LOCUS       NM_001107777            6671 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus sialic acid binding Ig like lectin 1 (Siglec1),
            mRNA.
ACCESSION   NM_001107777 XM_230608
VERSION     NM_001107777.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6671)
  AUTHORS   Kidder,D., Richards,H.E., Ziltener,H.J., Garden,O.A. and
            Crocker,P.R.
  TITLE     Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T
            cells with a distinct activation and glycosylation profile
  JOURNAL   J Immunol 190 (6), 2593-2602 (2013)
   PUBMED   23408841
REFERENCE   2  (bases 1 to 6671)
  AUTHORS   Nagase,R., Kajitani,N., Shikata,K., Ogawa,D., Kodera,R., Okada,S.,
            Kido,Y. and Makino,H.
  TITLE     Phenotypic change of macrophages in the progression of diabetic
            nephropathy; sialoadhesin-positive activated macrophages are
            increased in diabetic kidney
  JOURNAL   Clin Exp Nephrol 16 (5), 739-748 (2012)
   PUBMED   22526486
  REMARK    GeneRIF: sialoadhesin-positive macrophages were increased during
            the late stage of diabetes concomitantly with the increase of
            alpha-smooth muscle actin-positive mesangial cells, mesangial
            matrix area and type IV collagen.
REFERENCE   3  (bases 1 to 6671)
  AUTHORS   De Baere,M.I., Van Gorp,H., Delputte,P.L. and Nauwynck,H.J.
  TITLE     Interaction of the European genotype porcine reproductive and
            respiratory syndrome virus (PRRSV) with sialoadhesin
            (CD169/Siglec-1) inhibits alveolar macrophage phagocytosis
  JOURNAL   Vet Res 43 (1), 47 (2012)
   PUBMED   22630829
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6671)
  AUTHORS   Delputte,P.L., Van Gorp,H., Favoreel,H.W., Hoebeke,I., Delrue,I.,
            Dewerchin,H., Verdonck,F., Verhasselt,B., Cox,E. and Nauwynck,H.J.
  TITLE     Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that
            allows targeted delivery of toxins and antigens to macrophages
  JOURNAL   PLoS One 6 (2), e16827 (2011)
   PUBMED   21359217
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6671)
  AUTHORS   Van Breedam,W., Van Gorp,H., Zhang,J.Q., Crocker,P.R.,
            Delputte,P.L. and Nauwynck,H.J.
  TITLE     The M/GP(5) glycoprotein complex of porcine reproductive and
            respiratory syndrome virus binds the sialoadhesin receptor in a
            sialic acid-dependent manner
  JOURNAL   PLoS Pathog 6 (1), e1000730 (2010)
   PUBMED   20084110
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6671)
  AUTHORS   Vanderheijden,N., Delputte,P.L., Favoreel,H.W., Vandekerckhove,J.,
            Van Damme,J., van Woensel,P.A. and Nauwynck,H.J.
  TITLE     Involvement of sialoadhesin in entry of porcine reproductive and
            respiratory syndrome virus into porcine alveolar macrophages
  JOURNAL   J Virol 77 (15), 8207-8215 (2003)
   PUBMED   12857889
REFERENCE   7  (bases 1 to 6671)
  AUTHORS   Nakamura,K., Yamaji,T., Crocker,P.R., Suzuki,A. and Hashimoto,Y.
  TITLE     Lymph node macrophages, but not spleen macrophages, express high
            levels of unmasked sialoadhesin: implication for the adhesive
            properties of macrophages in vivo
  JOURNAL   Glycobiology 12 (3), 209-216 (2002)
   PUBMED   11971865
  REMARK    GeneRIF: Sialoadhesin is a macrophage-restricted adhesion molecule
            that recognizes N-acetylneuraminylalpha2-3galactose structure.
            Macrophages in lymph nodes express high levels of unmasked
            sialoadhesin.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On Oct 4, 2007 this sequence version replaced XM_230608.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00155304, SAMEA5756307
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..6671
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..6671
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /note="sialic acid binding Ig like lectin 1"
                     /db_xref="GeneID:311426"
                     /db_xref="RGD:1311953"
     exon            1..761
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     CDS             713..5542
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /note="sialic acid binding Ig-like lectin 1, sialoadhesin"
                     /codon_start=1
                     /product="sialoadhesin precursor"
                     /protein_id="NP_001101247.1"
                     /db_xref="GeneID:311426"
                     /db_xref="RGD:1311953"
                     /translation="MCALLSLLLLASVFTPGQTTWGVSSPKDVQGLTGSCLLIPCIFS
                     FPADVSVPNGITAIWYYDYSGKRQVVIHSGDPKLVDERFRGRAELTGNMDHKVCNLLL
                     KDLKLEDSGTYNFRFEISDGNRWSDVRGTTVTVTKDPSPPTITIPHELREGVEVNVNC
                     STPYLCLQEKQVSLHWQGQDPTRSVISNFQSLEPTGVYHQTTLHMAPSWQDHRRTLRC
                     QLSLATHSSQKEVYLQVQHAPKGVEILLSSSGRNILPGNLVTLTCRVNSSYPAVSSVD
                     WVKDGVNLTAKGHVLQLSSATWNDSGVYTCQATNNVGSLASPPLSLHVFMAEVKINPA
                     GPILENETVTLLCSTPKEAPQELRYSWYKNNILLEDAHAPTLHLPAVTRADTGFYFCE
                     VQNTQGSERSGPVSVVVRYPPLTPDLTTFLETQAGLVGIFHCSVISEPLATVVLSHGG
                     LTLASSSGENDFNPRFSISSAPNSVRLEIRDLQPADSGEYTCSATNSLGKSMSSLDFH
                     ANDPPRKLTFTARLDLDTSGDGDGRRGILLCQVDSDPPAQLQLLHKGHVVATSLPSMC
                     GSCSRRMKVSRASNSLQVEIQKPVLEDEGMYLCEASNTLGNSSVSASFNAKATVVVIT
                     PSDTLLEGTEASLTCNVTQEVAVSPANFSWFRNGVLWTQGPLETVRLQPLARTDAAVY
                     ACRLLTDDGAQLSAPVVLSVQYAPDPPKLSALLDVGQGHMAVFICTVDSYPLAHLSLF
                     RGERLLATSLEPQRLSHGRIQAKATANSLQLEVRELGLEDSGNYHCEATNVLGSANSS
                     LFFQVRGAWVQVSPSPELREGQAVVLSCQVPTGVPEGTSYRWFQDGRPLQESTSSILR
                     IAAISLRQAGAYHCQAQAPDTAAASLAAPVSLHVSYTPRHVTLSALLSTGPGRYGHLV
                     CSAQSDPPALLRLFHQNRLVASTLQGPEELASSNPRLHVAVSSNELRLEIQFTELEDG
                     GTYTCEATNTLGQASATADFDAQAVRVAVWPNATVQEGQQVNLSCLAWSTHQDSLSYT
                     WYKGGQQLLGVRSISLPSVTVSDATSYRCGVGLPGHTPHLSRPVTLDVLYAPRSLQLT
                     YLLESQGRRLALVLCTVDSRPPAQLTLSHGGQLLASSTEASVPNTLRLELQDPKPSDE
                     GLYSCSAQSPLGKVNTSLALRLEGVRVRMNPSATVPEGEPVTVTCEDPAALSPALYAW
                     FHNGHWLQEGPASSLQFPVTTQAHAGAYFCQVHDTQGTRSSRPASLQILYAPRDAVLS
                     SFRDSRTRHMVVIQCTVDSEPPAELVLSRNSKVLAASRELHSSAPGISHVQAARNALR
                     LQVQDTTFGDGNTYVCTARNTLGSISTTHKLLRETDIHVTAEPGLDVPEGTALNLSCH
                     LPGGSQPVGNSSFTWFWNRHLLHSAPVPTLSFTPVVRAQAGSYHCRAELSTGVTTSPP
                     VMLRVLYPPKTPTLTVFVEPQGGHQGILDCRVDSEPLASLTLQLGSQLVASNQPHSAP
                     TQPHIRVTAPPNALRLDIEELGPNNQGEYVCTASNALGSASASAYFGTRALQQLQLFQ
                     RLLWVLGFLAGFLGLLLGLGACYSWRKKNSSKLNVNENSAEMTTQKDNIQEETVAAV"
     exon            762..1121
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1421
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1688
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1943
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2243
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2564
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2822
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..3125
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3386
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3698
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3950
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4220
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            4221..4472
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            4473..4778
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            4779..5039
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            5040..5342
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            5343..5445
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            5446..5518
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
     exon            5519..6671
                     /gene="Siglec1"
                     /gene_synonym="Sn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacaagagt tggtctagag tctatgaagc ctagagtcta tgaagcctag agtctatgaa
       61 gcagagagaa aggggacaac ataggaggta agaaatggag gtctctcaaa atctcagggg
      121 caacgaggag tttttttgag agaggaatga ctctttaaag ccaacatctt atcaggaggc
      181 tgaaggagga ttctgtgaat ttgagaccac cctgagcttc caagttgaga actttatcta
      241 ccaacaagca aggcagcctc agcactttgg gaagttcagt cagattcagc ccagcttgta
      301 gctggaaagg ccgaaggcag aagacaaatc tcaaagaaat gcactgtgct tactggatgc
      361 tctggagtaa gttacagggt ctcatggact ccgggttctg tcagtttaag taacaggagg
      421 tggcagggaa aagagagacg tgcactgctg cccagccttg aggctgtgtc cttaaggggt
      481 ggagccaagg gacacagaag actttctggg gcatgccacc gaatgagagc atttccaagc
      541 atttctggtt ccctgctggt gactgtcaca gaagtcctta ggaactctgc cttccttttg
      601 ggttggccaa caaagcagtg aggtaaaccc tgtagactcg ggcactgaag tgctccagga
      661 acccatccta ccatcctgcc atctcaggca cctgacccac ctgagaacca ggatgtgtgc
      721 cctgctctcc ttgctcctgc tggcctcggt cttcacacca ggccagacca cgtggggtgt
      781 ctccagtccc aaggatgtgc agggcttgac tggatcttgc ctgctcattc cctgcatctt
      841 cagcttccct gctgatgtat cagtgcctaa tggcatcaca gccatctggt actatgacta
      901 ctcgggcaaa cggcaggtgg taatccactc aggggacccc aagctggtgg atgagcgctt
      961 caggggcaga gctgaactga cagggaacat ggatcacaag gtgtgcaacc tgttgctcaa
     1021 agacctgaag cttgaagact caggcaccta caacttccgc tttgagatca gtgatggcaa
     1081 ccgctggtct gatgtcagag gcaccacagt cactgtgaca aaggatccca gtccccccac
     1141 tattaccatc ccacatgagc tgcgtgaagg tgtggaggtg aacgtcaact gttccacacc
     1201 ctacctgtgc ctgcaggaga agcaggtcag cctgcattgg caaggccagg accccacccg
     1261 ctccgtcatc tccaacttcc agagcctcga gcccactggc gtctaccacc agacgaccct
     1321 acatatggcc ccatcctggc aggaccacag acggaccctg cgctgccagc tgtcattggc
     1381 cacgcacagt agtcagaaag aggtttatct acaagtgcag catgccccca aaggtgtgga
     1441 gatcctcctt agctcctcag gaaggaacat ccttccaggg aacctggtca cgctcacctg
     1501 ccgggtgaat agcagctatc ctgccgtcag ttctgtggat tgggtcaagg atggagtgaa
     1561 cctcacagcc aaggggcatg tgctccagct atcctcagca acctggaatg attctggggt
     1621 ctacacctgt caagcaacaa ataatgtggg ctctctggca tcacccccac tcagcctcca
     1681 cgtttttatg gctgaagtca agataaaccc agcagggccc atcttggaaa atgagacagt
     1741 gacactcctc tgtagcaccc ccaaggaggc accccaggag ctccgctaca gctggtacaa
     1801 gaacaacatt cttctggaag acgcccatgc cccaaccttg cacctgcctg cagtcaccag
     1861 ggctgatact ggcttctatt tctgtgaggt gcagaacacc cagggcagtg agcgctccgg
     1921 tccagtgagt gtggtggtca gatatccacc tcttactcca gacctgacca ccttcttgga
     1981 gacacaggct ggacttgtgg gcatcttcca ttgctctgtg atcagcgagc ccctggctac
     2041 tgtggtactg tcacacggag gtctcacatt ggcctccagc tctggagaaa atgacttcaa
     2101 cccccgattc agcatttcct ctgcccccaa ctccgtgcgc ctagaaatcc gagacttgca
     2161 gccagcggac agcggggagt acacatgctc agccaccaac tcccttggaa aatcaatgtc
     2221 cagcctagac ttccatgcaa atgatccccc aagaaagctc acattcactg ccaggctgga
     2281 tttggatacc tctggagacg gggatggacg gcgtggcatc ctcttgtgcc aagtagacag
     2341 tgatccccca gcccagctac agcttctcca caaaggtcat gttgtggcca cttctctgcc
     2401 atcaatgtgt gggagctgct ctcggcgcat gaaagtcagc agagcctcca actcactgca
     2461 ggtggagatc cagaagccgg tactagagga tgagggcatg tacctgtgtg aggctagcaa
     2521 cacactgggc aactcctctg tctcagcctc tttcaatgct aaggctactg tcgtggtcat
     2581 cacaccgtca gatacactgc ttgaaggcac agaagccagc ctaacttgta acgtgaccca
     2641 ggaggttgcc gtcagccctg ccaacttttc ttggttccgg aatggagtgc tgtggaccca
     2701 gggaccactg gagactgtga ggctgcagcc tctggccagg actgatgctg ccgtctatgc
     2761 ctgccgcctc ctcactgacg atggggccca gctctcggct cctgtggtcc taagtgtgca
     2821 gtatgcccca gaccctccaa agctgtcagc cctcctggat gtgggtcagg gccacatggc
     2881 tgtgttcatc tgcactgtgg acagctatcc cctggctcac ctgtctctat tccgtgggga
     2941 gcgcctcctg gccaccagct tggaacccca gcgtctatcc catggtagaa tccaggccaa
     3001 ggccacagcc aactccctgc agctagaggt ccgggaacta ggccttgaag actctggaaa
     3061 ctaccactgt gaagccacaa atgttcttgg atcagccaac agttcactct tcttccaggt
     3121 cagaggagcc tgggtccagg tttcgccatc acctgagctc cgagagggcc aggctgtggt
     3181 cctgagctgc caggtgccca caggggtgcc tgagggaacc tcataccgct ggtttcagga
     3241 tggccgcccc ctccaggagt caacctcatc tatattgcgc attgcagcca taagtctgag
     3301 gcaagctggt gcctaccatt gccaagctca ggctccagac acagctgcag ccagcctggc
     3361 tgcccctgtc agcctccatg tgtcctatac cccacgtcac gtgacactca gcgccctgct
     3421 gagcacgggc cctgggcgat acggccacct ggtgtgcagt gcacaaagtg accctccagc
     3481 tctgctgcga ctgttccacc agaatcgcct cgtggcctct accctacaag gcccggagga
     3541 attggcaagc agtaatcccc ggctgcatgt ggctgtgagc tccaatgagt tgcgcctgga
     3601 gatccaattc acagagctgg aggatggtgg gacctacaca tgtgaagcca ccaacacact
     3661 gggccaggca tctgctacag ctgacttcga tgcccaggct gtgcgtgtgg ccgtgtggcc
     3721 caatgccact gtgcaagagg ggcagcaggt gaacctcagc tgcttggcgt ggagcaccca
     3781 ccaggactca ctcagctaca catggtacaa gggcggccaa caactgcttg gtgtcagatc
     3841 catctccctg cccagcgtta cagtttcgga tgctacctcc taccgctgcg gtgtggggct
     3901 ccctggccac acaccccatc tctccagacc tgtgaccctg gatgtcctct acgctccccg
     3961 aagcctgcag ctgacctacc tcctggagag ccagggccgg cggctggccc tggtactgtg
     4021 tactgtggat agtcgcccac ctgcccagct aactctcagc cacggtggcc agctcctagc
     4081 ctcctccact gaagcttccg tccccaacac cctgcgccta gagcttcagg acccgaagcc
     4141 cagtgatgag gggctctaca gctgctctgc ccagagccca ctgggcaagg tcaacacatc
     4201 cctggcgctt cggctggaag gtgtacgagt gaggatgaat ccctctgcta ctgtacccga
     4261 gggggagcct gtcacagtga cctgcgagga ccctgctgcc ctctcacctg cactctatgc
     4321 ctggtttcac aatggccatt ggcttcagga gggaccagct tcgtcactcc agttcccagt
     4381 gacgacacag gctcatgctg gcgcttactt ttgccaggtg catgatactc agggcacgcg
     4441 gagctccaga cctgccagcc tgcaaattct ctatgccccc cgggatgctg tcctgtcttc
     4501 cttccgagac tccaggacca ggcacatggt cgtgattcag tgcaccgtgg acagtgaacc
     4561 acctgctgag ctggttctct cccgaaacag caaggtgcta gctgccagcc gtgagcttca
     4621 cagctcagca cccgggataa gccacgtcca ggcagcccgg aatgctcttc gactacaggt
     4681 gcaagacacg acttttggtg atggcaacac ttacgtttgc acagcccgga atacactggg
     4741 ctccatcagt accacccaca agcttctgag ggagactgat atacatgtga cagctgagcc
     4801 aggcttggat gtgccagagg gcacagctct aaacctgagc tgccacctcc ccggtggctc
     4861 ccagcctgtg ggcaactctt ccttcacgtg gttctggaat cgccatctcc tacattcagc
     4921 tcctgtgccc acactctcct tcacccctgt ggtccgggct caggctgggt cgtaccactg
     4981 cagggctgag ctctccactg gggttactac ctcacctccc gtcatgctcc gtgtcctcta
     5041 tcctcccaag actcccactc tcacagtgtt tgtggaacct cagggtggcc atcagggcat
     5101 cctcgactgt cgagtggaca gtgagcccct ggccagtctc accctccagc tgggcagtca
     5161 actagtagct tctaaccaac cgcacagcgc tcccacccag ccccacatcc gagtcactgc
     5221 tcctcccaat gccttgagac tggacataga ggagctcgga cctaacaatc aaggggagta
     5281 tgtgtgcaca gcctccaacg ctctgggctc tgcctcagcc tcagcctact ttgggaccag
     5341 agccctgcag cagctgcagc tgttccagag gctgctctgg gtcctgggat ttctggcagg
     5401 cttcctgggc ctgctgctgg gcctaggggc ctgttacagc tggagaaaga agaattctag
     5461 caaactgaat gtgaatgaga attcagcaga gatgaccact cagaaagata atatccagga
     5521 ggagacggtt gctgctgtct gacagctcag gtgctgtgaa caaggtcctg cctacctctg
     5581 tataagcagc acagagacat ctggctttcc tgacctgcct gacttgccct ccaagcctct
     5641 tgttcctaag aaaaaatgga tgaagggagg tttggggatg gaggtcaatc tgctgcctgc
     5701 agggctctga gactgactca gccatgttgc ccatgtctct ctgtgtggtt ttcctttgta
     5761 tcccttcgcc tttctcttca aggctcactt tgggactttc ttggtgggtt agagcagcat
     5821 ccatgtcctc gtggactttc tgagaccgtc tgtaccagcc aagatataag tcaggctgct
     5881 ctaacagaga ctcaatacag tgaccacagc acgacagagt cttggttttc tctcctggtc
     5941 tggttatgct ggttactttt ctccataccc caagtgttgc ctttgattat gaagctgagc
     6001 tgactgcagt ggccatggac cctacagtga aaaggaagag agaaggggaa gcatgcccat
     6061 ccccatggtc catggactgt atacaattgc accccaccca cttctcatca gctagaaatt
     6121 ggtcacgtaa acacactgta caacaaggga gactgggaaa tatagttttt tattctgagt
     6181 cttggctaca cttggatcct gtctttctga aagatcccaa ctgtggactc agccccagga
     6241 attttgatgt tgaagagagt agcattatca ggctagggtc tgaattggtg tcctgggaca
     6301 ttctgtttca tagtttcctg aaaggtacac tctcccttac attttaaact gaggaagcca
     6361 aaattttgtg gttcctagat gtcttactta tcgttctttt gctgcgagga ggagacacta
     6421 tgaccaagtt aaatctttta aaagaaagca tttatctggg gatttgctta cagttttaga
     6481 gtgttagtcc atgatcatca tggtagggag caggaagtgg ggggagggag aggaggagag
     6541 ggagatagac aaatagatat agtaggtaga tagatgatag atagatagat agatagatag
     6601 atagatagat agatagatag agacagacag acagacagac agacagacag acagacagac
     6661 agacagaccg a
//
