LOCUS       NM_001414959            3885 bp    mRNA    linear   ROD 13-NOV-2024
DEFINITION  Rattus norvegicus sirtuin 1 (Sirt1), transcript variant 1, mRNA.
ACCESSION   NM_001414959 XM_039098755
VERSION     NM_001414959.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3885)
  AUTHORS   Liu,J., Ma,X., Guo,W., Lu,B., Yue,Y., Yang,X., Wang,R., Wu,C.,
            Zhang,B., Li,X. and Luo,X.
  TITLE     Deacetylation of HnRNP U mediated by sirtuin1 ameliorates aged rat
            with liver fibrosis via inhibiting p53-related senescence and
            NLRP3-related inflammation
  JOURNAL   Int Immunopharmacol 141, 113026 (2024)
   PUBMED   39216234
  REMARK    GeneRIF: Deacetylation of HnRNP U mediated by sirtuin1 ameliorates
            aged rat with liver fibrosis via inhibiting p53-related senescence
            and NLRP3-related inflammation.
REFERENCE   2  (bases 1 to 3885)
  AUTHORS   Qiu,Z., Qi,B., Li,L., Cui,J., Liu,M. and Xia,Z.
  TITLE     ACTIVATION OF KLOTHO/SIRT1 SIGNALING PATHWAY ATTENUATES MYOCARDIAL
            ISCHEMIA REPERFUSION INJURY IN DIABETIC RATS
  JOURNAL   Shock 62 (3), 447-456 (2024)
   PUBMED   38904464
  REMARK    GeneRIF: ACTIVATION OF KLOTHO/SIRT1 SIGNALING PATHWAY ATTENUATES
            MYOCARDIAL ISCHEMIA REPERFUSION INJURY IN DIABETIC RATS.
REFERENCE   3  (bases 1 to 3885)
  AUTHORS   Jin,X., Zhang,Y., Zhou,Y., Luo,Y., Han,X., Gao,Y., Yu,H., Duan,Y.,
            Shi,L., Wu,Y. and Li,Y.
  TITLE     Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial
            Necroptosis by Activation of RIPK1 Acetylation
  JOURNAL   Circ Arrhythm Electrophysiol 17 (7), e012452 (2024)
   PUBMED   39012929
  REMARK    GeneRIF: Sirt1 Deficiency Promotes Age-Related AF Through Enhancing
            Atrial Necroptosis by Activation of RIPK1 Acetylation.
REFERENCE   4  (bases 1 to 3885)
  AUTHORS   Chen,M., Liu,J., Wu,W., Guo,T., Yuan,J., Wu,Z., Zheng,Z., Zhao,Z.,
            Lin,Q., Liu,N. and Chen,H.
  TITLE     SIRT1 restores mitochondrial structure and function in rats by
            activating SIRT3 after cerebral ischemia/reperfusion injury
  JOURNAL   Cell Biol Toxicol 40 (1), 31 (2024)
   PUBMED   38767771
  REMARK    GeneRIF: SIRT1 restores mitochondrial structure and function in
            rats by activating SIRT3 after cerebral ischemia/reperfusion
            injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3885)
  AUTHORS   Jin,X., Sun,X., Ma,X., Qin,Z., Gao,X., Kang,X., Li,H. and Sun,H.
  TITLE     SIRT1 maintains bone homeostasis by regulating osteoblast
            glycolysis through GOT1
  JOURNAL   Cell Mol Life Sci 81 (1), 204 (2024)
   PUBMED   38700532
  REMARK    GeneRIF: SIRT1 maintains bone homeostasis by regulating osteoblast
            glycolysis through GOT1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3885)
  AUTHORS   Vaziri,H., Dessain,S.K., Ng Eaton,E., Imai,S.I., Frye,R.A.,
            Pandita,T.K., Guarente,L. and Weinberg,R.A.
  TITLE     hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
  JOURNAL   Cell 107 (2), 149-159 (2001)
   PUBMED   11672523
REFERENCE   7  (bases 1 to 3885)
  AUTHORS   Luo,J., Nikolaev,A.Y., Imai,S., Chen,D., Su,F., Shiloh,A.,
            Guarente,L. and Gu,W.
  TITLE     Negative control of p53 by Sir2alpha promotes cell survival under
            stress
  JOURNAL   Cell 107 (2), 137-148 (2001)
   PUBMED   11672522
REFERENCE   8  (bases 1 to 3885)
  AUTHORS   Muth,V., Nadaud,S., Grummt,I. and Voit,R.
  TITLE     Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA
            polymerase I transcription
  JOURNAL   EMBO J 20 (6), 1353-1362 (2001)
   PUBMED   11250901
REFERENCE   9  (bases 1 to 3885)
  AUTHORS   Imai,S., Armstrong,C.M., Kaeberlein,M. and Guarente,L.
  TITLE     Transcriptional silencing and longevity protein Sir2 is an
            NAD-dependent histone deacetylase
  JOURNAL   Nature 403 (6771), 795-800 (2000)
   PUBMED   10693811
REFERENCE   10 (bases 1 to 3885)
  AUTHORS   Schilling,G., Becher,M.W., Sharp,A.H., Jinnah,H.A., Duan,K.,
            Kotzuk,J.A., Slunt,H.H., Ratovitski,T., Cooper,J.K., Jenkins,N.A.,
            Copeland,N.G., Price,D.L., Ross,C.A. and Borchelt,D.R.
  TITLE     Intranuclear inclusions and neuritic aggregates in transgenic mice
            expressing a mutant N-terminal fragment of huntingtin
  JOURNAL   Hum Mol Genet 8 (3), 397-407 (1999)
   PUBMED   9949199
  REMARK    Erratum:[Hum Mol Genet 1999 May;8(5):943]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 16, 2022 this sequence version replaced XM_039098755.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.64061.1,
                                           SRR26643297.53141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               JAXUCZ010000020.1  25305953-25306426
            475-591             JAXUCZ010000020.1  25308110-25308226
            592-833             JAXUCZ010000020.1  25309362-25309603
            834-986             JAXUCZ010000020.1  25313816-25313968
            987-1134            JAXUCZ010000020.1  25319790-25319937
            1135-1214           JAXUCZ010000020.1  25320574-25320653
            1215-1401           JAXUCZ010000020.1  25321898-25322084
            1402-1956           JAXUCZ010000020.1  25323897-25324451
            1957-3885           JAXUCZ010000020.1  25326072-25328000
FEATURES             Location/Qualifiers
     source          1..3885
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..3885
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /note="sirtuin 1"
                     /db_xref="GeneID:309757"
                     /db_xref="RGD:1308542"
     exon            1..474
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2288
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /EC_number="2.3.1.286"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Sir2alpha; sirtuin 1 ((silent mating type information
                     regulation 2, homolog) 1; NAD-dependent deacetylase
                     sirtuin-1; NAD-dependent protein deacetylase sirtuin-1;
                     NAD-dependent protein deacylase sirtuin-1"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-1
                     isoform 1"
                     /protein_id="NP_001401888.1"
                     /db_xref="GeneID:309757"
                     /db_xref="RGD:1308542"
                     /translation="MADEAALALQAGGSPSAAAAMEAASQPADEPLRKRPRRDGPGLG
                     RSPGEPSAAAAAAAAAAGCEAASAAAPAALWREAAGAAAASAEREAPATAAAGDGDNG
                     PGLRREPRAADDFDDDEGEEEDEAAAAAAAAIGYRDNLLLADEIITNGFHSCESDDDD
                     RASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIV
                     INILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYAR
                     LAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLL
                     RNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRC
                     PADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIP
                     HEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKP
                     PRTQKELVHLSELPPTPLHISEDSSSPERTVPQDSSVIATLVDQTIKNKVDDLEVSEP
                     KSCVEEKSQEVQTYRNVESINVENPDFKAVGSSTGDKNERTSVAETVRKCWPNRLAKE
                     QISKRLDGNQYLFVPPNRYIFHGAEVYSDSEDDALSSSSCGSNSDSGTCQSPSLEEPL
                     EDESEIEEFYNGLEDDADRPECAGGSGADGGDQEAVNEAIAMKQELTDVNCTPDKSEH
                     Y"
     exon            475..591
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            592..833
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..986
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1134
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1214
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1401
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1956
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..3885
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgccgcgc gtcgagcgga gcagaggagg cgagggcgga gggccagaga ggcagttgga
       61 agatggcgga cgaggcggcg ctcgcccttc aggccggcgg ctccccttcc gcggcggccg
      121 ccatggaggc cgcgtcgcag cccgctgacg aaccgctccg caagaggccg cgccgagacg
      181 ggcctggcct cgggcgcagc ccgggcgagc cgagcgcggc ggcggcggcc gcggcggctg
      241 ccgcggggtg tgaggcggcg agcgccgcgg ccccggcggc gctgtggcgg gaggcagcag
      301 gggcggcggc ggcgagcgcg gagcgggagg ccccggcgac agccgcggcc ggggacggag
      361 acaatgggcc cggcttgcgg cgggagccga gggccgccga cgacttcgac gacgacgagg
      421 gcgaggagga agacgaggcg gcggcggctg cggcggcagc aatcggctac cgagacaacc
      481 tcctgttggc tgatgagatc atcactaatg gctttcattc ctgtgaaagt gatgacgatg
      541 acagagcatc acacgcaagc tctagtgact ggactccaag gccacggata ggtccatata
      601 cttttgttca gcaacacctc atgattggca ccgatcctcg aacaattctt aaagatttat
      661 taccagaaac aattcctcca cctgagttgg atgatatgac actgtggcag attgttatta
      721 atatcctttc agaaccacca aagcggaaaa aaagaaaaga tattaataca attgaagatg
      781 ctgtgaagtt actacaagag tgcaaaaaga taatagttct gactggagct ggggtttctg
      841 tttcctgtgg gatacctgac ttcagatcaa gagatggtat ttatgctcgc cttgctgtgg
      901 acttcccgga tctcccagat cctcaagcca tgttcgatat tgagtatttt agaaaagacc
      961 caagaccatt cttcaagttt gcaaaggaaa tatatcccgg acagttccag ccatctctgt
     1021 gtcacaaatt catagctttg tcagataagg aaggaaaact acttcgaaat tatactcaaa
     1081 atatagatac cttggagcag gttgcaggaa tccaaaggat cattcagtgt catggttcct
     1141 ttgcaacagc atcttgcctg atttgtaaat acaaagttga ttgtgaagct gttcgtggag
     1201 atatttttaa tcaggtagtt cctcggtgtc ctaggtgccc agctgatgag ccacttgcca
     1261 tcatgaagcc agagattgtc ttctttggtg aaaacttacc agaacagttt catagagcca
     1321 tgaagtatga caaagatgaa gttgacctcc tcattgttat tgggtcttct ctgaaagtaa
     1381 gaccagtagc actaattcca agttctatac cccatgaagt gcctcaaata ttaataaata
     1441 gggaacctct gcctcatcta cattttgatg tagagcttct tggagactgc gatgtcataa
     1501 ttaatgagtt gtgtcatagg ttaggtggcg agtatgccaa actttgttgt aaccctgtaa
     1561 agctttcaga aattactgaa aaacctccac gaacacaaaa ggaattggtt catttatcag
     1621 agttgccacc aacacctctt catatttcag aagactcaag ttcacctgaa agaactgtac
     1681 cacaagactc ttctgtgatt gctacacttg tagaccaaac aataaagaac aaagttgacg
     1741 atttagaagt atctgaacca aaaagttgtg tggaagaaaa atcacaggaa gtacagactt
     1801 ataggaatgt tgagagcatt aatgtggaaa acccagattt caaggctgtt ggttccagta
     1861 ctggagacaa aaatgaaaga acttctgttg cagaaacagt gagaaaatgc tggcctaata
     1921 gacttgcaaa ggagcagatt agtaagcgtc ttgacggtaa tcaatacttg tttgtaccac
     1981 caaatcgtta catatttcat ggtgctgagg tatactcaga ctctgaagat gacgccttat
     2041 cctctagttc ctgtggcagt aacagtgaca gtggcacatg ccagagtcca agtttagaag
     2101 aacccttgga agatgaaagt gaaattgaag agttctacaa tggcttggaa gatgatgctg
     2161 acagaccgga gtgtgctgga ggatctggag ctgacggagg ggatcaagag gcagttaatg
     2221 aagctatagc catgaaacag gaattaacag atgtaaactg tacaccagac aaatcagagc
     2281 actattgaag ctgtccaggt acaggaattg ctccaccagc attgggaact ttagcatgtc
     2341 aaaaatgaat gtttactgtg aacttgaaca aggagatcag aaagatgtat tatttataga
     2401 ctggaaaata gattgtcttc ttggataatt tttaaagttc catcatttct gtactttaat
     2461 cagctgttgg ctgacttcat cttcctttca aggttcattt gtatgataca ttcgtatgta
     2521 tataatttct tcgtttttgc ctaattgagt ttcaacattt taaagttttc aaaagccatt
     2581 ggaatgttaa tgtaaaggga acagcttatc tagaccaaag aatggtattt cacacttttg
     2641 tttgtaacat tgaatagttt gaaaccctca atttctgttc tgctgaactt ttatttttag
     2701 cacagttaac tttttaaaca ctggcatttt ccaaaattta tggcagctaa ctttttaaaa
     2761 tcacaaatga cttgtaatgt gagaaggaag tcagcatcgc attgggagct cagagtttga
     2821 gcatatttat tgcatggttt tttgtacttg ctgcagacgt ggtaatgtcc aaacaggccc
     2881 ctgagactaa tctgataaat gatttggaaa tgtttcagtt cttctagaaa ctattgtgcc
     2941 tgtctatata ggtcccctta gtttgaatat ttgccattgt ttaattaaat acctatcact
     3001 gtggtagagc ctccatagat cttcaccaca aatactgcca agatgtgaat ttgaatatgc
     3061 aaagcctttc tgaccctaat gatggtactt ctactgggga gagtgtaata ttttggactg
     3121 ctgtttttcc attaacaagg aagcaaaggt ctcttaatta aagttccaaa gtaataagat
     3181 taattgtaac tcaaccagaa agtacattgt ctcctgttga ggatttggtg taatgtatcc
     3241 caagggatgt gtattatgga gatgaataca aatccaatag tcaatgaaac tagttcctat
     3301 ttatttaaaa gcttagcttg ccttaaaact agggatcaat tttctgaact gcagaaactt
     3361 ttagcctttc aaacagttca cacctcagaa ggtcagtatt ttacagactt ctttggaaca
     3421 ttgcccccaa atttaaatat tcacgttggt ttagtattta ttacaaaaaa atgatttgaa
     3481 atatagctgt tctttatgca taaaataccc agctaggacc gttactgcca gaggataaag
     3541 tattaagtag ctcatttccc tacctaaaat attctcaatc tgaatttatt tggctacact
     3601 aaagaatgca gtatatttag ttttccattt gcatgatgtg tttgtgctat agacaatatt
     3661 ttaaattgaa aaatttgttt taaattattt ttacagtgaa gactgttttc agctcttttt
     3721 atattgtaca tagactttta tgtaatctgg catatgtttt gtagaccgtt taatgactgg
     3781 attatcttcc tccaactttt gaaatacaaa aacagtgttt tatacttgta tcttgtttta
     3841 aagtcttata ttaaaattgt catttgactt tttccccgtt aactt
//
