LOCUS       NM_199376               1667 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SIL1 nucleotide exchange factor (Sil1), mRNA.
ACCESSION   NM_199376 XM_214586
VERSION     NM_199376.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1667)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   2  (bases 1 to 1667)
  AUTHORS   Zhao,L., Longo-Guess,C., Harris,B.S., Lee,J.W. and Ackerman,S.L.
  TITLE     Protein accumulation and neurodegeneration in the woozy mutant
            mouse is caused by disruption of SIL1, a cochaperone of BiP
  JOURNAL   Nat Genet 37 (9), 974-979 (2005)
   PUBMED   16116427
REFERENCE   3  (bases 1 to 1667)
  AUTHORS   Chung,K.T., Shen,Y. and Hendershot,L.M.
  TITLE     BAP, a mammalian BiP-associated protein, is a nucleotide exchange
            factor that regulates the ATPase activity of BiP
  JOURNAL   J Biol Chem 277 (49), 47557-47563 (2002)
   PUBMED   12356756
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062050.1.
            
            On Jan 11, 2004 this sequence version replaced XM_214586.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062050.1, SRR8487227.171200.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1667
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..1667
                     /gene="Sil1"
                     /note="SIL1 nucleotide exchange factor"
                     /db_xref="GeneID:291673"
                     /db_xref="RGD:735103"
     exon            1..72
                     /gene="Sil1"
                     /inference="alignment:Splign:2.1.0"
     exon            73..186
                     /gene="Sil1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1479
                     /gene="Sil1"
                     /note="nucleotide exchange factor SIL1; SIL1 homolog,
                     endoplasmic reticulum chaperone"
                     /codon_start=1
                     /product="nucleotide exchange factor SIL1 precursor"
                     /protein_id="NP_955408.1"
                     /db_xref="GeneID:291673"
                     /db_xref="RGD:735103"
                     /translation="MAPQHLPSTRMAPQGMLLGLLLASCLTFCLSCQNSNNFALTNPE
                     KSTHEDSDTKETRREEELDAEVLEVLNPTQEWQALQPGQAVPAGSHVRMNLQTGVNEV
                     KLQQEDKFQSNWKGFKRGRRLDINTNTYTSQDLKSALAKFKEGTEMENSKDELARQAT
                     VKQLFRPIEELKKEFDELNVVLETDMQIMVRLINKFNSSSSSLEEKVAALFDLEYYVH
                     QMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQK
                     LLVILATEQPLPAKKKVLFALCSLLRHFPYAQQQFLKLGGLQVLRSLVQEKSAKVLAV
                     RVVTLLYDLVTEKMFAEEEAELTQESSPEKLQQYRQVQLLPGLREQGWCEITAQLLAL
                     PEHDAREKVLQTLGALLATCRDRYRQDLELSRTLGSLQAEYQALASLELQEGEDDGYF
                     RELLASIDSLVKELR"
     exon            187..325
                     /gene="Sil1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..446
                     /gene="Sil1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..546
                     /gene="Sil1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..738
                     /gene="Sil1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..860
                     /gene="Sil1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..957
                     /gene="Sil1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1122
                     /gene="Sil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1629
                     /gene="Sil1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggttgcc gctgcagccg cctggaattg tggggattgt gtctgcccct aggctgcggt
       61 ggaaagccga aggtcctggt tatggctcct cagcacctgc cttcaactag gatggcccct
      121 caaggaatgc tgctggggct gctgttggct tcctgtttaa ctttctgcct cagttgtcag
      181 aactcaaata attttgcact caccaaccca gagaagagta cccacgagga ctcagataca
      241 aaggaaacca gaagagagga ggagctggat gccgaagtcc tagaggtgtt aaacccaacc
      301 caagagtggc aggctcttca accaggacag gctgttcctg caggatccca tgtgcgaatg
      361 aacctacaga ctggagtaaa cgaggtgaaa ctccaacaag aagacaaatt ccaaagtaat
      421 tggaaaggat ttaaaagagg cagaaggctg gacatcaata ccaacaccta cacgtctcag
      481 gacctcaaga gtgcactggc caagttcaag gaggggacag agatggagaa ttcaaaggat
      541 gaactggcaa gacaggccac ggtaaagcag ctcttccgcc ccatcgagga gctgaagaag
      601 gaatttgatg agctgaatgt tgttcttgag actgacatgc agattatggt tcggctgata
      661 aacaagttca acagctccag ctctagcctg gaagagaagg ttgctgcact ctttgatctt
      721 gagtactatg tccatcagat ggataacgca caggacctgc tgtcctttgg tggccttcaa
      781 gtggtgatta atgggctcaa cagcacagaa cccctggtga aggagtatgc tgcttttgtg
      841 ctgggggccg ccttttccag caatccaaag gtccaggtgg aagccattga aggaggagct
      901 ctgcagaagc tgctggtcat cctggccaca gagcagcctc tccccgccaa gaagaaggtc
      961 ctgtttgcac tgtgctcttt acttcgccac ttcccctacg cccagcagca gttcctgaag
     1021 ctcggggggc tgcaggtcct caggagcctg gtgcaggaga agagtgcgaa ggtactggcc
     1081 gtgcgagtgg tcaccttgct ctatgacctg gtcaccgaga agatgtttgc tgaggaggag
     1141 gctgagctga cccaggagtc ctccccagag aagctgcagc agtaccggca ggtgcagctc
     1201 ctgcccggcc tgcgggaaca gggctggtgt gagatcacgg cccagctcct ggcccttcca
     1261 gagcacgacg ctcgggagaa ggtgctgcag acgctgggcg ccctcctcgc cacctgccgg
     1321 gaccgctacc gtcaagacct ggagctgagc cggacactgg gcagtctcca ggcagagtac
     1381 caagccctgg cctccctgga gctccaagaa ggtgaagatg acggctactt ccgggaactg
     1441 ctggcctcca tcgacagctt ggtgaaggag ctaagatgag gctgccacgc tgagacagga
     1501 ctggatggat gctgctagtg agagctctgg tgggctcttc aggggacagc agccaggagg
     1561 aggacttccc tactggggca tgagcttttt ctgggcagag ctggctgggt cattaaacag
     1621 agacatgtaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
