LOCUS       NM_001106313            1393 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Rattus norvegicus sirtuin 3 (Sirt3), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001106313 XM_001058755 XM_215124
VERSION     NM_001106313.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Hu,H.J., Wang,X.H., Zhang,Z.Z., Ou,Y., Ning,Z.H., Yang,J.Y.,
            Huang,H., Tang,H.F. and Jiang,Z.S.
  TITLE     SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin
            II-induced atrial fibrosis and vulnerability to atrial fibrillation
            via suppression of the TGF-beta1/smad2/3 signalling pathway
  JOURNAL   Eur J Pharmacol 982, 176900 (2024)
   PUBMED   39168432
  REMARK    GeneRIF: SIRT3 sulfhydration using hydrogen sulfide inhibited
            angiotensin II-induced atrial fibrosis and vulnerability to atrial
            fibrillation via suppression of the TGF-beta1/smad2/3 signalling
            pathway.
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Zhou,H., Ji,Y., Li,J. and Sun,L.
  TITLE     The study on the role of O-GlcNAcylation of SIRT3 in regulating
            mitochondrial oxidative stress during simulate myocardial
            ischemia-reperfusion
  JOURNAL   Sci Rep 14 (1), 21201 (2024)
   PUBMED   39261577
  REMARK    GeneRIF: The study on the role of O-GlcNAcylation of SIRT3 in
            regulating mitochondrial oxidative stress during simulate
            myocardial ischemia-reperfusion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Zhu,D., Shi,C., Sun,S., Chen,X., Xu,Y., Wang,B., Xu,Z., Zhang,P.
            and Sun,M.
  TITLE     The SIRT3/GSK-3beta/GLUT4 axis might be involved in maternal
            hypoxia-induced skeletal muscle insulin resistance in old male rat
            offspring
  JOURNAL   Toxicol Appl Pharmacol 489, 117019 (2024)
   PUBMED   38950736
  REMARK    GeneRIF: The SIRT3/GSK-3beta/GLUT4 axis might be involved in
            maternal hypoxia-induced skeletal muscle insulin resistance in old
            male rat offspring.
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Chen,M., Liu,J., Wu,W., Guo,T., Yuan,J., Wu,Z., Zheng,Z., Zhao,Z.,
            Lin,Q., Liu,N. and Chen,H.
  TITLE     SIRT1 restores mitochondrial structure and function in rats by
            activating SIRT3 after cerebral ischemia/reperfusion injury
  JOURNAL   Cell Biol Toxicol 40 (1), 31 (2024)
   PUBMED   38767771
  REMARK    GeneRIF: SIRT1 restores mitochondrial structure and function in
            rats by activating SIRT3 after cerebral ischemia/reperfusion
            injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Zhou,J., Chen,Y., Li,Q., Wang,G. and Zhang,G.
  TITLE     The Mechanism of SIRT3 Regulating SRV2-Mediated Mitochondrial
            Fission of Fibroblasts to Inhibit Myocardial Fibrosis after Acute
            Myocardial Infarction
  JOURNAL   Ann Clin Lab Sci 54 (3), 335-346 (2024)
   PUBMED   39048173
  REMARK    GeneRIF: The Mechanism of SIRT3 Regulating SRV2-Mediated
            Mitochondrial Fission of Fibroblasts to Inhibit Myocardial Fibrosis
            after Acute Myocardial Infarction.
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   Hallows,W.C., Lee,S. and Denu,J.M.
  TITLE     Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
  JOURNAL   Proc Natl Acad Sci U S A 103 (27), 10230-10235 (2006)
   PUBMED   16790548
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Schwer,B., Bunkenborg,J., Verdin,R.O., Andersen,J.S. and Verdin,E.
  TITLE     Reversible lysine acetylation controls the activity of the
            mitochondrial enzyme acetyl-CoA synthetase 2
  JOURNAL   Proc Natl Acad Sci U S A 103 (27), 10224-10229 (2006)
   PUBMED   16788062
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Michishita,E., Park,J.Y., Burneskis,J.M., Barrett,J.C. and
            Horikawa,I.
  TITLE     Evolutionarily conserved and nonconserved cellular localizations
            and functions of human SIRT proteins
  JOURNAL   Mol Biol Cell 16 (10), 4623-4635 (2005)
   PUBMED   16079181
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   Schwer,B., North,B.J., Frye,R.A., Ott,M. and Verdin,E.
  TITLE     The human silent information regulator (Sir)2 homologue hSIRT3 is a
            mitochondrial nicotinamide adenine dinucleotide-dependent
            deacetylase
  JOURNAL   J Cell Biol 158 (4), 647-657 (2002)
   PUBMED   12186850
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Yang,Y.H., Chen,Y.H., Zhang,C.Y., Nimmakayalu,M.A., Ward,D.C. and
            Weissman,S.
  TITLE     Cloning and characterization of two mouse genes with homology to
            the yeast Sir2 gene
  JOURNAL   Genomics 69 (3), 355-369 (2000)
   PUBMED   11056054
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC167006.1.
            
            On May 11, 2008 this sequence version replaced NM_001106313.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167006.1, FQ218084.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1393
                     /gene="Sirt3"
                     /note="sirtuin 3"
                     /db_xref="GeneID:293615"
                     /db_xref="RGD:1308374"
     exon            1..29
                     /gene="Sirt3"
                     /inference="alignment:Splign:2.1.0"
     exon            30..218
                     /gene="Sirt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..945
                     /gene="Sirt3"
                     /note="SIRT3L mitochondrial"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-3,
                     mitochondrial"
                     /protein_id="NP_001099783.1"
                     /db_xref="GeneID:293615"
                     /db_xref="RGD:1308374"
                     /translation="MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFF
                     HNPKPFFTLAKELYPGHYRPNVAHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKL
                     VEAHGSFVSATCTVCRRSFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEQLPARF
                     LLHVADFALADLLLILGTSLEVEPFASLSESVQKSVPRLLINRDLVGSFALSPRRKDV
                     VQLGDVVQGVERLVDLLGWTQELQDLIQRENGKLDGQDG"
     exon            219..451
                     /gene="Sirt3"
                     /inference="alignment:Splign:2.1.0"
     exon            452..552
                     /gene="Sirt3"
                     /inference="alignment:Splign:2.1.0"
     exon            553..714
                     /gene="Sirt3"
                     /inference="alignment:Splign:2.1.0"
     exon            715..924
                     /gene="Sirt3"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1364
                     /gene="Sirt3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgcgctc agactgtggg gtccgggagt attacaggtg ggagaaggcc catatccctc
       61 tctgtgggag cctcaggcgg ctttggatgt ggaggacaca gtgagaagaa gctgtctctg
      121 caggacgtag ctgagctgct tcggaccaga gcctgcagta gggttgtggt catggtgggg
      181 gctggcatca gcacacccag tggtatccca gacttcagat ccccagggag tggcctctac
      241 agcaaccttc agcagtatga catcccgtac cctgaggcca tctttgaact aggcttcttt
      301 tttcacaacc ccaagccctt tttcacgttg gccaaggagc tgtaccctgg gcactacagg
      361 cccaatgtcg ctcactactt ccttcggctg cttcacgaca aggagctgct tctgcggctc
      421 tacacacaga acatcgacgg gcttgagaga gcatctggta tccctgcctc aaagctggtt
      481 gaagctcatg ggtcctttgt atcagctacg tgcacggtct gtcgaaggtc cttcccaggg
      541 gaagacatac gggctgacgt gatggcagac agggtgcccc gctgccctgt ctgtactggc
      601 gttgtgaaac ctgacattgt gttctttggg gagcagctgc cagcaaggtt cttactacat
      661 gtggctgatt tcgccttggc agatctgcta ctcattcttg ggacctccct ggaggtggag
      721 ccttttgcca gcttgtctga atcggtacag aaatcagtgc cccgactgct catcaatcga
      781 gacttggtgg ggtcctttgc tctgagtcct cgaaggaaag atgtggtcca gctaggggat
      841 gtagtccagg gtgtggaaag gctggtggac ctcctggggt ggacacaaga gctgcaggat
      901 ctcatccagc gggaaaatgg aaagctggat ggacaggacg gataagacag actatggctt
      961 acttcttcac ctgcgggaaa gtcgcacagg agatcatcct attcccaggg agacctcatg
     1021 tctgaaaaca gctccgacag gtttacaaac atgggccaga ccacaacatg tgtcctgggc
     1081 agtagtccca aggctgcctt tgttaaggct gaccagggac ctttaccctt ggggccatgt
     1141 gttaccatac aaaggagctc cacgtgtgtg ctctgtccac ccatcactgc tgaagcttgc
     1201 agtacagtgc tgctttctga cagaggcctt agttaccaag agggcagggc agcatgccca
     1261 tcgctagaca gctgatacgc taggctaatc tagcatgttg gtcggtaaag tggcatcttt
     1321 aactgaaaaa tcatttttcg catgaaataa atttagtata aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaaaa aaa
//
