LOCUS       NM_001004256            1370 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus sirtuin 5 (Sirt5), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001004256 XM_225227
VERSION     NM_001004256.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1370)
  AUTHORS   Li,J., Wei,G., Song,Z., Chen,Z., Gu,J., Zhang,L. and Wang,Z.
  TITLE     SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to
            Participate in Ischemia-Reperfusion Injury in Ischemic Stroke
  JOURNAL   Neurochem Res 49 (4), 998-1007 (2024)
   PUBMED   38170384
  REMARK    GeneRIF: SIRT5 Regulates Ferroptosis through the Nrf2/HO-1
            Signaling Axis to Participate in Ischemia-Reperfusion Injury in
            Ischemic Stroke.
REFERENCE   2  (bases 1 to 1370)
  AUTHORS   Mao,J., Wang,D., Wang,D., Wu,Q., Shang,Q., Gao,C., Wang,H.,
            Wang,H., Du,M., Peng,P., Jia,H., Xu,X., Wang,J., Yang,L. and Luo,Z.
  TITLE     SIRT5-related desuccinylation modification of AIFM1 protects
            against compression-induced intervertebral disc degeneration by
            regulating mitochondrial homeostasis
  JOURNAL   Exp Mol Med 55 (1), 253-268 (2023)
   PUBMED   36653443
  REMARK    GeneRIF: SIRT5-related desuccinylation modification of AIFM1
            protects against compression-induced intervertebral disc
            degeneration by regulating mitochondrial homeostasis.
REFERENCE   3  (bases 1 to 1370)
  AUTHORS   Yang,C.N., Lin,S.K., Kok,S.H., Wang,H.W., Lee,Y.L., Shun,C.T.,
            Chi,C.W., Yang,H. and Hong,C.Y.
  TITLE     The possible role of sirtuin 5 in the pathogenesis of apical
            periodontitis
  JOURNAL   Oral Dis 27 (7), 1766-1774 (2021)
   PUBMED   33191606
  REMARK    GeneRIF: The possible role of sirtuin 5 in the pathogenesis of
            apical periodontitis.
REFERENCE   4  (bases 1 to 1370)
  AUTHORS   Zhang,N., Zhang,H., Law,B.Y.K., Dias,I.R.S.R., Qiu,C.L., Zeng,W.,
            Dan Pan,H., Chen,J.Y., Bai,Y.F., Lv,J., Qu,L.Q., Chen,X., Huang,Q.,
            Zhang,W., Yang,L.J., Yu,L., Han,Y., Huang,G.X., Wang,H.M.,
            Sun,X.L., Zhang,Y., He,H.Q., Dan Luo,W., Xiao,Y., Zhou,J., Xu,T.,
            Huang,Q.C., Wu,M., Huang,Z.S., Liu,W., Wong,V.K.W. and Liu,L.
  TITLE     Sirtuin 5 deficiency increases disease severity in rats with
            adjuvant-induced arthritis
  JOURNAL   Cell Mol Immunol 17 (11), 1190-1192 (2020)
   PUBMED   32099074
  REMARK    GeneRIF: Sirtuin 5 deficiency increases disease severity in rats
            with adjuvant-induced arthritis.
REFERENCE   5  (bases 1 to 1370)
  AUTHORS   Wang,Y., Liu,Q., Huan,Y., Li,R., Li,C., Sun,S., Guo,N., Yang,M.,
            Liu,S. and Shen,Z.
  TITLE     Sirtuin 5 overexpression attenuates glucolipotoxicity-induced
            pancreatic beta cells apoptosis and dysfunction
  JOURNAL   Exp Cell Res 371 (1), 205-213 (2018)
   PUBMED   30098330
  REMARK    GeneRIF: Both diabetic rats and mice demonstrated significantly
            weakened SIRT5 expression in the pancreas, compared to wild-type
            animals, implying a possible correlation between SIRT5 and
            pancreatic beta cell function.
REFERENCE   6  (bases 1 to 1370)
  AUTHORS   Schlicker,C., Gertz,M., Papatheodorou,P., Kachholz,B., Becker,C.F.
            and Steegborn,C.
  TITLE     Substrates and regulation mechanisms for the human mitochondrial
            sirtuins Sirt3 and Sirt5
  JOURNAL   J Mol Biol 382 (3), 790-801 (2008)
   PUBMED   18680753
REFERENCE   7  (bases 1 to 1370)
  AUTHORS   Lieber,C.S., Leo,M.A., Wang,X. and Decarli,L.M.
  TITLE     Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5
            deacetylation function
  JOURNAL   Biochem Biophys Res Commun 373 (2), 246-252 (2008)
   PUBMED   18555008
  REMARK    GeneRIF: Alcohol decreases mitochondrial SIRT5 level.
REFERENCE   8  (bases 1 to 1370)
  AUTHORS   Nakamura,Y., Ogura,M., Tanaka,D. and Inagaki,N.
  TITLE     Localization of mouse mitochondrial SIRT proteins: shift of SIRT3
            to nucleus by co-expression with SIRT5
  JOURNAL   Biochem Biophys Res Commun 366 (1), 174-179 (2008)
   PUBMED   18054327
REFERENCE   9  (bases 1 to 1370)
  AUTHORS   Lombard,D.B., Alt,F.W., Cheng,H.L., Bunkenborg,J., Streeper,R.S.,
            Mostoslavsky,R., Kim,J., Yancopoulos,G., Valenzuela,D., Murphy,A.,
            Yang,Y., Chen,Y., Hirschey,M.D., Bronson,R.T., Haigis,M.,
            Guarente,L.P., Farese,R.V. Jr., Weissman,S., Verdin,E. and
            Schwer,B.
  TITLE     Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine
            acetylation
  JOURNAL   Mol Cell Biol 27 (24), 8807-8814 (2007)
   PUBMED   17923681
REFERENCE   10 (bases 1 to 1370)
  AUTHORS   Michishita,E., Park,J.Y., Burneskis,J.M., Barrett,J.C. and
            Horikawa,I.
  TITLE     Evolutionarily conserved and nonconserved cellular localizations
            and functions of human SIRT proteins
  JOURNAL   Mol Biol Cell 16 (10), 4623-4635 (2005)
   PUBMED   16079181
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078958.1.
            
            On Sep 10, 2004 this sequence version replaced XM_225227.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078958.1, SRR8487230.156078.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1370
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1370
                     /gene="Sirt5"
                     /note="sirtuin 5"
                     /db_xref="GeneID:306840"
                     /db_xref="RGD:1303285"
     exon            1..13
                     /gene="Sirt5"
                     /inference="alignment:Splign:2.1.0"
     exon            14..162
                     /gene="Sirt5"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..980
                     /gene="Sirt5"
                     /note="NAD-dependent deacetylase sirtuin-5; SIR2-like
                     protein 5; NAD-dependent lysine demalonylase and
                     desuccinylase sirtuin-5, mitochondrial; regulatory protein
                     SIR2 homolog 5"
                     /codon_start=1
                     /product="NAD-dependent protein deacylase sirtuin-5,
                     mitochondrial"
                     /protein_id="NP_001004256.1"
                     /db_xref="GeneID:306840"
                     /db_xref="RGD:1303285"
                     /translation="MRPLPVAPGRLFSQLCCGPKPSASPQSKICLTMARPSSNMADFR
                     KCFANAKHIVIISGAGVSAESGVPTFRGTGGYWRKWQAQHLATPLAFAHNPSQVWEFY
                     HYRREVMRNKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGT
                     LFKTRCTSCGNVAENYKSPICPALLGKGAPEPDTQESRIPVHKLPRCEEAGCGGLLRP
                     HVVWFGENLDPAILKEVDRELARCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNM
                     ETTPATNRFRFHFPGPCGVTLPEALAPHETERIS"
     exon            163..296
                     /gene="Sirt5"
                     /inference="alignment:Splign:2.1.0"
     exon            297..522
                     /gene="Sirt5"
                     /inference="alignment:Splign:2.1.0"
     exon            523..610
                     /gene="Sirt5"
                     /inference="alignment:Splign:2.1.0"
     exon            611..664
                     /gene="Sirt5"
                     /inference="alignment:Splign:2.1.0"
     exon            665..788
                     /gene="Sirt5"
                     /inference="alignment:Splign:2.1.0"
     exon            789..904
                     /gene="Sirt5"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1343
                     /gene="Sirt5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccttttg cagcctgccc agggaagtaa tccttcaaca aaaacctatg cgaccgctcc
       61 cggtcgctcc cggacgtctc ttctcccagc tgtgttgtgg accgaagcct tcagcctccc
      121 cacagagcaa gatctgcctc accatggctc gtccaagttc caatatggca gattttcgga
      181 agtgttttgc gaacgcaaag cacatagtca tcatctcggg ggctggtgtt agtgcggaga
      241 gtggggttcc aacattcaga ggaaccggag gctattggag aaaatggcaa gctcagcacc
      301 tggcgactcc tctggccttt gctcacaacc cctcacaggt gtgggagttt taccactacc
      361 ggagggaggt catgcggaac aaggaaccca accctgggca cctggccatt gcccaatgtg
      421 aagcccggct gcgtgaccag ggcagacggg ttgtggtcat cacccagaac attgatgagt
      481 tacatcgaaa ggctggcacc aagaacctgc tggaaatcca cggaacctta tttaaaactc
      541 ggtgtacctc gtgtggcaat gttgctgaga actacaagag tccgatttgt ccagccttat
      601 tgggaaaagg ggccccagaa ccagatactc aagagtccag aatcccagtc cacaaacttc
      661 cccggtgcga ggaggcagga tgtggaggct tgctgcgacc tcacgtggtg tggtttggag
      721 aaaacctgga tcctgccatt ctgaaagagg tggacagaga gctcgcccgc tgtgacctgt
      781 gtctagtggt gggaacgtcc tctgtggtct acccagctgc catgtttgcc cctcaggtgg
      841 cttccagggg ggtcccggtg gccgagttta acatggaaac caccccagcc accaacagat
      901 tcaggtttca ttttcccgga ccctgtggag taactcttcc tgaagccctt gctccccatg
      961 aaactgaaag gatttcttaa ttgccccatg gaaagaggag aagatcctgg agcacagatg
     1021 cagggcactg acaggagaag tggttttgtg gatggtgagc tgaacttcgg aaaaaatcta
     1081 aagataccct ccgagcctct agcagacagt cggctaagtg acggtttcag gatcacaaca
     1141 gcaaatgtgt tttatctgga agaagctgtc aaggtcttcc atgttatttg atttgacctg
     1201 aaatatgagt attttggatc tgatattttg gttagttact ggaaaggaaa aaactgtaat
     1261 caaattgttt gaaaagatgg gaattatccc gatcgtacct ttgcatcttg ggaaagacgg
     1321 aaatagagaa tttaaatccc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
