LOCUS       NM_001024887            1634 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus single Ig and TIR domain containing (Sigirr),
            mRNA.
ACCESSION   NM_001024887 XM_219479
VERSION     NM_001024887.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Wu,W., Wang,Y., Zou,J., Long,F., Yan,H., Zeng,L. and Chen,Y.
  TITLE     Bifidobacterium adolescentis protects against necrotizing
            enterocolitis and upregulates TOLLIP and SIGIRR in premature
            neonatal rats
  JOURNAL   BMC Pediatr 17 (1), 1 (2017)
   PUBMED   28056921
  REMARK    GeneRIF: This study demonstrated B. adolescentis prevents NEC in
            preterm neonatal rats and that the mechanism for this action might
            be associated with the alteration of TLR4, TOLLIP, and SIGIRR
            expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Sims,J.E. and Smith,D.E.
  TITLE     The IL-1 family: regulators of immunity
  JOURNAL   Nat Rev Immunol 10 (2), 89-102 (2010)
   PUBMED   20081871
  REMARK    Review article
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Wald,D., Qin,J., Zhao,Z., Qian,Y., Naramura,M., Tian,L., Towne,J.,
            Sims,J.E., Stark,G.R. and Li,X.
  TITLE     SIGIRR, a negative regulator of Toll-like receptor-interleukin 1
            receptor signaling
  JOURNAL   Nat Immunol 4 (9), 920-927 (2003)
   PUBMED   12925853
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Thomassen,E., Renshaw,B.R. and Sims,J.E.
  TITLE     Identification and characterization of SIGIRR, a molecule
            representing a novel subtype of the IL-1R superfamily
  JOURNAL   Cytokine 11 (6), 389-399 (1999)
   PUBMED   10346978
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097488.1.
            
            On Jun 17, 2005 this sequence version replaced XM_219479.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097488.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1634
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /note="single Ig and TIR domain containing"
                     /db_xref="GeneID:309106"
                     /db_xref="RGD:1306732"
     exon            1..45
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /inference="alignment:Splign:2.1.0"
     exon            46..207
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1430
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /note="TIR8; single immunoglobulin and toll-interleukin 1
                     receptor (TIR) domain; toll/interleukin-1 receptor 8;
                     single Ig IL-1R-related molecule; single immunoglobulin
                     domain-containing IL1R-related protein"
                     /codon_start=1
                     /product="single Ig IL-1-related receptor"
                     /protein_id="NP_001020058.1"
                     /db_xref="GeneID:309106"
                     /db_xref="RGD:1306732"
                     /translation="MAGVCDRVPNFLSPSEDQALGPALGSAVALNCTAWVFSRPQCPQ
                     PSVQWLKDGLALGNGSHFSLHQDFWVSDNFSEIVSSVLVFNLTKAEDYGTFTCSAWNV
                     SSHSFTLWRAGPAGHVAAVLASLLVLVVLLLVALLYVKCRLNVLLWYQDTYGEVEMND
                     GKLYDAYVSYSDRPEDRKFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLS
                     RCRRLIVVLSDAFLRRPWCSQSFREGLCRLLELTRRPIFITFEGQRREPIHPALRLLR
                     QHRHLVTLLLWKPGSVTPSSDFWKELQLALPRKVQYRPVEGDPQTRLQDDKDPMLIVR
                     GRAAQGRAMESELDPDPEGDLGVRGPVFGEPPTPLHESKVSIGEGHASEMDVSDLGSR
                     NYSARTDFYCLVSEDDV"
     exon            208..406
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /inference="alignment:Splign:2.1.0"
     exon            407..537
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /inference="alignment:Splign:2.1.0"
     exon            538..678
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /inference="alignment:Splign:2.1.0"
     exon            679..822
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /inference="alignment:Splign:2.1.0"
     exon            823..925
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1076
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1266
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1595
                     /gene="Sigirr"
                     /gene_synonym="RGD1306732"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgaaagc aggtgggtgg cagtcgtgtc tcagacttta tggagcctct gacctccaag
       61 acctcctgtc catctggttg aatagacaga aaggagtcct cctcagcgtt cagtggaccc
      121 agctgctcgg ttaaggagct accgtggtgc caggggtgga accagggttg agcctgcggt
      181 gaagaggtcc tgggagagcc atggcaggtg tctgtgacag ggtccctaat ttcctttccc
      241 catctgaaga ccaagccctg ggacctgccc ttggcagtgc agttgctttg aattgcacag
      301 cttgggtgtt ctctaggccc cagtgtcccc agccatcagt acaatggcta aaagatggtc
      361 tggcattggg caatggaagc cacttcagcc tccatcaaga cttctgggtc agtgacaact
      421 tctcggagat tgtgtccagt gttctggtgt tcaacttgac caaagctgag gactatggaa
      481 ccttcacttg ttctgcctgg aacgtcagct cccactcctt cactctctgg cgagctggcc
      541 ctgccggcca tgtggctgcg gtgctggctt ccctccttgt cctagtggtt ctgctgctgg
      601 tggcccttct ctatgttaag tgtcgtctga acgtgctgct ttggtaccaa gacacttacg
      661 gggaggtaga gatgaatgat gggaagttat acgatgcgta cgtgtcctat agcgaccgcc
      721 cagaggaccg caaatttgta aattttattc tgaagcctca gttggagcgg cgtcggggat
      781 acaagctctt cctagaggac cgcgacctct tgccgcgagc ggagccctct gccgaccttt
      841 tggtgaacct gagtcgctgt cggcgtctca tcgtggttct ttcagatgcc ttcctcagac
      901 gtccctggtg tagccagagc ttccgggagg gactgtgccg cctactggag ctcacccgca
      961 gacctatctt tatcaccttc gagggccaga ggcgtgagcc cattcaccct gctctccgtc
     1021 tcctgcgcca gcaccgccac ctcgtgaccc tgctgctttg gaagcctggc tccgtgacac
     1081 cttcctctga tttttggaaa gagctacagt tggcactacc acggaaggtg caatacagac
     1141 ccgtggaggg agacccccaa acccgacttc aggatgacaa agatcccatg ctaatcgtga
     1201 gaggacgtgc tgcccagggc cgggccatgg agtcagagct ggatccagac cctgagggag
     1261 acctgggtgt ccgtggacct gtctttgggg agccaccaac tccactacac gaaagcaagg
     1321 tctccatagg agagggccat gccagtgaaa tggatgtctc tgaccttggc tctcgaaact
     1381 acagtgcgcg aacagacttc tactgccttg tgtctgagga tgacgtgtag cccttatcct
     1441 agcagcccag agcatgagat catggcggca gcttccaggg tagaggtggg catcccttcc
     1501 tcctaggacc acaacaaccc ttgcttctat ccctgggccc ctgggaagga gtgtggtttc
     1561 agggcgtcac aaataaaatc ctcttggttc ctgccaaaaa aaaaaaaaaa aaaaaaaaaa
     1621 aaaaaaaaaa aaaa
//
