LOCUS       NM_013016               3856 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus signal-regulatory protein alpha (Sirpa), mRNA.
ACCESSION   NM_013016
VERSION     NM_013016.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3856)
  AUTHORS   Zhang,Y. and Hao,J.
  TITLE     Anti-tumor effect of PTEN and its effect on inhibition of the bone
            tumor through the CD47-SIRPalpha signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 40-44 (2023)
   PUBMED   38279488
  REMARK    GeneRIF: Anti-tumor effect of PTEN and its effect on inhibition of
            the bone tumor through the CD47-SIRPalpha signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3856)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (bases 1 to 3856)
  AUTHORS   Zhu,D., Pan,C., Li,L., Bian,Z., Lv,Z., Shi,L., Zhang,J., Li,D.,
            Gu,H., Zhang,C.Y., Liu,Y. and Zen,K.
  TITLE     MicroRNA-17/20a/106a modulate macrophage inflammatory responses
            through targeting signal-regulatory protein alpha
  JOURNAL   J Allergy Clin Immunol 132 (2), 426-36 (2013)
   PUBMED   23562609
REFERENCE   4  (bases 1 to 3856)
  AUTHORS   Zen,K., Guo,Y., Bian,Z., Lv,Z., Zhu,D., Ohnishi,H., Matozaki,T. and
            Liu,Y.
  TITLE     Inflammation-induced proteolytic processing of the SIRPalpha
            cytoplasmic ITIM in neutrophils propagates a proinflammatory state
  JOURNAL   Nat Commun 4, 2436 (2013)
   PUBMED   24026300
REFERENCE   5  (bases 1 to 3856)
  AUTHORS   Kajiho,Y., Harita,Y., Kurihara,H., Horita,S., Matsunaga,A.,
            Tsurumi,H., Kanda,S., Sugawara,N., Miura,K., Sekine,T., Hattori,S.,
            Hattori,M. and Igarashi,T.
  TITLE     SIRPalpha interacts with nephrin at the podocyte slit diaphragm
  JOURNAL   FEBS J 279 (17), 3010-3021 (2012)
   PUBMED   22747997
  REMARK    GeneRIF: In the glomeruli of CNS patients carrying mutations in
            NPHS1, where SD formation is disrupted, the expression of SIRPalpha
            as well as Neph1 and nephrin was significantly decreased,
            indicating that SIRPalpha is closely associated with the nephrin
            complex
REFERENCE   6  (bases 1 to 3856)
  AUTHORS   Ochi,F., Matozaki,T., Noguchi,T., Fujioka,Y., Yamao,T., Takada,T.,
            Tsuda,M., Takeda,H., Fukunaga,K., Okabayashi,Y. and Kasuga,M.
  TITLE     Epidermal growth factor stimulates the tyrosine phosphorylation of
            SHPS-1 and association of SHPS-1 with SHP-2, a SH2
            domain-containing protein tyrosine phosphatase
  JOURNAL   Biochem Biophys Res Commun 239 (2), 483-487 (1997)
   PUBMED   9344856
REFERENCE   7  (bases 1 to 3856)
  AUTHORS   Sano,S., Ohnishi,H., Omori,A., Hasegawa,J. and Kubota,M.
  TITLE     BIT, an immune antigen receptor-like molecule in the brain
  JOURNAL   FEBS Lett 411 (2-3), 327-334 (1997)
   PUBMED   9271230
REFERENCE   8  (bases 1 to 3856)
  AUTHORS   Ohnishi,H., Kubota,M. and Sano,S.
  TITLE     BIT (Bit) maps to mouse chromosome 2
  JOURNAL   Genomics 40 (3), 504-506 (1997)
   PUBMED   9073522
REFERENCE   9  (bases 1 to 3856)
  AUTHORS   Fujioka,Y., Matozaki,T., Noguchi,T., Iwamatsu,A., Yamao,T.,
            Takahashi,N., Tsuda,M., Takada,T. and Kasuga,M.
  TITLE     A novel membrane glycoprotein, SHPS-1, that binds the
            SH2-domain-containing protein tyrosine phosphatase SHP-2 in
            response to mitogens and cell adhesion
  JOURNAL   Mol Cell Biol 16 (12), 6887-6899 (1996)
   PUBMED   8943344
REFERENCE   10 (bases 1 to 3856)
  AUTHORS   Ohnishi,H., Kubota,M., Ohtake,A., Sato,K. and Sano,Si.
  TITLE     Activation of protein-tyrosine phosphatase SH-PTP2 by a
            tyrosine-based activation motif of a novel brain molecule
  JOURNAL   J Biol Chem 271 (41), 25569-25574 (1996)
   PUBMED   8810330
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013016.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U62328.1, D38468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               JAXUCZ010000003.1  137273554-137273868
            316-675             JAXUCZ010000003.1  137289742-137290101
            676-990             JAXUCZ010000003.1  137294612-137294926
            991-1326            JAXUCZ010000003.1  137295328-137295663
            1327-1440           JAXUCZ010000003.1  137297560-137297673
            1441-1465           JAXUCZ010000003.1  137300180-137300204
            1466-1505           JAXUCZ010000003.1  137306934-137306973
            1506-3856           JAXUCZ010000003.1  137308929-137311279
FEATURES             Location/Qualifiers
     source          1..3856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..3856
                     /gene="Sirpa"
                     /gene_synonym="Bit; Ptpns1; SHPS-1"
                     /note="signal-regulatory protein alpha"
                     /db_xref="GeneID:25528"
                     /db_xref="RGD:3449"
     exon            1..315
                     /gene="Sirpa"
                     /gene_synonym="Bit; Ptpns1; SHPS-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1763
                     /gene="Sirpa"
                     /gene_synonym="Bit; Ptpns1; SHPS-1"
                     /EC_number="3.1.3.48"
                     /note="Protein tyrosine phosphatase, non-receptor type
                     substrate 1 (SHP substrate 1); tyrosine-protein
                     phosphatase non-receptor type substrate 1; sirp-alpha-1;
                     inhibitory receptor SHPS-1; macrophage fusion receptor;
                     signal-regulatory protein alpha-1; CD172 antigen-like
                     family member A; macrophage membrane protein MFP150; brain
                     Ig-like molecule with tyrosine-based activation motifs;
                     Brain immunoglobulin like protein with tyrosine - based
                     activation motifs"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     substrate 1 precursor"
                     /protein_id="NP_037148.3"
                     /db_xref="GeneID:25528"
                     /db_xref="RGD:3449"
                     /translation="MEPAGPAPGRLGPLLFCLLLSASCFCAGASGKELKVTQADKSVS
                     VAAGDSATLNCTVSSLTPVGPIKWFKGEGQNRSPIYSFIGGEHFPRITNVSDATKRNN
                     MDFSICISNVTPEDAGTYYCVKFQKGIVEPDTEIKSGGGTTLYVLAKPSSPEVSGPDS
                     RGSPGQTVNFTCKSYGFSPRNITLKWLKDGKELSHLETTISSKSNVSYNISSTVSVKL
                     SPEDIHSRVICEVAHVTLEGRPLNGTANFSNIIRVSPTLKITQQPLTPASQVNLTCQV
                     QKFYPKALQLNWLENGNLSRTDKPEHFTDNRDGTYNYTSLFLVNSSAHREDVVFTCQV
                     EHDSQPAITENHTVRAFAHSSSGGSMETIPDNNAYYNWNVFIGVGVACALLVVLLMAA
                     LYLLRIKQKKAKGSTSSTRLHEPEKNAREITQIQDTNDINDITYADLNLPKEKKPAPR
                     VPEPNNHTEYASIETGKLPRPEDTLTYADLDMVHLNRAQPTPKPEPSFSEYASVQVQR
                     K"
     exon            316..675
                     /gene="Sirpa"
                     /gene_synonym="Bit; Ptpns1; SHPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..990
                     /gene="Sirpa"
                     /gene_synonym="Bit; Ptpns1; SHPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1326
                     /gene="Sirpa"
                     /gene_synonym="Bit; Ptpns1; SHPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1440
                     /gene="Sirpa"
                     /gene_synonym="Bit; Ptpns1; SHPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1465
                     /gene="Sirpa"
                     /gene_synonym="Bit; Ptpns1; SHPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1505
                     /gene="Sirpa"
                     /gene_synonym="Bit; Ptpns1; SHPS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..3856
                     /gene="Sirpa"
                     /gene_synonym="Bit; Ptpns1; SHPS-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctggctcc ctcgggtccg ctcccctttc ccgccggcct ggcccggcgt cacgctcccg
       61 gagtctcccc gctcggcggc gtctcattgt gggagggggt cagatcaccc cgccgggcgg
      121 tggcgctggg gggcagcgga gggggagggg ccttagtcgt tcgcccgcgc cgcccgcccg
      181 cctgccgagc gcgctcaccg ccgatctccc tccttgctct gcagccgcgg cccatggagc
      241 ccgccggccc ggcccctggc cgcctagggc cgctgctgtt ctgcctgctg ctctccgcgt
      301 cctgtttctg tgcaggagcc agcgggaaag aactgaaggt gactcaggct gacaaatcag
      361 tgtctgttgc tgctggagat tcggccactc tgaactgcac tgtgtcctcc ctgacgcctg
      421 tgggacccat taagtggttc aaaggagaag ggcaaaatcg gagcccgatc tacagtttca
      481 taggaggaga acactttcct cgaattacaa atgtttcaga tgctactaag agaaacaata
      541 tggactttag catctgtatc agtaatgtca ccccagaaga tgctggcacc tactactgtg
      601 tgaagttcca gaaaggaata gtagagcctg acacagaaat taaatctgga gggggaacaa
      661 cgctctatgt actcgccaaa ccttcttcac cggaagtatc gggcccagac tccaggggct
      721 ctcctggaca gacagtgaac ttcacctgca agtcttacgg cttctctccc cggaatatca
      781 ccctgaagtg gctcaaagat gggaaagaac tctcccattt ggagaccacc atctccagta
      841 aaagcaatgt ctcctacaac atctccagca cagtcagcgt gaaactaagc cccgaggaca
      901 ttcattctcg ggtcatctgc gaggtagccc acgtcacctt ggaaggacgc ccgcttaatg
      961 ggaccgctaa cttttctaac atcatccgag tttcacccac cttgaagatc acccaacagc
     1021 ccctgacgcc cgcgagccag gtgaacctca cctgccaggt gcagaagttc taccccaagg
     1081 ctctccagct gaactggctg gagaatggaa acttatcacg gacggacaag cccgagcatt
     1141 tcacagacaa cagggatggg acctataatt acacaagcct gttcctggtg aactcatctg
     1201 ctcacagaga ggatgtggta ttcacgtgcc aggtggagca tgacagtcag ccagcgatca
     1261 ccgaaaacca taccgtgcgg gcatttgccc actcgagtag tggaggcagc atggaaacca
     1321 tccctgataa taatgcttac tacaactgga acgtcttcat cggtgtgggt gtggcgtgtg
     1381 ctttgctagt agtcctgctg atggctgccc tctacctcct ccgaatcaaa cagaagaaag
     1441 ccaagggctc aacttcttcc acacggttgc acgagcccga gaagaatgcc agggaaataa
     1501 cccagatcca ggacacaaat gacatcaacg acatcacata cgcagacctg aatctgccca
     1561 aagagaagaa gcccgccccc cgggtccccg agcccaacaa ccacacagaa tatgcaagca
     1621 ttgagacagg caaactgcct aggccagagg ataccctcac ctatgctgac ctggacatgg
     1681 tccacctcaa ccgggcacag ccaaccccca agcctgagcc atccttctca gagtatgcca
     1741 gtgtccaagt ccagaggaag tgaatggggc tgtggttggc tctaggcccc atccccacaa
     1801 gttttcttgt cctacatgga gtggccatga tgaggacaac cagccagcca gccctgtctc
     1861 cagaaggcca ggtggcacag gtcctaggac caggggtaag ggtggcttct gtcttccctc
     1921 cgtggctctc caacacctct tggacaccca tgtccccttc ttctggagct gggtgttgca
     1981 gaaccagagg gggaactgga gaaagctgcc tagaatccaa gaagcgttgt gcctcagccc
     2041 atcacactgg gtctggatcc tggtcttggc aacccccagg ttgcttcctt gatgctccag
     2101 cgcctggtct tctgtgtgga gaagagttca ccatctccat ccaacttgag cttcggggcc
     2161 agactccctt tagatcagac cgccccatgt gtggaagaac tacaccagga gtcaacaagt
     2221 tttcagccaa cagtgctagc ctccccacct cccaggctga cgagccctga ggagaaggaa
     2281 ccctcttccc ctagaccagc agagactccc tgggcatgtt cagtgtggcc ccacccttcc
     2341 agtcccagct cgcttcctcc agctagcact aactcaacag cattgctctg tggacgcctg
     2401 taaattattg agaaatgtga actgtgcagt cttgaagcta aggtgttaga aaatttgatt
     2461 tgtgctgttt agttgttgtt gggtttcttt tcttttcttt ttttttcttc ctttttcttt
     2521 cttctttttt tcttttcccc cttaaaacaa cagcagcagc atcttggctc tttgtcatgt
     2581 gttgaatggt tgggtcttgt gaagtctgag gtctaacagt ttattgtccc ggaaggattt
     2641 tcttatagca gaaacagatt ttttttccaa ttcccagcac cctgaggacc aagaaggatc
     2701 cctctgttgt cattttcagc actcagcgtc actgggatga gccaggctct gtccccacag
     2761 ctggcccttg gcctccatgg ctactgtggt aagtgcagcc ttgtctaatc cagtgctgac
     2821 gttggccatt cctcattgag gagagaaggt cagtgacaaa ctcacaagca ctgcagaggc
     2881 atacggagag aagggacgct cggccagcac ccggtattcc agcgctctga ggtaatcagt
     2941 gcaaggagtc tgttattacc atcagacctc agcaggatca tactggaaca gaacctgatc
     3001 atacctgtga caacacagct gtgagccagg gcaaaccacc ccactgtccc agagtctggg
     3061 cagaggctct gacccccacc cttcaaactg gatgtcgggg cctggctggg cccaatggca
     3121 agcagatgtt gcaaccctag ctatctggtc ttaacatgca gctcagtaag ttgaggcgct
     3181 aatgtccccc catgccgggg gattcctggt tccggctctt caagtaagaa gctgattcaa
     3241 cctgcctgtt tctgtaggtg tgacagggat gtcaggaaaa cagccaggac tcatctctat
     3301 agggctggtg acctgatact tcccataaag gcatccagga gttagctgac ccaatagtca
     3361 gagttgacct cactggccta gcaaaccgta acttgtcttt ggcccagcca tggtcttggg
     3421 ctgtcttcta attccaaagg gttggtaggt aaagatccat cctcttcccc tctgccaaga
     3481 gacatcacgt gtgtacacac acacatgcgc gcgcgcacac acacacacac acacacacac
     3541 acacacacac acacgggtgt ataggtgagt taaaaggatg tcctcgctga catcctaatt
     3601 ttgtcttaag tttttttgga gggagaaagg aaagaggcag ggaagatacg tagctctagc
     3661 tttagtcagg cagcctgggg ggatccccaa gcctatgtat ggaaccctgg tacgaaagcg
     3721 ccctgtgagg agtgggattt cagttttatc tgtagaccag atgagaagga gaaaggcccc
     3781 attttgtaca tagttgcaac ttaaaatttt tggcttgcaa aatatttttg taataaagat
     3841 ttctgggtaa caatga
//
