LOCUS       NM_001421472            1036 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus SIGLEC family like 1 (Siglecl1), mRNA.
ACCESSION   NM_001421472 XM_017590105
VERSION     NM_001421472.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1036)
  AUTHORS   Li,S., Jiang,L., Yang,Y., Cao,J., Zhang,Q., Zhang,J., Wang,R.,
            Deng,X. and Li,Y.
  TITLE     Siglec1 enhances inflammation through miR-1260-dependent
            degradation of IkappaBalpha in COPD
  JOURNAL   Exp Mol Pathol 113, 104398 (2020)
   PUBMED   32007531
  REMARK    GeneRIF: the present study demonstrated that Siglec1 exerts its
            proinflammatory effects through increasing miR-1260, leading to
            decreased expression of IkappaBalpha.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On May 18, 2023 this sequence version replaced XM_017590105.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2740863.1,
                                           SRR26360186.1466248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               JAXUCZ010000001.1  103061019-103061309 c
            292-355             JAXUCZ010000001.1  103059319-103059382 c
            356-637             JAXUCZ010000001.1  103058307-103058588 c
            638-743             JAXUCZ010000001.1  103057852-103057957 c
            744-894             JAXUCZ010000001.1  103056924-103057074 c
            895-1036            JAXUCZ010000001.1  103053544-103053685 c
FEATURES             Location/Qualifiers
     source          1..1036
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1036
                     /gene="Siglecl1"
                     /note="SIGLEC family like 1"
                     /db_xref="GeneID:690483"
                     /db_xref="RGD:2324488"
     exon            1..291
                     /gene="Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..355
                     /gene="Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1011
                     /gene="Siglecl1"
                     /note="sialic acid-binding Ig-like lectin 10; sialic acid
                     binding Ig-like lectin 5-like"
                     /codon_start=1
                     /product="SIGLEC family-like protein 1"
                     /protein_id="NP_001408401.1"
                     /db_xref="GeneID:690483"
                     /db_xref="RGD:2324488"
                     /translation="MDLPHSHLEPARLLNSFCSVEKTLQCSCSFHGIPTPSVQWWVDG
                     TPVDVNSGHGHLQVTSTTLGPWDNSTLSLAKDPEMGTVLLCEGKNQHGIDGLSILLMS
                     RRGPLAPQIFLEALLQGVVYATLAVTLFFLCLLPFIMKLLKMKQAKKCVQMRAQQGST
                     AGTDQASHVKPPKPRKSRSEPPSEDQLLEKEDNLKLRKTMETASYTKFPLPWELQNPM
                     ETPEAPGP"
     exon            356..637
                     /gene="Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..743
                     /gene="Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..894
                     /gene="Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1036
                     /gene="Siglecl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcatccaa agccaattct ggatcggcag agagtgactg cacactggtc ggttcgccga
       61 gtgcctcttt ctatgctagc cagcctgtca gtcttcagta cttggccagc tgtttatctt
      121 gctcccctca gttacccggc caacctgtca tccctctgtc acttatttgt cctgtctctg
      181 tcgcactctt cttcatcctg tcacccctca gtcactttca gtgtgtcacc aagttaacct
      241 gaaaagaagc tagtggatca ccattctact aatagaacaa gccagaagcc tggaatagca
      301 ctgtgtgcct gggaattctt gctgttgcat atggacctgc cacattcaca cctcgaacct
      361 gccagactgc ttaactcctt ctgctctgtg gagaagacat tgcagtgcag ctgttccttc
      421 catgggatcc ccactccctc tgtgcagtgg tgggtggatg gtactcctgt ggatgtgaac
      481 agtggacatg gtcacctcca ggtgacctct accacacttg gtccctggga caacagcacc
      541 ctcagcctgg ccaaggaccc agaaatgggc acagttcttc tctgtgaggg aaagaaccaa
      601 catggaatcg atggtttgag catcctactg atgtcgagaa ggggcccttt ggctccccag
      661 atttttcttg aagctctgtt acaaggtgtt gtctacgcga ccttggcagt cacactattt
      721 tttctctgcc tcctcccctt cataatgaaa cttctcaaga tgaagcaggc aaagaagtgt
      781 gtgcagatga gggcacagca gggctctacg gctggaacag accaggcatc ccatgtgaag
      841 cccccaaagc ccaggaaatc cagaagtgag ccaccctctg aggatcagct cttggaaaag
      901 gaagataatc taaagctgag gaagaccatg gagactgcat cctatacaaa gttcccatta
      961 ccctgggaat tacaaaatcc catggagacc ccagaagccc caggtccata ataaacttga
     1021 agtcttgaga atttga
//
