LOCUS       NM_001271216            6248 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SIK family kinase 3 (Sik3), mRNA.
ACCESSION   NM_001271216 XM_003750505
VERSION     NM_001271216.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6248)
  AUTHORS   Cai,Y., Wang,X.L., Lu,J., Lin,X., Dong,J. and Guzman,R.J.
  TITLE     Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell
            Proliferation and Arterial Restenosis by Regulating AKT and
            PKA-CREB Signaling
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (9), 2431-2451 (2021)
   PUBMED   34196217
  REMARK    GeneRIF: Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle
            Cell Proliferation and Arterial Restenosis by Regulating AKT and
            PKA-CREB Signaling.
REFERENCE   2  (bases 1 to 6248)
  AUTHORS   Csukasi,F., Duran,I., Barad,M., Barta,T., Gudernova,I.,
            Trantirek,L., Martin,J.H., Kuo,C.Y., Woods,J., Lee,H., Cohn,D.H.,
            Krejci,P. and Krakow,D.
  TITLE     The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered
            mTOR signaling
  JOURNAL   Sci Transl Med 10 (459) (2018)
   PUBMED   30232230
REFERENCE   3  (bases 1 to 6248)
  AUTHORS   Sasagawa,S., Takemori,H., Uebi,T., Ikegami,D., Hiramatsu,K.,
            Ikegawa,S., Yoshikawa,H. and Tsumaki,N.
  TITLE     SIK3 is essential for chondrocyte hypertrophy during skeletal
            development in mice
  JOURNAL   Development 139 (6), 1153-1163 (2012)
   PUBMED   22318228
REFERENCE   4  (bases 1 to 6248)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 19, 2014 this sequence version replaced NM_001271216.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               JAXUCZ010000008.1  55209014-55209286
            274-390             JAXUCZ010000008.1  55319488-55319604
            391-454             JAXUCZ010000008.1  55323171-55323234
            455-616             JAXUCZ010000008.1  55345333-55345494
            617-741             JAXUCZ010000008.1  55367530-55367654
            742-865             JAXUCZ010000008.1  55368093-55368216
            866-984             JAXUCZ010000008.1  55388283-55388401
            985-1095            JAXUCZ010000008.1  55388936-55389046
            1096-1239           JAXUCZ010000008.1  55389283-55389426
            1240-1317           JAXUCZ010000008.1  55389879-55389956
            1318-1427           JAXUCZ010000008.1  55390068-55390177
            1428-1581           JAXUCZ010000008.1  55392085-55392238
            1582-1737           JAXUCZ010000008.1  55392466-55392621
            1738-1808           JAXUCZ010000008.1  55395892-55395962
            1809-1952           JAXUCZ010000008.1  55398039-55398182
            1953-2103           JAXUCZ010000008.1  55401714-55401864
            2104-2229           JAXUCZ010000008.1  55402503-55402628
            2230-2315           JAXUCZ010000008.1  55402874-55402959
            2316-2425           JAXUCZ010000008.1  55403355-55403464
            2426-2765           JAXUCZ010000008.1  55404223-55404562
            2766-3661           JAXUCZ010000008.1  55405691-55406586
            3662-3825           JAXUCZ010000008.1  55414432-55414595
            3826-3958           JAXUCZ010000008.1  55415126-55415258
            3959-4123           JAXUCZ010000008.1  55415973-55416137
            4124-6248           JAXUCZ010000008.1  55417014-55419138
FEATURES             Location/Qualifiers
     source          1..6248
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..6248
                     /gene="Sik3"
                     /note="SIK family kinase 3"
                     /db_xref="GeneID:684112"
                     /db_xref="RGD:1593938"
     CDS             1..4110
                     /gene="Sik3"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SIK3"
                     /protein_id="NP_001258145.2"
                     /db_xref="GeneID:684112"
                     /db_xref="RGD:1593938"
                     /translation="MAAAAASGAGGVAVAGAGGAGPAGRLLPPPAAGPPAAPAAVPPA
                     ACPPRPTAPASRGSMAARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQL
                     DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRM
                     AEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQL
                     LKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVL
                     SGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHRWMKLGDADPNFERLIAECQ
                     QLKEERQAEPLNDEVLLAMEDMGLDKERTLQSLRSDAYDHYSAIYSLLCDRHKKNKTL
                     RPGALPSTPQAMTFQAPVNIQAEQTGTAMNISVPQVQLINPENQIIEPDGAVNLDSDE
                     GEEPSPEALVRYLSMRRHTVGVADPRTEVMDEMQKLLPGFPGANPQTPFLQVAPNMNF
                     MHNLLPMQSLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLK
                     RPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQRYLANRSKRHTLAMTSPTAEIP
                     PDLQRQLGQQSFRSRVWPPHLVPDQHRSTYKDSNTLHLPTERFSPVRRFSDGAASIQA
                     FKAHLERMGNSSSIKQLQQECEQLQKMYGGQVDERTLEKTQQQHMLYQQEQHHQILQQ
                     QIQDSICPPQPSPPLQAACENQPTLLTHQLQRLRIQPSSPPPNHPSNHLFRQPSNSPP
                     PVSSAMISSHGATSPSQFQGLPSHGAIFQQQPENCSPPPSVALTCLGLQQASQSQPVT
                     IQLQEPVDMLSNMAGTTAGSAGRGIPISPSASQIQMQHRTSLMAPFGYGHRPLSKQLS
                     ADSAEAHSLSMNRFSPANYDQAHLHPHLFSEQSRGPPSSYSPSTGVGFPPAQALRVPP
                     LDQFPTFPPSAHQQPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHS
                     DIRLPPAEFAQLIKRQQQHRQQQQQQQQQQQQEYHELFRHMNQGDAVSLAPGLGGQNM
                     TEHQALSYQNADSYHRHHTSPQHLLQIRAQDCISQGPLPTPTRGYARQSPLMHSESME
                     EDCLCEGVKEGFADKSSSTLTKGCHDSPLLLCTSGPGDPEPLLGTVSQARELGIHPYG
                     HQPTATTFSRNKVPSRESVIGNCMERSSPGQAMELPDHNGLGYPARPLVSEHLRSRTL
                     QRHHTIQNSDDAYVQLDTLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDEEDEE
                     CGVSLGHEHPALGDGSQHLNSRYPATCVTDIMLNHKHPEVSFSMEQAGV"
     exon            1..273
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            274..390
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            391..454
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..616
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            617..741
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            742..865
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            866..984
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1095
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1239
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1317
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1427
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1581
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1737
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1808
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1952
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2103
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2229
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2315
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2425
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2765
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..3661
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3825
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3958
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..4123
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
     exon            4124..6248
                     /gene="Sik3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggcgg cggcggcgag cggagctggc ggggttgccg tggccggagc agggggagcc
       61 gggccggccg gtcgcctgct gcctccgccc gccgcggggc ccccggcagc ccccgccgca
      121 gtgcccccgg ccgcctgccc gccgcgtccc acagccccgg cctcccgcgg gtcgatggcc
      181 gctcgcatcg gctactacga gatcgaccgc accatcggca agggcaactt cgctgtggtc
      241 aagcgggcca cgcacctcgt caccaaggcc aaggttgcta ttaaaatcat agataagacc
      301 cagttggatg aagagaacct gaagaagatt ttccgggagg ttcagataat gaagatgctt
      361 tgccacccac atatcatcag gctctaccag gtcatggaga cagagcgcat gatttacctg
      421 gtgacagaat acgctagcgg aggggagata tttgaccact tggtggccca tggaagaatg
      481 gcggagaagg aagctcggcg gaagttcaaa cagattgtca cagctgtata tttttgtcac
      541 tgtcggaata tcgttcatcg tgatttaaaa gctgaaaatt tgcttctgga cgccaatctg
      601 aatatcaaaa tagcagactt tggcttcagc aacctcttca ctccgggtca gctgctaaag
      661 acgtggtgtg gcagtcctcc ctatgccgca ccagagctct tcgaaggcaa ggaatatgat
      721 gggcccaaag tggacatatg gagtcttgga gttgtcctct atgtgcttgt gtgtggcgcc
      781 ctgccgtttg atgggagcac actgcagaat ctgcgggccc gtgtgctgag cggcaagttc
      841 cgcatcccgt tcttcatgtc cacagagtgt gagcacttga tccgccacat gctggtgtta
      901 gatccaaata agcgtctctc aatggagcag atctgcaggc acaggtggat gaagctcgga
      961 gatgcagacc ccaactttga gaggttaata gcagaatgcc agcagctgaa ggaggaaagg
     1021 caggcagagc ccctcaatga tgaggttctc ttggccatgg aagacatggg actagacaag
     1081 gaacgcacac ttcagtcatt aagatcggat gcctatgacc actatagtgc gatctacagc
     1141 ctgctgtgcg atcgacacaa gaaaaacaaa actctgcgtc ctggagcact tcccagcacg
     1201 ccccaagcca tgacttttca ggcaccagtc aatatccagg cggagcagac aggcactgct
     1261 atgaacatta gcgtccccca agttcagctg atcaacccag agaaccaaat tatagagcct
     1321 gacggggccg tgaacttgga cagcgacgag ggtgaagagc cttctccaga agccttggtt
     1381 cgctatttgt caatgaggag gcacacggtg ggagtggctg acccacgcac ggaagttatg
     1441 gacgagatgc agaagctcct gcccggcttc cctggagcga acccacagac tccattcctg
     1501 caggtggccc ctaacatgaa cttcatgcac aacctgctgc ccatgcagag tctgcagcca
     1561 actgggcagc ttgagtacaa ggagcagtct ctattacagc cgcctacact acagctactg
     1621 aatggaatgg ggccccttgg ccgaagagcc tcagacggag gcgccaacat ccaactacat
     1681 gcccagcagc tgctcaagcg cccacgggga ccatccccac ttgtcaccat gacaccagca
     1741 gtgccagcag ttacccctgt ggatgaggag agctcggatg gggagccaga tcaggaagct
     1801 gtgcagaggt acttggcaaa taggtccaaa aggcacacac tggccatgac cagcccgaca
     1861 gctgagatcc caccggacct gcaacggcag ctaggacaac agtctttccg ttcccgggtc
     1921 tggcctcctc acctggtacc tgaccagcat cgctccacct acaaggactc caacaccctg
     1981 catctcccta cggagcgttt ctcccccgtg cgccggttct cagacggggc ggcaagcatc
     2041 caggccttca aagctcacct ggaaagaatg ggcaacagca gcagcatcaa acagttacaa
     2101 caggagtgtg agcagctaca gaagatgtac ggcgggcagg ttgacgagag aaccctggag
     2161 aagacccagc agcagcatat gctgtaccag caggagcagc accatcagat cctccagcag
     2221 caaattcaag attctatttg tcctcctcag ccctccccac ctcttcaggc tgcatgtgaa
     2281 aatcagccaa ccctcctcac ccaccagctg cagaggttaa ggattcaacc ttcaagccca
     2341 ccccccaacc accccagcaa ccatctcttc aggcagccaa gtaacagtcc tcccccagtc
     2401 agcagtgcca tgatctcttc tcacggtgct acgtctccct cccagtttca aggcttaccc
     2461 tcccatggtg caatcttcca gcagcaacct gagaactgtt ccccacctcc cagtgtagca
     2521 ctaacctgct tgggcctaca gcaggctagc cagtcacagc cagtgactat ccagctacag
     2581 gagccagttg acatgctcag caacatggct gggacaactg caggttctgc agggcggggt
     2641 atccccatca gccccagtgc cagtcagatt cagatgcagc accgtaccag cctaatggct
     2701 cccttcggct atgggcaccg gcccttgtcc aagcagctga gtgctgacag cgcagaggct
     2761 cacagcttga gcatgaatcg attctcccct gccaactacg accaggcgca tttacacccc
     2821 catctgttct cggagcagtc ccgagggccc cccagcagct acagcccttc aacaggagtg
     2881 gggtttcctc cggctcaagc cctgagagtt cctccgcttg accagttccc cactttccct
     2941 cccagcgccc atcagcagcc acactatacc acatcagcac tacagcaggc cctgctgtcc
     3001 cctacaccac cagactatac cagacaccag caggttcccc acatccttca aggactgctc
     3061 tctccccggc attcactcac cggccactcg gacattcggc tgcctccagc agagtttgcc
     3121 cagctcatca aaagacagca gcagcatcga cagcagcagc aacagcagca gcagcagcag
     3181 cagcaagaat accatgagct gttcaggcac atgaaccaag gggatgctgt tagcctagct
     3241 cccggcctcg ggggacagaa tatgacagag caccaggctt tatcttatca aaatgctgac
     3301 tcataccacc gccaccacac cagcccccag catctcctac agatcagagc gcaagattgt
     3361 atctcacagg gtcccttgcc cacccccacc cgtgggtatg cccgtcagtc accactaatg
     3421 cattcggaga gtatggaaga agactgcttg tgtgaagggg tcaaggaggg cttcgcggac
     3481 aaaagctcaa gcacactgac caaaggttgc catgacagcc ctctgctctt gtgtaccagt
     3541 gggcctgggg accccgagcc tttgctggga actgtgagtc aggcccggga actgggaatc
     3601 catccctacg gacaccagcc aacggccacc acattcagta gaaataaggt gcccagccga
     3661 gagtctgtca tagggaactg catggagaga agttctcctg gacaagcaat ggagctgccg
     3721 gaccacaacg gccttgggta tcctgcacgg cccttagtca gtgagcacct caggtcccgg
     3781 accctccaga gacaccacac catccagaac agcgacgatg cttatgtaca gctggatacc
     3841 ttgccaggaa tgagcctggt ggcaggaaag gcactgagct ctgcccggat gtcagatgca
     3901 gttcttagtc agtcttcact catgggcagc cagcagtttc aggatgagga agatgaagaa
     3961 tgtggggtga gcctgggcca tgagcaccca gccctgggtg acggtagcca gcatttaaac
     4021 tcccgctatc cagctacgtg tgttacagac atcatgctca accacaagca tccagaggtc
     4081 tccttcagca tggagcaggc tggcgtgtag cagagtatga agagtccgag tccagctcca
     4141 ggaggaggct gagtctagac caatagccca acagtgtcca gcagcgccgc accactctac
     4201 catgtgtctc cgccagaaca gtgcagctcc tttccccaca gtgggcacca gtaggccgtt
     4261 gcttggggtg ccagggactt ttgccatgtt tgcttgtatg accaaggcac caagaaaata
     4321 aacaggaaat ccatgtcctc tatctctcat gagccagcat ctggtgtgct tgagttgagt
     4381 tctgctgtct ggaggtttgc ttgtgttttg ttttgggaat tttccttcgg agataattta
     4441 ttctctttgc ctcgcccact ccttccccac ttgagctagt gctcgctctc tcgctctccc
     4501 ccatctcatt ttctcctacc atttctgaag tagaggaacc aggggttagt attcagaggc
     4561 tgagcctcag gaccatcccc tccacagcct gtcccagacc agcctctccc ctctgctcta
     4621 ctctgccagg aacaaatgct agaatggagc ttggtggcca agaaagagag gacagggcag
     4681 tggccctgcc tttggagaat ggaagagaag aagaaacctg agcctggaat ctggcacagt
     4741 ctcctgctgg cctcccctag aatcatatct ggcccagcag aattccatca gagcccagcg
     4801 caggctgaat ggcctggtgc tgacaggttg ccaaccagaa tggctcagtg tagtaccctc
     4861 tggtgtgtga ctcagttccc ctccaagtca ccaactggtt cccctcgaga gtgaacaccc
     4921 aggagtagtg cactgtgctg tttgtgtggc ctccattctt gttctctact gcgttgtaaa
     4981 aaggaccgtt ggtccgttcg tgtgtgcata tacatgagtg tccatgccct tccctcgtgg
     5041 cctctttgtc accgacagga atcagaggtt gcatggggtc ccttaacctt ctctccccag
     5101 catccttgac ccctacattt taattcttga tcatgtagga attgtttttg gtaaatgttg
     5161 ataatattgt tattaatgtt attattaata aagacaaaaa ggattttttt ttttgtttaa
     5221 aagagaaatg tttaaccaga ttctgtgcta ttgaactgtg gcttgcacct tctgtttgaa
     5281 gcgttttcct tggcattggc atcatgagcc actctcctgt gccagcgacg aatgcagtgg
     5341 cctcccccag ccgaagcagc acatatgcag tagctacgtc cacgtcattt cctttctctc
     5401 tgcagtcaga aaccaaagtc tggggcccag caaggcctgg cttctcttct ggtcttcaaa
     5461 gccagagggg catggtccct gctctgactc ccagcactca tttctgagag ccaggggcca
     5521 ccaacctctg aatgtgcatg gaagaaagcc gttgcctacc atggcatccg gatgttacca
     5581 gcagggtccc cacccagttt atccttcccc caccgaccca gaaagcttgc tcctgagccc
     5641 actgtccctt gaacggattt gttttcaatg tgagagcttg gctagggacc tgtcccatgg
     5701 tcccatatcc tccaatcgcc cctccactcc aggtgtcgct aattactagc tagaagtctg
     5761 actttcaaga aagcttagca agctattgtt ggcttccaag ctcagtccaa ctctgatgct
     5821 ccagccccgt cctgctgctc cccccgctcg gcctgacctg tttacatggt actggattga
     5881 tggaagagca gacaccaccc tccagagcca cccagacaaa agccagtgag cctattaacc
     5941 gtgccatctt gcgaactatt ttcaagctca ccattgcttt atatcgtagt agccaacacg
     6001 cgcagtatat gttgaatgta tatgaatcta cttcgctatt tctgttcttt gaaaatgtaa
     6061 gaagtatttt ttcctttctc atttctgttg agctaaataa taataataat aataataata
     6121 ataataatct ccagattcaa gttgctaaga gcgtttgtcc tttgtttgcg tgggacattt
     6181 acaacttagt gacttggttg gactgtagga ggttgtggaa ataaaacctg attatgttct
     6241 gacactga
//
