LOCUS       NP_001401888             741 aa            linear   ROD 25-MAR-2025
DEFINITION  NAD-dependent protein deacetylase sirtuin-1 isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001401888 XP_038954683
VERSION     NP_001401888.1
DBSOURCE    REFSEQ: accession NM_001414959.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 741)
  AUTHORS   Liu,J., Ma,X., Guo,W., Lu,B., Yue,Y., Yang,X., Wang,R., Wu,C.,
            Zhang,B., Li,X. and Luo,X.
  TITLE     Deacetylation of HnRNP U mediated by sirtuin1 ameliorates aged rat
            with liver fibrosis via inhibiting p53-related senescence and
            NLRP3-related inflammation
  JOURNAL   Int Immunopharmacol 141, 113026 (2024)
   PUBMED   39216234
  REMARK    GeneRIF: Deacetylation of HnRNP U mediated by sirtuin1 ameliorates
            aged rat with liver fibrosis via inhibiting p53-related senescence
            and NLRP3-related inflammation.
REFERENCE   2  (residues 1 to 741)
  AUTHORS   Qiu,Z., Qi,B., Li,L., Cui,J., Liu,M. and Xia,Z.
  TITLE     ACTIVATION OF KLOTHO/SIRT1 SIGNALING PATHWAY ATTENUATES MYOCARDIAL
            ISCHEMIA REPERFUSION INJURY IN DIABETIC RATS
  JOURNAL   Shock 62 (3), 447-456 (2024)
   PUBMED   38904464
  REMARK    GeneRIF: ACTIVATION OF KLOTHO/SIRT1 SIGNALING PATHWAY ATTENUATES
            MYOCARDIAL ISCHEMIA REPERFUSION INJURY IN DIABETIC RATS.
REFERENCE   3  (residues 1 to 741)
  AUTHORS   Jin,X., Zhang,Y., Zhou,Y., Luo,Y., Han,X., Gao,Y., Yu,H., Duan,Y.,
            Shi,L., Wu,Y. and Li,Y.
  TITLE     Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial
            Necroptosis by Activation of RIPK1 Acetylation
  JOURNAL   Circ Arrhythm Electrophysiol 17 (7), e012452 (2024)
   PUBMED   39012929
  REMARK    GeneRIF: Sirt1 Deficiency Promotes Age-Related AF Through Enhancing
            Atrial Necroptosis by Activation of RIPK1 Acetylation.
REFERENCE   4  (residues 1 to 741)
  AUTHORS   Chen,M., Liu,J., Wu,W., Guo,T., Yuan,J., Wu,Z., Zheng,Z., Zhao,Z.,
            Lin,Q., Liu,N. and Chen,H.
  TITLE     SIRT1 restores mitochondrial structure and function in rats by
            activating SIRT3 after cerebral ischemia/reperfusion injury
  JOURNAL   Cell Biol Toxicol 40 (1), 31 (2024)
   PUBMED   38767771
  REMARK    GeneRIF: SIRT1 restores mitochondrial structure and function in
            rats by activating SIRT3 after cerebral ischemia/reperfusion
            injury.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 741)
  AUTHORS   Jin,X., Sun,X., Ma,X., Qin,Z., Gao,X., Kang,X., Li,H. and Sun,H.
  TITLE     SIRT1 maintains bone homeostasis by regulating osteoblast
            glycolysis through GOT1
  JOURNAL   Cell Mol Life Sci 81 (1), 204 (2024)
   PUBMED   38700532
  REMARK    GeneRIF: SIRT1 maintains bone homeostasis by regulating osteoblast
            glycolysis through GOT1.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 741)
  AUTHORS   Vaziri,H., Dessain,S.K., Ng Eaton,E., Imai,S.I., Frye,R.A.,
            Pandita,T.K., Guarente,L. and Weinberg,R.A.
  TITLE     hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
  JOURNAL   Cell 107 (2), 149-159 (2001)
   PUBMED   11672523
REFERENCE   7  (residues 1 to 741)
  AUTHORS   Luo,J., Nikolaev,A.Y., Imai,S., Chen,D., Su,F., Shiloh,A.,
            Guarente,L. and Gu,W.
  TITLE     Negative control of p53 by Sir2alpha promotes cell survival under
            stress
  JOURNAL   Cell 107 (2), 137-148 (2001)
   PUBMED   11672522
REFERENCE   8  (residues 1 to 741)
  AUTHORS   Muth,V., Nadaud,S., Grummt,I. and Voit,R.
  TITLE     Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA
            polymerase I transcription
  JOURNAL   EMBO J 20 (6), 1353-1362 (2001)
   PUBMED   11250901
REFERENCE   9  (residues 1 to 741)
  AUTHORS   Imai,S., Armstrong,C.M., Kaeberlein,M. and Guarente,L.
  TITLE     Transcriptional silencing and longevity protein Sir2 is an
            NAD-dependent histone deacetylase
  JOURNAL   Nature 403 (6771), 795-800 (2000)
   PUBMED   10693811
REFERENCE   10 (residues 1 to 741)
  AUTHORS   Schilling,G., Becher,M.W., Sharp,A.H., Jinnah,H.A., Duan,K.,
            Kotzuk,J.A., Slunt,H.H., Ratovitski,T., Cooper,J.K., Jenkins,N.A.,
            Copeland,N.G., Price,D.L., Ross,C.A. and Borchelt,D.R.
  TITLE     Intranuclear inclusions and neuritic aggregates in transgenic mice
            expressing a mutant N-terminal fragment of huntingtin
  JOURNAL   Hum Mol Genet 8 (3), 397-407 (1999)
   PUBMED   9949199
  REMARK    Erratum:[Hum Mol Genet 1999 May;8(5):943]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 16, 2022 this sequence version replaced XP_038954683.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.64061.1,
                                           SRR26643297.53141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..741
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     Protein         1..741
                     /product="NAD-dependent protein deacetylase sirtuin-1
                     isoform 1"
                     /EC_number="2.3.1.286"
                     /note="Sir2alpha; sirtuin 1 ((silent mating type
                     information regulation 2, homolog) 1; NAD-dependent
                     deacetylase sirtuin-1; NAD-dependent protein deacetylase
                     sirtuin-1; NAD-dependent protein deacylase sirtuin-1"
                     /calculated_mol_wt=80586
     Region          248..483
                     /region_name="SIRT1"
                     /note="Eukaryotic group (class1) which includes human
                     sirtuins SIRT1-3 and yeast Hst1-4; and are members of the
                     SIR2 family of proteins, silent information regulator 2
                     (Sir2) enzymes which catalyze NAD+-dependent
                     protein/histone deacetylation. Sir2 proteins...; cd01408"
                     /db_xref="CDD:238699"
     Site            order(257,259..260,267..268,321,339..340,342,357,434,439,
                     460..461,475)
                     /site_type="other"
                     /note="NAD+ binding site [chemical binding]"
                     /db_xref="CDD:238699"
     Site            order(341,357,406,408..412,438..440)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238699"
     Site            order(365,368,389,392)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238699"
     CDS             1..741
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /coded_by="NM_001414959.1:63..2288"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:309757"
                     /db_xref="RGD:1308542"
ORIGIN      
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       61 agceaasaaa paalwreaag aaaasaerea pataaagdgd ngpglrrepr aaddfdddeg
      121 eeedeaaaaa aaaigyrdnl lladeiitng fhscesdddd rashasssdw tprprigpyt
      181 fvqqhlmigt dprtilkdll petipppeld dmtlwqivin ilseppkrkk rkdintieda
      241 vkllqeckki ivltgagvsv scgipdfrsr dgiyarlavd fpdlpdpqam fdieyfrkdp
      301 rpffkfakei ypgqfqpslc hkfialsdke gkllrnytqn idtleqvagi qriiqchgsf
      361 atasclicky kvdceavrgd ifnqvvprcp rcpadeplai mkpeivffge nlpeqfhram
      421 kydkdevdll ivigsslkvr pvalipssip hevpqilinr eplphlhfdv ellgdcdvii
      481 nelchrlgge yaklccnpvk lseitekppr tqkelvhlse lpptplhise dssspertvp
      541 qdssviatlv dqtiknkvdd levsepkscv eeksqevqty rnvesinven pdfkavgsst
      601 gdknertsva etvrkcwpnr lakeqiskrl dgnqylfvpp nryifhgaev ysdseddals
      661 ssscgsnsds gtcqspslee pledeseiee fyngleddad rpecaggsga dggdqeavne
      721 aiamkqeltd vnctpdkseh y
//
