVEEVPLYGNLHYLQTGRLSEESRSEEQDPSSGGLARG
                     AEEATCYTSLQLRPAQGRIPSSGTPIKYCEVVLDSEPKPQASGPEPELYASVCAQTRR
                     ARASFPDQAYANSQPAPS"
     exon            158..296
                     /gene="Sit1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..355
                     /gene="Sit1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..417
                     /gene="Sit1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..1204
                     /gene="Sit1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtgatgct gagctgtgga ggcccagttt aaggagacat tggggttgtc ggggctgtga
       61 caactgtcag gccataagtg ggactgaccc ccgactctca caccagcagc agtcatgagc
      121 agagagaaca actgtaccac agctgatcta gcatggggga ttccctccat cacccaggcg
      181 tggggactgt gggccctctt tggggttgtg acaatgctgc ttctcatctc attggctgca
      241 ctcttgtccc agtggacccg tggtcggaga aggacccagg aggaacaggg accaccctct
      301 ggaaggtccg tggaagaagt tcccctgtat gggaacctgc actatttaca gacaggacgg
      361 ctgtcggaag aatcaaggtc agaagagcag gacccatcct ccggaggcct tgccagggga
      421 gcagaggagg ccacgtgtta cacgagtctg cagctgcgac cagcccaagg tcggatcccc
      481 agctctggga cccccatcaa gtactgcgag gtggtgctgg actctgagcc aaagccccag
      541 gcctcaggcc ctgagccaga actttatgcc tccgtgtgtg cccagacacg cagagcccgt
      601 gcttcattcc cagatcaagc ctatgccaac agccagcctg cacccagctg aggaggacct
      661 ggaaccgtgg gcgcccatgg ctcagctgct gggtcaggga ctcctgctgc catggctagg
      721 gtatgcctgg tttctaacca tctccaggac attgagactt tgctgagtga caggtgatgg
      781 cctactctga acttcctaag ttggatgacg acatacatac atctcagagt aggaatgctc
      841 cgggttttct gaggacagat ttgcaaaggg agatcccctc cgcacttacc tttcctatgg
      901 gctcctgtaa gcccccaaag tcgttggttc acacctttcg ctccttttag ggtttaacaa
      961 ggttccccat gttctctcta agcttaccca gatacctcat tgtctcctca gacacaggaa
     1021 gtgggcaggg aggagtgggt aaacgccagg gaggatgtgg gtggttgtca tgcatgggag
     1081 cccacagctg gaaggctcct aaggtcccag gtttggtttc tgacccgaaa accctggaca
     1141 gagaatagcc ttcatgctgt ggcctctggc gtctcctggt tttcgaataa agcatctcaa
     1201 aacaaaaaaa aaaaaaaaaa aaaaaaaaa
//
