LOCUS       NM_001395640            5004 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus SIN3 transcription regulator family member A
            (Sin3a), mRNA.
ACCESSION   NM_001395640 XM_006243131
VERSION     NM_001395640.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5004)
  AUTHORS   Witteveen,J.S., Willemsen,M.H., Dombroski,T.C., van Bakel,N.H.,
            Nillesen,W.M., van Hulten,J.A., Jansen,E.J., Verkaik,D.,
            Veenstra-Knol,H.E., van Ravenswaaij-Arts,C.M., Wassink-Ruiter,J.S.,
            Vincent,M., David,A., Le Caignec,C., Schieving,J., Gilissen,C.,
            Foulds,N., Rump,P., Strom,T., Cremer,K., Zink,A.M., Engels,H., de
            Munnik,S.A., Visser,J.E., Brunner,H.G., Martens,G.J., Pfundt,R.,
            Kleefstra,T. and Kolk,S.M.
  TITLE     Haploinsufficiency of MeCP2-interacting transcriptional
            co-repressor SIN3A causes mild intellectual disability by affecting
            the development of cortical integrity
  JOURNAL   Nat Genet 48 (8), 877-887 (2016)
   PUBMED   27399968
REFERENCE   2  (bases 1 to 5004)
  AUTHORS   Delatte,B., Deplus,R. and Fuks,F.
  TITLE     Playing TETris with DNA modifications
  JOURNAL   EMBO J 33 (11), 1198-1211 (2014)
   PUBMED   24825349
  REMARK    Review article
REFERENCE   3  (bases 1 to 5004)
  AUTHORS   Dharap,A., Pokrzywa,C. and Vemuganti,R.
  TITLE     Increased binding of stroke-induced long non-coding RNAs to the
            transcriptional corepressors Sin3A and coREST
  JOURNAL   ASN Neuro 5 (4), 283-289 (2013)
   PUBMED   24063527
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5004)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   5  (bases 1 to 5004)
  AUTHORS   Icardi,L., Mori,R., Gesellchen,V., Eyckerman,S., De Cauwer,L.,
            Verhelst,J., Vercauteren,K., Saelens,X., Meuleman,P.,
            Leroux-Roels,G., De Bosscher,K., Boutros,M. and Tavernier,J.
  TITLE     The Sin3a repressor complex is a master regulator of STAT
            transcriptional activity
  JOURNAL   Proc Natl Acad Sci U S A 109 (30), 12058-12063 (2012)
   PUBMED   22783022
REFERENCE   6  (bases 1 to 5004)
  AUTHORS   Huang,Y., Myers,S.J. and Dingledine,R.
  TITLE     Transcriptional repression by REST: recruitment of Sin3A and
            histone deacetylase to neuronal genes
  JOURNAL   Nat Neurosci 2 (10), 867-872 (1999)
   PUBMED   10491605
REFERENCE   7  (bases 1 to 5004)
  AUTHORS   Boutell,J.M., Thomas,P., Neal,J.W., Weston,V.J., Duce,J.,
            Harper,P.S. and Jones,A.L.
  TITLE     Aberrant interactions of transcriptional repressor proteins with
            the Huntington's disease gene product, huntingtin
  JOURNAL   Hum Mol Genet 8 (9), 1647-1655 (1999)
   PUBMED   10441327
REFERENCE   8  (bases 1 to 5004)
  AUTHORS   Bach,I., Rodriguez-Esteban,C., Carriere,C., Bhushan,A., Krones,A.,
            Rose,D.W., Glass,C.K., Andersen,B., Izpisua Belmonte,J.C. and
            Rosenfeld,M.G.
  TITLE     RLIM inhibits functional activity of LIM homeodomain transcription
            factors via recruitment of the histone deacetylase complex
  JOURNAL   Nat Genet 22 (4), 394-399 (1999)
   PUBMED   10431247
REFERENCE   9  (bases 1 to 5004)
  AUTHORS   Rao,G., Alland,L., Guida,P., Schreiber-Agus,N., Chen,K., Chin,L.,
            Rochelle,J.M., Seldin,M.F., Skoultchi,A.I. and DePinho,R.A.
  TITLE     Mouse Sin3A interacts with and can functionally substitute for the
            amino-terminal repression of the Myc antagonist Mxi1
  JOURNAL   Oncogene 12 (5), 1165-1172 (1996)
   PUBMED   8649810
REFERENCE   10 (bases 1 to 5004)
  AUTHORS   Ayer,D.E., Lawrence,Q.A. and Eisenman,R.N.
  TITLE     Mad-Max transcriptional repression is mediated by ternary complex
            formation with mammalian homologs of yeast repressor Sin3
  JOURNAL   Cell 80 (5), 767-776 (1995)
   PUBMED   7889570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 27, 2021 this sequence version replaced XM_006243131.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1463724.1,
                                           SRR26360190.271594.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000008.1  66381783-66381919
            138-358             JAXUCZ010000008.1  66391620-66391840
            359-535             JAXUCZ010000008.1  66394098-66394274
            536-642             JAXUCZ010000008.1  66397575-66397681
            643-925             JAXUCZ010000008.1  66398377-66398659
            926-1177            JAXUCZ010000008.1  66399888-66400139
            1178-1330           JAXUCZ010000008.1  66400809-66400961
            1331-1489           JAXUCZ010000008.1  66401080-66401238
            1490-1579           JAXUCZ010000008.1  66403722-66403811
            1580-1698           JAXUCZ010000008.1  66406309-66406427
            1699-1909           JAXUCZ010000008.1  66406998-66407208
            1910-2026           JAXUCZ010000008.1  66408059-66408175
            2027-2265           JAXUCZ010000008.1  66409929-66410167
            2266-2449           JAXUCZ010000008.1  66411311-66411494
            2450-3023           JAXUCZ010000008.1  66412482-66413055
            3024-3193           JAXUCZ010000008.1  66415475-66415644
            3194-3367           JAXUCZ010000008.1  66419129-66419302
            3368-3460           JAXUCZ010000008.1  66422760-66422852
            3461-3555           JAXUCZ010000008.1  66423420-66423514
            3556-3763           JAXUCZ010000008.1  66428624-66428831
            3764-5004           JAXUCZ010000008.1  66430910-66432150
FEATURES             Location/Qualifiers
     source          1..5004
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5004
                     /gene="Sin3a"
                     /note="SIN3 transcription regulator family member A"
                     /db_xref="GeneID:363067"
                     /db_xref="RGD:1311598"
     exon            1..137
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            138..358
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..3994
                     /gene="Sin3a"
                     /note="transcriptional regulator, SIN3A; SIN3 homolog A,
                     transcription regulator; SIN3 transcription regulator
                     homolog A"
                     /codon_start=1
                     /product="paired amphipathic helix protein Sin3a"
                     /protein_id="NP_001382569.1"
                     /db_xref="GeneID:363067"
                     /db_xref="RGD:1311598"
                     /translation="MKRRLDDQESPVYAAQQRRIPGSTEAFSHQHRVLAPAPPVYEAV
                     SETMQSATGIQYSVAPNYQVSAVPQSSGSHGPAIAAVHSSHHHPAAVQPHGGQVVQSH
                     AHPAPSVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSID
                     TPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQP
                     QPQPPPQHPSQPSAQSAPTPAQPAPQPTPAKVSKPSQLQAHTPASQQTPPLPPYASPR
                     SPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHT
                     YQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDANSSVLLSKT
                     TAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHSGTGATPPVKKKPKLISLKE
                     SSMADASKHGVGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQLVSPF
                     LGKFPELFNWFKNFLGYKESVHLESFPKERATEGIAMEIDYASCKRLGSSYRALPKSY
                     QQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKKTQYEEHIYRCEDERFELDVVL
                     ETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADII
                     DGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQN
                     DTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHH
                     VKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEATGAPKKHN
                     GVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQA
                     ERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLD
                     GNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEVCVQVTDLYLAENN
                     NGATGGQLSSQTSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIELLDTEEE
                     NSDDPVEAERWSDYVERYMSSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEK
                     EGKEGNSKKTMENVESLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVS
                     KRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIKK
                     YRVKYGTVFKAP"
     exon            359..535
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            536..642
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            643..925
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1177
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1330
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1489
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1579
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1698
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1909
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2026
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2265
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2449
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..3023
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3193
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3367
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3460
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3555
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3763
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
     exon            3764..5004
                     /gene="Sin3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaccgctt cgtaggcgca aaggaggttg ccagtccgct cttgcgggcc tgtgcccgcg
       61 ccgttccggg gcctccgtgc tgggtgcgag gctcacgccg ggagcgacgc gcaggctgag
      121 tggctggagc ttttgcggtt tgtagtgcat ctctgagcat gagtgcagaa tgaagcgacg
      181 tttggatgac caggaatcac cagtgtatgc agcccagcag cgaaggattc ctggaagcac
      241 agaggctttt tctcaccagc accgggttct tgccccggcc cctcctgtgt atgaagcagt
      301 gtctgagacc atgcagtcag ctacaggcat tcagtactca gtggcaccca actaccaggt
      361 ttcagctgtg ccacaaagtt ctggcagtca tgggcctgcc atagcagcgg ttcatagcag
      421 tcatcatcac ccagcagctg tccagcctca cggaggtcag gtggtccaga gccatgccca
      481 tccagccccg tcagttgcac cagtgcaggg acagcagcaa tttcagaggc tgaaggtgga
      541 ggacgccctg tcctaccttg accaggtgaa gctgcagttc gggagtcagc ctcaggtcta
      601 caatgatttc ctcgacatca tgaaggaatt taaatctcag agcattgata ctccaggagt
      661 gattagccgc gtgtcccagc tatttaaagg ccaccctgac ctgatcatgg gcttcaatac
      721 ctttttgcct cctggctata aaattgaggt gcagacaaat gacatggtga atgtgacaac
      781 tcctggccag gttcatcaga ttcccaccca tggcatccag ccccagcccc agccaccacc
      841 tcagcatcct tcccagcctt cagcccagtc agctcccact cctgcccagc cagctcctca
      901 gcccacacct gccaaagtca gcaagccttc ccaactacaa gcacatacgc cagccagtca
      961 gcagactccc ccactcccac catatgcatc cccacgttct ccacccgtcc agcctcacac
     1021 accagtgaca atctccttgg gaacggctcc atctttgcag aacaatcaac ctgtggagtt
     1081 taatcatgcc atcaactatg ttaataagat caaaaacaga ttccagggcc aaccagacat
     1141 ctacaaagca ttcctggaga ttttgcacac ataccagaaa gaacagcgga atgccaagga
     1201 agctggagga aactatactc cagctttgac ggaacaagag gtgtatgccc aggtggctcg
     1261 tctcttcaaa aaccaggaag atctgttgtc tgagtttgga cagttcctgc cagatgccaa
     1321 cagctcggtg cttttaagca aaacaactgc tgagaaggtg gattctgtga gaaatgacca
     1381 tggaggcaca gtgaagaagc cccaactaaa taacaagcca cagaggccca gtcagaacgg
     1441 ctgccagatc cgcaggcact ctgggacagg agccacacct ccggtgaaga aaaaacccaa
     1501 actgattagt ctaaaggagt cttcgatggc agatgccagc aagcatggtg ttgggactga
     1561 atcgttattt tttgataagg ttcgaaaggc tctccggagt gcagaggcct atgaaaactt
     1621 ccttcgatgc cttgttatct ttaaccagga ggtgatctct cgggcggagc ttgtacaact
     1681 agtctctcct tttctgggga aattccctga attgtttaat tggtttaaaa actttttggg
     1741 ctataaggag tctgtgcatc tggaaagctt tccaaaggag cgcgccacag agggcattgc
     1801 tatggagata gactacgcct cttgtaaacg gctgggctcc agctaccggg cgctgccgaa
     1861 aagttaccag caacccaagt gtacagggcg gactcctctg tgtaaggagg ttttaaatga
     1921 tacctgggtt tccttcccct cttggtctga agactccact ttcgttagtt ctaagaagac
     1981 tcagtatgaa gaacatattt accgttgtga agatgaacga tttgagcttg atgtggttct
     2041 cgagaccaat cttgcaacaa tccgggtttt agaagcaata cagaaaaaac tttcccgctt
     2101 gtctgctgag gaacaagcca aatttcgctt agataatact cttggaggca cgtctgaagt
     2161 catccatcga aaagcactcc agaggatata tgctgacaaa gcagcggata tcattgatgg
     2221 cctgaggaag aatccctcca ttgctgttcc cattgtcctt aaaaggttga agatgaagga
     2281 ggaagagtgg cgggaagctc agagaggctt caacaaggtc tggcgagagc agaatgagaa
     2341 gtactactta aagtctttgg atcaccaggg catcaacttc aaacagaatg acactaaggt
     2401 cttgaggtct aagagcttac tcaatgagat cgagagcatc tatgatgaga ggcaagagca
     2461 ggctacagaa gagaatgctg gtgtacctgt tggcccacac ctctctcttg cctatgaaga
     2521 caagcagata ttagaagatg ctgctgctct gattatccat catgtgaaga ggcaaacagg
     2581 aattcagaaa gaggacaaat acaaaatcaa gcaaatcatg catcatttca ttcctgatct
     2641 gctgtttgct cagagagggg atctctcaga tgtggaagaa gaagaggagg aagaaatgga
     2701 tgtggatgaa gctacagggg cacctaagaa gcacaatggt gttgggggca gccccccaaa
     2761 gtccaagttg ttatttagta acacagcagc tcagaagtta agagggatgg atgaagtgta
     2821 caacctcttc tatgtcaata acaattggta tatctttatg cggctgcatc aaattctctg
     2881 cttaaggctg ctacggattt gttcccaagc tgagcggcaa attgaagaag aaaacagaga
     2941 gagagaatgg gaacgggagg tgctaggcat aaagagagat aagagtgata gtcctgccat
     3001 acagctgcgt ctcaaagaac ctatggatgt ggatgtagaa gattattacc cagctttcct
     3061 ggacatggtg cggagcctgc ttgatggcaa catagactca tcacaatatg aagattcact
     3121 gagagagatg ttcaccatcc atgcctacat tgcctttact atggacaaat taatccagag
     3181 catcgtcaga cagctgcagc atattgtcag cgacgaggtc tgtgtgcagg ttactgacct
     3241 ttacttggcg gaaaacaaca acggagccac tggaggccag ctgagcagtc agacatcgag
     3301 gagccttctg gagtcgacat accagcggaa agcagagcag ctcatgtcgg atgagaattg
     3361 ctttaagcta atgttcattc aaagtcaagg tcaagttcag ctgaccattg agctcctgga
     3421 cacagaagag gagaactcag atgaccctgt agaagcagag cgttggtcag actatgtgga
     3481 acgatatatg agttctgata ctacttctcc agaacttcga gaacatctgg cacagaaacc
     3541 agtatttctc ccaaggaatt tgcggcgtat tcggaagtgt cagcgtggtc gagagcaaca
     3601 ggaaaaagaa gggaaagaag gaaacagcaa gaagaccatg gagaatgtag agagcctgga
     3661 taagctggag tgtaggttca agctgaactc ctataagatg gtgtatgtga tcaagtcaga
     3721 ggactacatg taccggagga cagctctgct cagagctcac cagtcccacg agcgtgtaag
     3781 caagcgtctg catcagcggt tccaggcctg ggtagataaa tggaccaagg agcatgtgcc
     3841 tcgtgaaatg gcagcagaga ccagcaagtg gctcatgggt gaggggctag agggcctggt
     3901 accctgcacc accacctgtg atacagagac tctgcacttt gtgagcatta agaagtatcg
     3961 tgtcaaatac ggcacagtat tcaaagcccc ttaactgcag agccagagca ggtagctcag
     4021 aggtgtgtgt gtgtgtgtgt ggtgtgtctg tgtgtgtacg tgtgtctgtg tgtgggcatg
     4081 tgtactcacg tacacggaag aatcaaggaa gatgcctttc aagccaccag tgcaacctga
     4141 cacccagcag gatacatgaa agaaatgtgg atggctatct tagcaagctg gagctggcac
     4201 ttctccctag ggtgctctct ggacccaaca gggagtgaag tccatgcgag cagagacagg
     4261 cagctcgcgt gcatacacca gcagagatca actacaactt ctgtgacctg agcaatcagt
     4321 tgctgtcccc atggatagat gaggtgcatc ttgtcactgc tcctcttccc acctctgggg
     4381 gaagcgggga ctggatttgt tgataccccc acttgagcac atctaagatc tctgttagat
     4441 tttatctgag acctgtttgg ctttggaatt gataacttat ggatttggtt tctgagtcct
     4501 tgaagctcac cttcctccct cttctggttc tcaacctcaa caaattccag tcagccctcc
     4561 tttttagctc ccatgggact gttttgtacc tgcttctttc tagtctgccc tagtgccatc
     4621 caccagcttc tctctctctc tctctctctc tccccctctc tccctctctc tcgctctctc
     4681 gctctcgcac aggcacactc acacacacac gcacacacag ttttaacttg gttttccttt
     4741 ttgtaaataa tgtacatact gtcaattttt tattaaagaa ctatgctttg atgtgctagc
     4801 ataactgctc tagcttcttg tgtacaatag tactatgtgg gttcagattt agtacctata
     4861 aacagatgta caagacattt attacacttt ttaccaaagg gagatactgt tgtagtactt
     4921 ttgtgtaaaa cttgtcttcc cccaacaact tattttcttt ttcctttttt ttttaatgta
     4981 aataaagctt ggttcttaag gaaa
//
