LOCUS       NP_001100578             656 aa            linear   ROD 08-APR-2024
DEFINITION  single-minded homolog 2 [Rattus norvegicus].
ACCESSION   NP_001100578 XP_001055265 XP_221633
VERSION     NP_001100578.1
DBSOURCE    REFSEQ: accession NM_001107108.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 656)
  AUTHORS   Wang,X., Yang,Z., Sun,Y., Zhou,H., Chu,G., Zhang,J. and Meng,X.
  TITLE     Ethanol Activation of PKA Mediates Single-Minded 2 Expression in
            Neuronal Cells
  JOURNAL   Mol Neurobiol 52 (3), 1234-1244 (2015)
   PUBMED   25319570
  REMARK    GeneRIF: Ethanol at different concentrations induced Sim2
            accumulation in primary cultures of rat neurons.
REFERENCE   2  (residues 1 to 656)
  AUTHORS   Wang,X., Song,Y., Chen,L., Zhuang,G., Zhang,J., Li,M. and Meng,X.F.
  TITLE     Contribution of single-minded 2 to hyperglycaemia-induced
            neurotoxicity
  JOURNAL   Neurotoxicology 35, 106-112 (2013)
   PUBMED   23333261
  REMARK    GeneRIF: Sim2 may mediate neurotoxicity during hyperglycaemia and
            thereby play a critical role in the development of
            hyperglycaemia-induced cognitive deficits.
REFERENCE   3  (residues 1 to 656)
  AUTHORS   Ooe,N., Saito,K., Mikami,N., Nakatuka,I. and Kaneko,H.
  TITLE     Identification of a novel basic helix-loop-helix-PAS factor, NXF,
            reveals a Sim2 competitive, positive regulatory role in
            dendritic-cytoskeleton modulator drebrin gene expression
  JOURNAL   Mol Cell Biol 24 (2), 608-616 (2004)
   PUBMED   14701734
REFERENCE   4  (residues 1 to 656)
  AUTHORS   Goshu,E., Jin,H., Fasnacht,R., Sepenski,M., Michaud,J.L. and
            Fan,C.M.
  TITLE     Sim2 mutants have developmental defects not overlapping with those
            of Sim1 mutants
  JOURNAL   Mol Cell Biol 22 (12), 4147-4157 (2002)
   PUBMED   12024028
REFERENCE   5  (residues 1 to 656)
  AUTHORS   Woods,S.L. and Whitelaw,M.L.
  TITLE     Differential activities of murine single minded 1 (SIM1) and SIM2
            on a hypoxic response element. Cross-talk between basic
            helix-loop-helix/per-Arnt-Sim homology transcription factors
  JOURNAL   J Biol Chem 277 (12), 10236-10243 (2002)
   PUBMED   11782478
REFERENCE   6  (residues 1 to 656)
  AUTHORS   Ema,M., Morita,M., Ikawa,S., Tanaka,M., Matsuda,Y., Gotoh,O.,
            Saijoh,Y., Fujii,H., Hamada,H., Kikuchi,Y. and Fujii-Kuriyama,Y.
  TITLE     Two new members of the murine Sim gene family are transcriptional
            repressors and show different expression patterns during mouse
            embryogenesis
  JOURNAL   Mol Cell Biol 16 (10), 5865-5875 (1996)
   PUBMED   8927054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001055265.1, XP_221633.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.1828144.1,
                                           SRR26643287.26658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     Protein         1..656
                     /product="single-minded homolog 2"
                     /note="single-minded 2; single-minded family bHLH
                     transcription factor 2"
                     /calculated_mol_wt=72383
     Region          1..74
                     /region_name="bHLH_SF"
                     /note="basic Helix Loop Helix (bHLH) domain superfamily;
                     cl00081"
                     /db_xref="CDD:469605"
     Site            order(9..10,12,17,38..39)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381392"
     Site            order(15..16,19..20,22..23,27,39..40,43..44,47,49..50,
                     53..54)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381392"
     Region          79..140
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          91..194
                     /region_name="PAS_11"
                     /note="PAS domain; pfam14598"
                     /db_xref="CDD:464214"
     Site            order(104,108,114,127..130,156)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Region          243..329
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(245,249,255,268..271,297,302)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(265,269,277,280..281,309,311)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          358..649
                     /region_name="SIM_C"
                     /note="Single-minded protein C-terminus; pfam06621"
                     /db_xref="CDD:461963"
     CDS             1..656
                     /gene="Sim2"
                     /coded_by="NM_001107108.3:557..2527"
                     /db_xref="GeneID:304071"
                     /db_xref="RGD:1308016"
ORIGIN      
        1 mkeksknaak trrekengef yelakllplp saitsqldka siirlttsyl kmravfpegl
       61 gdawgqpsrt gpldsvakel gshllqtldg fvfvvasdgk imyisetasv hlglsqvelt
      121 gnsiyeyihp sdhdemtavl tahpplhhhl lqeyeiersf flrmkcvlak rnagltcsgy
      181 kvihcsgylk irqymldmsl ydscyqivgl vavgqslpps aiteiklhnn mfmfrasldl
      241 klifldsrvt eltgyepqdl iektlyhhvh gcdtfhlrya hhlllvkgqv ttkyyrllsk
      301 lggwvwvqsy atvvhnsrss rphcivsvny vlteveykel qlsldqvsts ksqeswrttl
      361 stsqetrksa kpkttkmrtk lrtnpypsqq yssfqmdkle csqagnwrts pptsavappe
      421 qqlhseasdl lygppyslpf syryghfpld shvfsskkpg lpakfgqpqg spcevarffl
      481 stlpassecq whyanslmps spspaknlse spvnaarhgl vpnyeapaat arrfgedpap
      541 ssfpscghyr eeptlgsaka arqasrdtar lalaratpec cappapepqa paqlpfvlln
      601 yhrvlarrgp lgsaapgape aagslrprhp gpvaasapga prphylgasv iitngr
//
