LOCUS       NM_001389245            6189 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus signal-induced proliferation-associated 1 like 1
            (Sipa1l1), transcript variant 2, mRNA.
ACCESSION   NM_001389245
VERSION     NM_001389245.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6189)
  AUTHORS   Zhi,W.J., Peng,R.Y., Li,H.J., Zou,Y., Yao,B.W., Wang,C.Z.,
            Liu,Z.H., Gao,X.H., Xu,X.P., Dong,J., Zhao,L., Zhou,H.M., Wang,L.F.
            and Hu,X.J.
  TITLE     Microwave radiation leading to shrinkage of dendritic spines in
            hippocampal neurons mediated by SNK-SPAR pathway
  JOURNAL   Brain Res 1679, 134-143 (2018)
   PUBMED   29180226
  REMARK    GeneRIF: The microwave radiation led to shrinkage and even loss of
            dendritic spines in hippocampus by SNK-SPAR pathway, resulting in
            the cognitive impairments.
REFERENCE   2  (bases 1 to 6189)
  AUTHORS   Chutabhakdikul,N. and Surakul,P.
  TITLE     Prenatal stress increased Snk Polo-like kinase 2, SCF beta-TrCP
            ubiquitin ligase and ubiquitination of SPAR in the hippocampus of
            the offspring at adulthood
  JOURNAL   Int J Dev Neurosci 31 (7), 560-567 (2013)
   PUBMED   23850969
  REMARK    GeneRIF: Prenatal stress increased spar in thr hippocampus of the
            offspring at adulthood in rats
REFERENCE   3  (bases 1 to 6189)
  AUTHORS   Chen,Y., Yuanxiang,P., Knopfel,T., Thomas,U. and Behnisch,T.
  TITLE     Hippocampal LTP triggers proteasome-mediated SPAR degradation in
            CA1 neurons
  JOURNAL   Synapse 66 (2), 142-150 (2012)
   PUBMED   21987493
  REMARK    GeneRIF: Long-term potentiation triggers downregulation of SPAR
            requiring ubiquitin proteasome system and NMDA receptor activation
            but not cyclin-dependent kinase (CDK)5.
REFERENCE   4  (bases 1 to 6189)
  AUTHORS   Lee,K.J., Lee,Y., Rozeboom,A., Lee,J.Y., Udagawa,N., Hoe,H.S. and
            Pak,D.T.
  TITLE     Requirement for Plk2 in orchestrated ras and rap signaling,
            homeostatic structural plasticity, and memory
  JOURNAL   Neuron 69 (5), 957-973 (2011)
   PUBMED   21382555
REFERENCE   5  (bases 1 to 6189)
  AUTHORS   Gong,X., Lu,X., Zhan,L., Sui,H., Qi,X., Ji,Z., Niu,X. and Liu,L.
  TITLE     Role of the SNK-SPAR pathway in the development of Alzheimer's
            disease
  JOURNAL   IUBMB Life 62 (3), 214-221 (2010)
   PUBMED   20146300
  REMARK    GeneRIF: the SNK-SPAR pathway may possibly play a crucial role in
            Amyloid beta-induced excitotoxic damage in the central nervous
            system by regulating synaptic stability.
REFERENCE   6  (bases 1 to 6189)
  AUTHORS   Noda,Y., Horikawa,S., Furukawa,T., Hirai,K., Katayama,Y., Asai,T.,
            Kuwahara,M., Katagiri,K., Kinashi,T., Hattori,M., Minato,N. and
            Sasaki,S.
  TITLE     Aquaporin-2 trafficking is regulated by PDZ-domain containing
            protein SPA-1
  JOURNAL   FEBS Lett 568 (1-3), 139-145 (2004)
   PUBMED   15196935
  REMARK    GeneRIF: SPA-1 directly binds to AQP2 and regulates at least in
            part AQP2 trafficking
REFERENCE   7  (bases 1 to 6189)
  AUTHORS   Pak,D.T. and Sheng,M.
  TITLE     Targeted protein degradation and synapse remodeling by an inducible
            protein kinase
  JOURNAL   Science 302 (5649), 1368-1373 (2003)
   PUBMED   14576440
  REMARK    GeneRIF: serum-inducible kinase bound to and phosphorylated
            spine-associated Rap guanosine triphosphatase activating protein
            (SPAR), a postsynaptic actin regulatory protein, leading to
            degradation of SPAR
REFERENCE   8  (bases 1 to 6189)
  AUTHORS   Roy,B.C., Kohu,K., Matsuura,K., Yanai,H. and Akiyama,T.
  TITLE     SPAL, a Rap-specific GTPase activating protein, is present in the
            NMDA receptor-PSD-95 complex in the hippocampus
  JOURNAL   Genes Cells 7 (6), 607-617 (2002)
   PUBMED   12059963
  REMARK    GeneRIF: findings suggest that SPAL may be involved in the
            NMDA-mediated organization of cytoskeletal networks and signal
            transduction
REFERENCE   9  (bases 1 to 6189)
  AUTHORS   Pak,D.T., Yang,S., Rudolph-Correia,S., Kim,E. and Sheng,M.
  TITLE     Regulation of dendritic spine morphology by SPAR, a
            PSD-95-associated RapGAP
  JOURNAL   Neuron 31 (2), 289-303 (2001)
   PUBMED   11502259
REFERENCE   10 (bases 1 to 6189)
  AUTHORS   Deguchi,M., Hata,Y., Takeuchi,M., Ide,N., Hirao,K., Yao,I.,
            Irie,M., Toyoda,A. and Takai,Y.
  TITLE     BEGAIN (brain-enriched guanylate kinase-associated protein), a
            novel neuronal PSD-95/SAP90-binding protein
  JOURNAL   J Biol Chem 273 (41), 26269-26272 (1998)
   PUBMED   9756850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2728258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                JAXUCZ010000006.1  107570638-107570695
            59-119              JAXUCZ010000006.1  107571207-107571267
            120-186             JAXUCZ010000006.1  107632972-107633038
            187-253             JAXUCZ010000006.1  107662417-107662483
            254-314             JAXUCZ010000006.1  107706024-107706084
            315-2108            JAXUCZ010000006.1  107738492-107740285
            2109-2239           JAXUCZ010000006.1  107753505-107753635
            2240-2428           JAXUCZ010000006.1  107757695-107757883
            2429-2603           JAXUCZ010000006.1  107770001-107770175
            2604-2707           JAXUCZ010000006.1  107779152-107779255
            2708-2865           JAXUCZ010000006.1  107782218-107782375
            2866-3439           JAXUCZ010000006.1  107789957-107790530
            3440-3714           JAXUCZ010000006.1  107791102-107791376
            3715-3984           JAXUCZ010000006.1  107795988-107796257
            3985-4131           JAXUCZ010000006.1  107809598-107809744
            4132-4256           JAXUCZ010000006.1  107812756-107812880
            4257-4375           JAXUCZ010000006.1  107814587-107814705
            4376-4818           JAXUCZ010000006.1  107817167-107817609
            4819-5058           JAXUCZ010000006.1  107828172-107828411
            5059-5224           JAXUCZ010000006.1  107829177-107829342
            5225-5471           JAXUCZ010000006.1  107834485-107834731
            5472-5618           JAXUCZ010000006.1  107837878-107838024
            5619-5733           JAXUCZ010000006.1  107844278-107844392
            5734-5815           JAXUCZ010000006.1  107847074-107847155
            5816-6189           JAXUCZ010000006.1  107847787-107848160
FEATURES             Location/Qualifiers
     source          1..6189
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..6189
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /note="signal-induced proliferation-associated 1 like 1"
                     /db_xref="GeneID:246212"
                     /db_xref="RGD:708497"
     exon            1..58
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            59..119
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            120..186
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            187..253
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            254..314
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            315..2108
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     CDS             611..5959
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /note="isoform 2 is encoded by transcript variant 2;
                     spine-associated Rap guanosine triphosphatase (GTPase)
                     activating protein (GAP); signal-induced
                     proliferation-associated 1-like protein 1; SIPA1-like
                     protein 1; SPA-1-like protein p1294; spine-associated Rap
                     GTPase-activating protein; SPA-1 like protein"
                     /codon_start=1
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform 2"
                     /protein_id="NP_001376174.1"
                     /db_xref="GeneID:246212"
                     /db_xref="RGD:708497"
                     /translation="MTSLKRSQTERPVTADRASVVSTDGTPKVHTDDFYMRRFRSQNG
                     SLGSSVMAAVGPPRSEGPHHITSTPGVPKMGVRARIADWPPRKENVKESSRSSQEIET
                     SSCLESLSSKGSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTGPAESMDSRFLMPEAYP
                     SSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKSGPSLHREYGSTSSIDKQGTS
                     GESFFGLLKGYKDDRADRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFK
                     EREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHY
                     DVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDL
                     NSKGSLGMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESTSFESA
                     LSSHCTNAGVAVLEVPKESLMLHLDRVRRYTVEHVDLGAYYYRKCFYQKEHWNYFGAD
                     ENLGPVAVSIRREKPEDMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTAR
                     GLPLKEVLEHVIPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQST
                     EEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEI
                     MFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVR
                     AHNPCTESVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKS
                     EKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSM
                     GAIVWAVRAKDYNKAMEFDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSSDSSL
                     KIFYERGECISVESFMSSEDIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEG
                     IVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDD
                     CTPRRSCSETYRMPVMEYKMNEGVSYEYKFPFRSNNKWQRNAGKGAHSPQVPSQLQSP
                     MTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQC
                     RNSPSNLSSSSETGSGGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSW
                     QRSEDSLADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSS
                     HSSSNTLSSNASSAHSDEKWYDGDRTESDLNSYNYLQGTSADSGIDTASYGLSHGSTA
                     SLGASTSSPRSGPGKEKVAPLWHSSSEVLSLADRTLETEGHGMDRKTESSLSLDIHSK
                     SQGGSSPLTRENSTFSINDATSHTSTMSSRHSASPVVFSSARSSPKEELHPTTSSQLA
                     PSFSSSSSSSSGPRTFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAH
                     TRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKNFKFHGLSSPQSPFPST
                     PTSRRALHRTLSDESIYSSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRP
                     SYTLGMKSLHGEFSASDSSLTDIQETRRQPIPDPGLMPLPDTASDLDWSNLVDAAKAY
                     EVQRASFFAASDENHRPLSAASNSDQLEEQALVQMKSYSSKDSSPTLASKVDQLEGML
                     KMLREDLKKEKEDKAHLQAEVEHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS"
     exon            2109..2239
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2428
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2603
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2707
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2865
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3439
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3714
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..3984
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            3985..4131
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            4132..4256
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            4257..4375
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            4376..4818
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            4819..5058
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5059..5224
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5225..5471
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5472..5618
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5619..5733
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5734..5815
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5816..6189
                     /gene="Sipa1l1"
                     /gene_synonym="Spa-1; Spa1; SPAL; Spar"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaccgccg gcaactttgt gagcgagttc agtacgtgcg tgagcgagtg agcggaaagg
       61 agagcgcgcg gacgacgcgc cccggacgcg cggcagcacc gggaagccca ggccaagcga
      121 tttcgggaga ttgccacaat ttggactcac aagcaagatt cactccaagc tttcagaggg
      181 catgaggtac ctttcagatg gttgctggct gctcagaaaa ctgctgtagg gaaactgcaa
      241 gtagtaccag gaggtcatgt gtcattagtg tggatgctgc tgtcttacgt ctgtggtcat
      301 ggcaccagaa tacaggggag catgggatta tggcaaccac agagccccag tgatgcaagt
      361 tctattcagt cttttctgaa ggaagcctgc tgttagagca caggaactgt tgtggattac
      421 aatgtttgaa agatacgggt tctcagtggt ctgaaaacac ggcatcattt aaccttttaa
      481 atgacaaggc ttaagatctc aacactactg ctgtattttc tggaagccat tctctaaagc
      541 aaaagtgcac atttaaaatg caaacatggt gatcctttct ccagggattt aagtgatcac
      601 tttttacgtc atgaccagct tgaagaggtc gcagaccgaa aggcctgtca ctgctgacag
      661 agcctctgtt gtcagcacag atggcacccc caaagttcac actgatgatt tctacatgcg
      721 tcgcttccgg tcccaaaatg gcagcttagg atcatcagtc atggctgcag tagggccccc
      781 tcgaagtgaa ggtcctcacc atataacctc aacccccgga gtccccaaga tgggggttag
      841 ggcaagaatt gcagattggc ctccaagaaa ggaaaatgta aaagaatcta gccgttcaag
      901 ccaggaaata gaaacctcaa gttgccttga gagcctgtcc tccaaaggca gtcctgtgag
      961 tcaggggagt tctgttagcc tcaattccaa tgactcagcc atgctgaaga gcatccagaa
     1021 caccctgaag aacaagacgg ggccagcgga gagcatggac tcgagattcc tcatgcctga
     1081 agcctacccc agctccccca ggaaagccct tcgccgaatc cgtcagcgta gcaacagtga
     1141 tatcaccata agtgagcttg atgtggatag ttttgatgaa tgtatctccc caacctacaa
     1201 gtcggggcca tcattgcaca gggaatatgg tagcacatct tcaatcgaca agcaggggac
     1261 atccggagaa agcttcttcg gtttgttaaa gggctataaa gacgacagag ctgaccgagg
     1321 tccaactcca accaaactca gtgacttcct catcactggt gggggcaagg gttctggttt
     1381 ctccttggat gtgatcgatg gacccatctc acagagagag aacctcaggc tattcaagga
     1441 aagggaaaaa ccactcaagc gacgctctaa gtctgaaact ggagactcat ccatttttcg
     1501 taaattacgc aatgccaaag gtgaagaact cgggaagtca tcagaccttg aagacaacag
     1561 atcagaggat tctgtgaggc cctggacatg tccaaagtgc tttgcccact atgatgtcca
     1621 gagcatattg tttgacttga atgaagccat tatgaacagg cataatgtga ttaagaggag
     1681 aaacaccaca acgggagctt ccgcagccgc tgtggcgtcc ttagtctcgg gacctttgtc
     1741 tcactcagcc agcttcagct ctcctatggg cagcacagag gacctcaatt ccaaaggaag
     1801 cctcggcatg gaccagggag atgacaagag caatgaactc gtcatgagct gtccgtactt
     1861 tcggaatgag attgggggag aaggtgagag gaaaatcagc ctgtccaagt ccaattctgg
     1921 ctcattcagt gggtgtgaga gcacgtcctt tgagtctgcc ctcagctctc actgcacaaa
     1981 cgcaggagtg gcggttctcg aagtgcccaa ggagagcttg atgctgcatc tagacagagt
     2041 gagacggtac actgtggagc acgtggatct tggagcatac tattacagga agtgcttcta
     2101 ccaaaaggaa cactggaact attttggggc tgatgaaaac ctcggtccag tggctgtgag
     2161 cattcgaagg gaaaaaccag aagacatgaa ggaaaatgga tctccctaca actaccgaat
     2221 aatttttaga actagtgagc tcatgacact gagagggtct gtcctggagg atgccattcc
     2281 ctccacagcc aagcactcga cagccagagg attgccgctg aaagaggtgc tggaacatgt
     2341 gatcccagag ctcaacgtgc agtgcctgcg tttggccttc aacacgccca aagtcacgga
     2401 gcagcttatg aaactggacg agcaagggct gaactatcag cagaaagtag gcatcatgta
     2461 ctgcaaagca ggccagagca ccgaggagga gatgtacaat aatgagtccg ctggcccggc
     2521 ctttgaggaa tttcttcagc tactgggaga gcgagttcgc ctaaaaggat ttgaaaagta
     2581 tcgtgcgcag ctcgacacca aaactgactc cactggaacc cactctctgt acacaaccta
     2641 caaagactat gagataatgt tccacgtctc caccatgctg ccctacacac ctaacaacaa
     2701 gcaacagctc ctgaggaagc ggcacattgg gaatgacatt gtgacaatag ttttccagga
     2761 gcctggagca caaccattta gcccgaaaaa catccgatct cactttcagc atgtttttgt
     2821 cattgtccgg gctcacaacc cctgcactga gagtgtctgt tacagtgtgg cagtcaccag
     2881 gtccagagat gtgccttctt ttggacctcc catccctaaa ggggtcacct tccccaagtc
     2941 aaacgtgttc agggacttcc ttttggccaa agtgattaat gcagaaaacg ctgctcataa
     3001 atcagagaag ttcagggcca tggcaacaag gacccgccag gaatacctga aagatctggc
     3061 agaaaagaat gtcaccaaca cacctattga cccttctggc aagtttccat ttatttctct
     3121 ggcttctaag aagaaggaaa agtctaagcc ttacccagga gctgagctca gtagcatggg
     3181 ggccattgtg tgggcagtcc gggccaaaga ctacaacaag gccatggaat tcgactgcct
     3241 ccttggaatc tccaatgagt tcatcgtcct cattgagcag gaaacaaaga gcgtggtttt
     3301 caattgctcc tgcagagatg tgatagggtg gacttccagc gacagcagcc ttaagatctt
     3361 ctatgagcgt ggagaatgca tttctgtgga gagcttcatg agcagtgaag atatcaaaga
     3421 aattgtcaaa aggctgcagt ttgtttcaaa aggttgtgaa tcagtggaga tgacgctgcg
     3481 aagaaatggg ctaggccagc ttggcttcca tgtcaactat gagggcatcg tggcggatgt
     3541 agaaccctat ggctatgcat ggcaagcagg tttgaggcag ggcagccgcc tggtggagat
     3601 ctgcaaggtg gcagtggcca ccctgagcca tgaacagatg atcgatctct tgagaacgtc
     3661 agtcacagtg aaagttgtca ttatccctcc ccatgatgac tgcacccctc ggaggagttg
     3721 ctcagaaacc taccgcatgc cagtgatgga gtacaagatg aatgaaggcg tttcctatga
     3781 gtacaagttt cccttccgga gtaacaacaa atggcagcgt aatgccggca agggtgccca
     3841 ctcgccccag gttccatcgc agctgcagag ccccatgact tcacggctga atgctgggaa
     3901 gggagatgga aagatgcccc ctccagaaag agccgccaac atccctcgaa gcatctccag
     3961 tgatgggcgc ccactggaaa ggaggctgtc tccgggttcg gacatctatg tgacagtctc
     4021 atccatggct ttggcgagat cccagtgccg taactccccc agcaacttgt catcgtccag
     4081 cgagactggc tctgggggtg gcacttacag acaaaaatcc atgcctgaag ggtttggagt
     4141 gagccgaaga tccccagctt ccatcgacag gcaaaacacc cagtcggata ttggtggcag
     4201 tggaaaatcc acacccagct ggcagagaag tgaggacagc cttgccgacc agatggagcc
     4261 tacatgccat ctcccagcag tatctaaggt actgcctgct ttccgagaga gccccagtgg
     4321 gaggttgatg cggcaggatc ccgtggttca cttgtctcca aacaagcaag gccattctga
     4381 cagccactac tccagccact ccagcagcaa cactctgtcc agcaacgcct cgagtgccca
     4441 cagtgacgag aagtggtacg atggagaccg caccgagtcc gacctcaaca gctataacta
     4501 cctacagggc acatctgctg acagcggcat cgacaccgcc tcatacggcc tcagccatgg
     4561 cagcacggcc tccctgggag cctccacatc ctcacctcgt tcagggccag gcaaagagaa
     4621 ggtggcaccc ctgtggcaca gctccagtga ggtgctctcc ctggcagatc ggaccttaga
     4681 gactgagggc catggcatgg acaggaaaac agagtcctcc ctgagcctgg acatccacag
     4741 caagagccaa ggcggttcaa gcccgctgac aagggagaac agcaccttca gcataaatga
     4801 tgccacatct cacaccagta ccatgagctc ccgacactct gccagcccag tggtgttctc
     4861 cagtgccaga agttcaccca aagaggagct tcaccccacc acgtcctccc agctcgcacc
     4921 ttccttctct tcctcttcct catcttcctc tggacctagg actttctatc cccgccaggg
     4981 cgccactagc aaatacctga ttggatggaa aaagccagaa ggaaccatta actccgtggg
     5041 atttatggat acaagaaagc gacatcagag tgatggtaat gagatagccc acactaggct
     5101 tcgagcctca accagggacc ttcgggcatc cccaaagcca acttccaagt ccaccattga
     5161 ggaggatcta aagaaactca tcgaccttga gagcccaact cctgaatcac agaaaaactt
     5221 caagttccat ggactgtcct ccccacagtc cccgttcccc agcaccccta cctcccggcg
     5281 ggccctgcac aggactctgt ctgatgagag catttacagc agccagaggg agcatttctt
     5341 cacctccagg gcctcacttc tagaccaagc cctgcccaat gatgtcctct tcagcagcac
     5401 ctacccatct ctccccaagt cgcttccact gaggaggcca tcttacacat tgggaatgaa
     5461 gtcgctgcat ggagagttct ctgcttccga cagctccctt accgacatcc aggagacccg
     5521 gaggcagcct attcctgacc ctggcctgat gcccctgcct gacactgctt cggacttgga
     5581 ctggtccaac ctagtagatg ccgccaaagc ctatgaggtc cagagagcct cattttttgc
     5641 tgctagtgat gaaaaccatc gccccttgag tgcggcctcc aacagcgacc agctagagga
     5701 gcaggccctg gtccagatga agtcgtacag cagtaaggac tcctctccca ctctggcttc
     5761 taaagtggac cagttggaag gtatgctgaa aatgcttcga gaagatttga agaaggaaaa
     5821 ggaagacaag gcccacctgc aggcagaggt tgagcacttg cgggaggaca acctgaggct
     5881 gcaggaggag tcccagaatg cctcggacaa gctgaagaag ttcacagagt gggtcttcaa
     5941 caccatagac atgagctagg gccagctgag gggaaaggag gagggcaggc tgctctgtat
     6001 gggcacccta aagcacccat tcatgccttg gaaagtattc tcagagtccc agcttcccag
     6061 tctgctcata ttggacagtg cacaatacaa caactgcaga tcaacaatca ttatctgcct
     6121 tttatagaaa agaaaaaaca aaaaattaat aaaaatttta aaagtaaaat aaaagtttaa
     6181 ctgctaaaa
//
