LOCUS       NM_030996               1555 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus sigma non-opioid intracellular receptor 1
            (Sigmar1), mRNA.
ACCESSION   NM_030996
VERSION     NM_030996.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Ke,H., Su,X., Dong,C., He,Z., Song,Q., Song,C., Zhou,J., Liao,W.,
            Wang,C., Yang,S. and Xiong,Y.
  TITLE     Sigma-1 receptor exerts protective effects on ameliorating
            nephrolithiasis by modulating endoplasmic reticulum-mitochondrion
            association and inhibiting endoplasmic reticulum stress-induced
            apoptosis in renal tubular epithelial cells
  JOURNAL   Redox Rep 29 (1), 2391139 (2024)
   PUBMED   39138590
  REMARK    GeneRIF: Sigma-1 receptor exerts protective effects on ameliorating
            nephrolithiasis by modulating endoplasmic reticulum-mitochondrion
            association and inhibiting endoplasmic reticulum stress-induced
            apoptosis in renal tubular epithelial cells.
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Denaro,S., Pasquinucci,L., Turnaturi,R., Alberghina,C.,
            Longhitano,L., Giallongo,S., Costanzo,G., Spoto,S., Grasso,M.,
            Zappala,A., Li Volti,G., Tibullo,D., Vicario,N., Parenti,R. and
            Parenti,C.
  TITLE     Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and
            Modulate Neuroinflammation in Chronic Neuropathic Pain
  JOURNAL   Mol Neurobiol 61 (5), 2672-2685 (2024)
   PUBMED   37922065
  REMARK    GeneRIF: Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia
            and Modulate Neuroinflammation in Chronic Neuropathic Pain.
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Li,Z., Zhou,J., Cui,S., Hu,S., Li,B., Liu,X., Zhang,C., Zou,Y.,
            Hu,Y., Yu,Y., Shen,B. and Yang,B.
  TITLE     Activation of sigma-1 receptor ameliorates sepsis-induced
            myocardial injury by mediating the Nrf2/HO1 signaling pathway to
            attenuate mitochondrial oxidative stress
  JOURNAL   Int Immunopharmacol 127, 111382 (2024)
   PUBMED   38141412
  REMARK    GeneRIF: Activation of sigma-1 receptor ameliorates sepsis-induced
            myocardial injury by mediating the Nrf2/HO1 signaling pathway to
            attenuate mitochondrial oxidative stress.
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   Tagashira,H., Bhuiyan,M.S., Shinoda,Y., Kawahata,I., Numata,T. and
            Fukunaga,K.
  TITLE     Sigma-1 receptor is involved in modification of ER-mitochondria
            proximity and Ca2+ homeostasis in cardiomyocytes
  JOURNAL   J Pharmacol Sci 151 (2), 128-133 (2023)
   PUBMED   36707178
  REMARK    GeneRIF: Sigma-1 receptor is involved in modification of
            ER-mitochondria proximity and Ca[2+] homeostasis in cardiomyocytes.
REFERENCE   5  (bases 1 to 1555)
  AUTHORS   Zhao,X., Liu,X., Chen,X., Han,X., Sun,Y., Fo,Y., Wang,X., Qu,C. and
            Yang,B.
  TITLE     Activation of the sigma-1 receptor exerts cardioprotection in a
            rodent model of chronic heart failure by stimulation of
            angiogenesis
  JOURNAL   Mol Med 28 (1), 87 (2022)
   PUBMED   35922746
  REMARK    GeneRIF: Activation of the sigma-1 receptor exerts cardioprotection
            in a rodent model of chronic heart failure by stimulation of
            angiogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1555)
  AUTHORS   Hayashi,T. and Su,T.P.
  TITLE     Regulating ankyrin dynamics: Roles of sigma-1 receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 491-496 (2001)
   PUBMED   11149946
REFERENCE   7  (bases 1 to 1555)
  AUTHORS   Alonso,G., Phan,V., Guillemain,I., Saunier,M., Legrand,A., Anoal,M.
            and Maurice,T.
  TITLE     Immunocytochemical localization of the sigma(1) receptor in the
            adult rat central nervous system
  JOURNAL   Neuroscience 97 (1), 155-170 (2000)
   PUBMED   10771347
REFERENCE   8  (bases 1 to 1555)
  AUTHORS   Dussossoy,D., Carayon,P., Belugou,S., Feraut,D., Bord,A.,
            Goubet,C., Roque,C., Vidal,H., Combes,T., Loison,G. and Casellas,P.
  TITLE     Colocalization of sterol isomerase and sigma(1) receptor at
            endoplasmic reticulum and nuclear envelope level
  JOURNAL   Eur J Biochem 263 (2), 377-386 (1999)
   PUBMED   10406945
REFERENCE   9  (bases 1 to 1555)
  AUTHORS   Seth,P., Fei,Y.J., Li,H.W., Huang,W., Leibach,F.H. and Ganapathy,V.
  TITLE     Cloning and functional characterization of a sigma receptor from
            rat brain
  JOURNAL   J Neurochem 70 (3), 922-931 (1998)
   PUBMED   9489711
REFERENCE   10 (bases 1 to 1555)
  AUTHORS   Jbilo,O., Vidal,H., Paul,R., De Nys,N., Bensaid,M., Silve,S.,
            Carayon,P., Davi,D., Galiegue,S., Bourrie,B., Guillemot,J.C.,
            Ferrara,P., Loison,G., Maffrand,J.P., Le Fur,G. and Casellas,P.
  TITLE     Purification and characterization of the human SR 31747A-binding
            protein. A nuclear membrane protein related to yeast sterol
            isomerase
  JOURNAL   J Biol Chem 272 (43), 27107-27115 (1997)
   PUBMED   9341151
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030996.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF004218.1, BC061978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               JAXUCZ010000005.1  61702615-61702799   c
            186-386             JAXUCZ010000005.1  61702278-61702478   c
            387-479             JAXUCZ010000005.1  61702052-61702144   c
            480-1555            JAXUCZ010000005.1  61700021-61701096   c
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1555
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1"
                     /note="sigma non-opioid intracellular receptor 1"
                     /db_xref="GeneID:29336"
                     /db_xref="RGD:68364"
     exon            1..185
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..706
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1"
                     /note="opioid receptor, sigma 1; sigma 1-type opioid
                     receptor; sigma1R; sigma1-receptor"
                     /codon_start=1
                     /product="sigma non-opioid intracellular receptor 1"
                     /protein_id="NP_112258.2"
                     /db_xref="GeneID:29336"
                     /db_xref="RGD:68364"
                     /translation="MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQ
                     LARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSE
                     YVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEAT
                     AVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYL
                     FGQDP"
     exon            186..386
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..479
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..1555
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttacgtt ggtggtacca ggctgcccgc tgggatgccg tgggctgtgg gccggcggtg
       61 ggcatggatc accctgtttc tgactattgt ggcggtgctg atccaggcgg tctggctgtg
      121 gctgggtact cagagcttcg tcttccagag agaagagata gctcagcttg ctcgacagta
      181 cgcagggctg gaccatgagc tggccttctc tcggctgatc gtggagctgc ggaggctgca
      241 cccaggccac gtgctgccgg atgaggagct gcagtgggtg tttgtgaacg cgggcggctg
      301 gatgggcgcc atgtgtcttt tgcacgcctc gctgtctgag tacgtgctgc tcttcggcac
      361 cgccctgggc tcccatggcc attcgggacg atactgggct gagatttcag ataccatcat
      421 ctctggcact ttccaccagt ggagagaggg caccacaaaa agtgaggtct attacccagg
      481 agagacggtt gtccatggac ctggagaggc aacagctgtg gagtggggac caaacacgtg
      541 gatggtggag tatggccggg gtgttattcc gtctaccctg gcatttgcac ttagtgacac
      601 tattttcagc acccaggact tcctcaccct cttctatacc cttcgcgcct atgcccgggg
      661 cctccggctt gagctcacca cctacctctt tggccaagac ccctgaccag acaggctgaa
      721 ggaagacctg cgagtggaca ggagcgggca ggaccacatc catttctcta ctcgctggga
      781 ctcatgttca ctgacagcag catataccat gcagataatt aagttcctgc tgtgtgagga
      841 aggacataca tacacataca tccagacaca gctcttgggg agcaatgaga cgcagagatg
      901 ctaagacttg tatgtactgt aagatcatgc actcacctcc atccagagag ggtccccgac
      961 gtatactcca ggggggcgcc cagtcatgtt tgaacacata ccacgagctt gactcacctg
     1021 actcaggctt ttccagagcc tcctgctggc attcggggct ctgagataga ggattggggt
     1081 agatgacaca gtctgcctcg ctctgatgcc gcattccagt agtgatctct ggtgaaggaa
     1141 aagaggagct gcccttcgga ggtcccgttc gcctgcagct gtgatgccct tccctccatc
     1201 cctttcctca ccatatgcct tatctccatt ccagtcccct gctatgcaag tgtccctgtg
     1261 gcttgtcctc catgccccca gcgaccagct gggaaagcag aggaatgtag aggaagctga
     1321 agggaaggga ggttctccac catggagacc ctcagggtta caatgggaaa gctggctgat
     1381 gcctggggcc agttcccaaa gagaggacct ggggaagtga gcctggctcc gagaagccac
     1441 cccattccaa aagaagcctt tagtgtatgt gtgcacacct tgtcggtctc cagacatttc
     1501 tgttgcattc tctgtcttcc tgtctctctc tgttaataaa aacagatcaa acagt
//
