LOCUS       NM_001107073            1717 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sirtuin 7 (Sirt7), mRNA.
ACCESSION   NM_001107073 XM_001081828 XM_221204
VERSION     NM_001107073.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1717)
  AUTHORS   Wang,Y., Wu,X.Q., Cai,J.R., Ji,H.X. and Xu,T.
  TITLE     SIRT7 silencing by miR-152-3p confers cell apoptosis and renal
            functional impairment induced by renal ischaemia/reperfusion injury
  JOURNAL   Int Urol Nephrol 55 (2), 367-376 (2023)
   PUBMED   35941302
  REMARK    GeneRIF: SIRT7 silencing by miR-152-3p confers cell apoptosis and
            renal functional impairment induced by renal ischaemia/reperfusion
            injury.
REFERENCE   2  (bases 1 to 1717)
  AUTHORS   Song,C.Y., Guo,Y., Chen,F.Y. and Liu,W.G.
  TITLE     Resveratrol Promotes Osteogenic Differentiation of Bone
            Marrow-Derived Mesenchymal Stem Cells Through miR-193a/SIRT7 Axis
  JOURNAL   Calcif Tissue Int 110 (1), 117-130 (2022)
   PUBMED   34477918
  REMARK    GeneRIF: Resveratrol Promotes Osteogenic Differentiation of Bone
            Marrow-Derived Mesenchymal Stem Cells Through miR-193a/SIRT7 Axis.
REFERENCE   3  (bases 1 to 1717)
  AUTHORS   Xu,S., Tao,H., Cao,W., Cao,L., Lin,Y., Zhao,S.M., Xu,W., Cao,J. and
            Zhao,J.Y.
  TITLE     Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac
            fibrosis
  JOURNAL   Signal Transduct Target Ther 6 (1), 54 (2021)
   PUBMED   33558457
  REMARK    GeneRIF: Ketogenic diets inhibit mitochondrial biogenesis and
            induce cardiac fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1717)
  AUTHORS   Chen,Q., Liu,Y., Ding,X., Li,Q., Qiu,F., Wang,M., Shen,Z., Zheng,H.
            and Fu,G.
  TITLE     Bone marrow mesenchymal stem cell-secreted exosomes carrying
            microRNA-125b protect against myocardial ischemia reperfusion
            injury via targeting SIRT7
  JOURNAL   Mol Cell Biochem 465 (1-2), 103-114 (2020)
   PUBMED   31858380
  REMARK    GeneRIF: the injection of BMSC-Exo-125b alleviated the pathological
            damages and down-regulated SIRT7 in myocardium tissues of I/R rats.
            BMSC-derived exosomes carrying miR-125b protected against
            myocardial I/R by targeting SIRT7.
REFERENCE   5  (bases 1 to 1717)
  AUTHORS   Bao,X., Liu,Z., Zhang,W., Gladysz,K., Fung,Y.M.E., Tian,G.,
            Xiong,Y., Wong,J.W.H., Yuen,K.W.Y. and Li,X.D.
  TITLE     Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics
  JOURNAL   Mol Cell 76 (4), 660-675 (2019)
   PUBMED   31542297
REFERENCE   6  (bases 1 to 1717)
  AUTHORS   Grummt,I.
  TITLE     The nucleolus-guardian of cellular homeostasis and genome integrity
  JOURNAL   Chromosoma 122 (6), 487-497 (2013)
   PUBMED   24022641
  REMARK    Review article
REFERENCE   7  (bases 1 to 1717)
  AUTHORS   Barber,M.F., Michishita-Kioi,E., Xi,Y., Tasselli,L., Kioi,M.,
            Moqtaderi,Z., Tennen,R.I., Paredes,S., Young,N.L., Chen,K.,
            Struhl,K., Garcia,B.A., Gozani,O., Li,W. and Chua,K.F.
  TITLE     SIRT7 links H3K18 deacetylation to maintenance of oncogenic
            transformation
  JOURNAL   Nature 487 (7405), 114-118 (2012)
   PUBMED   22722849
REFERENCE   8  (bases 1 to 1717)
  AUTHORS   Peserico,A. and Simone,C.
  TITLE     Physical and functional HAT/HDAC interplay regulates protein
            acetylation balance
  JOURNAL   J Biomed Biotechnol 2011, 371832 (2011)
   PUBMED   21151613
  REMARK    Review article
REFERENCE   9  (bases 1 to 1717)
  AUTHORS   Grob,A., Roussel,P., Wright,J.E., McStay,B., Hernandez-Verdun,D.
            and Sirri,V.
  TITLE     Involvement of SIRT7 in resumption of rDNA transcription at the
            exit from mitosis
  JOURNAL   J Cell Sci 122 (Pt 4), 489-498 (2009)
   PUBMED   19174463
REFERENCE   10 (bases 1 to 1717)
  AUTHORS   Michishita,E., Park,J.Y., Burneskis,J.M., Barrett,J.C. and
            Horikawa,I.
  TITLE     Evolutionarily conserved and nonconserved cellular localizations
            and functions of human SIRT proteins
  JOURNAL   Mol Biol Cell 16 (10), 4623-4635 (2005)
   PUBMED   16079181
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221204.4, XM_001081828.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1717
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1717
                     /gene="Sirt7"
                     /note="sirtuin 7"
                     /db_xref="GeneID:303745"
                     /db_xref="RGD:1305876"
     exon            1..116
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1229
                     /gene="Sirt7"
                     /EC_number="2.3.1.286"
                     /note="NAD-dependent deacetylase sirtuin-7; SIR2-like
                     protein 7; regulatory protein SIR2 homolog 7;
                     NAD-dependent protein deacylase sirtuin-7"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-7"
                     /protein_id="NP_001100543.1"
                     /db_xref="GeneID:303745"
                     /db_xref="RGD:1305876"
                     /translation="MAAGGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAER
                     SAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELRRKVRELAGAVRSARH
                     LVVYTGAGISTAASIPDYRGPNGVWTLLQKGRPVSAADLSEAEPTLTHMSITQLHKHK
                     LVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCIPNREYVRVFDVTERTALH
                     RHLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASKADTILCLGSSLKVLK
                     KYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMDELGLEIPVY
                     NRWQDPIFSLATPLRAGEEGSHSRKSLCRSREEPPPGDQSAPLASATPILGGWFGRGC
                     AKRAKRKKAA"
     exon            117..254
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            255..359
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            360..430
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            431..503
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            504..602
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            603..839
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            840..920
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1027
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1717
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcgcagt ccagggagcg atggcagccg gtggcggtct gagccgctcg gagcgcaaag
       61 cggctgagcg ggtccggagg ttgcgggagg agcagcagcg ggagcgcctc cgtcaggtgt
      121 cacgcatcct gaggaaggcg gctgcagagc gcagcgcgga ggagggccgg cttctagctg
      181 agagtgagga tctggtgacc gagcttcagg gtcggagccg gcggcgtgag ggcctcaagc
      241 gccgccagga ggaggtgtgt gatgacccag aggagttgcg gaggaaggtc cgcgaactag
      301 ccggagctgt ccgaagtgcc agacacttgg ttgtctacac aggcgctggg atcagcacgg
      361 cagcctctat cccagattac cggggtccta atggagtgtg gacactgctc cagaaaggaa
      421 ggcctgtgag tgctgccgac ctaagcgaag cagagcctac cctcacccac atgagcatca
      481 cccagctgca caagcataag ctggtgcaac acgtggtgtc tcagaactgc gacgggctcc
      541 acctgcgcag tgggctgcca cggaccgcca tctctgagct ccatgggaat atgtatattg
      601 aagtctgcac ctcctgcatc cctaacagag agtacgtccg agtgtttgac gtgacggagc
      661 gtaccgccct tcaccgacac ctgacaggcc ggacgtgcca caagtgtggg actcagcttc
      721 gggacaccat tgtgcacttt ggggagaggg ggacgctagg gcagcccctg aactgggagg
      781 cagcgactga ggccgctagc aaagcagaca caatcctgtg tttagggtcc agcttgaagg
      841 tactgaagaa gtacccccgt ctctggtgca tgacgaagcc cccaagccgt cggcccaaac
      901 tctacattgt gaacctgcag tggaccccga aggatgactg ggctgccctg aagcttcatg
      961 ggaaatgtga tgatgtaatg cggctcctca tggacgaact gggcctggag atccctgtct
     1021 acaaccggtg gcaggaccca atcttctcct tggcaactcc actccgtgct ggcgaagaag
     1081 gtagccacag taggaagtca ctgtgcagga gcagagaaga gcccccaccc ggggaccaga
     1141 gtgcccctct tgcctcagcc acccccatcc taggaggctg gttcggcagg ggctgtgcta
     1201 agcgtgcaaa aaggaagaaa gcggcgtagc cccggtgttg acaaagagca gtcggcacct
     1261 tgcagatggc ttgacccatg tttagggtcc tgtgtcacag tgaaggctag agtgccccca
     1321 ccagatctag tggaaagaac tctggggttg ggggtgacac ttcctggtga cggtcgtttt
     1381 tagccatctg tccttgtgga aagcctcact tgcactgctg tgatcgcccc actacgggct
     1441 tgatcttcaa ggacacctcc atcctatccc cccctataca aaggtggcag caaggccttt
     1501 gcaagaagag ctcccgtctt tcccaggcct ggcccacaga ggagtccacc actgccttac
     1561 ctcactctcc aggctagtct cagggcctcc ctctttctac tacttactac ttaaaagtgt
     1621 tcactttata gaaacctttt tctgtattgg gtatgcggca cagggaggat ctaagcctcc
     1681 ggtctgagca agtcttatta aacatctctc tattgcc
//
