LOCUS       NM_001107108            3683 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus SIM bHLH transcription factor 2 (Sim2), mRNA.
ACCESSION   NM_001107108 XM_001055265 XM_221633
VERSION     NM_001107108.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3683)
  AUTHORS   Wang,X., Yang,Z., Sun,Y., Zhou,H., Chu,G., Zhang,J. and Meng,X.
  TITLE     Ethanol Activation of PKA Mediates Single-Minded 2 Expression in
            Neuronal Cells
  JOURNAL   Mol Neurobiol 52 (3), 1234-1244 (2015)
   PUBMED   25319570
  REMARK    GeneRIF: Ethanol at different concentrations induced Sim2
            accumulation in primary cultures of rat neurons.
REFERENCE   2  (bases 1 to 3683)
  AUTHORS   Wang,X., Song,Y., Chen,L., Zhuang,G., Zhang,J., Li,M. and Meng,X.F.
  TITLE     Contribution of single-minded 2 to hyperglycaemia-induced
            neurotoxicity
  JOURNAL   Neurotoxicology 35, 106-112 (2013)
   PUBMED   23333261
  REMARK    GeneRIF: Sim2 may mediate neurotoxicity during hyperglycaemia and
            thereby play a critical role in the development of
            hyperglycaemia-induced cognitive deficits.
REFERENCE   3  (bases 1 to 3683)
  AUTHORS   Ooe,N., Saito,K., Mikami,N., Nakatuka,I. and Kaneko,H.
  TITLE     Identification of a novel basic helix-loop-helix-PAS factor, NXF,
            reveals a Sim2 competitive, positive regulatory role in
            dendritic-cytoskeleton modulator drebrin gene expression
  JOURNAL   Mol Cell Biol 24 (2), 608-616 (2004)
   PUBMED   14701734
REFERENCE   4  (bases 1 to 3683)
  AUTHORS   Goshu,E., Jin,H., Fasnacht,R., Sepenski,M., Michaud,J.L. and
            Fan,C.M.
  TITLE     Sim2 mutants have developmental defects not overlapping with those
            of Sim1 mutants
  JOURNAL   Mol Cell Biol 22 (12), 4147-4157 (2002)
   PUBMED   12024028
REFERENCE   5  (bases 1 to 3683)
  AUTHORS   Woods,S.L. and Whitelaw,M.L.
  TITLE     Differential activities of murine single minded 1 (SIM1) and SIM2
            on a hypoxic response element. Cross-talk between basic
            helix-loop-helix/per-Arnt-Sim homology transcription factors
  JOURNAL   J Biol Chem 277 (12), 10236-10243 (2002)
   PUBMED   11782478
REFERENCE   6  (bases 1 to 3683)
  AUTHORS   Ema,M., Morita,M., Ikawa,S., Tanaka,M., Matsuda,Y., Gotoh,O.,
            Saijoh,Y., Fujii,H., Hamada,H., Kikuchi,Y. and Fujii-Kuriyama,Y.
  TITLE     Two new members of the murine Sim gene family are transcriptional
            repressors and show different expression patterns during mouse
            embryogenesis
  JOURNAL   Mol Cell Biol 16 (10), 5865-5875 (1996)
   PUBMED   8927054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Sep 11, 2014 this sequence version replaced NM_001107108.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.1828144.1,
                                           SRR26643287.26658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-731               JAXUCZ010000011.1  46883859-46884589
            732-814             JAXUCZ010000011.1  46892718-46892800
            815-904             JAXUCZ010000011.1  46895685-46895774
            905-1013            JAXUCZ010000011.1  46902442-46902550
            1014-1099           JAXUCZ010000011.1  46903968-46904053
            1100-1299           JAXUCZ010000011.1  46906497-46906696
            1300-1406           JAXUCZ010000011.1  46911934-46912040
            1407-1554           JAXUCZ010000011.1  46917424-46917571
            1555-1723           JAXUCZ010000011.1  46918848-46919016
            1724-2132           JAXUCZ010000011.1  46919417-46919825
            2133-3683           JAXUCZ010000011.1  46921755-46923305
FEATURES             Location/Qualifiers
     source          1..3683
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3683
                     /gene="Sim2"
                     /note="SIM bHLH transcription factor 2"
                     /db_xref="GeneID:304071"
                     /db_xref="RGD:1308016"
     exon            1..731
                     /gene="Sim2"
                     /inference="alignment:Splign:2.1.0"
     CDS             557..2527
                     /gene="Sim2"
                     /note="single-minded 2; single-minded family bHLH
                     transcription factor 2"
                     /codon_start=1
                     /product="single-minded homolog 2"
                     /protein_id="NP_001100578.1"
                     /db_xref="GeneID:304071"
                     /db_xref="RGD:1308016"
                     /translation="MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIR
                     LTTSYLKMRAVFPEGLGDAWGQPSRTGPLDSVAKELGSHLLQTLDGFVFVVASDGKIM
                     YISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHPPLHHHLLQEYEIERSF
                     FLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLP
                     PSAITEIKLHNNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFH
                     LRYAHHLLLVKGQVTTKYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTE
                     VEYKELQLSLDQVSTSKSQESWRTTLSTSQETRKSAKPKTTKMRTKLRTNPYPSQQYS
                     SFQMDKLECSQAGNWRTSPPTSAVAPPEQQLHSEASDLLYGPPYSLPFSYRYGHFPLD
                     SHVFSSKKPGLPAKFGQPQGSPCEVARFFLSTLPASSECQWHYANSLMPSSPSPAKNL
                     SESPVNAARHGLVPNYEAPAATARRFGEDPAPSSFPSCGHYREEPTLGSAKAARQASR
                     DTARLALARATPECCAPPAPEPQAPAQLPFVLLNYHRVLARRGPLGSAAPGAPEAAGS
                     LRPRHPGPVAASAPGAPRPHYLGASVIITNGR"
     exon            732..814
                     /gene="Sim2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..904
                     /gene="Sim2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1013
                     /gene="Sim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1099
                     /gene="Sim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1299
                     /gene="Sim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1406
                     /gene="Sim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1554
                     /gene="Sim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1723
                     /gene="Sim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..2132
                     /gene="Sim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..3683
                     /gene="Sim2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaccgatc gcgggctccg gtcgcccggg ctaaggaagc agaaccgccg aggagggcag
       61 aagagcgcac cgagctcaag ctcggctcca gtcactgcca cctcgctccg ctcccgcccc
      121 atggctccgc ggcggccgcc gccgctgccg cccttgcctt ccgagggccc tcgccgcagc
      181 gggtaaaaac cctcctttaa ggactaaaca gtgtcgccga ctgctcgcct gccaaccata
      241 gccccaggaa ggtcggggcc cgagataccg gaggcgagga gagcgagcag gaagcaggtc
      301 cacaccggac tgtccatcct ccagcctcag gcagagagca gggctgcgca acgggtttgc
      361 gacggactca gggctggcgc ccgtgcagaa accgttgggt gctccaggcc ccgtcccccg
      421 cacctgcccg agcccggcac ccccccgact cacctgaccc ctggcgtccc cgtccccatc
      481 ccggctgccg cagcccaagc gggactccgc gggcctggag cgcagcgagg tctaatatgc
      541 ccagagccga ggcgcgatga aggagaagtc caaaaatgcg gccaaaacca ggagggagaa
      601 ggaaaatggc gagttttacg agctggccaa gctgctcccg ctgccttcgg ccatcacctc
      661 gcagctggac aaagcttcca tcatccggct caccaccagc tacctgaaga tgcgcgcagt
      721 cttcccggaa ggtctaggag atgcgtgggg acagccgagc agaacagggc ctctggacag
      781 cgtggccaaa gaactaggat cccatttgct gcagactcta gatggatttg tgtttgtggt
      841 ggcctctgat ggcaaaatca tgtatatatc ggagaccgct tctgtccatt taggcttgtc
      901 ccaggtggag ctcacaggca acagtattta cgaatacatc catccttctg accacgacga
      961 gatgacagca gtactgacgg cccacccacc gctccaccat cacctgctcc aagagtacga
     1021 gatagagcgg tctttctttc tccgaatgaa gtgcgtcttg gcaaaaagaa atgcaggcct
     1081 gacgtgcagt ggatacaagg tcattcactg cagtggctac ttaaagatca ggcagtacat
     1141 gctggacatg tccctgtatg actcctgtta ccagattgtg gggctggtgg ccgtgggcca
     1201 gtcgctgcca cccagcgcca tcacggagat caaactccac aacaatatgt tcatgttcag
     1261 agccagcctc gacctgaagc tcatcttcct ggattccagg gtgacagagc ttaccggcta
     1321 tgagccacag gacctgattg aaaaaacact ctaccatcat gtgcacggct gtgacacctt
     1381 ccacctccgc tatgcacacc acctcttgct tgtgaagggc caggtcacca ccaaatacta
     1441 ccggctgctt tcaaagctgg gcggctgggt ctgggtgcag agctacgcca ccgtggtgca
     1501 caacagccgt tcctcccggc ctcactgcat cgtgagtgtc aattatgttc tcacggaggt
     1561 cgaatacaag gaacttcagc tctctctgga ccaggtatcc acctctaagt cccaggagtc
     1621 ctggagaacc accttgtcta cctcacaaga aactaggaaa tcagctaaac ccaaaaccac
     1681 gaagatgagg acaaagctga gaaccaaccc atatccctca cagcaataca gctcgttcca
     1741 aatggacaaa ctggagtgca gccaggcggg aaactggaga acgagtcccc ccacaagtgc
     1801 tgtggctccc ccggaacagc agctccattc agaagccagc gaccttttat atgggccgcc
     1861 ctacagcctc cccttctcct accgttacgg acacttcccc ctggactctc atgtcttcag
     1921 cagcaagaag ccaggactgc ccgccaagtt cgggcagccc caaggatccc cgtgtgaggt
     1981 ggcacgcttt ttcctgagca cactgccagc cagcagcgag tgccagtggc attatgccaa
     2041 ctccctcatg cccagcagcc cttcaccagc taaaaacctt tctgagtctc ctgtgaatgc
     2101 tgcccggcat ggacttgtgc caaactatga agcgcccgcc gccaccgcgc gcaggttcgg
     2161 cgaggacccc gcaccctcaa gcttcccgag ctgcggccac taccgcgagg agccgacgct
     2221 gggctccgcc aaggcagctc gccaggcgtc ccgggacaca gcccgactgg cgctggcccg
     2281 agcgaccccc gagtgctgcg cgccgccggc ccccgagcca caggcgccgg cgcagctgcc
     2341 cttcgtgctg ctcaactacc accgcgtgct ggcgcgccgc gggccgctgg ggagcgctgc
     2401 gcccggagct ccggaggcgg ccggctcgct gcggccccga cacccgggcc cggtcgcagc
     2461 ctctgcaccc ggcgcgcccc ggccacacta cctgggcgcc tcggtcatca tcaccaacgg
     2521 caggtgaccc gccagggccg gtcccgcagg gcggcccaca agggagaagc catagaccag
     2581 gccttctctg gttccttttt cacccccaag gtccagcaga tggaggggcg aactgtatat
     2641 gcacgatata aattaattta tacagagaca actattttaa tagaactccg cagccgtctt
     2701 ttagattttt accgtagatg ccggtgtaga gggttggtac tcagttggag gaggacgggg
     2761 agaagggact gacgcccatc cttgtcacca agggccagtt tttatggggc tgagcatccg
     2821 gatgtcaacc tgtgacctca aactgctatt tccagagttc ttggtttcct caccatgaag
     2881 ccaatcaagc cgaggtccaa taatggggat tcaagacaat gcatgcagct tggcagacgg
     2941 atgccacttt aagctccaac cccgtccccc acccccagtg gtcctctgtt cccaggttga
     3001 gacagggtgg aaagtccctt cggagtcctt ctggacactt gtaaacgcaa aatgttatcc
     3061 ttgtaagtcc cacgagcaga caacagtttc tgctgtcttt gaactcatgc atctcatttt
     3121 aaaatccaat ccttctaaaa atacaaaagc caacaagccg aggctgagga ggcgaatgtg
     3181 caagactatt gtgtgagtgg acatgggtgt gcttcagaag cacattaaca agctcgctcg
     3241 taactgagcc cttaggaact ggttgacacc cacatgttgc accttcaaaa tatgaagtag
     3301 gcattaaatg caaaaaggat atatatatat atatatatat acatatatag ccaggcatgt
     3361 tagagaatgg ctctgtcaag tgtaattccc tggccacatc cttccagccc acacagacct
     3421 gctcgtgtcc tacgcttgta tttgcttgca agtaggaact actaaagcta gttaaattgc
     3481 atgtgcaata cggaaaccgg agcagaccgc accttgtgga agaaaaacag gcttaaggga
     3541 tgtaaggaaa gaggtgtata catttaagcg ttttctacac agcaagagct tcatacgaac
     3601 atgtgtgtaa caggtgaatg gagactcttt ttataaactt accagcagtg tttaaaaata
     3661 aactccatta cttttctttc aca
//
