LOCUS       NM_001107147            1521 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus sirtuin 4 (Sirt4), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001107147 XM_001080262 XM_039089499 XM_222243
VERSION     NM_001107147.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1521)
  AUTHORS   Chen,H., Kang,J., Zhang,F., Yan,T., Fan,W., He,H. and Huang,F.
  TITLE     SIRT4 regulates rat dental papilla cell differentiation by
            promoting mitochondrial functions
  JOURNAL   Int J Biochem Cell Biol 134, 105962 (2021)
   PUBMED   33636397
  REMARK    GeneRIF: SIRT4 regulates rat dental papilla cell differentiation by
            promoting mitochondrial functions.
REFERENCE   2  (bases 1 to 1521)
  AUTHORS   Camargo,T.F., Zanesco,A.M., Pacher,K.A.S., Andrade,T.A.M.,
            Alves,A.A. and do Amaral,M.E.C.
  TITLE     Physiological profile regulation during weight gain and loss by
            ovariectomized females: importance of SIRT1 and SIRT4
  JOURNAL   Am J Physiol Endocrinol Metab 319 (4), E769-E778 (2020)
   PUBMED   32865007
  REMARK    GeneRIF: Physiological profile regulation during weight gain and
            loss by ovariectomized females: importance of SIRT1 and SIRT4.
REFERENCE   3  (bases 1 to 1521)
  AUTHORS   Marin,C., Langdon,C., Alobid,I., Fuentes,M., Bonastre,M. and
            Mullol,J.
  TITLE     Recovery of Olfactory Function After Excitotoxic Lesion of the
            Olfactory Bulbs Is Associated with Increases in Bulbar SIRT1 and
            SIRT4 Expressions
  JOURNAL   Mol Neurobiol 56 (8), 5643-5653 (2019)
   PUBMED   30661205
  REMARK    GeneRIF: the association between recovery of olfactory function and
            the increase in bulbar SIRT1 and SIRT4 expression, is reported.
REFERENCE   4  (bases 1 to 1521)
  AUTHORS   Martin,J., Balmer,M.L., Rajendran,S., Maurhofer,O., Dufour,J.F. and
            St-Pierre,M.V.
  TITLE     Nutritional stress exacerbates hepatic steatosis induced by
            deletion of the histidine nucleotide-binding (Hint2) mitochondrial
            protein
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 310 (7), G497-G509 (2016)
   PUBMED   26767982
REFERENCE   5  (bases 1 to 1521)
  AUTHORS   Verdin,E.
  TITLE     NAD in aging, metabolism, and neurodegeneration
  JOURNAL   Science 350 (6265), 1208-1213 (2015)
   PUBMED   26785480
  REMARK    Review article
REFERENCE   6  (bases 1 to 1521)
  AUTHORS   Nakamura,Y., Ogura,M., Tanaka,D. and Inagaki,N.
  TITLE     Localization of mouse mitochondrial SIRT proteins: shift of SIRT3
            to nucleus by co-expression with SIRT5
  JOURNAL   Biochem Biophys Res Commun 366 (1), 174-179 (2008)
   PUBMED   18054327
REFERENCE   7  (bases 1 to 1521)
  AUTHORS   Lombard,D.B., Alt,F.W., Cheng,H.L., Bunkenborg,J., Streeper,R.S.,
            Mostoslavsky,R., Kim,J., Yancopoulos,G., Valenzuela,D., Murphy,A.,
            Yang,Y., Chen,Y., Hirschey,M.D., Bronson,R.T., Haigis,M.,
            Guarente,L.P., Farese,R.V. Jr., Weissman,S., Verdin,E. and
            Schwer,B.
  TITLE     Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine
            acetylation
  JOURNAL   Mol Cell Biol 27 (24), 8807-8814 (2007)
   PUBMED   17923681
REFERENCE   8  (bases 1 to 1521)
  AUTHORS   Ahuja,N., Schwer,B., Carobbio,S., Waltregny,D., North,B.J.,
            Castronovo,V., Maechler,P. and Verdin,E.
  TITLE     Regulation of insulin secretion by SIRT4, a mitochondrial
            ADP-ribosyltransferase
  JOURNAL   J Biol Chem 282 (46), 33583-33592 (2007)
   PUBMED   17715127
REFERENCE   9  (bases 1 to 1521)
  AUTHORS   Haigis,M.C., Mostoslavsky,R., Haigis,K.M., Fahie,K.,
            Christodoulou,D.C., Murphy,A.J., Valenzuela,D.M., Yancopoulos,G.D.,
            Karow,M., Blander,G., Wolberger,C., Prolla,T.A., Weindruch,R.,
            Alt,F.W. and Guarente,L.
  TITLE     SIRT4 inhibits glutamate dehydrogenase and opposes the effects of
            calorie restriction in pancreatic beta cells
  JOURNAL   Cell 126 (5), 941-954 (2006)
   PUBMED   16959573
REFERENCE   10 (bases 1 to 1521)
  AUTHORS   Michishita,E., Park,J.Y., Burneskis,J.M., Barrett,J.C. and
            Horikawa,I.
  TITLE     Evolutionarily conserved and nonconserved cellular localizations
            and functions of human SIRT proteins
  JOURNAL   Mol Biol Cell 16 (10), 4623-4635 (2005)
   PUBMED   16079181
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Mar 30, 2021 this sequence version replaced
            XM_039089499.1, NM_001107147.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000012.1  46791930-46791967
            39-218              JAXUCZ010000012.1  46793295-46793474
            219-707             JAXUCZ010000012.1  46793755-46794243
            708-1002            JAXUCZ010000012.1  46796278-46796572
            1003-1521           JAXUCZ010000012.1  46796906-46797424
FEATURES             Location/Qualifiers
     source          1..1521
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1521
                     /gene="Sirt4"
                     /note="sirtuin 4"
                     /db_xref="GeneID:304539"
                     /db_xref="RGD:1310413"
     exon            1..38
                     /gene="Sirt4"
                     /inference="alignment:Splign:2.1.0"
     exon            39..218
                     /gene="Sirt4"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1155
                     /gene="Sirt4"
                     /note="NAD-dependent ADP-ribosyltransferase sirtuin-4;
                     NAD-dependent protein deacetylase sirtuin-4"
                     /codon_start=1
                     /product="NAD-dependent protein lipoamidase sirtuin-4,
                     mitochondrial"
                     /protein_id="NP_001100617.2"
                     /db_xref="GeneID:304539"
                     /db_xref="RGD:1310413"
                     /translation="MVLLGVDRMRGLIFRPTRGRWITQMSQLRSHGSTGLFVPPSPPL
                     DHEKIKELQRFISLSKKLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHIDFIR
                     SAPVRQRYWARNFVGWPQFSSHQPNPAHWALSNWEKLGKLHWLVTQNVDALHSKAGNQ
                     RLTELHGCMHRVLCLSCGEQTARRVLQDRFQALNPSWSAEAQGVAPDGDVFLTEEQVR
                     SFRVPCCDRCGGPLKPDVVFFGDTVNPDKVDFVHQRVKEADSLLVVGSSLQVYSGYRF
                     ILTAREKKLPIAILNIGPTRSDDLACLKLDSRCGELLPLIDPQ"
     exon            219..707
                     /gene="Sirt4"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1002
                     /gene="Sirt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1521
                     /gene="Sirt4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacatgtaa gaagctagtc ccactgttgg gtgagaagag tccagaagag ggcctgaaac
       61 tggaattaaa gatggtctta agccaccact gtaggtgtta attgaaccca gcacctggtc
      121 ttctggaaga actttctatt ttcccagtgc tacaattcca ggcatggatt accatggcaa
      181 atttttcata gttgaatggt actcctggga gtggacagaa tgagggggtt gattttcagg
      241 ccgacaaggg gccgttggat cacccagatg agccagctgc gttcccatgg atccacaggg
      301 ttatttgtgc cgcccagccc ccctttggac catgaaaaga tcaaagagtt acagcgcttc
      361 attagccttt ccaagaaact gctagtgatg acaggcgcgg gaatctccac cgagtccggg
      421 atcccagact acaggtcaga aaaggtggga ctctacgccc gcactgaccg gagacccatc
      481 cagcacattg atttcatccg cagtgctccg gttcgccagc gctactgggc ccgaaacttt
      541 gtgggctggc ctcagttctc ctctcaccag cccaacccag cacactgggc tctgagcaac
      601 tgggagaaac ttgggaagct gcactggttg gtgacccaga acgtggacgc tctgcattcc
      661 aaggctggga atcagcggtt gacggagctg cacggatgca tgcacagggt cctgtgcctg
      721 agctgtgggg agcagactgc acgcagggtg ctgcaggacc gcttccaagc cctgaacccc
      781 agctggagtg ccgaggcgca gggcgtggct cccgacggtg acgtgttcct cacggaggag
      841 caggtccgga gctttcgggt cccgtgctgt gatcgatgcg gcggccctct gaaacccgac
      901 gtcgttttct ttggggacac ggtgaacccg gacaaggttg actttgtgca ccagcgtgtg
      961 aaagaagctg actcgctgct ggtggtggga tcgtccctgc aggtatactc cggttacagg
     1021 ttcatcctca ccgcccggga gaagaagctc ccaatcgcca ttctgaacat cggacccacg
     1081 aggtctgacg atttggcttg cctgaagctg gattcgcgct gtggagagct gctgccctta
     1141 atagacccac agtgacagca ccctgatgtc caaaggctgg aaaggacttt cctttgggtc
     1201 ccgctgctaa aggtaaagag agccctttca gataaagggt ctagcctcat gcttctaatc
     1261 ccagccctca gaagctgacg aaaacgagcc tggagctcaa ggccagtctg ggctatagtg
     1321 tgttctaggc tagatctggc cacagaggtg ataccctaac cacaaacaac aaaacaaaag
     1381 ccaggtgata gattcagctt cctggtacac ctagtagtca gatgcccaac aaaagagaca
     1441 attctagacg tcttaacacg tggctatata tgttaattaa aacgtgacgt ttcaattaaa
     1501 acgacctttt aaaaaaatac a
//
