LOCUS       NM_001031649            1656 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus sirtuin 6 (Sirt6), mRNA.
ACCESSION   NM_001031649 XM_234931
VERSION     NM_001031649.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1656)
  AUTHORS   Song,M., Yi,F., Zeng,F., Zheng,L., Huang,L., Sun,X., Huang,Q.,
            Deng,J., Wang,H. and Gu,W.
  TITLE     USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic
            Stroke Through Repressing m6A Modification of SIRT6
  JOURNAL   Mol Neurobiol 61 (9), 6658-6674 (2024)
   PUBMED   38340205
  REMARK    GeneRIF: USP18 Stabilized FTO Protein to Activate Mitophagy in
            Ischemic Stroke Through Repressing m6A Modification of SIRT6.
REFERENCE   2  (bases 1 to 1656)
  AUTHORS   Xu,H., Guo,H., Tang,Z., Hao,R., Wang,S. and Jin,P.
  TITLE     Follistatin-like 1 protects against doxorubicin-induced
            cardiotoxicity by preventing mitochondrial dysfunction through the
            SIRT6/Nrf2 signaling pathway
  JOURNAL   Cell Biol Int 48 (6), 795-807 (2024)
   PUBMED   38436106
  REMARK    GeneRIF: Follistatin-like 1 protects against doxorubicin-induced
            cardiotoxicity by preventing mitochondrial dysfunction through the
            SIRT6/Nrf2 signaling pathway.
REFERENCE   3  (bases 1 to 1656)
  AUTHORS   Jia,J., Tao,W., Chen,T., Zhong,Q., Sun,J., Xu,Y., Sui,X., Chen,C.
            and Zhang,Z.
  TITLE     SIRT6 Improves Hippocampal Neurogenesis Following Prolonged Sleep
            Deprivation Through Modulating Energy Metabolism in Developing rats
  JOURNAL   Mol Neurobiol 61 (2), 883-899 (2024)
   PUBMED   37668962
  REMARK    GeneRIF: SIRT6 Improves Hippocampal Neurogenesis Following
            Prolonged Sleep Deprivation Through Modulating Energy Metabolism in
            Developing rats.
            Erratum:[Mol Neurobiol. 2024 Jul 25. doi:
            10.1007/s12035-024-04380-5. PMID: 39052187]
REFERENCE   4  (bases 1 to 1656)
  AUTHORS   Ma,X. and Liu,M.
  TITLE     MiR-148b Caused Liver Injury in Rats with Traumatic Hemorrhagic
            Shock by Inhibiting SIRT6 Expression
  JOURNAL   Curr Mol Med 24 (11), 1390-1400 (2024)
   PUBMED   37587827
  REMARK    GeneRIF: MiR-148b Caused Liver Injury in Rats with Traumatic
            Hemorrhagic Shock by Inhibiting SIRT6 Expression.
REFERENCE   5  (bases 1 to 1656)
  AUTHORS   Moon,Y.J., Cui,B., Cho,S.Y., Hwang,J.W., Chung,H.C., Kwon,J.,
            Kim,D., Jang,K.Y., Kim,J.R. and Wang,S.I.
  TITLE     Sirtuin 6 Overexpression Improves Rotator Cuff Tendon-to-Bone
            Healing in the Aged
  JOURNAL   Cells 12 (16), 2035 (2023)
   PUBMED   37626845
  REMARK    GeneRIF: Sirtuin 6 Overexpression Improves Rotator Cuff
            Tendon-to-Bone Healing in the Aged.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1656)
  AUTHORS   Michishita,E., McCord,R.A., Berber,E., Kioi,M., Padilla-Nash,H.,
            Damian,M., Cheung,P., Kusumoto,R., Kawahara,T.L., Barrett,J.C.,
            Chang,H.Y., Bohr,V.A., Ried,T., Gozani,O. and Chua,K.F.
  TITLE     SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric
            chromatin
  JOURNAL   Nature 452 (7186), 492-496 (2008)
   PUBMED   18337721
REFERENCE   7  (bases 1 to 1656)
  AUTHORS   Kanfi,Y., Shalman,R., Peshti,V., Pilosof,S.N., Gozlan,Y.M.,
            Pearson,K.J., Lerrer,B., Moazed,D., Marine,J.C., de Cabo,R. and
            Cohen,H.Y.
  TITLE     Regulation of SIRT6 protein levels by nutrient availability
  JOURNAL   FEBS Lett 582 (5), 543-548 (2008)
   PUBMED   18242175
  REMARK    GeneRIF: Levels of the mammalian sirtuin, SIRT6, increased upon
            nutrient deprivation in cultured cells, in mice after fasting, and
            in rats fed a calorie-restricted diet.
REFERENCE   8  (bases 1 to 1656)
  AUTHORS   Mostoslavsky,R., Chua,K.F., Lombard,D.B., Pang,W.W., Fischer,M.R.,
            Gellon,L., Liu,P., Mostoslavsky,G., Franco,S., Murphy,M.M.,
            Mills,K.D., Patel,P., Hsu,J.T., Hong,A.L., Ford,E., Cheng,H.L.,
            Kennedy,C., Nunez,N., Bronson,R., Frendewey,D., Auerbach,W.,
            Valenzuela,D., Karow,M., Hottiger,M.O., Hursting,S., Barrett,J.C.,
            Guarente,L., Mulligan,R., Demple,B., Yancopoulos,G.D. and Alt,F.W.
  TITLE     Genomic instability and aging-like phenotype in the absence of
            mammalian SIRT6
  JOURNAL   Cell 124 (2), 315-329 (2006)
   PUBMED   16439206
REFERENCE   9  (bases 1 to 1656)
  AUTHORS   Michishita,E., Park,J.Y., Burneskis,J.M., Barrett,J.C. and
            Horikawa,I.
  TITLE     Evolutionarily conserved and nonconserved cellular localizations
            and functions of human SIRT proteins
  JOURNAL   Mol Biol Cell 16 (10), 4623-4635 (2005)
   PUBMED   16079181
REFERENCE   10 (bases 1 to 1656)
  AUTHORS   Liszt,G., Ford,E., Kurtev,M. and Guarente,L.
  TITLE     Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
  JOURNAL   J Biol Chem 280 (22), 21313-21320 (2005)
   PUBMED   15795229
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098923.1.
            
            On Aug 12, 2005 this sequence version replaced XM_234931.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098923.1, EV775977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1656
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1656
                     /gene="Sirt6"
                     /note="sirtuin 6"
                     /db_xref="GeneID:299638"
                     /db_xref="RGD:1305216"
     exon            1..99
                     /gene="Sirt6"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1026
                     /gene="Sirt6"
                     /EC_number="2.4.2.31"
                     /note="NAD-dependent deacetylase sirtuin-6; NAD-dependent
                     protein deacetylase sirtuin-6"
                     /codon_start=1
                     /product="NAD-dependent protein deacylase sirtuin-6"
                     /protein_id="NP_001026819.1"
                     /db_xref="GeneID:299638"
                     /db_xref="RGD:1305216"
                     /translation="MSVNYAAGLSPYADKGKCGLPEIFDPPEELECKVWELARLMWQS
                     STVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDITFENARPSKTHMALVQLE
                     RMGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECPKCKTQYVRDTVVGTMGLK
                     ATGRLCTVAKARGLRACRGELRDTILDWEDALPDRDLTLADEASRTADLSVTLGTSLQ
                     IRPSGNLPLATKRRGGRLVIVNLQPTKHDRQADLCIHGYVDEVMCKLMKHLGLEIPTW
                     DGPRVLEKALPPLPRPVAPKAEPPVHLNGSYKPKPDSPVPHRPPKRVKTEAAAS"
     exon            100..227
                     /gene="Sirt6"
                     /inference="alignment:Splign:2.1.0"
     exon            228..410
                     /gene="Sirt6"
                     /inference="alignment:Splign:2.1.0"
     exon            411..470
                     /gene="Sirt6"
                     /inference="alignment:Splign:2.1.0"
     exon            471..566
                     /gene="Sirt6"
                     /inference="alignment:Splign:2.1.0"
     exon            567..647
                     /gene="Sirt6"
                     /inference="alignment:Splign:2.1.0"
     exon            648..771
                     /gene="Sirt6"
                     /inference="alignment:Splign:2.1.0"
     exon            772..1628
                     /gene="Sirt6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttattgtt cccgtgcggc ggcagtgttg gtgatgtcgg tgaattatgc agcagggttg
       61 tcgccatacg cggataaggg caagtgcggg ctgcccgaga tattcgaccc accagaggag
      121 ctggaatgca aggtgtggga gctggcgcgg ctgatgtggc agtcctccac tgtggttttc
      181 cacaccggcg caggcatcag caccgcctcc ggcatccccg acttcagggg cccccatggc
      241 gtgtggacca tggaggaacg aggcctcgcc cccaagtttg acatcacctt tgagaatgcc
      301 cggccctcga agacccacat ggcccttgtt cagctggaac gcatgggctt cctcagcttc
      361 ctggtcagcc agaatgtaga cgggctacat gtgcgctcgg gcttccccag ggacaagctg
      421 gccgagctgc acggaaacat gtttgtagag gagtgcccca agtgtaagac gcagtacgtg
      481 agagacacgg tcgtgggtac catgggcctc aaggccactg gccggctctg caccgtggcc
      541 aaggcgaggg gacttcgggc ctgtagaggg gagctgagag acaccattct ggactgggag
      601 gatgcgttgc ctgaccggga cctaacgctc gctgatgagg ccagcaggac tgcagacctg
      661 tctgtcaccc tgggtacctc actgcagatc cgccccagcg ggaacctgcc ccttgccact
      721 aagcgccgcg gaggccgtct ggtcattgtc aacctgcaac ccacaaaaca tgaccgccag
      781 gctgatctgt gcatccatgg ctacgtggat gaggtgatgt gcaagctcat gaagcacctg
      841 gggctggaga tccccacctg ggatggaccc cgagtgctag agaaagccct gccaccgctg
      901 ccgcgcccag tagcacccaa ggctgagccc cctgtgcatc tcaatggttc ctataagccc
      961 aagcccgaca gccctgtacc ccacaggcct cccaaaagag tgaagacaga ggctgccgcc
     1021 agctgacccg agtgtgtggg gcgggactgg tgcttgaaga aaccacacat gttgggggtt
     1081 ctttgttttt tatatcctgg ggactaaacc caggtttgca tatcccacac cccggcctct
     1141 tttcagattt tcctttgaga ccagggttcc ctaaatctct caggctggcc tggaactcac
     1201 tactgtagcc caggctggcc tggagctagc cctgcccacc tcagcctcca ctgtagcagg
     1261 gatggcgggc agacacccag tgttcagcac agttccttcc gagtctcact gtgtcccttg
     1321 tccgggtcct tctgaggaat ctcagggcaa ggggagtccc acgcatgagg aagaggctgt
     1381 gccctgagga tgcacgtgcc tctccaccaa tcacacccca ctcaccactc aggatgtgcc
     1441 tggagcggca gctacacact ccacacacca ctgctgcccc ctgcactcac ccctggccct
     1501 gacacagagc caccaaggac ccatctatgc ataggagaga caagggccca ccaggcaccc
     1561 atctgtgcta agggccccag gcttccagaa gctcccaatg caataaaaaa attcatttca
     1621 ttcatttaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
