LOCUS       NM_001107641            7666 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SIM bHLH transcription factor 1 (Sim1), mRNA.
ACCESSION   NM_001107641 XM_001065493 XM_228329
VERSION     NM_001107641.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7666)
  AUTHORS   Wu,D., Su,X., Potluri,N., Kim,Y. and Rastinejad,F.
  TITLE     NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS
            family as multi-ligand binding transcription factors
  JOURNAL   Elife 5, e18790 (2016)
   PUBMED   27782878
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7666)
  AUTHORS   Caruana,G., Cullen-McEwen,L., Nelson,A.L., Kostoulias,X., Woods,K.,
            Gardiner,B., Davis,M.J., Taylor,D.F., Teasdale,R.D., Grimmond,S.M.,
            Little,M.H. and Bertram,J.F.
  TITLE     Spatial gene expression in the T-stage mouse metanephros
  JOURNAL   Gene Expr Patterns 6 (8), 807-825 (2006)
   PUBMED   16545622
REFERENCE   3  (bases 1 to 7666)
  AUTHORS   Woods,S.L. and Whitelaw,M.L.
  TITLE     Differential activities of murine single minded 1 (SIM1) and SIM2
            on a hypoxic response element. Cross-talk between basic
            helix-loop-helix/per-Arnt-Sim homology transcription factors
  JOURNAL   J Biol Chem 277 (12), 10236-10243 (2002)
   PUBMED   11782478
REFERENCE   4  (bases 1 to 7666)
  AUTHORS   Holder,J.L. Jr., Butte,N.F. and Zinn,A.R.
  TITLE     Profound obesity associated with a balanced translocation that
            disrupts the SIM1 gene
  JOURNAL   Hum Mol Genet 9 (1), 101-108 (2000)
   PUBMED   10587584
REFERENCE   5  (bases 1 to 7666)
  AUTHORS   Ema,M., Morita,M., Ikawa,S., Tanaka,M., Matsuda,Y., Gotoh,O.,
            Saijoh,Y., Fujii,H., Hamada,H., Kikuchi,Y. and Fujii-Kuriyama,Y.
  TITLE     Two new members of the murine Sim gene family are transcriptional
            repressors and show different expression patterns during mouse
            embryogenesis
  JOURNAL   Mol Cell Biol 16 (10), 5865-5875 (1996)
   PUBMED   8927054
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474025.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_228329.4, XM_001065493.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..7666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q13"
     gene            1..7666
                     /gene="Sim1"
                     /note="SIM bHLH transcription factor 1"
                     /db_xref="GeneID:309888"
                     /db_xref="RGD:1309949"
     exon            1..605
                     /gene="Sim1"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..2728
                     /gene="Sim1"
                     /note="single-minded 1; single-minded family bHLH
                     transcription factor 1"
                     /codon_start=1
                     /product="single-minded homolog 1"
                     /protein_id="NP_001101111.1"
                     /db_xref="GeneID:309888"
                     /db_xref="RGD:1309949"
                     /translation="MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIR
                     LTTSYLKMRVVFPEGLGEAWGHTSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIM
                     YISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSF
                     FLRMKCVLAKRNAGLTCGGYKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLP
                     PSAVTEIKLHSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFH
                     LRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTD
                     TEYKGLQLSLDQISPSKPTFSYTSSSTPTITDNRKGAKSRLSSSKSKSRTSPYPQYSG
                     FHTERSESDHDSQWGGSPLTDTASPQLLDPERPGSQHELSCAYRQFPDRGSLCYGFAL
                     DHSRLVEDRHFHTQACEGGRCEAGRYFLGAPPAGRDPWWGSRAALPLTKASPESRETY
                     ENSMPHITSVHRLHGRGHWDEDSVVSSPDPGSASESGDRYRSEQYQNSPHEPSKIETL
                     IRATQQMIKEEENRLQLRKAPPDQLASINGAGKKHSLCFANYQQPPPAGEVCHSSALT
                     STSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPSSDRITKSSLILAKDYLHSDMS
                     PHQTAGDHPAISPNCFGSHRQYFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSHFDV
                     TSHLRMQPDPAQGHKGTSVIITNGS"
     exon            606..688
                     /gene="Sim1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..778
                     /gene="Sim1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..887
                     /gene="Sim1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..973
                     /gene="Sim1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1173
                     /gene="Sim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1280
                     /gene="Sim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1428
                     /gene="Sim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1597
                     /gene="Sim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1997
                     /gene="Sim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..7666
                     /gene="Sim1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgatccgaaa gaagttaccg gcgattcctg ttctctacaa accggctcag aaccagaggg
       61 gctgaaaagc aaacgtcggg tgttattatg tcgatttccc aaggaccggg gttcccgccg
      121 cggatcagat gaaaaggttg gctcctccgg agtccttcca gcattttatg cgtagagtcc
      181 caaaggattg cccggatttg ctgtgaacca gagctctctt ttatgcttac acctcacatt
      241 ttcaagaaag cattttgttt gccgtgttgt cctgttccta gcatcattcg ggtctcctcc
      301 gagcaaatca cagcctcctc gtttaaagtt atgtttctac cgagtgtgat ctctaattga
      361 aagttaactt tttggttttg gatgagtctg tggagtttac gttgtaagaa gaaagggagc
      421 ctgagacacg atgaaagaga agtctaaaaa tgctgcccgg acgaggaggg agaaagaaaa
      481 cagtgaattt tacgaactgg ctaaattact gccgttaccc tcagccatca cctcgcaact
      541 ggacaaagcc tcgatcatca gactcacgac cagctatctc aaaatgagag tggtctttcc
      601 ggaagggctt ggcgaggcgt ggggtcacac cagtcgaacc agccctctgg ataacgttgg
      661 tcgcgaactc ggctctcatc tactccagac tctggatggc ttcatctttg tggtggcccc
      721 agatgggaag atcatgtaca tctcagagac agcttcagtt cacctgggcc tttctcaggt
      781 agaactgact gggaacagca tctatgaata tatccacccg gctgatcatg atgagatgac
      841 agcagtgctc acagcccatc aaccctacca ctctcacttt gtacaggagt acgagatcga
      901 acgctccttc tttctaagga tgaagtgtgt tttggccaag cggaatgctg gcctcacctg
      961 cggtggctac aaggtcattc actgtagcgg ctacctgaag atccgccagt acagcctgga
     1021 tatgtctccc tttgatgggt gctaccaaaa tgtgggtttg gtggctgtgg gtcactccct
     1081 gcctccgagc gctgtgacag agatcaaact acacagcaac atgttcatgt tccgagccag
     1141 tctggacatg aaactcattt tcctggactc cagggtagca gagctgactg ggtatgaacc
     1201 tcaggacttg attgagaaga ccctgtacca tcacgtgcac ggctgtgaca ccttccacct
     1261 acgctgtgca caccatttac tgttggtgaa gggtcaggtg accaccaagt actacaggtt
     1321 cttggcaaaa cacggcggct gggtctgggt gcagagttac gccaccatcg tacacaacag
     1381 ccgctcctcc aggccgcact gcatcgtcag cgttaactac gtcctcacag acacagaata
     1441 caaagggctg cagctctctc tggaccagat atcaccctct aagcccactt tctcctatac
     1501 cagcagttcc acacccacca tcactgacaa caggaagggg gccaagtcaa ggctctctag
     1561 tagcaagtca aaatccagga cctccccata tccccagtat tcgggattcc acactgaaag
     1621 atcagaatct gaccatgaca gccagtgggg tggaagtccc ctgactgata ctgcctcccc
     1681 acagctcctg gacccagaga ggcctggctc tcagcacgag ttgtcctgtg cgtacagaca
     1741 gtttccagat cgcggttctc tctgctatgg ctttgcgctg gaccattcca ggctggtgga
     1801 ggacaggcac ttccacaccc aagcctgcga gggagggcgg tgtgaggctg gcaggtactt
     1861 tctcggagca ccacctgctg ggagagatcc ctggtggggt tctcgagcag ctctgccgct
     1921 caccaaggcc tccccggaga gcagagaaac ctatgagaac agcatgccgc acatcacctc
     1981 tgtccacaga ctccacggtc gaggtcactg ggatgaagat agtgtggtca gctctccaga
     2041 ccctgggtca gccagtgaat ccggtgaccg ataccgctcc gaacagtatc aaaatagccc
     2101 acatgaacct agcaaaattg aaactctcat aagagccacc cagcagatga ttaaagagga
     2161 agagaacaga ttacagctaa ggaaagcccc tcccgaccaa ctggcttcca ttaacggggc
     2221 tgggaagaaa cactccctct gttttgcaaa ctatcaacag cccccaccgg caggtgaagt
     2281 ctgccacagc tctgctctta ccagcacttc accatgtgac cacatccagc agagagaggg
     2341 aaagatgctt agccctcacg aaaacgacta tgacaacagt cccactgcac tgtctcggat
     2401 aagtagtccc agttctgatc gcataacaaa gtccagttta atcctggcta aagactatct
     2461 acattcagat atgtctcctc atcagacagc aggagaccat cctgccatct ctccaaactg
     2521 ttttggctcc caccggcagt attttgataa gcatgcctat acgttaactg gttatgccct
     2581 ggaacattta tatgacagtg agactattag gaactattcc ttgggctgca atggctcaca
     2641 ctttgatgta acctcccatc taaggatgca gccggaccca gcgcaaggac acaagggaac
     2701 atctgttata ataaccaatg gaagttgatg tttttctaaa atattttgtt cttcaagggt
     2761 ctctgaaaca tatttatagt ctaatacccc attagcaaca tttactatgc cacagattgt
     2821 tagaaagtct aagttaaatt ttagggttac ttgatatgag tccctgtaaa atcaaagaaa
     2881 acatagcacc aacattcaag gttatacaca ggtaaatgag ccaaaaatga atacagaaat
     2941 tgcccacata ttatagagga gctataaccg acatgattga attgagaaat actaatgcaa
     3001 attgagcata tctaccacat ggaagggctg aagactagaa tcattttgtt gtgacaatct
     3061 agtagaactt atacatacag atcatacgct attcacaatc ttctatgtat gcgtctcatg
     3121 cataagtatt ataaatgact actcttcctt atctagcaca aagaaatgtc agttcccaaa
     3181 ataactaagg aagaattgga tgtatcttgt aacacaattt cttctttttc atttcaaact
     3241 agtccactca tttggttcag gcatagatta gagaaatggt tctggctctg gtacatgaat
     3301 gtgtttttac ctggtatcca ttacaaacgg tcaggaaaga ggtggttttc cacttgtttt
     3361 tgagttagac gtagagcagg attgcattgg cacaacagta aggaattttc taagtcacac
     3421 cactgatctg ttgggagata cataaaaaaa tatggtctac ttaattttaa gtggctcagt
     3481 gaagaaaagg gcagagcaga gtagagagag atactgaatc tccaagcaat gtttaagggg
     3541 gaggtaaaca acattttgga ggctaatgta caaaaggcac taaataagaa atttaaatca
     3601 gttcacccag acaaagtgtt ggcaagtaca aacggaacca gagatctgta aagcactagg
     3661 tggcaccagg ataagcattt aagaacattt cagagcacaa tgcgtcagta tgtggaaagc
     3721 cttagagtca ggagaggtaa aagcttaggc agaaggacaa gtggttcaaa gggtgcttgg
     3781 ggaagccaca gggaaaatgc tgactttctt tgctgcttgt aaactaagaa agcaacacac
     3841 ttgtccgtat gtccatgtgg cacagtagaa agtgaagtga actgtatgcc taggtctcca
     3901 tgctgacctt gctttcactt aatttggggc tcatagatgc atcgtttaca gtctgtgctt
     3961 cttggttatc tggtctgaaa ggcagctctt gtccatggtt ctgcgattca ttggtatgct
     4021 gaaagtaaac ttgtaagccg ttaaaactct gctgtaaatt ttcaagactg atggttctgg
     4081 attttccatt cacaagcaga agtctagata ctttgatatt taagcaaagt gtgggctctt
     4141 tcaggcagga agagttacag gcaactttct cttagatgca gccaaatata ggtgctagaa
     4201 atttatgaga gggaagaaaa atagcaaaat ttatttaatg cactattctc tagtattcaa
     4261 agaaaaatgt catgtgtggt taggaaagtt tcatagacaa tattttttag aattgccatg
     4321 cctgttattc ttgccatgtt taaggaggag catggacttt gataattatt gaaacattac
     4381 atggcgttgg acactcaggg attagtcctg tattttcatc acacgacatg atcatttggt
     4441 gacagtcttc atgacagtaa gttgagagtt gaataatggg ttgtttgtat atgggagaag
     4501 aggctacata aaactaaaca ctacttcttg ggtaatacag aacaatattg tcaataaaaa
     4561 tcaggaaaca tgcaaattag tgaaaagtaa ttagtttatg tacttaaata ttctttcaaa
     4621 aatattcaaa ggaaaatgaa aattaaattc taactccata agaaaaatat tcggtaattt
     4681 tgagaaaatt gggtcaaaga aactcacagg acaggtggtt tgaataaaac ttcaacatga
     4741 gggaggtttt caggatggtg aaggttttac agaattctat agatcagaca aatatctgat
     4801 gaatacgtat tttgggcaga aaatctctac aagtaggttc cattgacagg taggtatgcc
     4861 ttagtgcgtc agaggtaact tctgagagat gcttgtcact aaagtaattt tagcagagtt
     4921 tttatgtaga gaataactca tacaagaata aattgtgacc tccacagaga aagtctaaca
     4981 aggaggaaca atgcttccca gaatgccata attaatactt ttaaaggaag acaggattca
     5041 tttacatcac attttgatta ataatcttag tagactggcc catttaaaag acattaacca
     5101 ttaaacaaat gccaattttg cagtggcaat tttataatgt tgcatataat gcctcatagg
     5161 cttactatat atatagctta cattgtttta cagaatggca tgattattat aaatgaccca
     5221 aaattaattg atctttacaa ctaggtgact tcttactgtt catgtaggtg tataaaatga
     5281 atttgtaacc gacattattt tgttctgtac aggaacgtat ttgctcataa agaatgtgcc
     5341 atctgtttta aaaaatatgg ggtataaaat aaatacattc ccagtaactc gatcaattaa
     5401 tgttaagctt aaatttgctt cctctttaat ccttgatttt cctatcttta cttaaaggtg
     5461 gaaagtctga gaagcatgtt tccttctacc actttgggga ttcataaaaa tacgtgacat
     5521 ccaattatac aagaataacg cacacacagt tccttactct ctacaaagcc cattctatct
     5581 ggaaataata agaatatctc tgatgcccat ttgcttgttt taccaagata aaatttaaaa
     5641 ctgtggatga ccaatgaaat acgtattccc caaattttcc ttgggaaaat tctgttaaag
     5701 ttatttctga gaacatacag atgatgtatt ctttttttat ataattttaa ggttagaaat
     5761 actataggcc agacatttat gtgtgcttca gccccacaaa tcttttgaca ttacatgcaa
     5821 aatctaatgt ggtagctttt taaaaactgt acttgcctgt acatgacact atgacagaac
     5881 tgatagacat gcaaaaccag acaggatgta cttgacgatt ccttcagtgt ttatacagta
     5941 aaccacttat tatttcctgg ttatagttta tagggctaga gtattcccag caagaactgt
     6001 tcttaatgtt gtctgtaccc tgctgccact tactgccttt gggcagagaa tccaacttga
     6061 agtaagcttt aatgagatct cctaaaaagg acaatatttc catttccctt tctcttattt
     6121 taaatgaagt ttaattttag tacaagagta tttggaaaat atgaatatgc atctaaaggt
     6181 aaaatgagat aatttccctc cacccaacgt ctagataatg tacgtggtgg cagagctagc
     6241 aacactctga atacagactt gctgtgttac agctctatct cttgctctgt gattctctgt
     6301 ctgtttctct ctctccaaac ctgccaatga ccaagctgct tgcatgacct attagtactc
     6361 gcagtattgg gagcgacaga gtgagaactg agcacttgac tgggaatcac tcaccttact
     6421 actgtgatat agtaaccctt gttaaaaatt ttgaatgtct ggattttgga ttattagttc
     6481 attcaaatga tagacagaca cccaattttc tgaatgattt aaaaaagaaa ggaaatcctc
     6541 caaagacata gttgagaatt catataaatg ctataaatgc caggtttttt tttttttttg
     6601 tcgttgttgg tttttttgtt tttgtttttt tttttttttt tttgtgtgtg tgtgtgtgtg
     6661 aataaggatt tcactgtagg taaaaatctg ttggctagct cttactgtga aaatacatgg
     6721 tgggtaagac attctaaatt ttaggtgggt gtcaggacag ctgtgggtac atgcaagtgt
     6781 atcacaaata gaaaataatt cttgggggaa agttttatgt ggtacttata tcttgtgcac
     6841 aaaggttgta cgggtagtgc ttaaattcaa aaggtaagat gacactcaag tccatataga
     6901 catttgttcc aaactccttc tctaaaactg tgcagaaagt gcgcgcgcac acacacacac
     6961 acacacacac acacacacac acacaggcac acacgcacac acgcacacac tatgacttct
     7021 ttcttacttt gaggatttaa aaatgtgctg tatgcaatgt gaatgtatga tgtttcacac
     7081 aagaaactct aattgataat tttaatctaa gcattgtagt tttatgtact gagatttgct
     7141 gtgtgaactt gccttcataa cctaggtaag aggactttgt cctaatctgc taatcttaga
     7201 catatctagt caatttctac ccaataattg tgatgtgttt acatttcaaa agaaatgaaa
     7261 ttggcatgga caaatttttt ttacagtaat tgtaacttct tttcaaagga acagatttca
     7321 gaaagaaaga aaccagaggc acttcaagaa agataaaata ttttatgctt gttttttgat
     7381 tgacatgata taaaaaggat tatatttgtg agagaagata ctggttcgaa ataccctctt
     7441 gcaatgtata gtttttaggg atattatagt ataaacttgt aatctgaact tttactttgg
     7501 aatgtaagta ggaaataata gctatgtcaa tgatatcttg caaagtgtcc ccatttataa
     7561 ttatttatat tgtaaatagc tttctgaagt aaaattgaag ttaatgtgca taaaatgtat
     7621 ttattatgtg aggaattttt ggtttaaaat atagttacca atatgc
//
