LOCUS       NM_001415034            4021 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SIN3 transcription regulator family member B
            (Sin3b), transcript variant 2, mRNA.
ACCESSION   NM_001415034 XM_039094821
VERSION     NM_001415034.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4021)
  AUTHORS   Vega,A.V., Avila,G. and Matthews,G.
  TITLE     Interaction between the transcriptional corepressor Sin3B and
            voltage-gated sodium channels modulates functional channel
            expression
  JOURNAL   Sci Rep 3, 2809 (2013)
   PUBMED   24077057
  REMARK    GeneRIF: interaction with Sin3B influences Na(v)-channel
            trafficking or stability in the membrane.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4021)
  AUTHORS   Kong,Q., Zeng,W., Wu,J., Hu,W., Li,C. and Mao,B.
  TITLE     RNF220, an E3 ubiquitin ligase that targets Sin3B for
            ubiquitination
  JOURNAL   Biochem Biophys Res Commun 393 (4), 708-713 (2010)
   PUBMED   20170641
REFERENCE   3  (bases 1 to 4021)
  AUTHORS   Costa,Y., Speed,R.M., Gautier,P., Semple,C.A., Maratou,K.,
            Turner,J.M. and Cooke,H.J.
  TITLE     Mouse MAELSTROM: the link between meiotic silencing of unsynapsed
            chromatin and microRNA pathway?
  JOURNAL   Hum Mol Genet 15 (15), 2324-2334 (2006)
   PUBMED   16787967
REFERENCE   4  (bases 1 to 4021)
  AUTHORS   Popov,N., Wahlstrom,T., Hurlin,P.J. and Henriksson,M.
  TITLE     Mnt transcriptional repressor is functionally regulated during cell
            cycle progression
  JOURNAL   Oncogene 24 (56), 8326-8337 (2005)
   PUBMED   16103876
REFERENCE   5  (bases 1 to 4021)
  AUTHORS   Yang,Q., Kong,Y., Rothermel,B., Garry,D.J., Bassel-Duby,R. and
            Williams,R.S.
  TITLE     The winged-helix/forkhead protein myocyte nuclear factor beta
            (MNF-beta) forms a co-repressor complex with mammalian sin3B
  JOURNAL   Biochem J 345 Pt 2 (Pt 2), 335-343 (2000)
   PUBMED   10620510
REFERENCE   6  (bases 1 to 4021)
  AUTHORS   Rao,G., Alland,L., Guida,P., Schreiber-Agus,N., Chen,K., Chin,L.,
            Rochelle,J.M., Seldin,M.F., Skoultchi,A.I. and DePinho,R.A.
  TITLE     Mouse Sin3A interacts with and can functionally substitute for the
            amino-terminal repression of the Myc antagonist Mxi1
  JOURNAL   Oncogene 12 (5), 1165-1172 (1996)
   PUBMED   8649810
REFERENCE   7  (bases 1 to 4021)
  AUTHORS   Ayer,D.E., Lawrence,Q.A. and Eisenman,R.N.
  TITLE     Mad-Max transcriptional repression is mediated by ternary complex
            formation with mammalian homologs of yeast repressor Sin3
  JOURNAL   Cell 80 (5), 767-776 (1995)
   PUBMED   7889570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Dec 20, 2022 this sequence version replaced XM_039094821.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.50054.1,
                                           SRR26643298.70729.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000016.1  17193931-17194051   c
            122-228             JAXUCZ010000016.1  17193229-17193335   c
            229-382             JAXUCZ010000016.1  17191662-17191815   c
            383-580             JAXUCZ010000016.1  17186201-17186398   c
            581-724             JAXUCZ010000016.1  17183858-17184001   c
            725-841             JAXUCZ010000016.1  17176897-17177013   c
            842-931             JAXUCZ010000016.1  17175032-17175121   c
            932-1050            JAXUCZ010000016.1  17174664-17174782   c
            1051-1258           JAXUCZ010000016.1  17171899-17172106   c
            1259-1375           JAXUCZ010000016.1  17171549-17171665   c
            1376-1614           JAXUCZ010000016.1  17169881-17170119   c
            1615-1798           JAXUCZ010000016.1  17168617-17168800   c
            1799-2342           JAXUCZ010000016.1  17166190-17166733   c
            2343-2512           JAXUCZ010000016.1  17165867-17166036   c
            2513-2686           JAXUCZ010000016.1  17161467-17161640   c
            2687-2779           JAXUCZ010000016.1  17161177-17161269   c
            2780-2874           JAXUCZ010000016.1  17158886-17158980   c
            2875-3079           JAXUCZ010000016.1  17158410-17158614   c
            3080-4021           JAXUCZ010000016.1  17157352-17158293   c
FEATURES             Location/Qualifiers
     source          1..4021
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..4021
                     /gene="Sin3b"
                     /note="SIN3 transcription regulator family member B"
                     /db_xref="GeneID:683381"
                     /db_xref="RGD:1587989"
     exon            1..121
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..3310
                     /gene="Sin3b"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcriptional regulator, SIN3B; SIN3 homolog B,
                     transcription regulator; SIN3 transcription regulator
                     homolog B; paired amphipathic helix protein Sin3b"
                     /codon_start=1
                     /product="paired amphipathic helix protein Sin3b isoform
                     2"
                     /protein_id="NP_001401963.1"
                     /db_xref="GeneID:683381"
                     /db_xref="RGD:1587989"
                     /translation="MAHAGGGGSAGRGFGGSRWGRSGSGGHEKLPVHVEDALTYLDQV
                     KIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNAFLPLGYR
                     IDIPKNGKLNIQSPLSNQDNSHSHGDCGEDFKQMSYKEDRGQVPLESDSVEFNNAISY
                     VNKIKTRFLDHPEIYRSFLEILHTYQKEQLHTKGRPFRGMSEEEVFTEVANLFRGQED
                     LLSEFGQFLPEAKRSLFTGNGSCEMNSAQKNEEKSLEHKKRSRPSLLRPVSAPAKKKM
                     KLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSEL
                     LQLVSPFLGKFPELFAQFKSFLGVKELSFAPPMSDRSGDGISREIDYASCKRIGSSYR
                     ALPKTYQQPKCSGRTAICKEVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERF
                     ELDVVLETNLATIRVLESVQKKLSRMAPEDQEKLRLDDCLGGTSEVIQRRAIHRIYGD
                     KAPEVIESLKRNPATAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQA
                     VNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAA
                     ALISYYVKRQPAIQKEDQGTIRQLLHRFLPSLFFSQQRPATSDDSADERDRDSAEPER
                     RRPTDEKPPTDATPEPPKALDDVYSLFFANNNWYFFLRLHQTLCARLLKIYRQAQKQL
                     LEHRREQEREQLLCEGRREKATDPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSID
                     PTQYEDTLREMFTIHAYIGFTMDKLVQNIARQLHHLVSDDVCLKVVELYLNEQQRGAA
                     GGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRRGQVIMTIELLDTEEAQAED
                     PVEVQHLARYVEQYVGTEGASNSPTEGFLLKPVFLQRNLKKFQRWQCEQVRAMRGEAK
                     SSWKRLMGVESACDVDCRFRLGTHKMVFIVNSEDYMYRRGTLCRAKQVQPLVLLRHHR
                     HFEEWHGRWLEDNVSVAAAGLVQDWLMGEEEEDMVPCKTLCETAHVHGLPVTRYRVQY
                     SRRPASP"
     exon            122..228
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            229..382
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            383..580
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            581..724
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            725..841
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            842..931
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1050
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1258
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1375
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1614
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1798
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..2342
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2512
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2686
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2779
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2874
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3079
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..4021
                     /gene="Sin3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacgcgact ctgacttcca acatggcgca cgcaggcggt ggaggctccg cgggccgggg
       61 attcggtggc tcccgctggg gtcgttcggg ctctgggggg cacgagaagc tgccagtgca
      121 cgtggaggat gctctcacct acctcgacca ggtgaagatc cgctttggca gtgaccctgc
      181 cacctacaac ggcttcctgg agatcatgaa ggagttcaaa agccagagca ttgacacccc
      241 cggcgtgatt aggcgtgtgt cccagctctt ccatgagcac cctgacctca tcgtggggtt
      301 taatgctttc cttccgcttg gataccgcat agacattccc aagaacggca agttgaacat
      361 ccagtcacct ctgagcaacc aggacaactc tcatagccat ggtgactgtg gggaggactt
      421 caagcagatg tcctacaagg aggacagagg ccaggtgccc ctggagtccg actctgtgga
      481 gttcaacaat gctatcagct atgtgaacaa gatcaagacc cgctttctgg accaccctga
      541 gatctacagg tccttcctgg agatcctaca cacctaccag aaggagcagc tgcacactaa
      601 gggtcgtcca ttccgtggca tgtctgagga ggaagtcttc acagaggtgg ccaatctctt
      661 ccgtggtcag gaggacctac tgtcagagtt cggacagttc ctgcctgagg caaagcggtc
      721 cctgtttaca ggcaatgggt cgtgcgagat gaacagcgca cagaagaatg aggagaagag
      781 tctggaacac aagaagcgct cgcggccttc actgctgcgc cctgtgtctg cgccagccaa
      841 gaagaagatg aagctcagag gcaccaaaga cctgtccatc gctgccgtgg ggaaatacgg
      901 cacactgcag gaattctcct tctttgacaa ggtgcgcagg gtgctgaaga gccaggaggt
      961 gtacgagaac tttctgcgct gcatcgcgct cttcaaccag gagctggtgt ctgggtctga
     1021 gctgttgcag cttgtcagtc cattcctggg gaaatttcca gaactcttcg cacagttcaa
     1081 gtccttcctg ggagtgaaag agctgtcctt tgcaccacct atgagtgacc ggtctggaga
     1141 cggcataagc agagaaattg attatgcatc ttgtaagcga ataggatcca gctaccgggc
     1201 acttcccaag acctaccagc agcccaagtg cagcggaagg actgccatct gcaaggaggt
     1261 cctgaatgat acatgggtct ccttcccatc ctggtctgaa gactccacct ttgtcagctc
     1321 caagaagacg ccctatgagg agcagctgca tcgctgtgag gatgagcgat ttgaattgga
     1381 cgttgtcctc gagaccaacc tggccaccat ccgagtgctg gagagtgtgc agaagaagtt
     1441 gtcgaggatg gctcctgagg accaggagaa gctccgcctg gatgactgcc tgggcggcac
     1501 ctcggaggtg attcagcgcc gtgccataca ccgcatctac ggagacaagg ccccggaggt
     1561 cattgagagc ctgaagagga accccgccac cgccgtgcct gtcgtcctga aaaggctgaa
     1621 ggccaaggag gaggagtggc gggaggccca gcagggcttc aataagatct ggcgtgagca
     1681 gtacgagaaa gcatacctca agtccctgga ccaccaggcc gtgaacttca agcagaatga
     1741 caccaaggct ctgcgctcta agagcctgct caatgagatt gaaagcgtct acgatgagca
     1801 ccaggagcag cactccgagg gccgtagtgc accttccagc gagccgcacc tcatcttcgt
     1861 gtacgaggat cggcagatcc tagaggacgc agcggcactc atcagctact atgtgaagcg
     1921 acagccagcc attcagaaag aggaccaggg cactatccgc cagctgcttc accgcttcct
     1981 gcccagcctg ttcttctcac agcagcgccc tgccacctcc gacgactctg cggatgagcg
     2041 agaccgggac agcgctgagc ctgagcgccg ccggcccacg gatgagaagc ctcccacaga
     2101 tgcgacacca gagccaccca aggccctgga cgacgtatac agcctgttct tcgccaacaa
     2161 caactggtac ttcttcctgc ggctgcacca gacgctgtgt gctcgcctgc tcaagatcta
     2221 ccggcaggcg cagaagcagc tgctggagca ccggcgagag caggagaggg agcagctgct
     2281 gtgtgagggc cgccgtgaga aggccacaga ccctgccatg gagctgcgac tcaagcagcc
     2341 cagtgaggtg gagctggagg agtactaccc ggccttcctg gacatggtgc ggagcctact
     2401 ggaggggagc atcgacccca cgcagtatga ggacacactc cgtgagatgt tcaccatcca
     2461 tgcctacatt ggcttcacca tggacaagct ggtgcaaaac attgcccgcc agctgcacca
     2521 tctggtgagt gacgacgtgt gtctgaaggt ggtggagctg tacctgaatg agcagcagcg
     2581 aggggcagcg ggggggaacc tgtcctccag atgtgtccgt gctgcacggg agaccagcta
     2641 ccagtggaag gcggagcgct gcatggccga cgagaactgc ttcaaggtga tgttcctgca
     2701 gcgcagaggc caggtgatca tgaccataga gctcctggac acagaagagg cgcaggctga
     2761 ggaccctgtg gaggtacagc acctggctcg ctatgtggag cagtacgtgg ggactgaggg
     2821 tgcatccaac tcgcctactg aaggcttcct gctgaagcct gtgttcctgc agaggaacct
     2881 gaagaagttc cagcgctggc agtgtgagca ggtacgtgcc atgcggggtg aggctaagag
     2941 ctcctggaag cggctcatgg gcgtggagag cgcttgcgac gtggactgcc gtttccgcct
     3001 gggcacgcac aagatggtgt tcatcgtcaa ctccgaggac tacatgtacc gccgtgggac
     3061 actatgccgt gccaagcagg tgcagccgct ggtgttactg cgccaccacc ggcacttcga
     3121 ggagtggcat ggtcgctggt tggaggacaa tgtgagtgtg gcggctgcag ggctggtgca
     3181 ggactggctg atgggtgagg aagaggagga catggtgccc tgcaagacgc tctgcgagac
     3241 tgcgcacgtt cacgggctgc cggtgactcg ctaccgcgtg cagtacagcc gccgccctgc
     3301 ctcaccctga gtatctggag gggcccccag catagaaccc cacacgcacc acatatcctg
     3361 ctcccaagag ggtttttgtc actttgagcc cggggtcgca ccttgacctc aagcaagcaa
     3421 gctcttggca gtgcagaccg gaccctgggc aacaacagga tctgtcccca gtaaggtcgc
     3481 ccttccccac agagtttgag atgacgttca cacatgtatt tattactttc tgcgctcata
     3541 gtggttgtga cttttgaagc agcagctccc ctggcttccc atgggagaga cctccctgtg
     3601 ggcccctgaa ccacccacca tccctacagc tgccctctgc aaggccatgt cgccgtgcca
     3661 aacccaagat gtcctgagcc atttttgttt ttgttttttt gttttttgac cctgggcctg
     3721 ggcactgggg agcaggtgtg cctgcccagg cctggctgtg tgcctctcaa aggatccctg
     3781 ggcaccttgg gcacatcgta gtttcctgag acgagttttg cacgtgggga ccccaagccc
     3841 cctaggaccc tctgggcctc ccttctctag aggggagcct aggcagcctt gcatgcttct
     3901 gggatgagct ccttaatgtt ttgagcaatt tctgttccag ctttgaactt ccttcgcatc
     3961 tgttttgaat gtaggctttt ttttctattt atttgcacat taaagttaaa tattgatgca
     4021 a
//
