LOCUS       XM_056984533            6544 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus salt-inducible kinase 2 (Sik2),
            transcript variant X1, mRNA.
ACCESSION   XM_056984533
VERSION     XM_056984533.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051343.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 18, 2024 this sequence was replaced by
            NM_001427328.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6544
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6544
                     /gene="Sik2"
                     /note="salt-inducible kinase 2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 36 ESTs, 6 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     132 samples with support for all annotated introns"
                     /db_xref="GeneID:315649"
                     /db_xref="RGD:1559698"
     CDS             198..2996
                     /gene="Sik2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SIK2 isoform X1"
                     /protein_id="XP_056840513.1"
                     /db_xref="GeneID:315649"
                     /db_xref="RGD:1559698"
                     /translation="MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKT
                     EVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNG
                     EIFDYLANHGRLNESEARRKFWQILSAVDYCHSRKVVHRDLKAENLLLDNSMNIKIAD
                     FGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFD
                     GPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLIEVP
                     VQRPILYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLV
                     ERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTLHPPNLRLMRSTLLPQ
                     ASNVEAFSFPASSCPAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSSMMET
                     SIDEGLETEGEAEEDPSQAFEAFQATRSGQRRHTLSEVTNQLVVLPRAGKVFSMSDSP
                     SLDSVDSEYDMGSAQRDLNFPEDSPSLKDIMLANQPSPRMTPFISLRPANPAMQALSS
                     QRREAHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIR
                     SDADPTLTSTAPQLQDLSSSCPQEEISQRQESVSALSASMHPQLSPQRSLETPYLQHR
                     LQKPSLLPKAQNACPMYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAE
                     RSYPGPTQQLALPHPETAPTPQQPPSFSLTQALSPVLEPSSEQMRFSSFLSQYPDMQL
                     QPLPSTPSPRAPPPLPSQLQQQQQPPPPPPPPPPQQPGATPASLQFSYQTCGLPSTTS
                     SAPSYPASCHYPVDGAQQSNLTGAECPRSSGLQEALSALPGLFDYEMVEAVDPQHNGL
                     KMGAAHFRTAGTDRNRLA"
ORIGIN      
        1 acgtcggcgc acgtcagcgc cggcgcgcgc ctggctgggc cctgtggggc gggagggaag
       61 cagcgcccgg gcgagagccg cggccgtcgc ccagagccca ggcgcgccgc ccgacgccct
      121 cctgcccgct ccgcgccgct tcgtgccggc cccttcgttc acgctcccgt cgtcgtgttc
      181 tgcagcgggg gccaagcatg gtcatggcgg atggcccgag gcacttgcag cgcgggccgg
      241 tccgggtggg gttctacgac atcgagggca cgctgggcaa gggcaacttc gccgtggtga
      301 agctggggcg gcaccggatc accaagacgg aggtggctat aaaaataata gacaaatctc
      361 aactggatgc agtaaacctt gagaaaatct accgagaagt acaaataatg aaaatgctcg
      421 accatcctca cataattaaa ctgtatcagg tgatggagac caaaagtatg ttgtaccttg
      481 tgacagagta tgccaaaaac ggagaaattt ttgattatct tgctaatcat ggccggttaa
      541 atgaatctga agccagaaga aaattctggc aaattctgtc tgctgttgat tattgccaca
      601 gccggaaggt agtgcaccgt gacctgaagg ctgaaaatct cctgctggat aacagcatga
      661 atatcaaaat agcagatttc ggctttggaa atttctttaa aactggtgaa ctgctggcaa
      721 catggtgtgg cagcccccca tatgcagccc cagaagtctt tgaagggcag caatatgaag
      781 gaccacagct ggatatatgg agcatgggag ttgttcttta tgtccttgtc tgtggagctc
      841 tgccttttga tggaccaact ctccctattt tgagacagag agttttggaa ggaagattcc
      901 ggattccata tttcatgtca gaagattgtg aacacctcat tagaaggatg ttggtcctag
      961 atccttccaa acggctaagc atagctcaaa tcaaggaaca caagtggatg ctcatagagg
     1021 ttcctgtaca gaggcctatt ctctatccac aagaacagga aaacgagccg tccattggag
     1081 agtttaatga acaggttttg cgactgatgc acagccttgg gattgatcag cagaagacta
     1141 ttgagtcttt gcaaaacaag agctataatc actttgctgc catttatttc ttgttggtgg
     1201 aacgtctgaa atcacataga agcagttttc ctgtggagca gagacttgat ggccgccagc
     1261 gccggcctag caccattgct gaacaaacag ttgccaaggc acaaaccgtg gggctaccag
     1321 tgaccttgca tccaccgaac ctgaggctga tgcggtctac cctcctcccg caggcatcca
     1381 atgtggaggc cttttcattt ccagcatcca gctgtccagc agaagctgcc tttatggagg
     1441 aagagtgtgt tgacacgcca aaggtgaatg gctgtctgct tgaccctgta ccccctgtcc
     1501 tggtgaggaa gggatgccag tccctgccca gcagtatgat ggagacctcc attgatgaag
     1561 gattggagac agaaggagag gccgaggaag accccagtca ggcctttgaa gctttccagg
     1621 ccacacgcag tgggcagcga cggcacactc tgtcagaagt gactaaccaa ttggttgtgt
     1681 tgcccagggc aggaaaagtt ttctccatga gtgatagccc ctcccttgac agtgtggact
     1741 ctgagtatga tatggggtct gcccagaggg acctgaactt tccagaagac agcccttccc
     1801 tgaaggacat catgttggcc aatcagccat cgcctcgcat gactcctttc ataagcctca
     1861 gacctgccaa cccagccatg caggctctga gctcacagag gcgtgaagcc cataaccggt
     1921 cccctgtgag cttccgagaa ggccgcagag cgtctgatac ttcccttacg caaggaattg
     1981 tagcatttag acagcatctt cagaatcttg ctagaaccaa aggaattctg gagttgaaca
     2041 aagtacaatt gctgtatgag caaattaggt cagatgcaga ccctacctta acatcgactg
     2101 ctcctcagct ccaagacctt tcgagcagtt gccctcagga ggagatctct cagcggcagg
     2161 aaagtgtctc cgccctctct gccagcatgc accctcagct ttcaccacag cgaagcttgg
     2221 aaaccccgta cctgcagcac cgactccaga agcccagtct tctgccaaag gcccagaatg
     2281 cttgtccgat gtattgtaaa gaaccacctc gaagcctgga acagcagcta caggaacaca
     2341 ggctccaaca gaagcgactc ttcctgcaga agcagtctca gctgcaagcg tattttaatc
     2401 agatgcagat agcagagcgc tcctaccctg gaccaactca gcagctggct cttccccacc
     2461 cggagactgc accgacacct cagcagcccc catccttcag cctgacccag gccctcagcc
     2521 ctgtcctgga accctcttct gagcagatgc gatttagctc tttcctcagc caatacccag
     2581 atatgcagtt gcagcccctg ccctctacgc ccagcccccg ggctccacct cccttaccct
     2641 cacaactgca acagcagcag cagccaccac ccccaccccc accccctcca ccacagcagc
     2701 caggagctac tccagcctcc ttacagttct cctatcagac ttgtgggctg ccaagcacca
     2761 cttcttctgc accaagctat cctgcttcct gtcactatcc tgtggacgga gcccaacaga
     2821 gcaacctcac aggggcagag tgtcccagga gctcaggact tcaggaggcc ctctctgcgc
     2881 tccctggact ctttgactat gaaatggtag aagccgtgga cccacaacac aatggattga
     2941 aaatgggggc cgctcatttc aggactgcag gaacagaccg caacagattg gcataaaccc
     3001 ctgcccccca acaggctgtg agctgcttag cccaggagac ctagcagcta tggcaggaca
     3061 gttaggcgac agatgagggg ctgcggagag gctgtcagaa ggttaaaggc tgcagagaga
     3121 agttgggaac ctcatcagcg gccaagcctg ttaggcactg acacagagag gaggtgagga
     3181 cagtcgcctg gtgaagacca agaatcatcc agctggaacc agtcgtaagc tcccattttc
     3241 tccttcctca gtttcaagta gacatcccta gttccacggc tacctttatt tcatgagatg
     3301 gaggctggtg agagtagacg agctctctgc tcatctgatt gtttctgtgt ctgcccctaa
     3361 ctagtgaccc atggaagctt gcaagtcgtt tctcctcaca agtactaaag taacactaag
     3421 gcggcttagg cccactcttg tggagaggca gctttgaaat actgacatgt ttgcctgtcg
     3481 gttcacatca gcagtgtgta cactactgta tagtaaccct tagctttgtt atcttgtaaa
     3541 cgagcctctc caaagagact ggtgattcaa acatgaggta aaattttcat tcagcaaaaa
     3601 gtgcaatatg tgtggtactc ttttattttt tgcttatggt cttttgttat ccgtaggtat
     3661 tattactctg tgctttgggg gaaatgcttt agttttgcaa tttccgattg ggcaagtgtg
     3721 tctctagtat ttacatgcaa ctgacatgct ggtccctgta aggcaaagag agggtgttaa
     3781 tacaacagaa aagcaacgga tatggggtcc cactctattc ccagggagct gcctgaccag
     3841 caccagccct catcctgccc ctgacatggc ctgcctgaac tctgccacct taggaaaaaa
     3901 gatgggggca gttctgtatg tccataaccc tctagaatct acccagtggg agacaatgag
     3961 ggcccaggga aagcctttgg aagtgatggg aggtataaga gctggtctga acaaagccct
     4021 tcctcttgct ttgcatccta ggaaaaagga agccaaggtc tctttatccc agaaatcgag
     4081 aactcagaaa tatttaaact gggtcctggt gtcagggagg gagggaggac ttcaacctct
     4141 gcctctcatg ctccctccta acttttgtaa ttgagttact gcattgttac aggacccccc
     4201 attctgtacg ctcccctcct tccccctgtt ggacaattca ccctgtggag tagcaccctc
     4261 tgccctgccc cagagctctg ttaaatagga tagtcatcac agacccctct acctataccc
     4321 taggagcacc acacctaaga cagggctact aggactgggg aaagggtatg ctctcggctg
     4381 gagagagacc atgtggtgaa ccagaaactg aaggagctaa aagcagcagc ttctaggcca
     4441 gctgatcaag gaccccaggt gtgccagcag ctcaggacat gggacccatt gggctctcct
     4501 tcctctacag gttctccagc ctctaatcaa gcctgcttct taaatctatc aggatcagag
     4561 tttctccagt ctggattaca ctcatgccaa cagtgagtta agttccctgt tggtttacag
     4621 aaaactcata gcccaggtga ctttttcaca ttcctcctcc tctagagaca gtgtgtagtg
     4681 tcccttgatg acagtgattg aagtggcagt cgcagagtcc ctgtgccagg gctgaccttt
     4741 gctgtgtttg tgcccctaag ctgggccgct gctactgcct ccttggaagc cacacaagcc
     4801 gctccttctc tctgtgccta gacatcaaag gtagaaactg gagaacaggt agtaagttgg
     4861 agtcattgtc caggcaggga cttttgtcat tttgttggtt ccctggctcg ggagctcaga
     4921 gaagtgagag attccatgac tttcccacca tttccctggc atgtgagtga gataccgacc
     4981 gacccttcaa aggttctgtg ggccctggag tctctggcct cccaacacct tctcgctgat
     5041 tgcttgagcc attttcaccg gttccaacag cctggctgat tctggaagac tcccagcatt
     5101 cctagttgca ccacatcatc tgtccacatt ttatgtgagc aaattggggc aaatgtctgc
     5161 actgattgac agacagctta ggcaagtgtg gttcttacga gtccgagtcc cgtttactca
     5221 gcttgcctgc ccatattcac agcaatttac caagcacttc cgagtgcttg cttagatccc
     5281 tcaacacttc tgtaagctta gctagagaga gtctgtccat gtttctgaga aaagcaaagc
     5341 tcttaaggat acatgactta gctgagggca cagagctcag aagtggaggt agcagggtca
     5401 agctccttcc ttgcctggct tttggcttgt gttggagccc tgcccccaca actgcagcct
     5461 ccatagatgc ctggctctaa gtgctcttga gtgataactg cagccatctg ggtgacttgc
     5521 actgcgcagg gagacacaga cacctttcta taagtatata ttggaaggac atgcccctcc
     5581 tttatttcca aagggcagaa agggaccaac agagtcgact cgagaagata gacgcccaga
     5641 gaatcatgaa ctcaaccttt atcctaaagg gaaggcacta gaacaccttt ttcttttgaa
     5701 acacggtgta gcccaggctg tcctggcact cactccgtag agcagactgg ccgcaaactc
     5761 agagatgctc ttgcctctgc ctccaagtgc tggggttaaa ggaatatgtc actatgccca
     5821 ttgaatttct tcacaattaa gtcctgacaa gtaggaaggc ttattcgaca ctttcaggat
     5881 tacagaatgg taacatgctt gatggtagaa tgctaggact tttcagaacc aaaatgggcg
     5941 agtaagggta gctttaaaaa tagaagtaca aacaacatcc cgtggatggc atagtgttgc
     6001 atttccaagt acagataact gatgcctaca ctccaggatt tgctcagtca cggaaattca
     6061 agtggtgagg caccctcagt gctactcatg gtttgagaaa gagaaaagga gaaagcagca
     6121 ggaagggggc tacctacagg gtggcctctg ggggactgca gctgtgatag agtgctagag
     6181 actgtttgca ctttctagaa aggcaaggcc gtttgcttat tgcagaaaga acagctggat
     6241 tcactcgctc tgtgacttac ttaatctgtc tgtagtcagt tttttctttt gtacttttta
     6301 attactaaga gaaatttggc aacttcaaca gctttggtat tttgtgtgca aatcataata
     6361 gctccagtgt gaaaaatcaa agtgtcacct gtcactctgt taggaattgc ctaaaatgca
     6421 gtttaataaa tgatctttgt accaaatggt tatgtaaatg gagtaatttt ctgcaaggaa
     6481 aatgtactgt ttttatgttt ccaaccctcc tgaattaaaa taaaaaacac cttgttttct
     6541 aaaa
//
