LOCUS       NM_021693               2644 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus salt-inducible kinase 1 (Sik1), mRNA.
ACCESSION   NM_021693
VERSION     NM_021693.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Hsu,A., Duan,Q., McMahon,S., Huang,Y., Wood,S.A., Gray,N.S.,
            Wang,B., Bruneau,B.G. and Haldar,S.M.
  TITLE     Salt-inducible kinase 1 maintains HDAC7 stability to promote
            pathologic cardiac remodeling
  JOURNAL   J Clin Invest 130 (6), 2966-2977 (2020)
   PUBMED   32106109
  REMARK    GeneRIF: Salt-inducible kinase 1 maintains HDAC7 stability to
            promote pathologic cardiac remodeling.
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Song,D., Yin,L., Wang,C. and Wen,X.
  TITLE     Adenovirus-mediated expression of SIK1 improves hepatic glucose and
            lipid metabolism in type 2 diabetes mellitus rats
  JOURNAL   PLoS One 14 (6), e0210930 (2019)
   PUBMED   31233505
  REMARK    GeneRIF: SIK1 plays a crucial role in the regulation of glucose and
            lipid metabolism in the livers of HFD/STZ-induced T2DM rats, where
            it suppresses hepatic gluconeogenesis and lipogenesis by regulating
            the SIK1/CRTC2 and SIK1/SREBP-1c signalling pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Manfredi,L.H., Lustrino,D., Machado,J., Silveira,W.A., Zanon,N.M.,
            Navegantes,L.C. and Kettelhut,I.C.
  TITLE     Adrenodemedullation activates the Ca2+-dependent proteolysis in
            soleus muscles from rats exposed to cold
  JOURNAL   J Appl Physiol (1985) 122 (2), 317-326 (2017)
   PUBMED   27765842
REFERENCE   4  (bases 1 to 2644)
  AUTHORS   Hu,Z., Hu,J., Shen,W.J., Kraemer,F.B. and Azhar,S.
  TITLE     A Novel Role of Salt-Inducible Kinase 1 (SIK1) in the
            Post-Translational Regulation of Scavenger Receptor Class B Type 1
            Activity
  JOURNAL   Biochemistry 54 (46), 6917-6930 (2015)
   PUBMED   26567857
  REMARK    GeneRIF: role for SIK1 in the positive regulation of selective
            HDL-CE transport function of SR-B1 and steroidogenesis
REFERENCE   5  (bases 1 to 2644)
  AUTHORS   McTague,J., Ferguson,M., Chik,C.L. and Ho,A.K.
  TITLE     The adrenergic-regulated CRTC1 and CRTC2 phosphorylation and
            cellular distribution is independent of endogenous SIK1 in the male
            rat pinealocyte
  JOURNAL   Mol Cell Endocrinol 414, 156-167 (2015)
   PUBMED   26210066
  REMARK    GeneRIF: Results indicate that overexpressing SIK1 can
            phosphorylate CRTC1 and CRTC2 in the norepinephrine (NE)-stimulated
            pinealocytes. Howeve, the endogenous SIK1 does not appear to be the
            main regulator of their phosphorylation and intracellular
            localization.
REFERENCE   6  (bases 1 to 2644)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
REFERENCE   7  (bases 1 to 2644)
  AUTHORS   Horike,N., Takemori,H., Katoh,Y., Doi,J., Min,L., Asano,T.,
            Sun,X.J., Yamamoto,H., Kasayama,S., Muraoka,M., Nonaka,Y. and
            Okamoto,M.
  TITLE     Adipose-specific expression, phosphorylation of Ser794 in insulin
            receptor substrate-1, and activation in diabetic animals of
            salt-inducible kinase-2
  JOURNAL   J Biol Chem 278 (20), 18440-18447 (2003)
   PUBMED   12624099
REFERENCE   8  (bases 1 to 2644)
  AUTHORS   Takemori,H., Katoh,Y., Horike,N., Doi,J. and Okamoto,M.
  TITLE     ACTH-induced nucleocytoplasmic translocation of salt-inducible
            kinase. Implication in the protein kinase A-activated gene
            transcription in mouse adrenocortical tumor cells
  JOURNAL   J Biol Chem 277 (44), 42334-42343 (2002)
   PUBMED   12200423
REFERENCE   9  (bases 1 to 2644)
  AUTHORS   Katoh,Y., Takemori,H., Doi,J. and Okamoto,M.
  TITLE     Identification of the nuclear localization domain of salt-inducible
            kinase
  JOURNAL   Endocr Res 28 (4), 315-318 (2002)
   PUBMED   12530631
  REMARK    GeneRIF: Nucleocytoplasmic shuttling of SIK may play important role
            in transcriptional regulation of cAMP-responsive element
            (CRE)-dependent gene expression.
REFERENCE   10 (bases 1 to 2644)
  AUTHORS   Wang,Z., Takemori,H., Halder,S.K., Nonaka,Y. and Okamoto,M.
  TITLE     Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high
            salt diet-treated rat adrenal
  JOURNAL   FEBS Lett 453 (1-2), 135-139 (1999)
   PUBMED   10403390
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 27, 2020 this sequence version replaced NM_021693.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020480.1, SRR26643285.55193.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000020.1  9958591-9958646     c
            57-227              JAXUCZ010000020.1  9957789-9957959     c
            228-344             JAXUCZ010000020.1  9957012-9957128     c
            345-408             JAXUCZ010000020.1  9954483-9954546     c
            409-570             JAXUCZ010000020.1  9954171-9954332     c
            571-695             JAXUCZ010000020.1  9953923-9954047     c
            696-819             JAXUCZ010000020.1  9953709-9953832     c
            820-1043            JAXUCZ010000020.1  9952875-9953098     c
            1044-1199           JAXUCZ010000020.1  9952501-9952656     c
            1200-1322           JAXUCZ010000020.1  9951956-9952078     c
            1323-1539           JAXUCZ010000020.1  9951627-9951843     c
            1540-1821           JAXUCZ010000020.1  9950966-9951247     c
            1822-2050           JAXUCZ010000020.1  9950136-9950364     c
            2051-2644           JAXUCZ010000020.1  9949114-9949707     c
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2644
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /note="salt-inducible kinase 1"
                     /db_xref="GeneID:59329"
                     /db_xref="RGD:69407"
     exon            1..56
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            57..227
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2402
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /EC_number="2.7.11.1"
                     /note="SNF1-like kinase; SIK-1; protein kinase KID2;
                     salt-inducible protein kinase 1; serine/threonine-protein
                     kinase SNF1LK; serine/threonine-protein kinase SNF1-like
                     kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SIK1"
                     /protein_id="NP_067725.2"
                     /db_xref="GeneID:59329"
                     /db_xref="RGD:69407"
                     /translation="MVIMSEFSAVPTGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLA
                     RHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIV
                     TEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHNHHIVHRDLKTENLLLDGN
                     MDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLV
                     CGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHR
                     WMQADPTLLQQDDPAFSMQGYTSNLGDYNEQVLGIMQALGIDRQRTVESLQNSSYNHF
                     AAIYYLLLERLREHRSTQPSSRATPAPARQPQLRNSDLSSLEVPQEILPCDPFRPSLL
                     CPQPQALAQSVLQAEIDCDLHSSLQPLFFPLDTNCSGVFRHRSISPSSLLDTAISEEA
                     RQGPSLEEEQEVQEPLPGSTGRRHTLAEVSTHFSPLNPPCIIVSSSAAVSPSEGTSSD
                     SCLPFSASEGPAGLGGGLATPGLLGTSSPVRLASPFLGSQSATPVLQSQAGLGATVLP
                     PVSFQEGRRASDTSLTQGLKAFRQQLRKNARTKGFLGLNKIKGLARQVCQSSIRGSRG
                     GMSTFHTPAPSSGLQGCTASSREGRSLLEEVLHQQRLLQLQHHSAVSSDYQQAPQLSP
                     VPYVLTPCDGLLVSGIPLLPTPLLQPGMSPVASAAQLLDAHLHISAGPVALPTGPLPQ
                     CLTRLSPSCDPAGLPQGDCEMEDLTSGQRGTFVLVQ"
     exon            228..344
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            345..408
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            409..570
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            571..695
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            696..819
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1043
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1199
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1322
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1539
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1821
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..2050
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2644
                     /gene="Sik1"
                     /gene_synonym="Sik; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcaagca gccgagcgag tggcgtcccg ggtcgggcac acggagggcg gcggaggtgc
       61 ggcccgaagc catggtgatc atgtcggagt tcagcgcggt ccccacaggc accggccagg
      121 gccagcagaa gcccctccgg gtgggctttt acgacgtgga acgaaccctg ggcaaaggca
      181 attttgcagt ggttaagctg gcgcggcacc gagtcaccaa aacgcaggtt gcaattaaaa
      241 taattgacaa gacacggtta gattctagta atctggagaa gatctaccgg gaggtccagc
      301 tcatgaaact cctgaaccac ccaaatatta tcaagcttta ccaggttatg gagacaaaag
      361 acatgctgta cattgtcacg gagtttgcca aaaatggaga aatgttcgat tatctgactt
      421 ccaacgggca cttgagtgaa aacgaggcta ggaagaaatt ctggcagatc ctgtcagccg
      481 tggagtactg ccacaaccat cacatcgtcc accgggacct taagacagag aaccttctgc
      541 tggacggcaa catggacatc aagctggcag attttggatt tgggaatttc tacaagccag
      601 gggagcctct gtctacttgg tgtgggagcc ccccctatgc tgctcccgaa gtctttgagg
      661 ggaaggagta tgaaggtccc cagctggaca tctggagcct cggcgtggtg ctgtatgtcc
      721 tggtctgtgg ctccctccct tttgatggac ccaacctgcc tacgctgaga cagcgggtgc
      781 tggagggccg cttccgcatc cccttcttca tgtctcaaga ctgtgagaca ctgatcagac
      841 gcatgctggt agtggacccc gccaagcgca tcaccattgc ccagatccgc cagcaccgat
      901 ggatgcaggc cgaccccacc ctcctgcagc aggacgaccc tgccttctcc atgcagggct
      961 acacctccaa cctgggcgac tacaacgagc aggtgctggg catcatgcag gccctgggca
     1021 tcgaccggca gaggacagta gagtctctac agaacagcag ctacaaccac tttgcggcta
     1081 tttactacct cctgctcgag cgcctcaggg agcatcgaag cacccagccc tcatcccggg
     1141 ccacccctgc acctgccaga cagcctcagc tccgaaactc agacctcagc agtctggagg
     1201 ttcctcaaga aattctccca tgtgaccctt tccggccctc tctgctgtgc ccgcagcccc
     1261 aggccttggc tcagtctgtc ctgcaggctg agatagactg tgatctccac agttcgcttc
     1321 agcccttatt cttccccctg gataccaact gcagcggagt gttccggcac cgatccatct
     1381 cccccagcag cctgctggac acagctatca gtgaggaggc caggcagggt cccagcctgg
     1441 aggaggagca ggaggtccag gaacccctgc ctggcagcac tggccggagg catacactgg
     1501 ctgaagtttc cacccacttc tccccgctca accctccttg cataattgtc tcctcctctg
     1561 ccgctgtgag tccctcggaa ggaactagct ctgacagctg cctccccttc tctgcaagcg
     1621 aaggtcctgc agggcttggt ggtggcctgg ccaccccagg gcttctgggc accagctctc
     1681 cagtcagatt ggcctcaccc ttcctgggat cacagtcagc cacccctgtg ctacagagtc
     1741 aggcaggtct gggtgcgact gtcttacctc ctgtcagctt ccaggaggga cggagagcgt
     1801 cggatacgtc tctcactcaa gggctgaagg ccttccggca gcagctaagg aaaaacgcga
     1861 ggaccaaggg gttcctggga ctgaacaaga tcaaaggatt ggcccgtcag gtgtgccagt
     1921 cctccatccg aggttcccgg ggagggatga gtaccttcca caccccggcc ccaagctcag
     1981 gtctgcaagg ctgcacggcc agcagtcgcg agggcaggag cctgctcgaa gaggtgctgc
     2041 accagcagag gctgctccag ttacagcacc actcagccgt ctcatctgac taccagcagg
     2101 ccccccaact gtcccccgtc ccctacgtgc tcactccctg tgatggcctt ctcgtgtctg
     2161 gaatcccact gctgccaacg cccctcctcc agcccggcat gtcccccgtg gcgtctgccg
     2221 cgcagctcct ggatgcccac ttgcacatca gtgctggccc agtggccctc cccactggtc
     2281 ccctgccaca gtgcctcacc aggctgtccc caagctgtga tcctgctggg ctgccgcagg
     2341 gggattgtga gatggaggac ctgacctctg gccagcgggg gacgttcgtc ctggtacagt
     2401 gagggtgact ctgccacacc cctgcccccc caccccacgg atggactctt ccaagcaata
     2461 atttcagagt atgtgaagat ggtttcggac tcaaaagcca agaactttct agacgtgaaa
     2521 caagcaatat gtttggtgta cgggcttttt taggagtttt tttgtttttg tttttgtttt
     2581 tgtttttgtt tttttccttg cactgagtga cctcaatgat aagtagggat ggaaactttc
     2641 tgaa
//
