LOCUS       NM_001004089            3574 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus signal-induced proliferation-associated 1
            (Sipa1), mRNA.
ACCESSION   NM_001004089 XM_006230849 XM_341996
VERSION     NM_001004089.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3574)
  AUTHORS   Boone,M. and Deen,P.M.
  TITLE     Physiology and pathophysiology of the vasopressin-regulated renal
            water reabsorption
  JOURNAL   Pflugers Arch 456 (6), 1005-1024 (2008)
   PUBMED   18431594
  REMARK    Review article
REFERENCE   2  (bases 1 to 3574)
  AUTHORS   Stork,P.J. and Dillon,T.J.
  TITLE     Multiple roles of Rap1 in hematopoietic cells: complementary versus
            antagonistic functions
  JOURNAL   Blood 106 (9), 2952-2961 (2005)
   PUBMED   16076873
  REMARK    Review article
REFERENCE   3  (bases 1 to 3574)
  AUTHORS   Noda,Y., Horikawa,S., Furukawa,T., Hirai,K., Katayama,Y., Asai,T.,
            Kuwahara,M., Katagiri,K., Kinashi,T., Hattori,M., Minato,N. and
            Sasaki,S.
  TITLE     Aquaporin-2 trafficking is regulated by PDZ-domain containing
            protein SPA-1
  JOURNAL   FEBS Lett 568 (1-3), 139-145 (2004)
   PUBMED   15196935
REFERENCE   4  (bases 1 to 3574)
  AUTHORS   Hattori,M., Tsukamoto,N., Nur-e-Kamal,M.S., Rubinfeld,B., Iwai,K.,
            Kubota,H., Maruta,H. and Minato,N.
  TITLE     Molecular cloning of a novel mitogen-inducible nuclear protein with
            a Ran GTPase-activating domain that affects cell cycle progression
  JOURNAL   Mol Cell Biol 15 (1), 552-560 (1995)
   PUBMED   7799964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 6, 2022 this sequence version replaced
            XM_006230849.4, NM_001004089.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223350.1, FQ228273.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN11044071 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                JAXUCZ010000001.1  212379851-212379932 c
            83-886              JAXUCZ010000001.1  212376694-212377497 c
            887-1014            JAXUCZ010000001.1  212376006-212376133 c
            1015-1191           JAXUCZ010000001.1  212375744-212375920 c
            1192-1366           JAXUCZ010000001.1  212372904-212373078 c
            1367-1470           JAXUCZ010000001.1  212372407-212372510 c
            1471-1628           JAXUCZ010000001.1  212371991-212372148 c
            1629-2238           JAXUCZ010000001.1  212371276-212371885 c
            2239-2513           JAXUCZ010000001.1  212370730-212371004 c
            2514-2732           JAXUCZ010000001.1  212369385-212369603 c
            2733-2844           JAXUCZ010000001.1  212369184-212369295 c
            2845-2953           JAXUCZ010000001.1  212368992-212369100 c
            2954-3055           JAXUCZ010000001.1  212368804-212368905 c
            3056-3110           JAXUCZ010000001.1  212368659-212368713 c
            3111-3189           JAXUCZ010000001.1  212368325-212368403 c
            3190-3574           JAXUCZ010000001.1  212367867-212368251 c
FEATURES             Location/Qualifiers
     source          1..3574
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3574
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /note="signal-induced proliferation-associated 1"
                     /db_xref="GeneID:361710"
                     /db_xref="RGD:1303184"
     exon            1..82
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            83..886
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..3336
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /note="signal-induced proliferation-associated gene 1"
                     /codon_start=1
                     /product="signal-induced proliferation-associated protein
                     1"
                     /protein_id="NP_001004089.2"
                     /db_xref="GeneID:361710"
                     /db_xref="RGD:1303184"
                     /translation="MWAGGVGSPRRGMAPAPTDDLFARKLRQPARPPLTPHTFEPRPA
                     RGPLLRSGSDAGEVRPPTPASPRARAHSHEDTSRPAATPTRLFTDPLALLGLPAEEPE
                     PTFPPVLEPRWFAHYDVQSLLFDWAPRPRATGSHTESNSGTLALAEDQTTTSDLLLGA
                     PGFVSELGGEGELGLGGPISPPVPPALPNASVSVLEEPQTRTTAYSLEHADLGAGYYR
                     KYFYGKEHQNFFGLDEALGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQLRTLRGTIS
                     EDALPPGPPRGLSPRKLLEHVAPRLSPTCLRLGSASPKVPRTLLTLDEQVLSFQRKVG
                     ILYCRAGQGSEEEMYNNQEAGAAFMQFLTLLGDVVRLKGFENYRAQLDTKTDSTGTHS
                     LYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRS
                     HFQHVFLVVRAHAPCTPHTSYRVAVSRTQDTPAFGPALPEGGGPFAANADFRAFLLAK
                     ALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRATP
                     RSPGAELQAAGALMWGVRAAPGARVSAGAETGGPDHAEVPCLLGISAETLVLVTPRDG
                     RVVFNCACRDVLAWTFSDHQLDLYHGRGEAITLRLDGAPGQAVGEVVARLQLVSRGCE
                     TRELALPRDGQGRLGFEVDAEGFITHVERFTFAETTGLRPGARLLRVCGQTLPKLGPE
                     AAAQMLRSASKVCVTVLPPDESGRPRRSFSELYTLSLKEPSRRAAPEPEQDETEKLVT
                     LPAAKQLLHFCLKDGGSPPGPGDLTEERTEFLHSHNSLSPRSSMSDEAPVLPNTTPDL
                     LLVTAVTTLAPGTDRETPPSQDQSGSSSSHEDTSDSAPELRASILPRTLSLRNSISKI
                     MSEAGSETLEDEWQSISEIASTCNTILESLSREGQPILESGDPKETSKCNSEPEPGSL
                     SEKVSHLESMLRKLQEDLQREKADRAALEEEVRSLRHNNQRLLAESESAATRLLLASK
                     QLGSPTTDLA"
     exon            887..1014
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1191
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1366
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1470
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1628
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..2238
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2513
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2732
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2844
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2953
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3055
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3110
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3189
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3574
                     /gene="Sipa1"
                     /gene_synonym="Spa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcggagg cgccgggagc ggtgtgagca ggcagcggga ccctggtgcg gaaggcagga
       61 gcggccagcg agagcacgag aggcccatct aagcagcccc ctcctcctgc agtgcaggaa
      121 ccactgaaac ctcagccttc tggctgggca ccaaggaccc gtgcccacca atgcggcccg
      181 gcccccagag agtcaggccc acagagcacg cccatgtggg ccggcggtgt ggggagccct
      241 cggcggggca tggcccctgc acctaccgat gacctctttg cccgtaagct gcgccaaccc
      301 gcccggcccc cactgacacc acatactttt gagccaaggc cagctcgggg gccactcctg
      361 cgcagtggca gtgatgctgg tgaagtccgg cctcctacac cagccagccc ccgtgcccgt
      421 gcccacagcc atgaggatac cagccgccct gctgcaaccc ctactcggct cttcactgac
      481 ccactggcac tactggggtt gccagctgag gagccagagc ccaccttccc accagtgcta
      541 gaaccccgat ggtttgctca ctacgatgtg cagagcttgc tctttgactg ggctccacga
      601 cctcgggcga caggcagcca taccgagtct aactctggga ctctggcctt agctgaggac
      661 cagactacca cctcagatct actgctcggg gcacctggct ttgtgagcga gcttggtggg
      721 gagggtgagc tagggctggg tggaccaata tccccacctg tgccccctgc actgcctaat
      781 gcgtctgtgt cagtcctgga ggagccacag acccggacca cagcttacag cctggagcac
      841 gcagatctgg gtgcaggcta ctaccgcaag tacttctatg gcaaagaaca ccagaacttc
      901 tttgggctgg atgaggcgct gggtccggtg gcagtgagcc tacgacggga ggagaaagag
      961 ggcagcggag ggggcaccct acacagttat cgggtcatcg tacggaccac gcagctccgg
     1021 actctccgtg gcaccatctc ggaggatgca ctgcctcccg gccccccgag gggcctatct
     1081 ccgaggaagc ttctggaaca cgtggctcca cggctgagcc caacctgcct gcgcctgggt
     1141 tcagcctctc ccaaggtgcc ccgcacgctg cttactctag atgagcaagt gctgagtttc
     1201 caacgcaagg tgggcatcct gtactgccgg gccggccaag gctctgagga agagatgtac
     1261 aacaaccagg aagccggagc agccttcatg cagttcctca ccctgctggg tgatgtggtg
     1321 cgactcaaag gcttcgagaa ttaccgggcc cagctggata ccaaaacgga ttccacgggc
     1381 acacattcac tctataccac ctaccaagac catgagatca tgtttcacgt gtccacgatg
     1441 ctgccttaca cgcctaataa ccagcaacag ctcctgagga agcgtcatat cggcaatgat
     1501 attgtgacca tcgtgttcca ggagccgggt agcaagccct tctgccccac aactatccgc
     1561 tctcacttcc agcacgtttt cttggtggtg cgtgcgcatg ccccctgcac cccacacacc
     1621 tcatacaggg tggcagtgag ccgcacacag gacactcctg ccttcgggcc ggcgctgcca
     1681 gaaggcggag gcccctttgc agccaatgct gatttccggg cctttctgtt ggccaaggca
     1741 ctcaatggtg agcaagcggc cggtcatgca cgccagttcc acgccatggc tacacgcaca
     1801 cgtcaacagt acctgcagga cctggctact aatgaagtga ccactacttc gctggattcg
     1861 gcttcgcggt ttggcctacc atctctgggg ggcaggcgcc gggcaacccc tcggagccca
     1921 ggcgcagagc tgcaggcggc gggcgcgcta atgtggggcg tgcgcgcggc tccaggggcg
     1981 cgggtctcag cgggagctga aacaggcggc ccagaccacg ccgaggtgcc atgcttgttg
     2041 ggcatctcag cagagaccct ggtgctagtg acacctcgcg acggccgcgt ggtcttcaat
     2101 tgtgcctgtc gcgatgtatt ggcctggacc ttctcagacc atcaacttga tctataccac
     2161 gggcgcggag aggcgatcac gctacgactc gatggggccc cagggcaagc cgtgggcgaa
     2221 gtcgtggcac gtctgcagct ggtgagccgg ggctgtgaga ccagagaact agccctgccc
     2281 agagatggcc aaggtcgcct gggcttcgag gtggatgcag agggtttcat cacgcacgtg
     2341 gaacgcttca cgttcgcgga gaccacgggg cttcggcctg gagcacgtct gctgcgcgta
     2401 tgtggccaga cgctgcccaa gctgggtcca gaagctgctg cccagatgct gcgctctgcg
     2461 tccaaggtct gcgtcacggt cctgccccca gatgagagcg gccggccgcg aaggagcttt
     2521 tccgagctgt acacgctgtc tctgaaggaa cccagccgcc gtgcggcccc agagccagaa
     2581 caagatgaga ctgagaagct ggtcaccttg cccgctgcaa agcagctgct acatttttgc
     2641 ctgaaggacg gtggtagtcc tccggggcct ggggatctca ctgaggagag gacagagttc
     2701 ctgcacagcc acaactccct gtcacctcgc agctccatgt ccgatgaggc tccagtcctg
     2761 cccaacacca ctccagacct cctcctcgtc accgctgtca ccacattggc acccggtact
     2821 gacagagaga cgcccccttc ccaggaccag tcgggaagct ccagtagtca tgaagacacc
     2881 agtgactcgg caccagaatt gagggcctcc atcctgccca gaaccttgtc tcttcggaat
     2941 tccatcagta aaattatgtc agaagccggc agcgagaccc tggaggatga gtggcagtcc
     3001 atctcagaga tcgcctccac ttgcaacaca attctggagt cactgtcccg ggagggacag
     3061 cccatcctag agagtggaga ccccaaggaa acttcaaagt gtaattctga gccagaacct
     3121 gggagcctgt cagaaaaggt ctctcaccta gagtccatgc tgaggaagct ccaggaggac
     3181 ctgcagaggg agaaggcgga cagggcagcc ctggaggaag aggttcggag cctcagacac
     3241 aacaaccaga ggctgctggc ggagtcagag agtgccgcca cccgcctgct cctggcctct
     3301 aagcagctgg gttcacccac tactgacctt gcctgagttc cagcctggac ctgcttggga
     3361 ctgcctggcc cctcagagca gctgggtcat actagtgacc ttcctcagga cgtctcccct
     3421 gcgctgaggc gcatctaagc actgcccccg ctttcaggcc catttggtgg ctgatacctg
     3481 tccctgtttg taaatattct gtaaagaaaa ggggacatca gagtttaaaa aacaaaaaaa
     3541 cagaaaacaa aaaaaacaca aaaaccctga gcaa
//
