LOCUS       NM_001372090            3184 bp    mRNA    linear   ROD 14-DEC-2022
DEFINITION  Rattus norvegicus sirtuin 1 (Sirt1), mRNA.
ACCESSION   NM_001372090 XM_008772947
VERSION     NM_001372090.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3184)
  AUTHORS   Harchegani AB, Rostami S, Mohsenifar Z, Dafchahi AB, Moghadam FM,
            Jaafarzadeh M, Saraabestan SS and Ranji N.
  TITLE     Anti-apoptotic properties of N-Acetyl cysteine and its effects on
            of Liver X receptor and Sirtuin 1 expression in the liver of rats
            exposed to Lead
  JOURNAL   J Trace Elem Med Biol 74, 127070 (2022)
   PUBMED   36155419
  REMARK    GeneRIF: Anti-apoptotic properties of N-Acetyl cysteine and its
            effects on of Liver X receptor and Sirtuin 1 expression in the
            liver of rats exposed to Lead.
REFERENCE   2  (bases 1 to 3184)
  AUTHORS   Rizk FH, Soliman NA, Abo-Elnasr SE, Mahmoud HA, Abdel Ghafar MT,
            Elkholy RA, ELshora OA, Mariah RA, Amin Mashal SS and El Saadany
            AA.
  TITLE     Fisetin ameliorates oxidative glutamate testicular toxicity in rats
            via central and peripheral mechanisms involving SIRT1 activation
  JOURNAL   Redox Rep 27 (1), 177-185 (2022)
   PUBMED   36047349
  REMARK    GeneRIF: Fisetin ameliorates oxidative glutamate testicular
            toxicity in rats via central and peripheral mechanisms involving
            SIRT1 activation.
REFERENCE   3  (bases 1 to 3184)
  AUTHORS   Deng Y, Zou J, Hong Y, Peng Q, Fu X, Duan R, Chen J and Chen X.
  TITLE     Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive
            Impairment Probably via Downregulating Hippocampal SIRT1 in
            Vascular Dementia Rats
  JOURNAL   Cells 11 (22), 3650 (2022)
   PUBMED   36429082
  REMARK    GeneRIF: Higher Circulating Trimethylamine N-Oxide Aggravates
            Cognitive Impairment Probably via Downregulating Hippocampal SIRT1
            in Vascular Dementia Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3184)
  AUTHORS   Li J, Zeng X, Yang X and Ding H.
  TITLE     Lycopene ameliorates skin aging by regulating the insulin
            resistance pathway and activating SIRT1
  JOURNAL   Food Funct 13 (21), 11307-11320 (2022)
   PUBMED   36226790
  REMARK    GeneRIF: Lycopene ameliorates skin aging by regulating the insulin
            resistance pathway and activating SIRT1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3184)
  AUTHORS   Han HF, Liu SZ, Zhang X, Wei M, Huang X and Yu WB.
  TITLE     Duodenal-jejunal bypass increases intraduodenal bile acids and
            upregulates duodenal SIRT1 expression in high-fat diet and
            streptozotocin-induced diabetic rats
  JOURNAL   World J Gastroenterol 28 (31), 4338-4350 (2022)
   PUBMED   36159018
  REMARK    GeneRIF: Duodenal-jejunal bypass increases intraduodenal bile acids
            and upregulates duodenal SIRT1 expression in high-fat diet and
            streptozotocin-induced diabetic rats.
REFERENCE   6  (bases 1 to 3184)
  AUTHORS   Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK,
            Guarente L and Weinberg RA.
  TITLE     hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
  JOURNAL   Cell 107 (2), 149-159 (2001)
   PUBMED   11672523
REFERENCE   7  (bases 1 to 3184)
  AUTHORS   Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L and
            Gu W.
  TITLE     Negative control of p53 by Sir2alpha promotes cell survival under
            stress
  JOURNAL   Cell 107 (2), 137-148 (2001)
   PUBMED   11672522
REFERENCE   8  (bases 1 to 3184)
  AUTHORS   Muth V, Nadaud S, Grummt I and Voit R.
  TITLE     Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA
            polymerase I transcription
  JOURNAL   EMBO J 20 (6), 1353-1362 (2001)
   PUBMED   11250901
REFERENCE   9  (bases 1 to 3184)
  AUTHORS   Imai S, Armstrong CM, Kaeberlein M and Guarente L.
  TITLE     Transcriptional silencing and longevity protein Sir2 is an
            NAD-dependent histone deacetylase
  JOURNAL   Nature 403 (6771), 795-800 (2000)
   PUBMED   10693811
REFERENCE   10 (bases 1 to 3184)
  AUTHORS   Schilling G, Becher MW, Sharp AH, Jinnah HA, Duan K, Kotzuk JA,
            Slunt HH, Ratovitski T, Cooper JK, Jenkins NA, Copeland NG, Price
            DL, Ross CA and Borchelt DR.
  TITLE     Intranuclear inclusions and neuritic aggregates in transgenic mice
            expressing a mutant N-terminal fragment of huntingtin
  JOURNAL   Hum Mol Genet 8 (3), 397-407 (1999)
   PUBMED   9949199
  REMARK    Erratum:[Hum Mol Genet 1999 May;8(5):943]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000324.1 and CV104479.1.
            
            On Aug 10, 2019 this sequence version replaced XM_008772947.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132305,
                              SAMD00132307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JACYVU010000324.1  21038966-21039118
            154-278             JACYVU010000324.1  21044326-21044450
            279-426             JACYVU010000324.1  21044941-21045088
            427-506             JACYVU010000324.1  21045725-21045804
            507-693             JACYVU010000324.1  21047049-21047235
            694-1248            JACYVU010000324.1  21049048-21049602
            1249-3163           JACYVU010000324.1  21051223-21053137
            3164-3184           CV104479.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..3184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..3184
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /note="sirtuin 1"
                     /db_xref="GeneID:309757"
                     /db_xref="RGD:1308542"
     exon            1..153
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            154..278
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1580
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /EC_number="2.3.1.286"
                     /note="Sir2alpha; sirtuin 1 ((silent mating type
                     information regulation 2, homolog) 1; NAD-dependent
                     deacetylase sirtuin-1; NAD-dependent protein deacylase
                     sirtuin-1"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-1"
                     /protein_id="NP_001359019.1"
                     /db_xref="GeneID:309757"
                     /db_xref="RGD:1308542"
                     /translation="MCLCSGRKAILEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNI
                     DTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLA
                     IMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQIL
                     INREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKEL
                     VHLSELPPTPLHISEDSSSPERTVPQDSSVIATLVDQTIKNKVDDLEVSEPKSCVEEK
                     SQEVQTYRNVESINVENPDFKAVGSSTGDKNERTSVAETVRKCWPNRLAKEQISKRLD
                     GNQYLFVPPNRYIFHGAEVYSDSEDDALSSSSCGSNSDSGTCQSPSLEEPLEDESEIE
                     EFYNGLEDDADRPECAGGSGADGGDQEAVNEAIAMKQELTDVNCTPDKSEHY"
     exon            279..426
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..506
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..693
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..1248
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..3164
                     /gene="Sirt1"
                     /gene_synonym="Sir2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttctgttt cctgtgggat acctgacttc agatcaagag atggtattta tgctcgcctt
       61 gctgtggact tcccggatct cccagatcct caagccatgt tcgatattga gtattttaga
      121 aaagacccaa gaccattctt caagtttgca aagaagaaac agcattgaag cattatttgg
      181 ggggaaaaac acacacacaa aatccagcaa ctcagcattc atgagcagct ctgttctata
      241 ccagtatgtg cctgtgcagt ggaaggaaag caattttgga aatatatccc ggacagttcc
      301 agccatctct gtgtcacaaa ttcatagctt tgtcagataa ggaaggaaaa ctacttcgaa
      361 attatactca aaatatagat accttggagc aggttgcagg aatccaaagg atcattcagt
      421 gtcatggttc ctttgcaaca gcatcttgcc tgatttgtaa atacaaagtt gattgtgaag
      481 ctgttcgtgg agatattttt aatcaggtag ttcctcggtg tcctaggtgc ccagctgatg
      541 agccacttgc catcatgaag ccagagattg tcttctttgg tgaaaactta ccagaacagt
      601 ttcatagagc catgaagtat gacaaagatg aagttgacct cctcattgtt attgggtctt
      661 ctctgaaagt aagaccagta gcactaattc caagttctat accccatgaa gtgcctcaaa
      721 tattaataaa tagggaacct ctgcctcatc tacattttga tgtagagctt cttggagact
      781 gcgatgtcat aattaatgag ttgtgtcata ggttaggtgg cgagtatgcc aaactttgtt
      841 gtaaccctgt aaagctttca gaaattactg aaaaacctcc acgaacacaa aaggaattgg
      901 ttcatttatc agagttgcca ccaacacctc ttcatatttc agaagactca agttcacctg
      961 aaagaactgt accacaagac tcttctgtga ttgctacact tgtagaccaa acaataaaga
     1021 acaaagttga cgatttagaa gtatctgaac caaaaagttg tgtggaagaa aaatcacagg
     1081 aagtacagac ttataggaat gttgagagca ttaatgtgga aaacccagat ttcaaggctg
     1141 ttggttccag tactggagac aaaaatgaaa gaacttctgt tgcagaaaca gtgagaaaat
     1201 gctggcctaa tagacttgca aaggagcaga ttagtaagcg tcttgacggt aatcaatact
     1261 tgtttgtacc accaaatcgt tacatatttc atggtgctga ggtatactca gactctgaag
     1321 atgacgcctt atcctctagt tcctgtggca gtaacagtga cagtggcaca tgccagagtc
     1381 caagtttaga agaacccttg gaagatgaaa gtgaaattga agagttctac aatggcttgg
     1441 aagatgatgc tgacagaccg gagtgtgctg gaggatctgg agctgacgga ggggatcaag
     1501 aggcagttaa tgaagctata gccatgaaac aggaattaac agatgtaaac tgtacaccag
     1561 acaaatcaga gcactattga agctgtccag gtacaggaat tgctccacca gcattgggaa
     1621 ctttagcatg tcaaaaatga atgtttactg tgaacttgaa caaggagatc agaaagatgt
     1681 attatttata gactggaaaa tagattgtct tcttggataa tttttaaagt tccatcattt
     1741 ctgtacttta atcagctgtt ggctgacttc atcttccttt caaggttcat ttgtatgata
     1801 cattcgtatg tatataattt cttcgttttt gcctaattga gtttcaacat tttaaagttt
     1861 tcaaaagcca ttggaatgtt aatgtaaagg gaacagctta tctagaccaa agaatggtat
     1921 ttcacacttt tgtttgtaac attgaatagt ttgaaaccct caatttctgt tctgctgaac
     1981 ttttattttt agcacagtta actttttaaa cactggcatt ttccaaaatt tatggcagct
     2041 aactttttaa aatcacaaat gacttgtaat gtgagaagga agtcagcatc gcattgggag
     2101 ctcagagttt gagcatattt attgcatggt tttttgtact tgctgcagac gtggtaatgt
     2161 ccaaacaggc ccctgagact aatctgataa atgatttgga aatgtttcag ttcttctaga
     2221 aactattgtg cctgtctata taggtcccct tagtttgaat atttgccatt gtttaattaa
     2281 atacctatca ctgtggtaga gcctccatag atcttcacca caaatactgc caagatgtga
     2341 atttgaatat gcaaagcctt tctgacccta atgatggtac ttctactggg gagagtgtaa
     2401 tattttggac tgctgttttt ccattaacaa ggaagcaaag gtctcttaat taaagttcca
     2461 aagtaataag attaattgta actcaaccag aaagtacatt gtctcctgtt gaggatttgg
     2521 tgtaatgtat cccaagggat gtgtattatg gagatgaata caaatccaat agtcaatgaa
     2581 actagttcct atttatttaa aagcttagct tgccttaaaa ctagggatca attttctgaa
     2641 ctgcagaaac ttttagcctt tcaaacagtt cacacctcag aaggtcagta ttttacagac
     2701 ttctttggaa cattgccccc aaatttaaat attcacgttg gtttagtatt tattacaaaa
     2761 aaatgatttg aaatatagct gttctttatg cataaaatac ccagctagga ccgttactgc
     2821 cagaggataa agtattaagt agctcatttc cctacctaaa atattctcaa tctgaattta
     2881 tttggctaca ctaaagaatg cagtatattt agttttccat ttgcatgatg tgtttgtgct
     2941 atagacaata ttttaaattg aaaaatttgt tttaaattat ttttacagtg aagactgttt
     3001 tcagctcttt ttatattgta catagacttt tatgtaatct ggcatatgtt ttgtagaccg
     3061 tttaatgact ggattatctt cctccaactt ttgaaataca aaaacagtgt tttatacttg
     3121 tatcttgttt taaagtctta tattaaaatt gtcatttgac ttttaaaaaa aaaaaaaaaa
     3181 aaaa
//
