LOCUS       NM_001399630            1777 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sirtuin 2 (Sirt2), transcript variant 1, mRNA.
ACCESSION   NM_001399630 XM_006228676
VERSION     NM_001399630.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1777)
  AUTHORS   Wang,C., Zhu,Y., Chen,R., Zhu,X. and Zhang,X.
  TITLE     microRNA-143 targets SIRT2 to mediate the histone acetylation of
            PLAUR and modulates functions of astrocytes in spinal cord injury
  JOURNAL   Chem Biol Interact 390, 110854 (2024)
   PUBMED   38161044
  REMARK    GeneRIF: microRNA-143 targets SIRT2 to mediate the histone
            acetylation of PLAUR and modulates functions of astrocytes in
            spinal cord injury.
REFERENCE   2  (bases 1 to 1777)
  AUTHORS   Zhu,W. and Ma,Z.
  TITLE     SIRT2 overexpression decreases remifentanil-stimulated
            post-surgical hyperalgesia via microglia
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 268-274 (2023)
   PUBMED   38063126
  REMARK    GeneRIF: SIRT2 overexpression decreases remifentanil-stimulated
            post-surgical hyperalgesia via microglia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1777)
  AUTHORS   Zhang,X., Liu,S., Liu,X. and Wang,J.
  TITLE     Inhibiting silence information regulator 2 and glutaminase in the
            amygdala can improve social behavior in autistic rats
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 51 (6), 707-715 (2022)
   PUBMED   36915976
  REMARK    GeneRIF: Inhibiting silence information regulator 2 and glutaminase
            in the amygdala can improve social behavior in autistic rats.
REFERENCE   4  (bases 1 to 1777)
  AUTHORS   Keskin-Aktan,A., Akbulut,K.G., Abdi,S. and Akbulut,H.
  TITLE     SIRT2 and FOXO3a expressions in the cerebral cortex and hippocampus
            of young and aged male rats: antioxidant and anti-apoptotic effects
            of melatonin
  JOURNAL   Biol Futur 73 (1), 71-85 (2022)
   PUBMED   34708398
  REMARK    GeneRIF: SIRT2 and FOXO3a expressions in the cerebral cortex and
            hippocampus of young and aged male rats: antioxidant and
            anti-apoptotic effects of melatonin.
REFERENCE   5  (bases 1 to 1777)
  AUTHORS   Wang,Y., Wu,C.J., Du,Y., Liu,Y.Q., Cai,J.R., Wu,X.Q. and Hu,S.Q.
  TITLE     SIRT2 tyrosine nitration by peroxynitrite in response to renal
            ischemia/reperfusion injury
  JOURNAL   Free Radic Res 55 (11-12), 1104-1118 (2021)
   PUBMED   34979841
  REMARK    GeneRIF: SIRT2 tyrosine nitration by peroxynitrite in response to
            renal ischemia/reperfusion injury.
REFERENCE   6  (bases 1 to 1777)
  AUTHORS   De Smet,C., Nishimori,H., Furnari,F.B., Bogler,O., Huang,H.J. and
            Cavenee,W.K.
  TITLE     A novel seven transmembrane receptor induced during the early steps
            of astrocyte differentiation identified by differential expression
  JOURNAL   J Neurochem 81 (3), 575-588 (2002)
   PUBMED   12065666
REFERENCE   7  (bases 1 to 1777)
  AUTHORS   Finnin,M.S., Donigian,J.R. and Pavletich,N.P.
  TITLE     Structure of the histone deacetylase SIRT2
  JOURNAL   Nat Struct Biol 8 (7), 621-625 (2001)
   PUBMED   11427894
REFERENCE   8  (bases 1 to 1777)
  AUTHORS   Yang,Y.H., Chen,Y.H., Zhang,C.Y., Nimmakayalu,M.A., Ward,D.C. and
            Weissman,S.
  TITLE     Cloning and characterization of two mouse genes with homology to
            the yeast Sir2 gene
  JOURNAL   Genomics 69 (3), 355-369 (2000)
   PUBMED   11056054
REFERENCE   9  (bases 1 to 1777)
  AUTHORS   Frye,R.A.
  TITLE     Characterization of five human cDNAs with homology to the yeast
            SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may
            have protein ADP-ribosyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 260 (1), 273-279 (1999)
   PUBMED   10381378
REFERENCE   10 (bases 1 to 1777)
  AUTHORS   Suzuki,E., Kojima,N., Yoshimura,K., Uyemura,K., Obata,K. and
            Akagawa,K.
  TITLE     Cloning and sequence analysis of cDNA for a possible DNA-binding
            protein 5E5 in the nervous system
  JOURNAL   J Biochem 118 (1), 122-128 (1995)
   PUBMED   8537300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 12, 2022 this sequence version replaced XM_006228676.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.334692.1,
                                           SRR22399492.2301635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000001.1  93181472-93181572
            102-148             JAXUCZ010000001.1  93182326-93182372
            149-197             JAXUCZ010000001.1  93186696-93186744
            198-311             JAXUCZ010000001.1  93186988-93187101
            312-353             JAXUCZ010000001.1  93192364-93192405
            354-460             JAXUCZ010000001.1  93192506-93192612
            461-517             JAXUCZ010000001.1  93192699-93192755
            518-586             JAXUCZ010000001.1  93194287-93194355
            587-716             JAXUCZ010000001.1  93199042-93199171
            717-776             JAXUCZ010000001.1  93201354-93201413
            777-832             JAXUCZ010000001.1  93201630-93201685
            833-909             JAXUCZ010000001.1  93201770-93201846
            910-961             JAXUCZ010000001.1  93201928-93201979
            962-1032            JAXUCZ010000001.1  93203496-93203566
            1033-1099           JAXUCZ010000001.1  93203675-93203741
            1100-1777           JAXUCZ010000001.1  93203822-93204499
FEATURES             Location/Qualifiers
     source          1..1777
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1777
                     /gene="Sirt2"
                     /note="sirtuin 2"
                     /db_xref="GeneID:361532"
                     /db_xref="RGD:621481"
     exon            1..101
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1252
                     /gene="Sirt2"
                     /EC_number="2.3.1.286"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NAD-dependent deacetylase sirtuin-2; 5E5 antigen;
                     SIR2-like protein 2; regulatory protein SIR2 homolog 2;
                     NAD-dependent protein deacetylase sirtuin-2; NAD-dependent
                     protein defatty-acylase sirtuin-2"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-2
                     isoform 1"
                     /protein_id="NP_001386559.1"
                     /db_xref="GeneID:361532"
                     /db_xref="RGD:621481"
                     /translation="MAEPDPSDPLENQAGKVQEAQDSDSDTEGGATGGEAEMDFLRNL
                     FTQTLGLGSQKERLLDELTLEGVTRYMQSERCRRVICLVGAGISTSAGIPDFRSPSTG
                     LYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFIRLLKEKGL
                     LLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCGKEYTMSWMKEKIFSEAT
                     PKCEKCQNVVKPDIVFFGENLPPRFFSCMQSDFSKVDLLIIMGTSLQVQPFASLISKA
                     PLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADL
                     LGWKKELEDLVRREHANIDAQSGSQASNPSATVSPRKSPPPAKEAARTKEKEEH"
     exon            102..148
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            149..197
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            198..311
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            312..353
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..460
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..517
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..586
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..716
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..776
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..832
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..909
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..961
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1032
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1099
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1777
                     /gene="Sirt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcctctctc ggctccttct tgtttccgct gccgtcacgg gacagagcag tcggtgacag
       61 tcccgagagc ccccaccccg ttcccatggc cgagccggac ccctctgacc ctctggagaa
      121 ccaggcaggg aaggtgcagg aggctcagga ttcagactcg gacactgagg gaggagccac
      181 tggcggagag gcagagatgg acttcctacg gaatttattc acccagaccc tgggcctggg
      241 ttcccagaag gagcgtctgc tggacgagct gacccttgaa ggagtgacac gctacatgca
      301 gagcgagcgc tgtcgcaggg tcatctgttt ggtgggagct ggaatctcca catccgcagg
      361 aatccctgac ttccgctccc catccactgg cctctatgca aacttggaga aataccacct
      421 tccataccca gaggccatct ttgagatcag ctacttcaag aaacatccag aacccttctt
      481 tgcccttgct aaggagctct atcctgggca gttcaagccg accatctgcc actacttcat
      541 ccgcctgctg aaggagaagg ggctgctgct gcgctgctac acgcagaata ttgacactct
      601 ggaacgagtg gcagggctgg agccccagga cctggtggag gcccacggca ccttctacac
      661 atcacactgt gtcaacacct cctgtggaaa agagtacacg atgagctgga tgaaagagaa
      721 gatcttctca gaagcaactc ccaagtgtga gaagtgtcag aatgtggtaa agcccgatat
      781 cgtgtttttc ggtgagaacc tcccaccgcg cttcttctcc tgcatgcagt cagacttctc
      841 aaaggtggac ctcctcatca tcatgggcac ctccctgcag gtgcagccct tcgcctccct
      901 catcagcaag gcaccactag ccaccccacg actgctcatt aacaaggaga agacaggcca
      961 gacggatccc ttcctgggca tgatgatggg cttgggaggc ggcatggatt ttgactccaa
     1021 gaaggcttac agggacgtgg cctggctggg tgactgtgac caaggctgcc tggctctcgc
     1081 tgacctcctg ggatggaaga aggagctgga agaccttgtc cggagggagc atgccaacat
     1141 agatgcccag tcagggtcac aggcctccaa ccccagcgct accgtctccc ctagaaagtc
     1201 cccacctcct gccaaggagg cggccaggac caaagagaaa gaggaacact agtaaccact
     1261 gtctcccatg caggacagct gagtcccagc cagcactggt ccctctaaca tgcagcttgt
     1321 gtgagctcat tgacccttca ttctcttaac cactttcttg aaaccagggt ccccaactca
     1381 atcccagaaa gttctaatat acctaagggc cgaggcctgt gcagtctcta accacagccc
     1441 acacacagcc tccaaccacc tagggcaaga agcagcctcc tcccctaacg tctaactatt
     1501 cccagagagc agttacccta actgtgccag aataaggcat ttctctattg ttttcagtgg
     1561 ggactcagct aaatcaagtt aatctaccct gcataggggc tggaccctcc aaatataact
     1621 tcacgcaggg gctggggccc ggtggggtct gaggactgcc aggctctgcc tccaacaaag
     1681 tggctccctt ccccggggcc ccacgcgcct gccatggtgg gcaagccgga gggcaagttg
     1741 attagaaaca aattaaaact cagaacaaag caactaa
//
